PKMTs methylate histone lysines

No Pathway Network information available for PKMTs methylate histone lysines

Pathways in the PKMTs methylate histone lysines SuperPath

#	Name	Source	Genes
1	PKMTs methylate histone lysines	Reactome	AEBP2 ASH1L ASH2L ATF7IP DOT1L DPY30 EED EHMT1 EHMT2 EZH2 H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 KMT2A KMT2B KMT2C KMT2D KMT5A KMT5B KMT5C MECOM NFKB1 NFKB2 NSD1 NSD2 NSD3 PRDM16 PRDM9 RBBP4 RBBP5 RBBP7 RELA SETD1A SETD1B SETD2 SETD3 SETD6 SETD7 SETDB1 SETDB2 SMYD2 SMYD3 SUV39H1 SUV39H2 SUZ12 WDR5 (see all 70) (see less)
2	Histone modifications	WikiPathways	AEBP2 ASH1L DOT1L EED EHMT1 EHMT2 EZH1 EZH2 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C7 H4C8 H4C9 KMT2A KMT2B KMT2C KMT2D KMT2E KMT5A KMT5B KMT5C LOC105377622 NSD1 PRDM2 SET SETBP1 SETD1A SETD1B SETD2 SETD3 SETD4 SETD5 SETD6 SETD9 SETDB1 SETDB2 SETMAR SMYD1 SMYD2 SMYD3 SMYD4 SMYD5 SUV39H1 SUV39H2 (see all 65) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	EHMT2	Euchromatic Histone Lysine Methyltransferase 2	Protein Coding	2
2	H4C16	H4 Histone 16	Protein Coding	2
3	AEBP2	AE Binding Protein 2	Protein Coding	2
4	H3C14	H3 Clustered Histone 14	Protein Coding	2
5	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	2
6	SETD1B	SET Domain Containing 1B, Histone Lysine Methyltransferase	Protein Coding	2
7	SETD2	SET Domain Containing 2, Histone Lysine Methyltransferase	Protein Coding	2
8	H3C15	H3 Clustered Histone 15	Protein Coding	2
9	KMT5A	Lysine Methyltransferase 5A	Protein Coding	2
10	KMT2A	Lysine Methyltransferase 2A	Protein Coding	2
11	KMT5B	Lysine Methyltransferase 5B	Protein Coding	2
12	ASH1L	ASH1 Like Histone Lysine Methyltransferase	Protein Coding	2
13	SMYD2	SET And MYND Domain Containing 2	Protein Coding	2
14	KMT2C	Lysine Methyltransferase 2C	Protein Coding	2
15	NSD1	Nuclear Receptor Binding SET Domain Protein 1	Protein Coding	2
16	SMYD3	SET And MYND Domain Containing 3	Protein Coding	2
17	H3C13	H3 Clustered Histone 13	Protein Coding	2
18	SUV39H1	SUV39H1 Histone Lysine Methyltransferase	Protein Coding	2
19	SUV39H2	SUV39H2 Histone Lysine Methyltransferase	Protein Coding	2
20	EHMT1	Euchromatic Histone Lysine Methyltransferase 1	Protein Coding	2
21	SETD6	SET Domain Containing 6, Protein Lysine Methyltransferase	Protein Coding	2
22	KMT2D	Lysine Methyltransferase 2D	Protein Coding	2
23	H4C9	H4 Clustered Histone 9	Protein Coding	2
24	H3C1	H3 Clustered Histone 1	Protein Coding	2
25	H3C4	H3 Clustered Histone 4	Protein Coding	2
26	H3C6	H3 Clustered Histone 6	Protein Coding	2
27	H3C11	H3 Clustered Histone 11	Protein Coding	2
28	H3C8	H3 Clustered Histone 8	Protein Coding	2
29	H3C12	H3 Clustered Histone 12	Protein Coding	2
30	H3C10	H3 Clustered Histone 10	Protein Coding	2
31	H4C1	H4 Clustered Histone 1	Protein Coding	2
32	H4C4	H4 Clustered Histone 4	Protein Coding	2
33	H4C6	H4 Clustered Histone 6	Protein Coding	2
34	H4C12	H4 Clustered Histone 12	Protein Coding	2
35	H4C11	H4 Clustered Histone 11	Protein Coding	2
36	H4C3	H4 Clustered Histone 3	Protein Coding	2
