PI Metabolism

Pathway network for the PI Metabolism SuperPath

Sources:

Reactome
WikiPathways

Pathways in the PI Metabolism SuperPath

#	Name	Source	Genes
1	PI Metabolism	Reactome	ARF1 ARF3 BMX ENPP6 FIG4 GDE1 GDPD1 GDPD3 GDPD5 INPP4A INPP4B INPP5D INPP5E INPP5F INPP5J INPP5K INPPL1 MTM1 MTMR1 MTMR10 MTMR12 MTMR14 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 MTMR8 MTMR9 OCRL PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PIK3R6 PIKFYVE PIP4K2A PIP4K2B PIP4K2C PIP4P1 PIP5K1A PIP5K1B PIP5K1C PITPNB PLEKHA1 PLEKHA2 PLEKHA3 PLEKHA4 PLEKHA5 PLEKHA6 PLEKHA8 PNPLA6 PNPLA7 PTEN PTPN13 RAB14 RAB4A RAB5A RUFY1 SACM1L SBF1 SBF2 SYNJ1 SYNJ2 TNFAIP8 TNFAIP8L1 TNFAIP8L2 TNFAIP8L3 TPTE TPTE2 VAC14 (see all 84) (see less)
2	Synthesis of PIPs at the plasma membrane	Reactome	ARF1 BMX INPP4A INPP4B INPP5D INPP5J INPP5K INPPL1 MTM1 MTMR1 MTMR14 MTMR2 MTMR3 MTMR6 MTMR8 MTMR9 OCRL PI4K2A PI4K2B PIK3C2A PIK3C2B PIK3C2G PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PIK3R6 PIP4K2A PIP4K2B PIP4K2C PIP5K1A PIP5K1B PIP5K1C PLEKHA1 PLEKHA2 PLEKHA3 PLEKHA4 PLEKHA5 PLEKHA6 PLEKHA8 PTEN PTPN13 RAB14 RAB4A RAB5A RUFY1 SBF2 SYNJ1 SYNJ2 (see all 53) (see less)
3	Phosphoinositides metabolism	WikiPathways	INPP5D MTM1 MTMR1 MTMR10 MTMR11 MTMR12 MTMR2 MTMR3 MTMR4 MTMR6 MTMR7 MTMR8 MTMR9 OCRL PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R4 PIKFYVE PIP4K2A PIP4K2B PIP4K2C PIP4P1 PIP4P2 PIP5K1A PIP5K1B PIP5K1C PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCH1 PLCH2 PLCZ1 PTEN SACM1L SBF1 SBF2 (see all 49) (see less)
4	Synthesis of PIPs at the Golgi membrane	Reactome	ARF1 ARF3 FIG4 INPP5E OCRL PI4K2A PI4K2B PI4KA PI4KB PIK3C2A PIK3C2G PIK3C3 PIK3R4 PIKFYVE SACM1L TPTE TPTE2 VAC14 (see all 18) (see less)
5	Synthesis of PIPs at the early endosome membrane	Reactome	FIG4 INPP4A INPP4B INPP5F MTM1 MTMR10 MTMR12 MTMR2 MTMR4 PI4K2A PI4K2B PIK3C2A PIK3C3 PIK3R4 PIKFYVE VAC14 (see all 16) (see less)
6	Synthesis of PIPs at the late endosome membrane	Reactome	FIG4 MTM1 MTMR2 MTMR4 MTMR7 MTMR9 PIK3C2A PIK3C3 PIK3R4 PIKFYVE VAC14 (see all 11) (see less)
7	Glycerophospholipid catabolism	Reactome	ENPP6 GDE1 GDPD1 GDPD3 GDPD5 PNPLA6 PNPLA7 (see all 7) (see less)
8	Synthesis of PIPs at the ER membrane	Reactome	MTMR2 PI4K2B PI4KA SACM1L SBF1
9	PI and PC transport between ER and Golgi membranes	Reactome	PITPNB

