PI3K / Akt Signaling

No Pathway Network information available for PI3K / Akt Signaling

Pathways in the PI3K / Akt Signaling SuperPath

#	Name	Source	Genes
1	PI3K / Akt Signaling	Cell Signaling Technology	AKT1 AKT1S1 AKT2 AKT3 ATP6V1B2 BAD BORCS6 BRF2 CAD DDIT4 DEPTOR DPYSL2 ERAS FKBP5 FNIP2 FOXA2 FOXO1 FOXO3 FOXO4 GRB10 GSK3A GSK3B HTT INPP4B INPPL1 KIF1B LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 LARS1 MACC1 MAP4K3 MAPKAP1 MDM2 MIOS MOB1A MOB1B NDRG1 NDRG2 NDRG3 NDRG4 NOP53 NOS1 NOS3 NPRL2 NR4A1 PARK7 PDPK1 PHLDA3 PI4KA PIK3C2A PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PPP1R10 PRKD2 PRR5L PTEN RANBP3 RHEB RPS6KB2 RRAGB SEMA4B SGK1 SGK2 SGK3 SH3BP4 SPAG5 SYAP1 TBC1D7 TCL1A THEM4 TNS2 TSC1 TSC2 WDR59 WNK1 WNK4 WWTR1 YAP1 YBX1 ZFP36L1 ZFYVE26 (see all 92) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
2	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
3	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
4	ATP6V1B2	ATPase H+ Transporting V1 Subunit B2	Protein Coding	1
5	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
6	BORCS6	BLOC-1 Related Complex Subunit 6	Protein Coding	1
7	ZFP36L1	ZFP36 Ring Finger Protein Like 1	Protein Coding	1
8	CAD	Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, And Dihydroorotase	Protein Coding	1
9	DPYSL2	Dihydropyrimidinase Like 2	Protein Coding	1
10	THEM4	Thioesterase Superfamily Member 4	Protein Coding	1
11	DDIT4	DNA Damage Inducible Transcript 4	Protein Coding	1
12	DEPTOR	DEP Domain Containing MTOR Interacting Protein	Protein Coding	1
13	PARK7	Parkinsonism Associated Deglycase	Protein Coding	1
14	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
15	ERAS	ES Cell Expressed Ras	Protein Coding	1
16	FKBP5	FKBP Prolyl Isomerase 5	Protein Coding	1
17	FNIP2	Folliculin Interacting Protein 2	Protein Coding	1
18	FOXA2	Forkhead Box A2	Protein Coding	1
19	FOXO1	Forkhead Box O1	Protein Coding	1
20	FOXO3	Forkhead Box O3	Protein Coding	1
21	FOXO4	Forkhead Box O4	Protein Coding	1
22	NOP53	NOP53 Ribosome Biogenesis Factor	Protein Coding	1
23	GRB10	Growth Factor Receptor Bound Protein 10	Protein Coding	1
24	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
25	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
26	LAMTOR5	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5	Protein Coding	1
27	HTT	Huntingtin	Protein Coding	1
28	INPP4B	Inositol Polyphosphate-4-Phosphatase Type II B	Protein Coding	1
29	MAP4K3	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3	Protein Coding	1
30	KIF1B	Kinesin Family Member 1B	Protein Coding	1
31	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	1
32	LAMTOR2	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 2	Protein Coding	1
33	LAMTOR3	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3	Protein Coding	1
34	LAMTOR4	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4	Protein Coding	1
35	LARS1	Leucyl-TRNA Synthetase 1	Protein Coding	1
36	MACC1	MET Transcriptional Regulator MACC1	Protein Coding	1
37	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
38	MIOS	Meiosis Regulator For Oocyte Development	Protein Coding	1
