Platelet homeostasis

Pathway network for the Platelet homeostasis SuperPath

Sources:

Reactome

Pathways in the Platelet homeostasis SuperPath

#	Name	Source	Genes
1	Platelet homeostasis	Reactome	APOB ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 CALM1 CALM2 CALM3 FGR GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GUCY1A1 GUCY1A2 GUCY1B1 IRAG1 ITPR1 ITPR2 ITPR3 KCNMA1 KCNMB1 KCNMB2 KCNMB3 KCNMB4 LRP8 MAPK14 NOS1 NOS2 NOS3 ORAI1 ORAI2 P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 PAFAH2 PDE10A PDE11A PDE1A PDE1B PDE2A PDE5A PDE9A PECAM1 PLA2G4A PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKG1 PRKG2 PTGIR PTPN11 PTPN6 SLC8A1 SLC8A2 SLC8A3 SRI STIM1 TRPC3 TRPC6 TRPC7 (see all 88) (see less)
2	Platelet calcium homeostasis	Reactome	ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 CALM1 CALM2 CALM3 ITPR1 ITPR2 ITPR3 ORAI1 ORAI2 P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 SLC8A1 SLC8A2 SLC8A3 SRI STIM1 TRPC3 TRPC6 TRPC7 (see all 30) (see less)
3	Prostacyclin signalling through prostacyclin receptor	Reactome	GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PTGIR (see all 19) (see less)
4	Platelet sensitization by LDL	Reactome	APOB FGR LRP8 MAPK14 PECAM1 PLA2G4A PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PTPN11 PTPN6 (see all 17) (see less)
5	Elevation of cytosolic Ca2+ levels	Reactome	ITPR1 ITPR2 ITPR3 ORAI1 ORAI2 P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 STIM1 TRPC3 TRPC6 TRPC7 (see all 16) (see less)
6	Reduction of cytosolic Ca++ levels	Reactome	ATP2A1 ATP2A2 ATP2A3 ATP2B1 ATP2B2 ATP2B3 ATP2B4 CALM1 CALM2 CALM3 SLC8A1 SLC8A2 SLC8A3 SRI (see all 14) (see less)

