Plasma lipoprotein assembly, remodeling, and clearance

Pathway network for the Plasma lipoprotein assembly, remodeling, and clearance SuperPath

Sources:

Reactome

Pathways in the Plasma lipoprotein assembly, remodeling, and clearance SuperPath

#	Name	Source	Genes
1	Plasma lipoprotein assembly, remodeling, and clearance	Reactome	A2M ABCA1 ABCG1 ALB AMN ANGPTL3 ANGPTL4 ANGPTL8 AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOA1 APOA2 APOA4 APOA5 APOB APOBR APOC1 APOC2 APOC3 APOC4 APOE APOF BMP1 CES3 CETP CIDEC CLTA CLTC CREB3L3 CUBN FGF21 FURIN GPIHBP1 HDLBP LCAT LDLR LDLRAP1 LIPA LIPC LIPG LMF1 LMF2 LPA LPL LSR MBTPS1 MBTPS2 MTTP MYLIP NCEH1 NPC1 NPC2 NR1H2 NR1H3 P4HB PCSK5 PCSK6 PCSK9 PLTP PRKACA PRKACB PRKACG RPS27A SAR1B SCARB1 SOAT1 SOAT2 UBA52 UBB UBC VLDLR ZDHHC8 (see all 75) (see less)
2	Plasma lipoprotein clearance	Reactome	AMN AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOA1 APOB APOBR APOC1 APOC4 APOE CES3 CLTA CLTC CUBN HDLBP LDLR LDLRAP1 LIPA LIPC LSR MYLIP NCEH1 NPC1 NPC2 NR1H2 NR1H3 PCSK9 RPS27A SCARB1 SOAT1 SOAT2 UBA52 UBB UBC VLDLR (see all 37) (see less)
3	Plasma lipoprotein remodeling	Reactome	ABCG1 ALB ANGPTL3 ANGPTL4 ANGPTL8 APOA1 APOA2 APOA4 APOA5 APOB APOC2 APOC3 APOE APOF CETP CIDEC CREB3L3 FGF21 FURIN GPIHBP1 LCAT LIPC LIPG LMF1 LMF2 LPA LPL MBTPS1 MBTPS2 MTTP P4HB PCSK5 PCSK6 PLTP (see all 34) (see less)
4	Assembly of active LPL and LIPC lipase complexes	Reactome	ANGPTL3 ANGPTL4 ANGPTL8 APOA4 APOA5 APOC2 CIDEC CREB3L3 FGF21 FURIN GPIHBP1 LIPC LMF1 LMF2 LPL MBTPS1 MBTPS2 PCSK5 PCSK6 (see all 19) (see less)
5	LDL clearance	Reactome	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 APOB CES3 CLTA CLTC LDLR LDLRAP1 LIPA LSR NCEH1 NPC1 NPC2 PCSK9 SOAT1 SOAT2 (see all 19) (see less)
6	Plasma lipoprotein assembly	Reactome	A2M ABCA1 APOA1 APOA2 APOA4 APOB APOC1 APOC2 APOC3 APOC4 APOE BMP1 MTTP P4HB PRKACA PRKACB PRKACG SAR1B ZDHHC8 (see all 19) (see less)
7	VLDLR internalisation and degradation	Reactome	AP2A1 AP2A2 AP2B1 AP2M1 AP2S1 CLTA CLTC MYLIP NR1H2 NR1H3 PCSK9 RPS27A UBA52 UBB UBC VLDLR (see all 16) (see less)
8	HDL remodeling	Reactome	ABCG1 ALB APOA1 APOC2 APOC3 APOE CETP LCAT LIPG PLTP (see all 10) (see less)
9	Chylomicron assembly	Reactome	APOA1 APOA2 APOA4 APOB APOC2 APOC3 APOE MTTP P4HB SAR1B (see all 10) (see less)
10	Chylomicron remodeling	Reactome	APOA1 APOA2 APOA4 APOA5 APOB APOC2 APOC3 APOE GPIHBP1 LPL (see all 10) (see less)
11	HDL assembly	Reactome	A2M ABCA1 APOA1 BMP1 PRKACA PRKACB PRKACG ZDHHC8 (see all 8) (see less)
12	LDL remodeling	Reactome	APOB APOF CETP LPA MTTP P4HB (see all 6) (see less)
13	VLDL clearance	Reactome	APOB APOBR APOC1 APOC4 LSR VLDLR (see all 6) (see less)
14	VLDL assembly	Reactome	APOB APOC1 APOC4 MTTP P4HB
15	Chylomicron clearance	Reactome	APOB APOE LDLR LDLRAP1 LIPC
16	HDL clearance	Reactome	AMN APOA1 CUBN HDLBP SCARB1
17	Defective ABCA1 causes TGD	Reactome	ABCA1 APOA1

