PI3K/AKT/mTOR - vitamin D3 signaling

No Pathway Network information available for PI3K/AKT/mTOR - vitamin D3 signaling

Pathways in the PI3K/AKT/mTOR - vitamin D3 signaling SuperPath

#	Name	Source	Genes
1	PI3K/AKT/mTOR - vitamin D3 signaling	WikiPathways	AKT1 CD80 CD86 CYP24A1 GSK3B HK3 HLA-DRA IL10 IL12A LDHA MTOR MYC PDHA1 PFKFB4 PIK3CA PRKAA2 RELA RXRA SLC2A3 TSC1 TSC2 VDR (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PFKFB4	6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4	Protein Coding	1
2	CD86	CD86 Molecule	Protein Coding	1
3	CD80	CD80 Molecule	Protein Coding	1
4	VDR	Vitamin D Receptor	Protein Coding	1
5	TSC2	TSC Complex Subunit 2	Protein Coding	1
6	TSC1	TSC Complex Subunit 1	Protein Coding	1
7	SLC2A3	Solute Carrier Family 2 Member 3	Protein Coding	1
8	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
9	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
10	PRKAA2	Protein Kinase AMP-Activated Catalytic Subunit Alpha 2	Protein Coding	1
11	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
12	PDHA1	Pyruvate Dehydrogenase E1 Subunit Alpha 1	Protein Coding	1
13	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
14	LDHA	Lactate Dehydrogenase A	Protein Coding	1
15	IL12A	Interleukin 12A	Protein Coding	1
16	IL10	Interleukin 10	Protein Coding	1
17	HLA-DRA	Major Histocompatibility Complex, Class II, DR Alpha	Protein Coding	1
18	HK3	Hexokinase 3	Protein Coding	1
19	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
20	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
21	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
22	CYP24A1	Cytochrome P450 Family 24 Subfamily A Member 1	Protein Coding	1