Gene overlap in member pathways for Platelet homeostasis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	P2RX2	Purinergic Receptor P2X 2	Protein Coding	3
2	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	3
3	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	3
4	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	3
5	ATP2A1	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 1	Protein Coding	3
6	ATP2A2	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2	Protein Coding	3
7	ATP2A3	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 3	Protein Coding	3
8	ATP2B1	ATPase Plasma Membrane Ca2+ Transporting 1	Protein Coding	3
9	ATP2B2	ATPase Plasma Membrane Ca2+ Transporting 2	Protein Coding	3
10	ATP2B3	ATPase Plasma Membrane Ca2+ Transporting 3	Protein Coding	3
11	ATP2B4	ATPase Plasma Membrane Ca2+ Transporting 4	Protein Coding	3
12	P2RX1	Purinergic Receptor P2X 1	Protein Coding	3
13	P2RX3	Purinergic Receptor P2X 3	Protein Coding	3
14	P2RX4	Purinergic Receptor P2X 4	Protein Coding	3
15	P2RX5	Purinergic Receptor P2X 5	Protein Coding	3
16	P2RX7	Purinergic Receptor P2X 7	Protein Coding	3
17	TRPC7	Transient Receptor Potential Cation Channel Subfamily C Member 7	Protein Coding	3
18	SLC8A2	Solute Carrier Family 8 Member A2	Protein Coding	3
19	SLC8A1	Solute Carrier Family 8 Member A1	Protein Coding	3
20	SLC8A3	Solute Carrier Family 8 Member A3	Protein Coding	3
21	SRI	Sorcin	Protein Coding	3
22	STIM1	Stromal Interaction Molecule 1	Protein Coding	3
23	TRPC3	Transient Receptor Potential Cation Channel Subfamily C Member 3	Protein Coding	3
24	TRPC6	Transient Receptor Potential Cation Channel Subfamily C Member 6	Protein Coding	3
25	CALM1	Calmodulin 1	Protein Coding	3
26	ORAI2	ORAI Calcium Release-Activated Calcium Modulator 2	Protein Coding	3
27	CALM2	Calmodulin 2	Protein Coding	3
28	CALM3	Calmodulin 3	Protein Coding	3
29	ORAI1	ORAI Calcium Release-Activated Calcium Modulator 1	Protein Coding	3
30	P2RX6	Purinergic Receptor P2X 6	Protein Coding	3
31	GNB5	G Protein Subunit Beta 5	Protein Coding	2
32	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	2
33	FGR	FGR Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	2
34	GNAS	GNAS Complex Locus	Protein Coding	2
35	GNB1	G Protein Subunit Beta 1	Protein Coding	2
36	GNB2	G Protein Subunit Beta 2	Protein Coding	2
37	GNB3	G Protein Subunit Beta 3	Protein Coding	2
38	GNG3	G Protein Subunit Gamma 3	Protein Coding	2
39	GNG4	G Protein Subunit Gamma 4	Protein Coding	2
40	GNG5	G Protein Subunit Gamma 5	Protein Coding	2
41	GNG7	G Protein Subunit Gamma 7	Protein Coding	2
42	GNG10	G Protein Subunit Gamma 10	Protein Coding	2
43	GNG11	G Protein Subunit Gamma 11	Protein Coding	2
44	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	2
45	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	2
46	APOB	Apolipoprotein B	Protein Coding	2
47	PECAM1	Platelet And Endothelial Cell Adhesion Molecule 1	Protein Coding	2
48	GNG13	G Protein Subunit Gamma 13	Protein Coding	2
49	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	2
50	GNG2	G Protein Subunit Gamma 2	Protein Coding	2
51	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	2
52	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	2
53	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	2
54	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	2
55	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	2
56	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	2
57	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	2
58	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	2
59	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	2
60	GNG12	G Protein Subunit Gamma 12	Protein Coding	2
61	PTGIR	Prostaglandin I2 Receptor	Protein Coding	2
62	PTPN6	Protein Tyrosine Phosphatase Non-Receptor Type 6	Protein Coding	2
63	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	2
64	GNB4	G Protein Subunit Beta 4	Protein Coding	2
65	LRP8	LDL Receptor Related Protein 8	Protein Coding	2
66	GNG8	G Protein Subunit Gamma 8	Protein Coding	2
67	KCNMB2	Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 2	Protein Coding	1
68	IRAG1	Inositol 1,4,5-Triphosphate Receptor Associated 1	Protein Coding	1
69	PDE10A	Phosphodiesterase 10A	Protein Coding	1
70	KCNMB3	Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 3	Protein Coding	1
71	KCNMB4	Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4	Protein Coding	1
72	GUCY1A2	Guanylate Cyclase 1 Soluble Subunit Alpha 2	Protein Coding	1
73	GUCY1A1	Guanylate Cyclase 1 Soluble Subunit Alpha 1	Protein Coding	1
74	GUCY1B1	Guanylate Cyclase 1 Soluble Subunit Beta 1	Protein Coding	1
75	KCNMA1	Potassium Calcium-Activated Channel Subfamily M Alpha 1	Protein Coding	1
76	KCNMB1	Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 1	Protein Coding	1
77	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
78	NOS2	Nitric Oxide Synthase 2	Protein Coding	1
79	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
80	PAFAH2	Platelet Activating Factor Acetylhydrolase 2	Protein Coding	1
81	PDE11A	Phosphodiesterase 11A	Protein Coding	1
82	PDE1A	Phosphodiesterase 1A	Protein Coding	1
83	PDE2A	Phosphodiesterase 2A	Protein Coding	1
84	PDE9A	Phosphodiesterase 9A	Protein Coding	1
85	PDE1B	Phosphodiesterase 1B	Protein Coding	1
86	PRKG1	Protein Kinase CGMP-Dependent 1	Protein Coding	1
87	PRKG2	Protein Kinase CGMP-Dependent 2	Protein Coding	1
88	PDE5A	Phosphodiesterase 5A	Protein Coding	1