37	H4C8	H4 Clustered Histone 8	Protein Coding	2
38	H4C2	H4 Clustered Histone 2	Protein Coding	2
39	H4C5	H4 Clustered Histone 5	Protein Coding	2
40	H4C13	H4 Clustered Histone 13	Protein Coding	2
41	SETDB2	SET Domain Bifurcated Histone Lysine Methyltransferase 2	Protein Coding	2
42	SETD3	SET Domain Containing 3, Actin N3(Tau)-Histidine Methyltransferase	Protein Coding	2
43	DOT1L	DOT1 Like Histone Lysine Methyltransferase	Protein Coding	2
44	KMT5C	Lysine Methyltransferase 5C	Protein Coding	2
45	EED	Embryonic Ectoderm Development	Protein Coding	2
46	H3C7	H3 Clustered Histone 7	Protein Coding	2
47	SETD1A	SET Domain Containing 1A, Histone Lysine Methyltransferase	Protein Coding	2
48	KMT2B	Lysine Methyltransferase 2B	Protein Coding	2
49	SETDB1	SET Domain Bifurcated Histone Lysine Methyltransferase 1	Protein Coding	2
50	WDR5	WD Repeat Domain 5	Protein Coding	1
51	MECOM	MDS1 And EVI1 Complex Locus	Protein Coding	1
52	SUZ12	SUZ12 Polycomb Repressive Complex 2 Subunit	Protein Coding	1
53	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
54	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
55	NSD3	Nuclear Receptor Binding SET Domain Protein 3	Protein Coding	1
56	H4C15	H4 Clustered Histone 15	Protein Coding	1
57	ATF7IP	Activating Transcription Factor 7 Interacting Protein	Protein Coding	1
58	PRDM9	PR/SET Domain 9	Protein Coding	1
59	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
60	RBBP5	RB Binding Protein 5, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	1
61	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	1
62	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
63	PRDM16	PR/SET Domain 16	Protein Coding	1
64	NSD2	Nuclear Receptor Binding SET Domain Protein 2	Protein Coding	1
65	SETD7	SET Domain Containing 7, Histone Lysine Methyltransferase	Protein Coding	1
66	H3C3	H3 Clustered Histone 3	Protein Coding	1
67	H3C2	H3 Clustered Histone 2	Protein Coding	1
68	H4C14	H4 Clustered Histone 14	Protein Coding	1
69	DPY30	Dpy-30 Histone Methyltransferase Complex Regulatory Subunit	Protein Coding	1
70	ASH2L	ASH2 Like, Histone Lysine Methyltransferase Complex Subunit	Protein Coding	1
71	PRDM2	PR/SET Domain 2	Protein Coding	1
72	SET	SET Nuclear Proto-Oncogene	Protein Coding	1
73	KMT2E	Lysine Methyltransferase 2E (Inactive)	Protein Coding	1
74	SETD5	SET Domain Containing 5	Protein Coding	1
75	H3-3B	H3.3 Histone B	Protein Coding	1
76	H3-3A	H3.3 Histone A	Protein Coding	1
77	SETBP1	SET Binding Protein 1	Protein Coding	1
78	SMYD4	SET And MYND Domain Containing 4	Protein Coding	1
79	SMYD1	SET And MYND Domain Containing 1	Protein Coding	1
80	SETD9	SET Domain Containing 9	Protein Coding	1
81	LOC105377622	Uncharacterized LOC105377622	RNA Gene	1
82	SMYD5	SMYD Family Member 5	Protein Coding	1
83	H4C7	H4 Clustered Histone 7	Protein Coding	1
84	SETMAR	SET And Mariner Transposase Domain Methyltransferase	Protein Coding	1
85	SETD4	SET Domain Containing 4	Protein Coding	1
86	EZH1	Enhancer Of Zeste 1 Polycomb Repressive Complex 2 Subunit	Protein Coding	1