Gene overlap in member pathways for Plasma lipoprotein assembly, remodeling, and clearance SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	APOB	Apolipoprotein B	Protein Coding	11
2	APOA1	Apolipoprotein A1	Protein Coding	10
3	APOE	Apolipoprotein E	Protein Coding	8
4	APOC2	Apolipoprotein C2	Protein Coding	7
5	APOA4	Apolipoprotein A4	Protein Coding	6
6	APOC3	Apolipoprotein C3	Protein Coding	6
7	MTTP	Microsomal Triglyceride Transfer Protein	Protein Coding	6
8	P4HB	Prolyl 4-Hydroxylase Subunit Beta	Protein Coding	6
9	APOA2	Apolipoprotein A2	Protein Coding	5
10	APOC1	Apolipoprotein C1	Protein Coding	5
11	APOC4	Apolipoprotein C4	Protein Coding	5
12	LIPC	Lipase C, Hepatic Type	Protein Coding	5
13	CETP	Cholesteryl Ester Transfer Protein	Protein Coding	4
14	APOA5	Apolipoprotein A5	Protein Coding	4
15	AP2M1	Adaptor Related Protein Complex 2 Subunit Mu 1	Protein Coding	4
16	AP2S1	Adaptor Related Protein Complex 2 Subunit Sigma 1	Protein Coding	4
17	CLTA	Clathrin Light Chain A	Protein Coding	4
18	CLTC	Clathrin Heavy Chain	Protein Coding	4
19	AP2A1	Adaptor Related Protein Complex 2 Subunit Alpha 1	Protein Coding	4
20	AP2A2	Adaptor Related Protein Complex 2 Subunit Alpha 2	Protein Coding	4
21	AP2B1	Adaptor Related Protein Complex 2 Subunit Beta 1	Protein Coding	4
22	ABCA1	ATP Binding Cassette Subfamily A Member 1	Protein Coding	4
23	PCSK9	Proprotein Convertase Subtilisin/Kexin Type 9	Protein Coding	4
24	LDLRAP1	Low Density Lipoprotein Receptor Adaptor Protein 1	Protein Coding	4
25	GPIHBP1	Glycosylphosphatidylinositol Anchored High Density Lipoprotein Binding Protein 1	Protein Coding	4
26	LDLR	Low Density Lipoprotein Receptor	Protein Coding	4
27	LPL	Lipoprotein Lipase	Protein Coding	4
28	LSR	Lipolysis Stimulated Lipoprotein Receptor	Protein Coding	4
29	VLDLR	Very Low Density Lipoprotein Receptor	Protein Coding	4
30	NR1H3	Nuclear Receptor Subfamily 1 Group H Member 3	Protein Coding	3
31	NPC2	NPC Intracellular Cholesterol Transporter 2	Protein Coding	3
32	A2M	Alpha-2-Macroglobulin	Protein Coding	3
33	ALB	Albumin	Protein Coding	3
34	CES3	Carboxylesterase 3	Protein Coding	3
35	FGF21	Fibroblast Growth Factor 21	Protein Coding	3
36	ANGPTL3	Angiopoietin Like 3	Protein Coding	3
37	MYLIP	Myosin Regulatory Light Chain Interacting Protein	Protein Coding	3
38	ZDHHC8	ZDHHC Palmitoyltransferase 8	Protein Coding	3
39	HDLBP	High Density Lipoprotein Binding Protein	Protein Coding	3
40	APOF	Apolipoprotein F	Protein Coding	3
41	LCAT	Lecithin-Cholesterol Acyltransferase	Protein Coding	3
42	LIPA	Lipase A, Lysosomal Acid Type	Protein Coding	3
43	LPA	Lipoprotein(A)	Protein Coding	3
44	NPC1	NPC Intracellular Cholesterol Transporter 1	Protein Coding	3
45	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	3
46	PCSK6	Proprotein Convertase Subtilisin/Kexin Type 6	Protein Coding	3
47	SAR1B	Secretion Associated Ras Related GTPase 1B	Protein Coding	3
48	ANGPTL4	Angiopoietin Like 4	Protein Coding	3
49	PCSK5	Proprotein Convertase Subtilisin/Kexin Type 5	Protein Coding	3
50	MBTPS2	Membrane Bound Transcription Factor Peptidase, Site 2	Protein Coding	3
51	PLTP	Phospholipid Transfer Protein	Protein Coding	3
52	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	3
53	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	3
54	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	3
55	ANGPTL8	Angiopoietin Like 8	Protein Coding	3
56	APOBR	Apolipoprotein B Receptor	Protein Coding	3
57	NCEH1	Neutral Cholesterol Ester Hydrolase 1	Protein Coding	3
58	RPS27A	Ribosomal Protein S27a	Protein Coding	3
59	CIDEC	Cell Death Inducing DFFA Like Effector C	Protein Coding	3
60	LMF1	Lipase Maturation Factor 1	Protein Coding	3
61	BMP1	Bone Morphogenetic Protein 1	Protein Coding	3
62	SOAT1	Sterol O-Acyltransferase 1	Protein Coding	3
63	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	3
64	UBB	Ubiquitin B	Protein Coding	3
65	UBC	Ubiquitin C	Protein Coding	3
66	NR1H2	Nuclear Receptor Subfamily 1 Group H Member 2	Protein Coding	3
67	CUBN	Cubilin	Protein Coding	3
68	AMN	Amnion Associated Transmembrane Protein	Protein Coding	3
69	SOAT2	Sterol O-Acyltransferase 2	Protein Coding	3
70	CREB3L3	CAMP Responsive Element Binding Protein 3 Like 3	Protein Coding	3
71	MBTPS1	Membrane Bound Transcription Factor Peptidase, Site 1	Protein Coding	3
72	LMF2	Lipase Maturation Factor 2	Protein Coding	3
73	LIPG	Lipase G, Endothelial Type	Protein Coding	3
74	SCARB1	Scavenger Receptor Class B Member 1	Protein Coding	3
75	ABCG1	ATP Binding Cassette Subfamily G Member 1	Protein Coding	3

