Plasma membrane estrogen receptor signaling

No Pathway Network information available for Plasma membrane estrogen receptor signaling

Pathways in the Plasma membrane estrogen receptor signaling SuperPath

#	Name	Source	Genes
1	Plasma membrane estrogen receptor signaling	PubChem	AKT1 BCAR1 ESR1 ESR2 GNA13 GNB1 GNG2 GRB2 HBEGF IGF1R MAPK11 MMP2 MMP9 MSN NOS3 PELP1 PIK3CA PIK3R1 RHOA ROCK2 SHC1 SOS1 SRC STRN (see all 24) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
2	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
3	MSN	Moesin	Protein Coding	1
4	PELP1	Proline, Glutamate And Leucine Rich Protein 1	Protein Coding	1
5	STRN	Striatin	Protein Coding	1
6	ESR2	Estrogen Receptor 2	Protein Coding	1
7	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	1
8	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
9	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
10	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
11	BCAR1	BCAR1 Scaffold Protein, Cas Family Member	Protein Coding	1
12	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
13	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
14	RHOA	Ras Homolog Family Member A	Protein Coding	1
15	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
16	GNB1	G Protein Subunit Beta 1	Protein Coding	1
17	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
18	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
19	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
20	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
21	SHC1	SHC Adaptor Protein 1	Protein Coding	1
22	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
23	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
24	ESR1	Estrogen Receptor 1	Protein Coding	1