Gene overlap in member pathways for PI Metabolism SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	6
2	MTMR2	Myotubularin Related Protein 2	Protein Coding	6
3	PIKFYVE	Phosphoinositide Kinase, FYVE-Type Zinc Finger Containing	Protein Coding	5
4	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	5
5	MTM1	Myotubularin 1	Protein Coding	5
6	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	5
7	PI4K2B	Phosphatidylinositol 4-Kinase Type 2 Beta	Protein Coding	5
8	SACM1L	SAC1 Like Phosphatidylinositide Phosphatase	Protein Coding	4
9	OCRL	OCRL Inositol Polyphosphate-5-Phosphatase	Protein Coding	4
10	PIK3C2G	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma	Protein Coding	4
11	PI4K2A	Phosphatidylinositol 4-Kinase Type 2 Alpha	Protein Coding	4
12	VAC14	VAC14 Component Of PIKFYVE Complex	Protein Coding	4
13	MTMR9	Myotubularin Related Protein 9	Protein Coding	4
14	MTMR4	Myotubularin Related Protein 4	Protein Coding	4
15	FIG4	FIG4 Phosphoinositide 5-Phosphatase	Protein Coding	4
16	PIP5K1C	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Gamma	Protein Coding	3
17	INPP4A	Inositol Polyphosphate-4-Phosphatase Type I A	Protein Coding	3
18	INPP5D	Inositol Polyphosphate-5-Phosphatase D	Protein Coding	3
19	ARF1	ARF GTPase 1	Protein Coding	3
20	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	3
21	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	3
22	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	3
23	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	3
24	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	3
25	PI4KA	Phosphatidylinositol 4-Kinase Alpha	Protein Coding	3
26	PIP4K2A	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Alpha	Protein Coding	3
27	MTMR12	Myotubularin Related Protein 12	Protein Coding	3
28	MTMR10	Myotubularin Related Protein 10	Protein Coding	3
29	MTMR8	Myotubularin Related Protein 8	Protein Coding	3
30	PTEN	Phosphatase And Tensin Homolog	Protein Coding	3
31	SBF1	SET Binding Factor 1	Protein Coding	3
32	PIP4K2C	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Gamma	Protein Coding	3
33	SBF2	SET Binding Factor 2	Protein Coding	3
34	PIP5K1A	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha	Protein Coding	3
35	PIP5K1B	Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Beta	Protein Coding	3
36	PIP4K2B	Phosphatidylinositol-5-Phosphate 4-Kinase Type 2 Beta	Protein Coding	3
37	MTMR1	Myotubularin Related Protein 1	Protein Coding	3
38	INPP4B	Inositol Polyphosphate-4-Phosphatase Type II B	Protein Coding	3
39	MTMR3	Myotubularin Related Protein 3	Protein Coding	3
40	MTMR6	Myotubularin Related Protein 6	Protein Coding	3
41	MTMR7	Myotubularin Related Protein 7	Protein Coding	3
42	PNPLA6	Patatin Like Domain 6, Lysophospholipase	Protein Coding	2
43	ENPP6	Ectonucleotide Pyrophosphatase/Phosphodiesterase 6	Protein Coding	2
44	PIK3R6	Phosphoinositide-3-Kinase Regulatory Subunit 6	Protein Coding	2
45	PLEKHA6	Pleckstrin Homology Domain Containing A6	Protein Coding	2
46	INPP5F	Inositol Polyphosphate-5-Phosphatase F	Protein Coding	2
47	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	2
48	PITPNB	Phosphatidylinositol Transfer Protein Beta	Protein Coding	2