Disorders associated with Plasma lipoprotein assembly, remodeling, and clearance SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Tangier disease	Direct
2	Familial hypercholesterolemia	Enrichment	APOB, APOE, LDLR, LDLRAP1	10.44
3	Homozygous familial hypercholesterolemia	Enrichment	APOB, LDLR, LDLRAP1, PCSK9	9.65
4	Lipid metabolism disorder	Enrichment	APOE, LDLR, LIPC	9.29
5	Hyperlipoproteinemia, type iii	Enrichment	APOE, LDLR	6.96
6	Hyperalphalipoproteinemia 1	Enrichment	APOC3, CETP, SCARB1	6.79
7	Hypercholesterolemia, familial, 2	Enrichment	APOB, LDLR	6.49
8	Hypercholesterolemia, familial, 4	Enrichment	LDLR, LDLRAP1	6.49
9	Hyperlipoproteinemia, type i	Enrichment	GPIHBP1, LPL	6.31
10	Familial lipoprotein lipase deficiency	Enrichment	GPIHBP1, LPL	6.31
11	Hypercholesterolemia, familial, 1	Enrichment	APOA2, APOB, LDLR, PCSK9	6.23
12	Hypoalphalipoproteinemia, primary, 2	Enrichment	ABCA1, APOA1	6.04
13	Hyperlipidemia, familial combined, 3	Enrichment	APOB, LDLR	5.96
14	Megaloblastic anemia	Enrichment	AMN, CUBN	5.79
15	Hypoalphalipoproteinemia, primary, 1	Enrichment	ABCA1, APOA1	5.74
16	Lipase deficiency, combined	Enrichment	LMF1, LPL	5.73
17	Niemann-pick disease, type c2	Enrichment	NPC1, NPC2	5.73
18	Niemann-pick disease type c, severe perinatal form	Enrichment	NPC1, NPC2	5.73
19	Niemann-pick disease type c, severe early infantile neurologic onset	Enrichment	NPC1, NPC2	5.73
20	Niemann-pick disease type c, juvenile neurologic onset	Enrichment	NPC1, NPC2	5.73
21	Niemann-pick disease type c, adult neurologic onset	Enrichment	NPC1, NPC2	5.73
22	Niemann-pick disease type c, late infantile neurologic onset	Enrichment	NPC1, NPC2	5.73
23	Imerslund-grasbeck syndrome 1	Enrichment	AMN, CUBN	5.64
24	Coronary artery anomaly	Enrichment	APOC3, LPL	5.53
25	Coronary heart disease 5	Enrichment	APOB, LDLR	5.41
26	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	4.96
27	Hypertriglyceridemia 1	Enrichment	APOA5, CREB3L3	4.95
28	Niemann-pick disease, type c1	Enrichment	NPC1, NPC2	4.73
29	Niemann-pick disease	Enrichment	NPC1, NPC2	4.73
30	Osteogenesis imperfecta, type i	Enrichment	MBTPS2, P4HB	4.04
31	Cole-carpenter syndrome 1	Enrichment	P4HB	3.43
32	Abetalipoproteinemia	Enrichment	MTTP	3.43
33	Sea-blue histiocyte disease	Enrichment	APOE	3.43
34	Lipoprotein glomerulopathy	Enrichment	APOE	3.43
35	Hepatic lipase deficiency	Enrichment	LIPC	3.43
36	High density lipoprotein cholesterol level quantitative trait locus 12	Enrichment	LIPC	3.43
37	Hyperlipidemia due to hepatic triglyceride lipase deficiency	Enrichment	LIPC	3.43
38	High density lipoprotein cholesterol level quantitative trait locus 6	Enrichment	SCARB1	3.43
39	Vitamin b12 deficiency	Enrichment	AMN	3.43
40	Lipoprotein quantitative trait locus	Enrichment	LPA	3.35
41	Cerebellar hypoplasia	Enrichment	VLDLR	3.35
42	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	3.23
43	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	3.23
44	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	3.23
45	Hypoalphalipoproteinemia	Enrichment	ABCA1	3.23
46	Abdominal obesity-metabolic syndrome 1	Enrichment	MTTP	3.13