Disorders associated with Plasma membrane estrogen receptor signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast cancer	Enrichment	AKT1, ESR1, PIK3CA, SHC1	5.07
2	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	5.05
3	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1, SRC	4.82
4	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	4.35
5	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.35
6	Hereditary breast carcinoma	Enrichment	AKT1, ESR1, PIK3CA	4.21
7	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.97
8	Meningioma	Enrichment	AKT1, PIK3CA	3.71
9	Macrodactyly	Enrichment	PIK3CA	2.75
10	Proteus syndrome	Enrichment	AKT1	2.75
11	Immunodeficiency 50	Enrichment	MSN	2.75
12	Noonan syndrome 4	Enrichment	SOS1	2.75
13	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.75
14	Cowden syndrome 5	Enrichment	PIK3CA	2.75
15	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.75
16	Short syndrome	Enrichment	PIK3R1	2.75
17	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.75
18	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.75
19	Ovarian dysgenesis 8	Enrichment	ESR2	2.75
20	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.75
21	Cowden syndrome 6	Enrichment	AKT1	2.75
22	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.75
23	Thrombocytopenia 6	Enrichment	SRC	2.75
24	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.75
25	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.75
26	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.75
27	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.75
28	Hypospadias	Enrichment	PIK3CA	2.75
29	Rare venous malformation	Enrichment	PIK3CA	2.75
30	Diaphragmatic eventration	Enrichment	PIK3CA	2.75
31	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.75
32	Rare combined vascular malformation	Enrichment	PIK3CA	2.75
33	Cavernous lymphangioma	Enrichment	PIK3CA	2.75
34	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.75
35	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.75
36	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.75
37	Macrodactyly of toe	Enrichment	PIK3CA	2.75
38	Fibromatosis, gingival, 1	Enrichment	SOS1	2.45
39	Pulmonic stenosis	Enrichment	SOS1	2.45
40	Keratosis, seborrheic	Enrichment	PIK3CA	2.45
41	Noonan syndrome 8	Enrichment	PIK3CA	2.45
42	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.45
43	Metaphyseal anadysplasia 2	Enrichment	MMP9	2.45
44	Metaphyseal anadysplasia	Enrichment	MMP9	2.45
45	Cerebral visual impairment	Enrichment	GNB1	2.45
46	Thyroid carcinoma, familial medullary	Enrichment	ESR2	2.28
47	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.28
48	Nuchal bleb, familial	Enrichment	SOS1	2.28
49	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP2	2.28
50	Estrogen resistance	Enrichment	ESR1	2.28
51	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.28
52	Immunodeficiency 14	Enrichment	PIK3R1	2.28
53	Migraine without aura	Enrichment	ESR1	2.28
54	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	2.28
55	Keratoacanthoma	Enrichment	PIK3CA	2.28
56	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.15
57	Arthrogryposis multiplex congenita 3, myogenic type	Enrichment	ESR1	2.15
58	Cerebrovascular disease	Enrichment	PIK3CA	2.15
59	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.15
60	Gingival fibromatosis	Enrichment	SOS1	2.15
61	Capillary malformations, congenital	Enrichment	PIK3CA	2.05
62	Alzheimer disease 2	Enrichment	NOS3	2.05
63	Insulin-like growth factor i	Enrichment	IGF1R	2.05
64	Pre-eclampsia	Enrichment	NOS3	2.05
65	Hemimegalencephaly	Enrichment	PIK3CA	2.05
66	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.98
67	Cowden syndrome 1	Enrichment	PIK3CA	1.98
68	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.98
69	Nevus, epidermal	Enrichment	PIK3CA	1.91
70	Myelofibrosis	Enrichment	SRC	1.91
71	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.91
72	Noonan syndrome 3	Enrichment	SOS1	1.91
73	Gallbladder cancer	Enrichment	PIK3CA	1.91
74	Overgrowth syndrome	Enrichment	PIK3R1	1.91
75	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.87
76	Hypothyroidism	Enrichment	GNB1	1.85
77	Arteriovenous malformation	Enrichment	PIK3CA	1.80
78	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.80
79	Stroke, ischemic	Enrichment	NOS3	1.76
80	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.76
81	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.76
82	Migraine with or without aura 1	Enrichment	ESR1	1.71
83	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.71
84	Myelodysplastic syndrome	Enrichment	GNB1	1.71
85	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.71
86	Microcephaly	Enrichment	GNB1, IGF1R	1.70
87	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.68
88	Aortic valve disease 1	Enrichment	SOS1	1.64
89	Nk-cell enteropathy	Enrichment	IGF1R	1.64
90	Osteoporosis	Enrichment	SRC	1.61
91	46,xy partial gonadal dysgenesis	Enrichment	SOS1	1.61
92	Lynch syndrome	Enrichment	PIK3CA	1.58
93	Noonan syndrome and noonan-related syndrome	Enrichment	SOS1	1.58
94	Alzheimer disease, familial, 1	Enrichment	NOS3	1.53
95	Hypertension, essential	Enrichment	NOS3	1.53
96	Cleft palate, isolated	Enrichment	GNB1	1.53
97	Endometrial cancer	Enrichment	PIK3CA	1.44
98	Hepatocellular carcinoma	Enrichment	PIK3CA	1.42
99	Myocardial infarction	Enrichment	ESR1	1.42
100	Noonan syndrome 1	Enrichment	SOS1	1.40
101	Rasopathy	Enrichment	SOS1	1.35
102	Strabismus	Enrichment	GNB1	1.33
103	Bladder cancer	Enrichment	PIK3CA	1.30
104	Prostate cancer	Enrichment	PIK3CA	1.30
105	Lung cancer	Enrichment	PIK3CA	1.26
106	Dystonia	Enrichment	GNB1	1.22
107	Cerebral palsy	Enrichment	GNB1	1.18
108	Gastric cancer	Enrichment	PIK3CA	1.13
109	Thrombocytopenia	Enrichment	SRC	1.09
110	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	1.07
111	Hypertelorism	Enrichment	PIK3CA	1.05
112	Hereditary breast ovarian cancer syndrome	Enrichment	BCAR1	1.03
113	Primary ovarian insufficiency	Enrichment	NOS3	1.00
114	Autism spectrum disorder	Enrichment	GNB1	0.75

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Plasma membrane estrogen receptor signaling

Pathway Network for Plasma membrane estrogen receptor signaling

Member Pathways for Plasma membrane estrogen receptor signaling

Pathways in the Plasma membrane estrogen receptor signaling SuperPath

Associated Genes for Plasma membrane estrogen receptor signaling

Associated Disorders for Plasma membrane estrogen receptor signaling

Disorders associated with Plasma membrane estrogen receptor signaling SuperPath

STRING Interaction Network for Plasma membrane estrogen receptor signaling

Sources for Plasma membrane estrogen receptor signaling