PKC-gamma calcium signaling pathway in ataxia

No Pathway Network information available for PKC-gamma calcium signaling pathway in ataxia

Pathways in the PKC-gamma calcium signaling pathway in ataxia SuperPath

#	Name	Source	Genes
1	PKC-gamma calcium signaling pathway in ataxia	WikiPathways	ATP2B2 CA8 CACNA1A GNA11 GNA14 GNA15 GNAQ GRIA1 GRIA2 GRIA3 GRIA4 GRM1 HOMER3 ITPR1 LOC105372522 PDK1 PLCB2 PLCB3 PLCB4 PRKCG RYR3 TRPC3 (see all 22) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLCB3	Phospholipase C Beta 3	Protein Coding	1
2	PLCB2	Phospholipase C Beta 2	Protein Coding	1
3	GNA14	G Protein Subunit Alpha 14	Protein Coding	1
4	HOMER3	Homer Scaffold Protein 3	Protein Coding	1
5	CACNA1A	Calcium Voltage-Gated Channel Subunit Alpha1 A	Protein Coding	1
6	CA8	Carbonic Anhydrase 8	Protein Coding	1
7	TRPC3	Transient Receptor Potential Cation Channel Subfamily C Member 3	Protein Coding	1
8	PRKCG	Protein Kinase C Gamma	Protein Coding	1
9	PLCB4	Phospholipase C Beta 4	Protein Coding	1
10	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	1
11	GRM1	Glutamate Metabotropic Receptor 1	Protein Coding	1
12	GRIA4	Glutamate Ionotropic Receptor AMPA Type Subunit 4	Protein Coding	1
13	GRIA3	Glutamate Ionotropic Receptor AMPA Type Subunit 3	Protein Coding	1
14	GRIA2	Glutamate Ionotropic Receptor AMPA Type Subunit 2	Protein Coding	1
15	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	1
16	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
17	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
18	LOC105372522	Uncharacterized LOC105372522	RNA Gene	1
19	RYR3	Ryanodine Receptor 3	Protein Coding	1
20	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
21	ATP2B2	ATPase Plasma Membrane Ca2+ Transporting 2	Protein Coding	1
22	GNA15	G Protein Subunit Alpha 15	Protein Coding	1