49	INPP5J	Inositol Polyphosphate-5-Phosphatase J	Protein Coding	2
50	GDPD1	Glycerophosphodiester Phosphodiesterase Domain Containing 1	Protein Coding	2
51	INPPL1	Inositol Polyphosphate Phosphatase Like 1	Protein Coding	2
52	PNPLA7	Patatin Like Domain 7, Lysophospholipase	Protein Coding	2
53	ARF3	ARF GTPase 3	Protein Coding	2
54	RAB14	RAB14, Member RAS Oncogene Family	Protein Coding	2
55	GDE1	Glycerophosphodiester Phosphodiesterase 1	Protein Coding	2
56	INPP5K	Inositol Polyphosphate-5-Phosphatase K	Protein Coding	2
57	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
58	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
59	PI4KB	Phosphatidylinositol 4-Kinase Beta	Protein Coding	2
60	PLEKHA5	Pleckstrin Homology Domain Containing A5	Protein Coding	2
61	INPP5E	Inositol Polyphosphate-5-Phosphatase E	Protein Coding	2
62	PLEKHA4	Pleckstrin Homology Domain Containing A4	Protein Coding	2
63	PTPN13	Protein Tyrosine Phosphatase Non-Receptor Type 13	Protein Coding	2
64	RAB4A	RAB4A, Member RAS Oncogene Family	Protein Coding	2
65	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	2
66	PLEKHA1	Pleckstrin Homology Domain Containing A1	Protein Coding	2
67	PLEKHA2	Pleckstrin Homology Domain Containing A2	Protein Coding	2
68	MTMR14	Myotubularin Related Protein 14	Protein Coding	2
69	PLEKHA3	Pleckstrin Homology Domain Containing A3	Protein Coding	2
70	BMX	BMX Non-Receptor Tyrosine Kinase	Protein Coding	2
71	TPTE	Transmembrane Phosphatase With Tensin Homology	Protein Coding	2
72	GDPD3	Glycerophosphodiester Phosphodiesterase Domain Containing 3	Protein Coding	2
73	RUFY1	RUN And FYVE Domain Containing 1	Protein Coding	2
74	GDPD5	Glycerophosphodiester Phosphodiesterase Domain Containing 5	Protein Coding	2
75	PLEKHA8	Pleckstrin Homology Domain Containing A8	Protein Coding	2
76	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	2
77	SYNJ1	Synaptojanin 1	Protein Coding	2
78	SYNJ2	Synaptojanin 2	Protein Coding	2
79	PIP4P1	Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 1	Protein Coding	2
80	TPTE2	Transmembrane Phosphoinositide 3-Phosphatase And Tensin Homolog 2	Protein Coding	2
81	TNFAIP8L1	TNF Alpha Induced Protein 8 Like 1	Protein Coding	1
82	TNFAIP8	TNF Alpha Induced Protein 8	Protein Coding	1
83	TNFAIP8L3	TNF Alpha Induced Protein 8 Like 3	Protein Coding	1
84	TNFAIP8L2	TNF Alpha Induced Protein 8 Like 2	Protein Coding	1
85	MTMR11	Myotubularin Related Protein 11	Protein Coding	1
86	PIP4P2	Phosphatidylinositol-4,5-Bisphosphate 4-Phosphatase 2	Protein Coding	1
87	PLCH1	Phospholipase C Eta 1	Protein Coding	1
88	PLCH2	Phospholipase C Eta 2	Protein Coding	1
89	PLCB3	Phospholipase C Beta 3	Protein Coding	1
90	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
91	PLCD3	Phospholipase C Delta 3	Protein Coding	1
92	PLCB4	Phospholipase C Beta 4	Protein Coding	1
93	PLCD4	Phospholipase C Delta 4	Protein Coding	1
94	PLCD1	Phospholipase C Delta 1	Protein Coding	1
95	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
96	PLCB1	Phospholipase C Beta 1	Protein Coding	1
97	PLCB2	Phospholipase C Beta 2	Protein Coding	1
98	PLCZ1	Phospholipase C Zeta 1	Protein Coding	1
99	PLCG2	Phospholipase C Gamma 2	Protein Coding	1