39	MOB1A	MOB Kinase Activator 1A	Protein Coding	1
40	MOB1B	MOB Kinase Activator 1B	Protein Coding	1
41	NDRG1	N-Myc Downstream Regulated 1	Protein Coding	1
42	NDRG2	NDRG Family Member 2	Protein Coding	1
43	NDRG3	NDRG Family Member 3	Protein Coding	1
44	NDRG4	NDRG Family Member 4	Protein Coding	1
45	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
46	NPRL2	NPR2 Like, GATOR1 Complex Subunit	Protein Coding	1
47	NR4A1	Nuclear Receptor Subfamily 4 Group A Member 1	Protein Coding	1
48	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	1
49	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
50	PHLDA3	Pleckstrin Homology Like Domain Family A Member 3	Protein Coding	1
51	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	1
52	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
53	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
54	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
55	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
56	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
57	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
58	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
59	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
60	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	1
61	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
62	PI4KA	Phosphatidylinositol 4-Kinase Alpha	Protein Coding	1
63	PPP1R10	Protein Phosphatase 1 Regulatory Subunit 10	Protein Coding	1
64	AKT1S1	AKT1 Substrate 1	Protein Coding	1
65	PRKD2	Protein Kinase D2	Protein Coding	1
66	PRR5L	Proline Rich 5 Like	Protein Coding	1
67	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
68	RANBP3	RAN Binding Protein 3	Protein Coding	1
69	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
70	RRAGB	Ras Related GTP Binding B	Protein Coding	1
71	SEMA4B	Semaphorin 4B	Protein Coding	1
72	SGK1	Serum/Glucocorticoid Regulated Kinase 1	Protein Coding	1
73	SGK2	Serum/Glucocorticoid Regulated Kinase 2	Protein Coding	1
74	SGK3	Serum/Glucocorticoid Regulated Kinase Family Member 3	Protein Coding	1
75	SH3BP4	SH3 Domain Binding Protein 4	Protein Coding	1
76	INPPL1	Inositol Polyphosphate Phosphatase Like 1	Protein Coding	1
77	MAPKAP1	MAPK Associated Protein 1	Protein Coding	1
78	SPAG5	Sperm Associated Antigen 5	Protein Coding	1
79	SYAP1	Synapse Associated Protein 1	Protein Coding	1
80	WWTR1	WW Domain Containing Transcription Regulator 1	Protein Coding	1
81	TBC1D7	TBC1 Domain Family Member 7	Protein Coding	1
82	TCL1A	TCL1 Family AKT Coactivator A	Protein Coding	1
83	TNS2	Tensin 2	Protein Coding	1
84	BRF2	BRF2 General Transcription Factor IIIB Subunit	Protein Coding	1
85	TSC1	TSC Complex Subunit 1	Protein Coding	1
86	TSC2	TSC Complex Subunit 2	Protein Coding	1
87	WDR59	WD Repeat Domain 59	Protein Coding	1
88	WNK1	WNK Lysine Deficient Protein Kinase 1	Protein Coding	1
89	WNK4	WNK Lysine Deficient Protein Kinase 4	Protein Coding	1
90	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	1
91	YBX1	Y-Box Binding Protein 1	Protein Coding	1
92	ZFYVE26	Zinc Finger FYVE-Type Containing 26	Protein Coding	1