Disorders associated with PKMTs methylate histone lysines SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Autism spectrum disorder	Enrichment	EED, EHMT1, KMT2A, KMT2C, KMT5B, SETD1A, SETD2, SETD5	7.33
2	Weaver syndrome	Enrichment	EZH2, NSD1, SUZ12	6.88
3	Complex neurodevelopmental disorder	Enrichment	H4C3, H4C5, H4C9, KMT2B, KMT2E, SETD1A, SETD5	5.70
4	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	4.65
5	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	4.65
6	Kleefstra syndrome	Enrichment	EHMT1, KMT2C	4.65
7	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	4.65
8	Kleefstra syndrome due to a point mutation	Enrichment	EHMT1, KMT2C	4.65
9	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H4C1, H4C9	4.17
10	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	4.17
11	Lymphoma	Enrichment	KMT2D, SETBP1	3.65
12	Kabuki syndrome 1	Enrichment	KMT2A, KMT2D	3.48
13	Kleefstra syndrome 1	Enrichment	EHMT1, KMT2C	3.48
14	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.27
15	Glioma susceptibility 1	Enrichment	H3-3A, H3C1	3.21
16	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	KMT2E, SETD1A	3.10
17	Leukemia, acute myeloid	Enrichment	KMT2A, NSD1, SETBP1	3.04
18	Polymicrogyria	Enrichment	EHMT1, SETD5	3.00
19	Autosomal dominant non-syndromic intellectual disability	Enrichment	ASH1L, SET, SETD1B	2.76
20	Myeloma, multiple	Enrichment	H3C1, KMT2C, KMT2D	2.61
21	Dandy-walker syndrome	Enrichment	KMT2D, SETD2	2.53
22	Branchial cleft anomalies	Enrichment	KMT2D	2.32
23	Intellectual developmental disorder, autosomal dominant 23	Enrichment	SETD5	2.32
24	Neurodevelopmental disorder with speech impairment and dysmorphic facies	Enrichment	SETD1A	2.32
25	Intellectual developmental disorder, autosomal dominant 70	Enrichment	SETD2	2.32
26	Schinzel-giedion midface retraction syndrome	Enrichment	SETBP1	2.32
27	Nil-deshwar neurodevelopmental syndrome	Enrichment	DOT1L	2.32
28	Epilepsy, early-onset, 2, with or without developmental delay	Enrichment	SETD1A	2.32
29	Intellectual developmental disorder with seizures and language delay	Enrichment	SETD1B	2.32
30	Intellectual developmental disorder, autosomal dominant 29	Enrichment	SETBP1	2.32
31	Branchial arch abnormalities, choanal atresia, athelia, hearing loss, and hypothyroidism syndrome	Enrichment	KMT2D	2.32
32	Kleefstra syndrome 2	Enrichment	KMT2C	2.32
33	Intellectual developmental disorder, autosomal dominant 51	Enrichment	KMT5B	2.32
34	Intellectual developmental disorder, autosomal dominant 52	Enrichment	ASH1L	2.32
35	Setbp1 haploinsufficiency disorder	Enrichment	SETBP1	2.32
36	Cohen-gibson syndrome	Enrichment	EED	2.32
37	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.32
38	Intellectual developmental disorder, autosomal dominant 68	Enrichment	KMT2B	2.32
39	Generalized isolated dystonia	Enrichment	KMT2B	2.32
40	Luscan-lumish syndrome	Enrichment	SETD2	2.32
41	Rabin-pappas syndrome	Enrichment	SETD2	2.32
42	Kmt2b-related disorders	Enrichment	KMT2B	2.32