47	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	3.13
48	Hypobetalipoproteinemia	Enrichment	APOB	3.13
49	Alzheimer disease 3	Enrichment	APOE	3.13
50	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	3.13
51	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	3.13
52	Hyperthyroxinemia, familial dysalbuminemic	Enrichment	ALB	3.13
53	Apolipoprotein c-iii deficiency	Enrichment	APOC3	3.13
54	Congenital analbuminemia	Enrichment	ALB	3.13
55	Analbuminemia	Enrichment	ALB	3.13
56	Tubulointerstitial kidney disease, autosomal dominant 6	Enrichment	APOA4	3.13
57	Aapoaii amyloidosis	Enrichment	APOA2	3.13
58	Hyperlipoproteinemia, type id	Enrichment	GPIHBP1	3.13
59	Familial apolipoprotein a5 deficiency	Enrichment	APOA5	3.13
60	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome	Enrichment	VLDLR	3.05
61	Cole-carpenter syndrome	Enrichment	P4HB	2.96
62	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	LDLR	2.96
63	Alzheimer disease 4	Enrichment	APOE	2.96
64	Syndromic x-linked intellectual disability najm type	Enrichment	LDLR	2.96
65	Proteinuria, chronic benign	Enrichment	CUBN	2.96
66	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	2.96
67	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.93
68	Osteogenesis imperfecta, type xiii	Enrichment	BMP1	2.93
69	Fibrolamellar carcinoma	Enrichment	PRKACA	2.93
70	Hypocalciuric hypercalcemia, familial, type iii	Enrichment	AP2S1	2.93
71	Hypercholesterolemia, familial, 3	Enrichment	PCSK9	2.93
72	Olmsted syndrome, x-linked	Enrichment	MBTPS2	2.85
73	Osteogenesis imperfecta, type xix	Enrichment	MBTPS2	2.85
74	Keratosis follicularis spinulosa decalvans, x-linked	Enrichment	MBTPS2	2.85
75	Lipodystrophy, familial partial, type 5	Enrichment	CIDEC	2.85
76	Hypertriglyceridemia 2	Enrichment	CREB3L3	2.85
77	Plasma triglyceride level quantitative trait locus	Enrichment	ANGPTL4	2.85
78	Cataract, alopecia, oral mucosal disorder, and psoriasis-like syndrome	Enrichment	MBTPS1	2.85
79	Ifap syndrome	Enrichment	MBTPS2	2.85
80	Bresek syndrome	Enrichment	MBTPS2	2.85
81	Cholesteryl ester storage disease	Enrichment	LIPA	2.85
82	Wolman disease	Enrichment	LIPA	2.85
83	Lysosomal acid lipase deficiency	Enrichment	LIPA	2.85
84	Macular degeneration, age-related, 1	Enrichment	APOE	2.83
85	Imerslund-grasbeck syndrome 2	Enrichment	AMN	2.83
86	Fish-eye disease	Enrichment	LCAT	2.83
87	Apolipoprotein c-ii deficiency	Enrichment	APOC2	2.83
88	Lecithin:cholesterol acyltransferase deficiency	Enrichment	LCAT	2.83
89	Familial apolipoprotein c-ii deficiency	Enrichment	APOC2	2.83
90	Chylomicron retention disease	Enrichment	SAR1B	2.83
91	Hyperlipoproteinemia, type v	Enrichment	APOA5	2.83
92	High bone mass osteogenesis imperfecta	Enrichment	BMP1	2.75
93	Alzheimer disease 2	Enrichment	APOE	2.73
94	Amyloidosis, hereditary systemic 2	Enrichment	APOA1	2.73
95	Cowden syndrome 1	Enrichment	LDLR	2.66
96	Intellectual developmental disorder, autosomal dominant 60, with seizures	Enrichment	AP2M1	2.63
97	Submucosal cleft palate	Enrichment	UBB	2.63
98	Cleft hard palate	Enrichment	UBB	2.63
99	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	VLDLR	2.58