Disorders associated with PI3K / Akt Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hemimegalencephaly	Enrichment	AKT3, PIK3CA, PTEN, RHEB	8.01
2	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	5.92
3	Focal cortical dysplasia, type ii	Enrichment	RHEB, TSC1, TSC2	5.92
4	Isolated focal cortical dysplasia type ii	Enrichment	RHEB, TSC1, TSC2	5.92
5	Adult hepatocellular carcinoma	Enrichment	PIK3CA, TSC1, TSC2	4.61
6	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	4.61
7	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.34
8	Meningioma	Enrichment	AKT1, PIK3CA, PTEN	4.20
9	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	3.87
10	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.87
11	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	3.87
12	Hamartoma	Enrichment	TSC1, TSC2	3.87
13	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	3.87
14	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	3.57
15	Malignant epithelioid hemangioendothelioma	Enrichment	WWTR1, YAP1	3.57
16	Tuberous sclerosis	Enrichment	TSC1, TSC2	3.57
17	Ovarian cancer	Enrichment	AKT1, KIF1B, PIK3CA, PTEN, TSC2	3.21
18	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	3.17
19	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	3.17
20	Bladder cancer	Enrichment	PIK3CA, PTEN, TSC1	3.01
21	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.70
22	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, SGK2	2.54
23	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA, PTEN	2.49
24	Myeloma, multiple	Enrichment	PIK3R2, SGK1, YAP1	2.19
25	Macrodactyly	Enrichment	PIK3CA	2.17
26	Proteus syndrome	Enrichment	AKT1	2.17
27	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.17
28	Charcot-marie-tooth disease, axonal, type 2a1	Enrichment	KIF1B	2.17
29	Deafness, congenital, with onychodystrophy, autosomal dominant	Enrichment	ATP6V1B2	2.17
30	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.17
31	Vacterl association with hydrocephalus	Enrichment	PTEN	2.17
32	Immunodeficiency due to defect in mapbp-interacting protein	Enrichment	LAMTOR2	2.17
33	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.17
34	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	2.17
35	Infantile liver failure syndrome 1	Enrichment	LARS1	2.17
36	Cowden syndrome 5	Enrichment	PIK3CA	2.17
37	Neuroblastoma 1	Enrichment	KIF1B	2.17
38	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.17
39	Accelerated tumor formation	Enrichment	MDM2	2.17
40	Pseudohypoaldosteronism, type iib	Enrichment	WNK4	2.17
41	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.17
42	Lessel-kubisch syndrome	Enrichment	MDM2	2.17
43	Short syndrome	Enrichment	PIK3R1	2.17
44	Pseudohypoaldosteronism, type iic	Enrichment	WNK1	2.17
45	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.17
46	Spastic paraplegia 15, autosomal recessive	Enrichment	ZFYVE26	2.17
47	Papillary tumor of the pineal region	Enrichment	PTEN	2.17
48	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	2.17
49	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.17
50	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.17
51	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.17
52	Parkinson disease 7, autosomal recessive early-onset	Enrichment	PARK7	2.17
53	Charcot-marie-tooth disease type 2a1	Enrichment	KIF1B	2.17
54	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.17
55	Zimmermann-laband syndrome 2	Enrichment	ATP6V1B2	2.17
56	Cowden syndrome 6	Enrichment	AKT1	2.17
57	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.17
58	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.17
59	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.17
60	Glioma susceptibility 2	Enrichment	PTEN	2.17
61	Lopes-maciel-rodan syndrome	Enrichment	HTT	2.17
62	Spastic paraplegia 84, autosomal recessive	Enrichment	PI4KA	2.17
63	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.17
64	Hypospadias	Enrichment	PIK3CA	2.17
65	Capillary hemangioma	Enrichment	AKT3	2.17
66	Non-acquired combined pituitary hormone deficiency	Enrichment	FOXA2	2.17
67	Rare venous malformation	Enrichment	PIK3CA	2.17
68	Diaphragmatic eventration	Enrichment	PIK3CA	2.17
69	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.17