Disorders associated with PI Metabolism SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Yunis-varon syndrome	Enrichment	FIG4, VAC14	6.22
2	Charcot-marie-tooth disease type 4	Enrichment	FIG4, MTMR2, SBF1, SBF2	5.41
3	Spermatogenic failure 17	Enrichment	PIK3C2G, PLCZ1	4.89
4	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.35
5	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.35
6	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.35
7	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	4.05
8	Hemimegalencephaly	Enrichment	PIK3CA, PTEN	3.90
9	Cowden syndrome 1	Enrichment	PIK3CA, PTEN	3.72
10	Charcot-marie-tooth disease type 4b1	Enrichment	MTMR2	3.43
11	Charcot-marie-tooth disease, demyelinating, type 4b1	Enrichment	MTMR2	3.43
12	Spastic paraplegia 84, autosomal recessive	Enrichment	PI4KA	3.43
13	Gastrointestinal defects and immunodeficiency syndrome 2	Enrichment	PI4KA	3.43
14	Pi4ka-related disorder	Enrichment	PI4KA	3.43
15	Cowden syndrome	Enrichment	PIK3CA, PTEN	3.34
16	Laurence-moon syndrome	Enrichment	PNPLA6	3.29
17	Oliver-mcfarlane syndrome	Enrichment	PNPLA6	3.29
18	Boucher-neuhauser syndrome	Enrichment	PNPLA6	3.29
19	Spastic paraplegia 39, autosomal recessive	Enrichment	PNPLA6	3.29
20	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	3.18
21	Neurodevelopmental disorder with spasticity, hypomyelinating leukodystrophy, and brain abnormalities	Enrichment	PI4KA	3.13
22	Combined immunodeficiency-multiple intestinal atresia	Enrichment	PI4KA	3.13
23	Corneal dystrophy, fleck	Enrichment	PIKFYVE	3.09
24	Polymicrogyria, bilateral temporooccipital	Enrichment	FIG4	3.09
25	Oculoskeletodental syndrome	Enrichment	PIK3C2A	3.09
26	Amyotrophic lateral sclerosis 11	Enrichment	FIG4	3.09
27	Charcot-marie-tooth disease, demyelinating, type 4j	Enrichment	FIG4	3.09
28	Charcot-marie-tooth disease type 4j	Enrichment	FIG4	3.09
29	Oculocerebrodental syndrome	Enrichment	PIK3C2A	3.09
30	Qualitative or quantitative defects of myotubularin	Enrichment	MTM1	3.09
31	Meningioma	Enrichment	PIK3CA, PTEN	3.08
32	Gordon holmes syndrome	Enrichment	PNPLA6	2.99
33	Heparin cofactor ii deficiency	Enrichment	PI4KA	2.96
34	Charcot-marie-tooth disease, demyelinating, type 4b3	Enrichment	SBF1	2.96
35	Charcot-marie-tooth disease type 4b3	Enrichment	SBF1	2.96
36	Neurodevelopmental disorder with growth impairment, quadriparesis, and poor or absent speech	Enrichment	INPP4A	2.93
37	Lowe oculocerebrorenal syndrome	Enrichment	OCRL	2.88
38	Impaired intellectual development, truncal obesity, retinal dystrophy, and micropenis syndrome	Enrichment	INPP5E	2.88
39	Deafness, autosomal dominant 87	Enrichment	PI4KB	2.88
40	Striatonigral degeneration, childhood-onset	Enrichment	VAC14	2.79
41	Respiratory system disease	Enrichment	MTM1	2.79
42	X-linked myotubular myopathy-abnormal genitalia syndrome	Enrichment	MTM1	2.79
43	Pectus excavatum	Enrichment	ARF3, INPP4A	2.70
44	Charcot-marie-tooth disease	Enrichment	FIG4, SBF1, SBF2	2.69
45	Interstitial nephritis, karyomegalic	Enrichment	MTMR10	2.63
46	Neurodevelopmental disorder with hyperkinetic movements, seizures, and structural brain abnormalities	Enrichment	PI4K2A	2.63
47	Myopathy, centronuclear, x-linked	Enrichment	MTM1	2.61
48	Endometrial cancer	Enrichment	PIK3CA, PTEN	2.59
49	Hypogonadotropic hypogonadism 1 with or without anosmia	Enrichment	PNPLA6	2.59
50	Dent disease 2	Enrichment	OCRL	2.58
51	Periventricular nodular heterotopia 8	Enrichment	ARF1	2.58
52	Short femur	Enrichment	INPP5E	2.58
53	Bilateral perisylvian polymicrogyria	Enrichment	PI4KA	2.48
54	Macrodactyly	Enrichment	PIK3CA	2.44
55	Vacterl association with hydrocephalus	Enrichment	PTEN	2.44
56	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.44
57	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	2.44
58	Cowden syndrome 5	Enrichment	PIK3CA	2.44
59	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.44
60	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.44
61	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.44
62	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.44
63	Papillary tumor of the pineal region	Enrichment	PTEN	2.44
64	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.44
65	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.44
66	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.44
67	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.44
