Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

No Pathway Network information available for Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

Pathways in the Platelet Aggregation Inhibitor Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics	PharmGKB	ADCY3 CD36 COL1A1 COL1A2 COL3A1 COL4A1 COL4A2 CYP1A2 CYP2B6 CYP2C19 CYP2C9 CYP3A4 CYP3A5 F2 F2R F2RL3 FGA FGB FGG GNA11 GNA12 GNA13 GNA15 GNAI1 GNAI2 GNAI3 GNAQ GNAS GNB3 GP1BB GP5 GP6 GP9 ITGA2 ITGA2B ITGB3 P2RX1 P2RY1 P2RY12 PLA2G2A PLA2G4A PLA2G4B PLCB1 PLCG2 PTGDR PTGER2 PTGIR PTGS1 TBXA2R TBXAS1 VWF (see all 51) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PTGDR	Prostaglandin D2 Receptor	Protein Coding	1
2	PTGER2	Prostaglandin E Receptor 2	Protein Coding	1
3	PTGIR	Prostaglandin I2 Receptor	Protein Coding	1
4	PTGS1	Prostaglandin-Endoperoxide Synthase 1	Protein Coding	1
5	VWF	Von Willebrand Factor	Protein Coding	1
6	FGA	Fibrinogen Alpha Chain	Protein Coding	1
7	FGB	Fibrinogen Beta Chain	Protein Coding	1
8	FGG	Fibrinogen Gamma Chain	Protein Coding	1
9	TBXA2R	Thromboxane A2 Receptor	Protein Coding	1
10	TBXAS1	Thromboxane A Synthase 1	Protein Coding	1
11	ITGA2	Integrin Subunit Alpha 2	Protein Coding	1
12	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
13	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
14	GP6	Glycoprotein VI Platelet	Protein Coding	1
15	PLCB1	Phospholipase C Beta 1	Protein Coding	1
16	F2	Coagulation Factor II, Thrombin	Protein Coding	1
17	F2R	Coagulation Factor II Thrombin Receptor	Protein Coding	1
18	GNA11	G Protein Subunit Alpha 11	Protein Coding	1
19	GNA12	G Protein Subunit Alpha 12	Protein Coding	1
20	GNA15	G Protein Subunit Alpha 15	Protein Coding	1
21	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
22	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
23	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
24	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
25	GNAS	GNAS Complex Locus	Protein Coding	1
26	GNB3	G Protein Subunit Beta 3	Protein Coding	1
27	GP1BB	Glycoprotein Ib Platelet Subunit Beta	Protein Coding	1
28	GP5	Glycoprotein V Platelet	Protein Coding	1
29	GP9	Glycoprotein IX Platelet	Protein Coding	1
30	PLA2G2A	Phospholipase A2 Group IIA	Protein Coding	1
31	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
32	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
33	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	1
34	CYP2B6	Cytochrome P450 Family 2 Subfamily B Member 6	Protein Coding	1
35	CYP2C19	Cytochrome P450 Family 2 Subfamily C Member 19	Protein Coding	1
36	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	1
37	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	1
38	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	1
39	F2RL3	F2R Like Thrombin Or Trypsin Receptor 3	Protein Coding	1
40	GNA13	G Protein Subunit Alpha 13	Protein Coding	1
41	P2RX1	Purinergic Receptor P2X 1	Protein Coding	1
42	P2RY1	Purinergic Receptor P2Y1	Protein Coding	1
43	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	1
44	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	1
45	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	1
46	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	1
47	COL4A2	Collagen Type IV Alpha 2 Chain	Protein Coding	1
48	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	1
49	ADCY3	Adenylate Cyclase 3	Protein Coding	1
50	P2RY12	Purinergic Receptor P2Y12	Protein Coding	1
51	PLA2G4B	Phospholipase A2 Group IVB	Protein Coding	1