70	Autosomal dominant deafness - onychodystrophy syndrome	Enrichment	ATP6V1B2	2.17
71	Rare combined vascular malformation	Enrichment	PIK3CA	2.17
72	Gastrointestinal defects and immunodeficiency syndrome 2	Enrichment	PI4KA	2.17
73	Cavernous lymphangioma	Enrichment	PIK3CA	2.17
74	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.17
75	Juvenile huntington disease	Enrichment	HTT	2.17
76	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.17
77	Isolated megalencephaly	Enrichment	TBC1D7	2.17
78	Primary immunodeficiency syndrome due to p14 deficiency	Enrichment	LAMTOR2	2.17
79	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.17
80	Silver-russell syndrome due to maternal uniparental disomy of chromosome 7	Enrichment	GRB10	2.17
81	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.17
82	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.17
83	Macrodactyly of toe	Enrichment	PIK3CA	2.17
84	Pi4ka-related disorder	Enrichment	PI4KA	2.17
85	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.17
86	Diffuse large b-cell lymphoma	Enrichment	FOXO1, PTEN	2.14
87	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.06
88	Amyotrophic lateral sclerosis-parkinsonism/dementia complex 1	Enrichment	PARK7	1.87
89	Schneckenbecken dysplasia	Enrichment	INPPL1	1.87
90	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	1.87
91	Keratosis, seborrheic	Enrichment	PIK3CA	1.87
92	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.87
93	Developmental and epileptic encephalopathy 50	Enrichment	CAD	1.87
94	Neurodevelopmental disorder with spasticity, hypomyelinating leukodystrophy, and brain abnormalities	Enrichment	PI4KA	1.87
95	Noonan syndrome 8	Enrichment	PIK3CA	1.87
96	Charcot-marie-tooth disease, demyelinating, type 4d	Enrichment	NDRG1	1.87
97	Senior-loken syndrome 7	Enrichment	AKT3	1.87
98	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.87
99	Immune system disease	Enrichment	PIK3CD	1.87
100	Bardet-biedl syndrome 16	Enrichment	AKT3	1.87
101	Combined immunodeficiency-multiple intestinal atresia	Enrichment	PI4KA	1.87
102	Charcot-marie-tooth disease type 4d	Enrichment	NDRG1	1.87
103	Vacterl with hydrocephalus	Enrichment	PTEN	1.87
104	Juvenile polyposis of infancy	Enrichment	PTEN	1.87
105	Breast cancer	Enrichment	AKT1, PIK3CA, PTEN	1.84
106	Prostate cancer	Enrichment	PIK3CA, PTEN	1.79
107	Zimmermann-laband syndrome 1	Enrichment	ATP6V1B2	1.69
108	Opsismodysplasia	Enrichment	INPPL1	1.69
109	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.69
110	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.69
111	Heparin cofactor ii deficiency	Enrichment	PI4KA	1.69
112	Leber congenital amaurosis 13	Enrichment	ZFYVE26	1.69
113	Tuberous sclerosis 2	Enrichment	TSC2	1.69
114	Deafness, onychodystrophy, osteodystrophy, impaired intellectual development, and seizures syndrome	Enrichment	ATP6V1B2	1.69
115	Macrocephaly/megalencephaly syndrome, autosomal recessive	Enrichment	TBC1D7	1.69
116	Epilepsy, familial focal, with variable foci 2	Enrichment	NPRL2	1.69
117	Dedifferentiated liposarcoma	Enrichment	MDM2	1.69
118	Xanthinuria, type ii	Enrichment	TSC2	1.69
119	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.69
120	Well-differentiated liposarcoma	Enrichment	MDM2	1.69
121	Keratoacanthoma	Enrichment	PIK3CA	1.69
122	Huntington disease	Enrichment	HTT	1.57
123	Neuropathy, hereditary sensory and autonomic, type iia	Enrichment	WNK1	1.57
124	Macular dystrophy with or without cone dysfunction	Enrichment	ZFYVE26	1.57
125	Hereditary sensory and autonomic neuropathy type 2	Enrichment	WNK1	1.57
126	Cerebrovascular disease	Enrichment	PIK3CA	1.57
127	Newborn respiratory distress syndrome	Enrichment	NPRL2	1.57
128	Idiopathic achalasia	Enrichment	NOS1	1.57
129	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.57
130	Glioma	Enrichment	PTEN	1.57
131	Pseudomyogenic hemangioendothelioma	Enrichment	WWTR1	1.57
132	Capillary malformations, congenital	Enrichment	PIK3CA	1.48
133	Alzheimer disease 2	Enrichment	NOS3	1.48
134	Multiple endocrine neoplasia, type iia	Enrichment	KIF1B	1.48
135	Rhabdomyosarcoma 2	Enrichment	FOXO1	1.48
136	Macrocephaly/autism syndrome	Enrichment	PTEN	1.48
137	Major depressive disorder	Enrichment	FKBP5	1.48