43	Acute myeloid leukemia with mll rearrangement	Enrichment	KMT2A	2.32
44	5q35 microduplication syndrome	Enrichment	NSD1	2.32
45	Cleft lip	Enrichment	SETD5	2.32
46	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.29
47	Imagawa-matsumoto syndrome	Enrichment	SUZ12	2.29
48	Left ventricular noncompaction 8	Enrichment	PRDM16	2.29
49	Radioulnar synostosis with amegakaryocytic thrombocytopenia 2	Enrichment	MECOM	2.29
50	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.29
51	Rauch-steindl syndrome	Enrichment	NSD2	2.29
52	Holoprosencephaly 2	Enrichment	NSD1	2.02
53	Complement component c1s deficiency	Enrichment	KMT2D	2.02
54	Choanal atresia, posterior	Enrichment	KMT2D	2.02
55	O'donnell-luria-rodan syndrome	Enrichment	KMT2E	2.02
56	3p25.3 microdeletion syndrome	Enrichment	SETD5	2.02
57	Dystonia 28, childhood-onset	Enrichment	KMT2B	2.02
58	Intellectual developmental disorder, autosomal dominant 58	Enrichment	SET	2.02
59	Deletion 5q35	Enrichment	NSD1	2.02
60	3q26 microduplication syndrome	Enrichment	SETD5	2.02
61	Acute myeloid leukemia with t(9;11)(p22;q23)	Enrichment	KMT2A	2.02
62	Teratoma	Enrichment	SETBP1	2.02
63	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	KMT2A	2.02
64	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KMT2A	2.02
65	Macroglossia	Enrichment	NSD2	1.99
66	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.99
67	Immunodeficiency, common variable, 10	Enrichment	NFKB2	1.99
68	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.99
69	Rela fusion-positive ependymoma	Enrichment	RELA	1.99
70	Fissured tongue	Enrichment	NSD2	1.99
71	Radioulnar synostosis	Enrichment	MECOM	1.99
72	Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)	Enrichment	MECOM	1.99
73	Common variable immunodeficiency 12	Enrichment	NFKB1	1.99
74	Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome	Enrichment	MECOM	1.99
75	Dystonia 12	Enrichment	KMT2B	1.84
76	Nail disease	Enrichment	SETBP1	1.84
77	Hydronephrosis	Enrichment	SETBP1	1.84
78	Mixed phenotype acute leukemia with t	Enrichment	KMT2A	1.84
79	Microtia-anotia	Enrichment	KMT2D	1.72
80	Intellectual developmental disorder, autosomal dominant 26	Enrichment	KMT2D	1.72
81	Sotos syndrome 1	Enrichment	NSD1	1.72
82	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.69
83	Sotos syndrome	Enrichment	NSD1	1.62
84	Kbg syndrome	Enrichment	SETD5	1.62
85	Pre-eclampsia	Enrichment	NSD1	1.62
86	Amblyopia	Enrichment	KMT2D	1.62
87	Acute megakaryocytic leukemia	Enrichment	KMT2A	1.62
88	Thrombocytopenia	Enrichment	MECOM, NSD2	1.59
89	Hypoglycemia	Enrichment	NSD2	1.59
90	Endometrial stromal sarcoma	Enrichment	SUZ12	1.59
91	Wiedemann-steiner syndrome	Enrichment	KMT2A	1.55
92	Dyskeratosis congenita, autosomal dominant 1	Enrichment	MECOM	1.51
93	Wolf-hirschhorn syndrome	Enrichment	NSD2	1.51
94	Schizophrenia	Enrichment	EHMT1, SETD1A	1.49
95	Leukemia, chronic myeloid	Enrichment	SETBP1	1.48
96	Overgrowth syndrome	Enrichment	NSD1	1.48
97	Dyskeratosis congenita, autosomal dominant 2	Enrichment	MECOM	1.45