Disorders associated with PI3K/AKT/mTOR - vitamin D3 signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Focal cortical dysplasia, type ii	Enrichment	MTOR, TSC1, TSC2	7.83
2	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, TSC1, TSC2	7.83
3	Adult hepatocellular carcinoma	Enrichment	PIK3CA, TSC1, TSC2	6.51
4	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	5.60
5	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	5.12
6	Hamartoma	Enrichment	TSC1, TSC2	5.12
7	Tuberous sclerosis	Enrichment	TSC1, TSC2	4.82
8	Hemimegalencephaly	Enrichment	MTOR, PIK3CA	4.60
9	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.43
10	Cowden syndrome	Enrichment	AKT1, PIK3CA	4.05
11	Meningioma	Enrichment	AKT1, PIK3CA	3.78
12	Behcet syndrome	Enrichment	IL10, IL12A	3.37
13	Ovarian cancer	Enrichment	AKT1, PIK3CA, TSC2	3.25
14	Hepatocellular carcinoma	Enrichment	PIK3CA, VDR	3.25
15	Bladder cancer	Enrichment	PIK3CA, TSC1	3.00
16	Macrodactyly	Enrichment	PIK3CA	2.79
17	Proteus syndrome	Enrichment	AKT1	2.79
18	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.79
19	Cowden syndrome 5	Enrichment	PIK3CA	2.79
20	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.79
21	Graft-versus-host disease	Enrichment	IL10	2.79
22	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.79
23	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.79
24	Cowden syndrome 6	Enrichment	AKT1	2.79
25	Graham little-piccardi-lassueur syndrome	Enrichment	HLA-DRA	2.79
26	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.79
27	Rickets	Enrichment	VDR	2.79
28	Hypospadias	Enrichment	PIK3CA	2.79
29	Rare venous malformation	Enrichment	PIK3CA	2.79
30	Diaphragmatic eventration	Enrichment	PIK3CA	2.79
31	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.79
32	Rare combined vascular malformation	Enrichment	PIK3CA	2.79
33	Cavernous lymphangioma	Enrichment	PIK3CA	2.79
34	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.79
35	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.79
36	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.79
37	Macrodactyly of toe	Enrichment	PIK3CA	2.79
38	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.64
39	Burkitt lymphoma	Enrichment	MYC	2.49
40	Fanconi-bickel syndrome	Enrichment	LDHA	2.49
41	Hypercalcemia, infantile, 1	Enrichment	CYP24A1	2.49
42	Keratosis, seborrheic	Enrichment	PIK3CA	2.49
43	Noonan syndrome 8	Enrichment	PIK3CA	2.49
44	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.49
45	Cebalid syndrome	Enrichment	MTOR	2.49
46	Rela fusion-positive ependymoma	Enrichment	RELA	2.49
47	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.49
48	Smith-kingsmore syndrome	Enrichment	MTOR	2.49
49	Autosomal recessive infantile hypercalcemia	Enrichment	CYP24A1	2.49
50	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.31
51	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	2.31
52	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	2.31
53	Tuberous sclerosis 2	Enrichment	TSC2	2.31
54	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.31
55	Xanthinuria, type ii	Enrichment	TSC2	2.31
56	Keratoacanthoma	Enrichment	PIK3CA	2.31
57	Huntington disease	Enrichment	SLC2A3	2.19
58	Pyruvate dehydrogenase e1-alpha deficiency	Enrichment	PDHA1	2.19
59	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.19
60	Cerebrovascular disease	Enrichment	PIK3CA	2.19
61	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.19
62	Breast cancer	Enrichment	AKT1, PIK3CA	2.19
63	Capillary malformations, congenital	Enrichment	PIK3CA	2.09
64	Vitamin d-dependent rickets, type 2a	Enrichment	VDR	2.09
65	Colorectal cancer	Enrichment	AKT1, PIK3CA	2.06
66	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	2.01
67	Cowden syndrome 1	Enrichment	PIK3CA	2.01
68	Hemihyperplasia, isolated	Enrichment	PIK3CA	2.01
69	Keratoconus	Enrichment	TSC1	2.01
70	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10	2.01
71	Lung squamous cell carcinoma	Enrichment	PIK3CA	2.01
72	Nevus, epidermal	Enrichment	PIK3CA	1.95
73	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.95
74	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.95
75	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.95
76	Polycystic kidney disease 1	Enrichment	TSC2	1.95
77	Gallbladder cancer	Enrichment	PIK3CA	1.95
78	Overgrowth syndrome	Enrichment	MTOR	1.95
79	Rheumatoid arthritis	Enrichment	IL10	1.84
80	Arteriovenous malformation	Enrichment	PIK3CA	1.84
81	Primary biliary cholangitis	Enrichment	IL12A	1.84
82	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.79
83	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.75
84	Inherited cancer-predisposing syndrome	Enrichment	TSC1, TSC2	1.72
85	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.71
86	Pulmonary disease, chronic obstructive	Enrichment	VDR	1.68
87	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.62
88	Lynch syndrome	Enrichment	PIK3CA	1.62
89	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.62
90	Kidney disease	Enrichment	TSC1	1.62
91	Rare genetic intellectual disability	Enrichment	MTOR	1.62
92	Sudden infant death syndrome	Enrichment	PDHA1	1.56
93	Human immunodeficiency virus type 1	Enrichment	IL10	1.54
94	Endometrial cancer	Enrichment	PIK3CA	1.47
95	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.44
96	Prostate cancer	Enrichment	PIK3CA	1.34
97	Lung cancer	Enrichment	PIK3CA	1.30
98	Systemic lupus erythematosus	Enrichment	IL10	1.21
99	Gastric cancer	Enrichment	PIK3CA	1.17
100	West syndrome	Enrichment	TSC2	1.16
101	Hypertelorism	Enrichment	PIK3CA	1.09
102	Myeloma, multiple	Enrichment	RXRA	1.06
103	Congenital nervous system abnormality	Enrichment	TSC2	0.80
104	Nervous system disease	Enrichment	TSC2	0.80
105	Autism spectrum disorder	Enrichment	TSC2	0.79

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PI3K/AKT/mTOR - vitamin D3 signaling

Pathway Network for PI3K/AKT/mTOR - vitamin D3 signaling

Member Pathways for PI3K/AKT/mTOR - vitamin D3 signaling

Pathways in the PI3K/AKT/mTOR - vitamin D3 signaling SuperPath

Associated Genes for PI3K/AKT/mTOR - vitamin D3 signaling

Associated Disorders for PI3K/AKT/mTOR - vitamin D3 signaling

Disorders associated with PI3K/AKT/mTOR - vitamin D3 signaling SuperPath

STRING Interaction Network for PI3K/AKT/mTOR - vitamin D3 signaling

Sources for PI3K/AKT/mTOR - vitamin D3 signaling