Disorders associated with PKC-gamma calcium signaling pathway in ataxia SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Anastomosing haemangioma	Enrichment	GNA11, GNA14, GNAQ	8.43
2	Melanoma, uveal	Enrichment	GNA11, GNAQ, PLCB4	7.13
3	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	5.60
4	Capillary malformations, congenital	Enrichment	GNA11, GNAQ	4.60
5	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.79
6	Spinocerebellar ataxia 41	Enrichment	TRPC3	2.79
7	Sturge-weber syndrome	Enrichment	GNAQ	2.79
8	Spinocerebellar ataxia, autosomal recessive 13	Enrichment	GRM1	2.79
9	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.79
10	Congenital myopathy 20	Enrichment	RYR3	2.79
11	Deafness, autosomal dominant 82	Enrichment	ATP2B2	2.79
12	Intellectual developmental disorder, x-linked, syndromic, wu type	Enrichment	GRIA3	2.79
13	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.79
14	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.79
15	Spinocerebellar ataxia, autosomal recessive 34	Enrichment	CA8	2.79
16	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.79
17	Neurodevelopmental disorder with language impairment and behavioral abnormalities	Enrichment	GRIA2	2.79
18	Neurodevelopmental disorder with or without seizures and gait abnormalities	Enrichment	GRIA4	2.79
19	Intellectual developmental disorder, autosomal dominant 67	Enrichment	GRIA1	2.79
20	Spinocerebellar ataxia 44	Enrichment	GRM1	2.79
21	Intellectual developmental disorder, autosomal recessive 76	Enrichment	GRIA1	2.79
22	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.79
23	Syndromic x-linked intellectual disability 94	Enrichment	GRIA3	2.79
24	Sporadic hemiplegic migraine	Enrichment	CACNA1A	2.79
25	Gria2-related neurodevelopmental disorder	Enrichment	GRIA2	2.79
26	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.79
27	Kaposiform hemangioendothelioma	Enrichment	GNA14	2.79
28	Chondromyxoid fibroma	Enrichment	GRM1	2.79
29	Benign paroxysmal torticollis of infancy	Enrichment	CACNA1A	2.79
30	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.49
31	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.49
32	Alternating hemiplegia of childhood 1	Enrichment	CACNA1A	2.49
33	Angioma, tufted	Enrichment	GNA14	2.49
34	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.49
35	Ocular melanoma	Enrichment	PLCB4	2.49
36	Progressive bulbar palsy	Enrichment	CACNA1A	2.49
37	Gillespie syndrome	Enrichment	ITPR1	2.31
38	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	2.31
39	Neurodevelopmental disorder with hypotonia, language delay, and skeletal defects with or without seizures	Enrichment	CACNA1A	2.31
40	Hereditary episodic ataxia	Enrichment	CACNA1A	2.31
41	Migraine, familial hemiplegic, 1	Enrichment	CACNA1A	2.19
42	Spinocerebellar ataxia 6	Enrichment	CACNA1A	2.19
43	Amyotrophy, monomelic	Enrichment	RYR3	2.19
44	Developmental and epileptic encephalopathy 2	Enrichment	CACNA1A	2.19
45	Auriculocondylar syndrome 1	Enrichment	PLCB4	2.19
46	Spinocerebellar ataxia 15	Enrichment	ITPR1	2.19
47	Developmental and epileptic encephalopathy 42	Enrichment	CACNA1A	2.19
48	Developmental and epileptic encephalopathy 52	Enrichment	CACNA1A	2.19
49	Hereditary ataxia	Enrichment	PRKCG	2.19
50	Episodic ataxia	Enrichment	CACNA1A	2.19
51	Familial or sporadic hemiplegic migraine	Enrichment	CACNA1A	2.19
52	Episodic ataxia, type 2	Enrichment	CACNA1A	2.09
53	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	2.01
54	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	CA8	2.01
55	Deafness, autosomal recessive 12	Enrichment	ATP2B2	2.01
56	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	2.01
57	Lennox-gastaut syndrome	Enrichment	CACNA1A	1.89
58	Alternating hemiplegia of childhood	Enrichment	CACNA1A	1.89
59	Difference of sex development	Enrichment	CACNA1A	1.89
60	Hydrops fetalis	Enrichment	RYR3	1.84
61	Migraine with or without aura 1	Enrichment	CACNA1A	1.75
62	Multiple sclerosis	Enrichment	ITPR1	1.65
63	Anterior segment dysgenesis	Enrichment	ITPR1	1.62
64	Auditory neuropathy	Enrichment	CACNA1A	1.38
65	Strabismus	Enrichment	CACNA1A	1.37
66	Dystonia	Enrichment	GRIA3	1.26
67	Developmental and epileptic encephalopathy	Enrichment	GRIA3	1.25
68	Cerebral palsy	Enrichment	CACNA1A	1.21
69	West syndrome	Enrichment	GRIA3	1.16
70	Body mass index quantitative trait locus 11	Enrichment	GRIA4	1.11
71	Autosomal dominant non-syndromic intellectual disability	Enrichment	GRIA1	1.11
72	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ATP2B2	1.09
73	Spastic ataxia	Enrichment	ITPR1	1.08
74	Undetermined early-onset epileptic encephalopathy	Enrichment	CACNA1A	1.06
75	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIA1	1.05
76	Primary ovarian insufficiency	Enrichment	RYR3	1.04
77	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ATP2B2	0.87
78	Congenital nervous system abnormality	Enrichment	CACNA1A	0.80
79	Nervous system disease	Enrichment	CACNA1A	0.80
80	Autism spectrum disorder	Enrichment	GRIA1	0.79
81	Complex neurodevelopmental disorder	Enrichment	GRIA4	0.74

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PKC-gamma calcium signaling pathway in ataxia

Pathway Network for PKC-gamma calcium signaling pathway in ataxia

Member Pathways for PKC-gamma calcium signaling pathway in ataxia

Pathways in the PKC-gamma calcium signaling pathway in ataxia SuperPath

Associated Genes for PKC-gamma calcium signaling pathway in ataxia

Associated Disorders for PKC-gamma calcium signaling pathway in ataxia

Disorders associated with PKC-gamma calcium signaling pathway in ataxia SuperPath

STRING Interaction Network for PKC-gamma calcium signaling pathway in ataxia

Sources for PKC-gamma calcium signaling pathway in ataxia