100	Hypobetalipoproteinemia, familial, 2	Enrichment	ANGPTL3	2.55
101	Developmental and epileptic encephalopathy 23	Enrichment	ANGPTL3	2.55
102	Spondyloepiphyseal dysplasia, kondo-fu type	Enrichment	MBTPS1	2.55
103	Transient infantile hypertriglyceridemia and hepatosteatosis	Enrichment	CREB3L3	2.55
104	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	ALB	2.53
105	Osteogenesis imperfecta, type iii	Enrichment	BMP1, MBTPS2	2.52
106	Uvula, bifid	Enrichment	UBB	2.45
107	Cleft soft palate	Enrichment	UBB	2.45
108	Intellectual developmental disorder, autosomal dominant 56	Enrichment	CLTC	2.45
109	Ifap syndrome 1, with or without bresheck syndrome	Enrichment	MBTPS2	2.38
110	Keratosis follicularis spinulosa decalvans	Enrichment	MBTPS2	2.38
111	Mutilating palmoplantar keratoderma with periorificial keratotic plaques	Enrichment	MBTPS2	2.38
112	Nasopharyngeal carcinoma	Enrichment	NPC1	2.38
113	Neurologic, endocrine, and pancreatic disease, multisystem, infantile-onset 1	Enrichment	CLTC	2.33
114	Alzheimer's disease	Enrichment	APOE	2.32
115	Chronic kidney disease	Enrichment	CUBN	2.32
116	Alzheimer disease, familial, 1	Enrichment	APOE	2.20
117	Inflammatory myofibroblastic tumor	Enrichment	CLTC	2.15
118	Noonan syndrome 3	Enrichment	CLTC	2.08
119	Renal cell carcinoma with mit translocations	Enrichment	CLTC	2.08
120	Myoclonic-atonic epilepsy	Enrichment	AP2M1	1.98
121	Brittle bone disorder	Enrichment	BMP1	1.87
122	Cardiomyopathy, dilated, 1a	Enrichment	LPL	1.81
123	Type 2 diabetes mellitus	Enrichment	LIPC	1.81
124	Multiple sclerosis	Enrichment	NR1H3	1.79
125	Osteogenesis imperfecta, type iv	Enrichment	MBTPS2	1.74
126	Autism spectrum disorder	Enrichment	CUBN	1.40
127	Breast cancer	Enrichment	ABCA1	1.36
128	Congenital nervous system abnormality	Enrichment	VLDLR	1.34
129	Nervous system disease	Enrichment	VLDLR	1.34
130	Dystonia	Enrichment	NPC1	1.32
131	Autosomal dominant non-syndromic intellectual disability	Enrichment	CLTC	1.24
132	Undetermined early-onset epileptic encephalopathy	Enrichment	CLTC	1.19
133	Microcephaly	Enrichment	NPC2	0.80

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² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Plasma lipoprotein assembly, remodeling, and clearance

Pathway Network for Plasma lipoprotein assembly, remodeling, and clearance

Pathway network for the Plasma lipoprotein assembly, remodeling, and clearance SuperPath

Member Pathways for Plasma lipoprotein assembly, remodeling, and clearance

Pathways in the Plasma lipoprotein assembly, remodeling, and clearance SuperPath

Gene overlap in member pathways for Plasma lipoprotein assembly, remodeling, and clearance SuperPath

Associated Genes for Plasma lipoprotein assembly, remodeling, and clearance

Associated Disorders for Plasma lipoprotein assembly, remodeling, and clearance

Disorders associated with Plasma lipoprotein assembly, remodeling, and clearance SuperPath

STRING Interaction Network for Plasma lipoprotein assembly, remodeling, and clearance

Sources for Plasma lipoprotein assembly, remodeling, and clearance