138	Liver failure, infantile, transient	Enrichment	LARS1	1.48
139	Pre-eclampsia	Enrichment	NOS3	1.48
140	Hemangioma	Enrichment	PTEN	1.48
141	Acute megakaryocytic leukemia	Enrichment	PTEN	1.48
142	Gastric cancer	Enrichment	PIK3CA, PTEN	1.46
143	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.40
144	Li-fraumeni syndrome	Enrichment	MDM2	1.40
145	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.40
146	Parkinson disease 6, autosomal recessive early-onset	Enrichment	PARK7	1.40
147	Keratoconus	Enrichment	TSC1	1.40
148	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.40
149	Nevus, epidermal	Enrichment	PIK3CA	1.33
150	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.33
151	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.33
152	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.33
153	Epilepsy, familial focal, with variable foci 1	Enrichment	NPRL2	1.33
154	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.33
155	Leukoencephalopathy, brain calcifications, and cysts	Enrichment	BORCS6	1.33
156	Polycystic kidney disease 1	Enrichment	TSC2	1.33
157	Gallbladder cancer	Enrichment	PIK3CA	1.33
158	Megacolon	Enrichment	AKT3	1.33
159	Follicular thyroid carcinoma	Enrichment	PTEN	1.33
160	Overgrowth syndrome	Enrichment	PIK3R1	1.33
161	Neuroblastoma	Enrichment	KIF1B	1.28
162	Combined pituitary hormone deficiency	Enrichment	FOXA2	1.28
163	Arteriovenous malformation	Enrichment	PIK3CA	1.23
164	Bilateral perisylvian polymicrogyria	Enrichment	PI4KA	1.23
165	Inherited cancer-predisposing syndrome	Enrichment	PTEN, TSC1, TSC2	1.22
166	Stroke, ischemic	Enrichment	NOS3	1.18
167	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.18
168	Polymicrogyria	Enrichment	AKT3	1.18
169	Melanoma	Enrichment	PTEN	1.18
170	Asthma	Enrichment	FKBP5	1.14
171	Meningioma, familial	Enrichment	PTEN	1.14
172	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.14
173	Uterine corpus cancer	Enrichment	PTEN	1.14
174	Early-onset parkinson's disease	Enrichment	PARK7	1.11
175	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.11
176	Microphthalmia/coloboma 12	Enrichment	YAP1	1.07
177	Nk-cell enteropathy	Enrichment	PIK3CB	1.07
178	Coloboma of macula	Enrichment	YAP1	1.01
179	Lynch syndrome	Enrichment	PIK3CA	1.01
180	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.01
181	Kidney disease	Enrichment	TSC1	1.01
182	Rhabdomyosarcoma	Enrichment	PTEN	0.99
183	Alzheimer disease, familial, 1	Enrichment	NOS3	0.96
184	Hypertension, essential	Enrichment	NOS3	0.96
185	Charcot-marie-tooth disease type 4	Enrichment	NDRG1	0.94
186	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	KIF1B	0.88
187	Hepatocellular carcinoma	Enrichment	PIK3CA	0.86
188	Precursor t-cell acute lymphoblastic leukemia	Enrichment	TCL1A	0.84
189	Developmental and epileptic encephalopathy 1	Enrichment	CAD	0.81
190	Congenital nervous system abnormality	Enrichment	PTEN, TSC2	0.79
191	Nervous system disease	Enrichment	PTEN, TSC2	0.79
192	Autism spectrum disorder	Enrichment	PTEN, TSC2	0.77
193	Lung cancer	Enrichment	PIK3CA	0.71
194	Eye disease	Enrichment	ZFYVE26	0.67
195	Charcot-marie-tooth disease	Enrichment	NDRG1	0.61
196	Type 2 diabetes mellitus	Enrichment	AKT2	0.60
197	Hereditary spastic paraplegia	Enrichment	ZFYVE26	0.60
198	West syndrome	Enrichment	TSC2	0.59
199	Autosomal dominant non-syndromic intellectual disability	Enrichment	DPYSL2	0.54
200	Hypertelorism	Enrichment	PIK3CA	0.53
201	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.50
202	Primary ovarian insufficiency	Enrichment	NOS3	0.48
203	Leber plus disease	Enrichment	ZFYVE26	0.32
204	Complex neurodevelopmental disorder	Enrichment	HTT	0.24
205	Retinitis pigmentosa	Enrichment	ZFYVE26	0.12
206	Hereditary retinal dystrophy	Enrichment	ZFYVE26	0.06
207	Fundus dystrophy	Enrichment	ZFYVE26	0.06

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PI3K / Akt Signaling

Pathway Network for PI3K / Akt Signaling

Member Pathways for PI3K / Akt Signaling

Pathways in the PI3K / Akt Signaling SuperPath

Associated Genes for PI3K / Akt Signaling

Associated Disorders for PI3K / Akt Signaling

Disorders associated with PI3K / Akt Signaling SuperPath

STRING Interaction Network for PI3K / Akt Signaling

Sources for PI3K / Akt Signaling