Disorders associated with Platelet Aggregation Inhibitor Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Thrombocytopenia	Enrichment	FGG, GP1BB, GP9, ITGA2B, ITGB3, P2RY12, VWF	9.34
2	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	GP1BB, ITGA2, ITGA2B, ITGB3	8.58
3	Dysfibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	7.30
4	Familial dysfibrinogenemia	Enrichment	FGA, FGB, FGG	7.30
5	Familial hypofibrinogenemia	Enrichment	FGA, FGB, FGG	7.30
6	Afibrinogenemia, congenital	Enrichment	FGA, FGB, FGG	6.70
7	Spastic paraplegia 4, autosomal dominant	Enrichment	COL3A1, FGG, GNAS	5.56
8	Autosomal dominant macrothrombocytopenia	Enrichment	GP1BB, ITGA2B, ITGB3	5.23
9	Ehlers-danlos syndrome, arthrochalasia type, 2	Enrichment	COL1A1, COL1A2	4.86
10	Ehlers-danlos/osteogenesis imperfecta syndrome	Enrichment	COL1A1, COL1A2	4.86
11	Phakomatosis cesioflammea	Enrichment	GNA11, GNAQ	4.86
12	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	4.38
13	High bone mass osteogenesis imperfecta	Enrichment	COL1A1, COL1A2	4.38
14	Anastomosing haemangioma	Enrichment	GNA11, GNAQ	4.38
15	Ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2, COL3A1	4.33
16	Ehlers-danlos syndrome, arthrochalasia type, 1	Enrichment	COL1A1, COL1A2	4.08
17	Brain small vessel disease 1 with or without ocular anomalies	Enrichment	COL4A1, COL4A2	4.08
18	Osteogenesis imperfecta with normal sclerae, dominant form	Enrichment	COL1A1, COL1A2	4.08
19	Capillary malformations, congenital	Enrichment	GNA11, GNAQ	3.86
20	Bernard-soulier syndrome	Enrichment	GP1BB, GP9	3.86
21	Familial porencephaly	Enrichment	COL4A1, COL4A2	3.86
22	Ehlers-danlos syndrome, classic type, 1	Enrichment	COL1A1, COL1A2	3.69
23	Melanoma, uveal	Enrichment	GNA11, GNAQ	3.69
24	Osteogenesis imperfecta, type i	Enrichment	COL1A1, COL1A2	3.69
25	Hemorrhage, intracerebral	Enrichment	COL4A1, COL4A2	3.69
26	Keratoconus	Enrichment	COL1A1, COL4A1	3.69
27	Classic ehlers-danlos syndrome	Enrichment	COL1A1, COL1A2	3.69
28	Osteogenesis imperfecta, type ii	Enrichment	COL1A1, COL1A2	3.54
29	Thrombophilia due to thrombin defect	Enrichment	F2, FGA	3.54
30	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	3.54
31	Cerebral palsy	Enrichment	COL4A1, COL4A2, F2	3.38
32	Primary bone dysplasia	Enrichment	COL1A1, COL1A2	3.21
33	Osteochondrodysplasia	Enrichment	COL1A1, COL1A2	3.13
34	Osteogenesis imperfecta, type iv	Enrichment	COL1A1, COL1A2	2.98
35	Osteoporosis	Enrichment	COL1A1, COL1A2	2.91
36	Osteogenesis imperfecta, type iii	Enrichment	COL1A1, COL1A2	2.85
37	Hypertension, essential	Enrichment	CYP3A5, GNB3	2.74
38	Brittle bone disorder	Enrichment	COL1A1, COL1A2	2.48
39	Hypocalciuric hypercalcemia, familial, type ii	Enrichment	GNA11	2.42
40	Ehlers-danlos syndrome, cardiac valvular type	Enrichment	COL1A2	2.42
41	Von willebrand disease, type 1	Enrichment	VWF	2.42
42	Drug metabolism, poor, cyp2c19-related	Enrichment	CYP2C19	2.42
43	Asthma-related traits 1	Enrichment	PTGDR	2.42
44	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.42
45	Coronary heart disease 7	Enrichment	CD36	2.42
46	Osseous heteroplasia, progressive	Enrichment	GNAS	2.42
47	Prothrombin deficiency, congenital	Enrichment	F2	2.42
48	Von willebrand disease, type 2	Enrichment	VWF	2.42
49	Ghosal hematodiaphyseal dysplasia	Enrichment	TBXAS1	2.42
50	Bleeding disorder, platelet-type, 11	Enrichment	GP6	2.42
51	Sturge-weber syndrome	Enrichment	GNAQ	2.42
52	Ventricular tachycardia, familial	Enrichment	GNAI2	2.42
53	Acrogeria, gottron type	Enrichment	COL3A1	2.42