Disorders associated with Platelet homeostasis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	7.31
2	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	6.29
3	Stormorken syndrome	Enrichment	ORAI1, STIM1	5.88
4	Myopathy, tubular aggregate, 1	Enrichment	ORAI1, STIM1	4.44
5	Long qt syndrome	Enrichment	CALM1, CALM2	3.34
6	Intellectual developmental disorder, autosomal dominant 66	Enrichment	ATP2B1	2.99
7	Deafness, autosomal dominant 82	Enrichment	ATP2B2	2.99
8	Long qt syndrome 16	Enrichment	CALM3	2.99
9	Long qt syndrome 15	Enrichment	CALM2	2.99
10	Rhabdomyolysis 2	Enrichment	ATP2A2	2.99
11	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.93
12	Deafness, autosomal dominant 41	Enrichment	P2RX2	2.93
13	Focal segmental glomerulosclerosis 2	Enrichment	TRPC6	2.93
14	Spinocerebellar ataxia 41	Enrichment	TRPC3	2.93
15	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.93
16	Immunodeficiency 10	Enrichment	STIM1	2.93
17	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.93
18	Metachondromatosis	Enrichment	PTPN11	2.90
19	Leopard syndrome 1	Enrichment	PTPN11	2.90
20	Houge-janssens syndrome 4	Enrichment	PPP2R5C	2.90
21	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.90
22	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.90
23	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.90
24	Vegetative pyoderma gangrenosum	Enrichment	PTPN6	2.90
25	Bullous pyoderma gangrenosum	Enrichment	PTPN6	2.90
26	Pustular pyoderma gangrenosum	Enrichment	PTPN6	2.90
27	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.90
28	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.90
29	Classic pyoderma gangrenosum	Enrichment	PTPN6	2.90
30	Malignant astrocytoma	Enrichment	PTPN11	2.90
31	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.85
32	Osseous heteroplasia, progressive	Enrichment	GNAS	2.85
33	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.85
34	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.85
35	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.85
36	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.85
37	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.85
38	Disorders of gnas inactivation	Enrichment	GNAS	2.85
39	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.85
40	Sick sinus syndrome 4	Enrichment	GNB2	2.85
41	Monostotic fibrous dysplasia	Enrichment	GNAS	2.85
42	Mazabraud syndrome	Enrichment	GNAS	2.85
43	Acrokeratosis verruciformis	Enrichment	ATP2A2	2.69
44	Spinocerebellar ataxia, x-linked 1	Enrichment	ATP2B3	2.69
45	Brody disease	Enrichment	ATP2A1	2.69
46	Spinocerebellar ataxia, x-linked 5	Enrichment	ATP2B3	2.69
47	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.69
48	Long qt syndrome 14	Enrichment	CALM1	2.69
49	Dental caries	Enrichment	ATP2B3	2.69
50	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.63
51	Immunodeficiency 9	Enrichment	ORAI1	2.63
52	Myopathy, tubular aggregate, 2	Enrichment	ORAI1	2.63
53	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.60
54	Hypobetalipoproteinemia, familial, 1	Enrichment	APOB	2.60
55	Werner syndrome	Enrichment	PTPN11	2.60
56	Hypobetalipoproteinemia	Enrichment	APOB	2.60
57	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.60
58	Congenital long qt syndrome	Enrichment	ITPR3, PTPN11	2.58
59	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.55
60	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.55
61	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.55
62	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.55
63	Pseudohypoparathyroidism	Enrichment	GNAS	2.55
64	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.55
65	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.55
66	Cerebral visual impairment	Enrichment	GNB1	2.55
67	Darier-white disease	Enrichment	ATP2A2	2.51
68	Intellectual developmental disorder, autosomal dominant 30, with speech delay and behavioral abnormalities	Enrichment	ATP2B1	2.51
69	Muscular atrophy	Enrichment	ATP2B3	2.51
70	Gillespie syndrome	Enrichment	ITPR1	2.45