98	Cornelia de lange syndrome 1	Enrichment	KMT2A	1.37
99	Charge syndrome	Enrichment	KMT2D	1.37
100	Cornelia de lange syndrome	Enrichment	KMT2A	1.37
101	Ventricular septal defect	Enrichment	NSD2	1.34
102	Autism	Enrichment	KMT2B, KMT2D	1.33
103	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.30
104	Myelodysplastic syndrome	Enrichment	SETBP1	1.29
105	Atrial heart septal defect	Enrichment	SETBP1	1.29
106	Interatrial communication	Enrichment	SETBP1	1.29
107	Specific learning disability	Enrichment	KMT2B	1.29
108	Juvenile myelomonocytic leukemia	Enrichment	SETBP1	1.25
109	Neural tube defects	Enrichment	KMT5B	1.22
110	Nk-cell enteropathy	Enrichment	SETD5	1.22
111	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	NSD2	1.19
112	Clubfoot	Enrichment	NSD2	1.19
113	Chromosome 1p36 deletion syndrome	Enrichment	PRDM16	1.19
114	Protein-deficiency anemia	Enrichment	NSD2	1.19
115	Renal cell carcinoma, nonpapillary	Enrichment	SETD2	1.16
116	Corpus callosum, agenesis of	Enrichment	SETD2	1.16
117	Isolated corpus callosum agenesis	Enrichment	SETD2	1.16
118	Rare genetic intellectual disability	Enrichment	KMT2A	1.16
119	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	SETD2	1.16
120	Male infertility with spermatogenesis disorder	Enrichment	KMT2D	1.16
121	Hydrocephalus, congenital, 1	Enrichment	SETD2	1.13
122	Cleft palate, isolated	Enrichment	SETD5	1.11
123	Beckwith-wiedemann syndrome	Enrichment	NSD1	1.08
124	Syndromic intellectual disability	Enrichment	NSD2	1.07
125	Congenital nervous system abnormality	Enrichment	KMT2D, SETBP1	1.04
126	Nervous system disease	Enrichment	KMT2D, SETBP1	1.04
127	Precursor t-cell acute lymphoblastic leukemia	Enrichment	SET	0.98
128	Scoliosis	Enrichment	NSD1	0.96
129	Microcephaly	Enrichment	KMT2A, KMT2D	0.93
130	Hydrops fetalis, nonimmune	Enrichment	NSD1	0.93
131	Strabismus	Enrichment	KMT2D	0.91
132	Non-immune hydrops fetalis	Enrichment	NSD1	0.86
133	Lung cancer	Enrichment	KMT2D	0.85
134	Inherited cancer-predisposing syndrome	Enrichment	EZH2, MECOM	0.83
135	Dystonia	Enrichment	KMT2B	0.81
136	Fetal akinesia deformation sequence 1	Enrichment	SETBP1	0.79
137	Left ventricular noncompaction	Enrichment	PRDM16	0.78
138	Epilepsy	Enrichment	SETD1B	0.76
139	Distal arthrogryposis	Enrichment	SETBP1	0.74
140	Hypertrophic cardiomyopathy	Enrichment	NSD2	0.70
141	Hypertelorism	Enrichment	NSD1	0.65
142	Familial isolated dilated cardiomyopathy	Enrichment	PRDM16	0.62
143	Primary ovarian insufficiency	Enrichment	MECOM	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PKMTs methylate histone lysines

Pathway Network for PKMTs methylate histone lysines

Member Pathways for PKMTs methylate histone lysines

Pathways in the PKMTs methylate histone lysines SuperPath

Associated Genes for PKMTs methylate histone lysines

Associated Disorders for PKMTs methylate histone lysines

Disorders associated with PKMTs methylate histone lysines SuperPath

STRING Interaction Network for PKMTs methylate histone lysines

Sources for PKMTs methylate histone lysines