54	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.42
55	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.42
56	Von willebrand disease, type 3	Enrichment	VWF	2.42
57	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.42
58	Combined osteogenesis imperfecta and ehlers-danlos syndrome 2	Enrichment	COL1A2	2.42
59	Bleeding disorder, platelet-type, 13	Enrichment	TBXA2R	2.42
60	Porencephaly	Enrichment	COL4A1	2.42
61	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.42
62	Platelet glycoprotein iv deficiency	Enrichment	CD36	2.42
63	Efavirenz, poor metabolism of	Enrichment	CYP2B6	2.42
64	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.42
65	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.42
66	Hypocalcemia, autosomal dominant 2	Enrichment	GNA11	2.42
67	Disorders of gnas inactivation	Enrichment	GNAS	2.42
68	Pregnancy loss, recurrent 2	Enrichment	F2	2.42
69	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.42
70	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.42
71	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	2.42
72	Von willebrand's disease	Enrichment	VWF	2.42
73	Asphyxia neonatorum	Enrichment	COL1A1	2.42
74	Col4a1-related disorders	Enrichment	COL4A1	2.42
75	Congenital fibrinogen deficiency	Enrichment	FGG	2.42
76	Prothrombin deficiency	Enrichment	F2	2.42
77	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.42
78	Col4a1 or col4a2-related cerebral small vessel disease	Enrichment	COL4A1	2.42
79	Bleeding diathesis due to thromboxane synthesis deficiency	Enrichment	TBXA2R	2.42
80	Abdominal aortic aneurysm	Enrichment	COL3A1	2.42
81	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.42
82	Monostotic fibrous dysplasia	Enrichment	GNAS	2.42
83	Phakomatosis cesiomarmorata	Enrichment	GNA11	2.42
84	Mazabraud syndrome	Enrichment	GNAS	2.42
85	Ehlers-danlos syndrome, vascular type	Enrichment	COL3A1	2.12
86	Epiphyseal dysplasia, multiple, 1	Enrichment	COL1A1	2.12
87	Ehlers-danlos syndrome, hypermobility type	Enrichment	COL3A1	2.12
88	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.12
89	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.12
90	Bruck syndrome 1	Enrichment	COL1A2	2.12
91	Cutis marmorata telangiectatica congenita	Enrichment	GNA11	2.12
92	Dermatofibrosarcoma protuberans	Enrichment	COL1A1	2.12
93	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.12
94	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.12
95	Bleeding disorder, platelet-type, 8	Enrichment	P2RY12	2.12
96	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.12
97	Bleeding disorder, platelet-type, 14	Enrichment	TBXAS1	2.12
98	Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1	Enrichment	COL4A2	2.12
99	Combined osteogenesis imperfecta and ehlers-danlos syndrome 1	Enrichment	COL1A1	2.12
100	Polymicrogyria with or without vascular-type ehlers-danlos syndrome	Enrichment	COL3A1	2.12
101	Aortic dissection	Enrichment	COL3A1	2.12
102	Autosomal dominant hypocalcemia	Enrichment	GNA11	2.12
103	Pseudohypoparathyroidism	Enrichment	GNAS	2.12
104	Stickler syndrome, type ii	Enrichment	COL1A1	2.12
105	Body mass index quantitative trait locus 19	Enrichment	ADCY3	2.12
106	Hypopituitarism	Enrichment	GNAI2	2.12
107	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.12
108	Dentinogenesis imperfecta	Enrichment	COL1A2	2.12
109	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.95
110	Mccune-albright syndrome	Enrichment	GNAS	1.95
111	Retinal arteries, tortuosity of	Enrichment	COL4A1	1.95