68	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.44
69	Glioma susceptibility 2	Enrichment	PTEN	2.44
70	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.44
71	Holoprosencephaly 14	Enrichment	PLCH1	2.44
72	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.44
73	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.44
74	Hypospadias	Enrichment	PIK3CA	2.44
75	Rare venous malformation	Enrichment	PIK3CA	2.44
76	Diaphragmatic eventration	Enrichment	PIK3CA	2.44
77	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.44
78	Rare combined vascular malformation	Enrichment	PIK3CA	2.44
79	Cavernous lymphangioma	Enrichment	PIK3CA	2.44
80	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.44
81	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.44
82	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.44
83	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.44
84	Macrodactyly of toe	Enrichment	PIK3CA	2.44
85	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.41
86	Developmental and epileptic encephalopathy 53	Enrichment	SYNJ1	2.41
87	Short syndrome	Enrichment	PIK3R1	2.41
88	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.41
89	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.41
90	Muscular dystrophy, congenital, with cataracts and impaired intellectual development	Enrichment	INPP5K	2.41
91	Uvula, bifid	Enrichment	ARF3	2.40
92	Dent disease	Enrichment	OCRL	2.40
93	Interstitial lung disease	Enrichment	INPP5E	2.40
94	Kyphosis	Enrichment	ARF3	2.40
95	Respiratory failure	Enrichment	INPP5E	2.40
96	Pseudovaginal perineoscrotal hypospadias	Enrichment	FIG4	2.39
97	Bladder cancer	Enrichment	PIK3CA, PTEN	2.31
98	Prostate cancer	Enrichment	PIK3CA, PTEN	2.31
99	Coach syndrome 1	Enrichment	INPP5E	2.18
100	Joubert syndrome with ocular defect	Enrichment	INPP5E	2.18
101	Dyskeratosis congenita, autosomal dominant 1	Enrichment	INPP4A	2.15
102	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	PNPLA6	2.14
103	Lethal congenital contracture syndrome 3	Enrichment	PIP5K1C	2.14
104	Keratosis, seborrheic	Enrichment	PIK3CA	2.14
105	Neutrophilia, hereditary	Enrichment	PIP4K2B	2.14
106	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.14
107	Noonan syndrome 8	Enrichment	PIK3CA	2.14
108	Neutropenia, severe congenital, 7, autosomal recessive	Enrichment	PIP4K2B	2.14
109	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.14
110	Severe congenital neutropenia 7	Enrichment	PIP4K2B	2.14
111	Ocular melanoma	Enrichment	PLCB4	2.14
112	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	PIP5K1A	2.14
113	Immune system disease	Enrichment	PIK3CD	2.14
114	B-lymphoblastic leukemia/lymphoma with hyperdiploidy	Enrichment	PIP4K2A	2.14
115	Vacterl with hydrocephalus	Enrichment	PTEN	2.14
116	Juvenile polyposis of infancy	Enrichment	PTEN	2.14
117	Schneckenbecken dysplasia	Enrichment	INPPL1	2.11
118	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.11
119	Parkinson disease 20, early-onset	Enrichment	SYNJ1	2.11
120	Patent ductus arteriosus	Enrichment	INPP5E	2.10
121	Dyskeratosis congenita, autosomal dominant 2	Enrichment	INPP4A	2.08
122	Gastric cancer	Enrichment	PIK3CA, PTEN	1.98
123	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.97
124	Nephrotic syndrome, type 3	Enrichment	PLCE1	1.97
125	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.97
126	Keratoacanthoma	Enrichment	PIK3CA	1.97
127	Hereditary breast carcinoma	Enrichment	PIK3CA, PTEN	1.96
128	Opsismodysplasia	Enrichment	INPPL1	1.93
129	Atypical juvenile parkinsonism	Enrichment	SYNJ1	1.93
130	Kallmann syndrome	Enrichment	PNPLA6	1.93
131	Congenital myopathy 4a, autosomal dominant	Enrichment	MTM1	1.92
132	Primary bone dysplasia	Enrichment	INPP5E	1.88
133	Auriculocondylar syndrome 1	Enrichment	PLCB4	1.84
134	Charcot-marie-tooth disease, demyelinating, type 4b2	Enrichment	SBF2	1.84
135	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.84
136	Charcot-marie-tooth disease type 4b2	Enrichment	SBF2	1.84
137	Cerebrovascular disease	Enrichment	PIK3CA	1.84
138	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.84
139	Glioma	Enrichment	PTEN	1.84
140	Osteochondrodysplasia	Enrichment	INPP5E	1.84
141	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.81
142	Centronuclear myopathy	Enrichment	MTM1	1.77
143	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	INPP5E	1.77