112	Asthma, nasal polyps, and aspirin intolerance	Enrichment	PTGER2	1.95
113	Periventricular nodular heterotopia 1	Enrichment	VWF	1.95
114	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	GNA11	1.95
115	Coumarin resistance	Enrichment	CYP2C9	1.95
116	Caffey disease	Enrichment	COL1A1	1.95
117	Brain small vessel disease 2	Enrichment	COL4A2	1.95
118	Microangiopathy and leukoencephalopathy, pontine, autosomal dominant	Enrichment	COL4A1	1.95
119	Nizon-isidor syndrome	Enrichment	P2RY12	1.95
120	Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps	Enrichment	COL4A1	1.95
121	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.95
122	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.95
123	Cerebral sinovenous thrombosis	Enrichment	F2	1.95
124	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	COL1A1, COL3A1	1.93
125	Phenylketonuria	Enrichment	COL1A1	1.83
126	Schizencephaly	Enrichment	COL4A1	1.83
127	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.83
128	Auriculocondylar syndrome 1	Enrichment	GNAI3	1.83
129	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.83
130	Achromatopsia 4	Enrichment	GNAI3	1.83
131	Blood platelet disease	Enrichment	CD36	1.83
132	Cerebral malaria	Enrichment	CD36	1.83
133	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	1.82
134	Amyloidosis, hereditary systemic 2	Enrichment	FGA	1.73
135	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.73
136	Familial cerebral saccular aneurysm	Enrichment	COL3A1	1.73
137	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.65
138	Anterior segment dysgenesis 5	Enrichment	COL4A1	1.65
139	Brachydactyly	Enrichment	GNAS	1.58
140	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.48
141	Primary hyperaldosteronism	Enrichment	GNAS	1.48
142	Familial thoracic aortic aneurysm and dissection	Enrichment	COL3A1	1.48
143	Peters-plus syndrome	Enrichment	COL4A1	1.43
144	Stroke, ischemic	Enrichment	F2	1.43
145	Familial colorectal cancer	Enrichment	PLA2G2A	1.43
146	Digeorge syndrome	Enrichment	GP1BB	1.35
147	Aortic aneurysm, familial thoracic 1	Enrichment	COL3A1	1.29
148	Walker-warburg syndrome	Enrichment	COL4A1	1.29
149	Corpus callosum, agenesis of	Enrichment	COL4A1	1.26
150	Anterior segment dysgenesis	Enrichment	COL4A1	1.26
151	Isolated corpus callosum agenesis	Enrichment	COL4A1	1.26
152	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	COL4A1	1.26
153	Myocardial infarction	Enrichment	ITGB3	1.10
154	Malaria	Enrichment	CD36	1.08
155	Congenital stationary night blindness	Enrichment	GNB3	1.08
156	Cakut	Enrichment	COL4A1	0.92
157	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.84
158	Centralopathic epilepsy	Enrichment	PLCB1	0.82
159	West syndrome	Enrichment	PLCB1	0.82
160	Hypertelorism	Enrichment	COL1A1	0.75
161	Colorectal cancer	Enrichment	PLA2G2A	0.55
162	Microcephaly	Enrichment	COL4A1	0.43

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

Pathway Network for Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

Member Pathways for Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

Pathways in the Platelet Aggregation Inhibitor Pathway, Pharmacodynamics SuperPath

Associated Genes for Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

Associated Disorders for Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

Disorders associated with Platelet Aggregation Inhibitor Pathway, Pharmacodynamics SuperPath

STRING Interaction Network for Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

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