144	Clubfoot	Enrichment	INPP5E	1.77
145	Capillary malformations, congenital	Enrichment	PIK3CA	1.75
146	Macrocephaly/autism syndrome	Enrichment	PTEN	1.75
147	Hemangioma	Enrichment	PTEN	1.75
148	Acute megakaryocytic leukemia	Enrichment	PTEN	1.75
149	Periventricular nodular heterotopia	Enrichment	ARF1	1.73
150	Hereditary spastic paraplegia	Enrichment	PNPLA6	1.67
151	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.67
152	Melanoma, uveal	Enrichment	PLCB4	1.67
153	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.67
154	Breast adenocarcinoma	Enrichment	PIK3CA	1.67
155	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.67
156	Cleft palate, isolated	Enrichment	INPP5E	1.65
157	Myopathy, centronuclear, 1	Enrichment	MTMR14	1.63
158	Cleft lip with or without cleft palate	Enrichment	PLEKHA5	1.63
159	Heart, malformation of	Enrichment	ARF3	1.63
160	Nevus, epidermal	Enrichment	PIK3CA	1.60
161	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	1.60
162	Squamous cell carcinoma, head and neck	Enrichment	PTEN	1.60
163	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.60
164	Gallbladder cancer	Enrichment	PIK3CA	1.60
165	Follicular thyroid carcinoma	Enrichment	PTEN	1.60
166	Overgrowth syndrome	Enrichment	PIK3R1	1.57
167	Spastic ataxia	Enrichment	PNPLA6	1.57
168	Breast cancer	Enrichment	PIK3CA, PTEN	1.52
169	Scoliosis	Enrichment	ARF3	1.50
170	Myopathy	Enrichment	MTM1	1.50
171	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.49
172	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.49
173	Arteriovenous malformation	Enrichment	PIK3CA	1.49
174	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.49
175	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.45
176	Melanoma	Enrichment	PTEN	1.45
177	Meningioma, familial	Enrichment	PTEN	1.41
178	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.41
179	Uterine corpus cancer	Enrichment	PTEN	1.41
180	Isolated joubert syndrome	Enrichment	INPP5E	1.41
181	Autism spectrum disorder	Enrichment	SBF1	1.40
182	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.37
183	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	1.34
184	Dystonia	Enrichment	ARF3	1.34
185	Early-onset parkinson's disease	Enrichment	SYNJ1	1.34
186	Nk-cell enteropathy	Enrichment	PIK3CB	1.34
187	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	FIG4	1.34
188	Ovarian cancer	Enrichment	PIK3CA, PTEN	1.29
189	Lynch syndrome	Enrichment	PIK3CA	1.28
190	Rhabdomyosarcoma	Enrichment	PTEN	1.25
191	Alobar holoprosencephaly	Enrichment	PLCH1	1.22
192	Joubert syndrome 1	Enrichment	INPP5E	1.19
193	Autosomal dominant non-syndromic intellectual disability	Enrichment	ARF3	1.19
194	Diffuse large b-cell lymphoma	Enrichment	PTEN	1.18
195	Focal segmental glomerulosclerosis	Enrichment	PLCE1	1.16
196	Hepatocellular carcinoma	Enrichment	PIK3CA	1.12
197	Autism	Enrichment	ARF3	1.04
198	Developmental and epileptic encephalopathy 1	Enrichment	SYNJ1	1.03
199	Retinitis pigmentosa	Enrichment	PNPLA6	0.98
200	Lung cancer	Enrichment	PIK3CA	0.96
201	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	0.94
202	Leber plus disease	Enrichment	INPP5E	0.92
203	Microcephaly	Enrichment	INPP4A	0.87
204	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.86
205	Hereditary retinal dystrophy	Enrichment	PNPLA6	0.85
206	Fundus dystrophy	Enrichment	PNPLA6	0.85
207	Centralopathic epilepsy	Enrichment	PLCB1	0.84
208	Nephrotic syndrome	Enrichment	PLCE1	0.84
209	West syndrome	Enrichment	PLCB1	0.83
210	Hypertelorism	Enrichment	PIK3CA	0.76
211	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	0.74
212	Myeloma, multiple	Enrichment	PIK3R2	0.71
213	Undetermined early-onset epileptic encephalopathy	Enrichment	SYNJ1	0.71
214	Congenital nervous system abnormality	Enrichment	PTEN	0.50
215	Nervous system disease	Enrichment	PTEN	0.50
216	Inherited cancer-predisposing syndrome	Enrichment	PTEN	0.42

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PI Metabolism

Pathway Network for PI Metabolism

Pathway network for the PI Metabolism SuperPath

Member Pathways for PI Metabolism

Pathways in the PI Metabolism SuperPath

Gene overlap in member pathways for PI Metabolism SuperPath

Associated Genes for PI Metabolism

Associated Disorders for PI Metabolism

Disorders associated with PI Metabolism SuperPath

STRING Interaction Network for PI Metabolism

Sources for PI Metabolism