71	Hypercholesterolemia, familial, 2	Enrichment	APOB	2.43
72	Neutrophilic dermatosis, acute febrile	Enrichment	PTPN6	2.43
73	Tricuspid valve insufficiency	Enrichment	PTPN11	2.43
74	Mccune-albright syndrome	Enrichment	GNAS	2.38
75	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.38
76	Myopathy, autophagic vacuolar, infantile-onset	Enrichment	STIM1	2.33
77	Spinocerebellar ataxia 15	Enrichment	ITPR1	2.33
78	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.30
79	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.30
80	Hypertension, essential	Enrichment	GNB3, NOS3	2.27
81	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	2.25
82	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	2.25
83	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	2.25
84	Familial sick sinus syndrome	Enrichment	GNB2	2.25
85	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ATP2B2, P2RX2	2.23
86	Spastic ataxia	Enrichment	ATP2B3, ITPR1	2.22
87	Pierre robin syndrome	Enrichment	ATP2B1	2.21
88	Deafness, autosomal recessive 12	Enrichment	ATP2B2	2.21
89	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	2.21
90	Hyperlipidemia, familial combined, 3	Enrichment	APOB	2.20
91	Lymphoma	Enrichment	PTPN11	2.20
92	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.19
93	Dyskinesia, limb and orofacial, infantile-onset	Enrichment	PDE10A	2.19
94	Aortic aneurysm, familial thoracic 8	Enrichment	PRKG1	2.19
95	Spondylometaphyseal dysplasia, pagnamenta type	Enrichment	PRKG2	2.19
96	Intellectual developmental disorder with paroxysmal dyskinesia or seizures	Enrichment	PDE2A	2.19
97	Moyamoya disease 6 with or without achalasia	Enrichment	GUCY1A1	2.19
98	Striatal degeneration, autosomal dominant 2	Enrichment	PDE10A	2.19
99	Epilepsy, idiopathic generalized 16	Enrichment	KCNMA1	2.19
100	Cerebellar atrophy, developmental delay, and seizures	Enrichment	KCNMA1	2.19
101	Moyamoya disease with early-onset achalasia	Enrichment	GUCY1A1	2.19
102	Childhood-onset benign chorea with striatal involvement	Enrichment	PDE10A	2.19
103	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	2.15
104	Megacolon	Enrichment	SLC8A1	2.14
105	Patent ductus arteriosus	Enrichment	PTPN11	2.13
106	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	2.08
107	Noonan syndrome 3	Enrichment	PTPN11	2.06
108	Myocardial infarction	Enrichment	GUCY1A1, LRP8	2.05
109	Brachydactyly	Enrichment	GNAS	2.01
110	Homozygous familial hypercholesterolemia	Enrichment	APOB	2.00
111	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.95
112	Hypothyroidism	Enrichment	GNB1	1.95
113	Coronary heart disease 5	Enrichment	APOB	1.95
114	Leukemia, chronic lymphocytic	Enrichment	P2RX7	1.93
115	Primary hyperaldosteronism	Enrichment	GNAS	1.90
116	Hypertension, diastolic	Enrichment	KCNMB1	1.89
117	Pigmented nodular adrenocortical disease, primary, 2	Enrichment	PDE11A	1.89
118	Acromesomelic dysplasia 4	Enrichment	PRKG2	1.89
119	Liang-wang syndrome	Enrichment	KCNMA1	1.89
120	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PDE11A	1.89
121	Isolated micronodular adrenocortical disease	Enrichment	PDE11A	1.89
122	Strabismus	Enrichment	GNB1, PTPN11	1.88
123	Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly	Enrichment	ATP2B1	1.87
124	Clubfoot	Enrichment	ATP2B1	1.87
125	Pectus excavatum	Enrichment	PTPN11	1.86
126	Specific learning disability	Enrichment	PTPN11	1.86
127	Periventricular nodular heterotopia	Enrichment	ATP2B1	1.84
128	Epicanthus	Enrichment	PTPN11	1.83
129	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	1.83
130	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.82
131	Myelodysplastic syndrome	Enrichment	GNB1	1.82
132	Hypercholesterolemia, familial, 1	Enrichment	APOB	1.79
133	Multiple sclerosis	Enrichment	ITPR1	1.79
134	Sudden infant death syndrome	Enrichment	CALM2	1.76
135	Anterior segment dysgenesis	Enrichment	ITPR1	1.76
136	Familial hypercholesterolemia	Enrichment	APOB	1.73
137	Noonan syndrome and noonan-related syndrome	Enrichment	PTPN11	1.73
138	Paroxysmal nonkinesigenic dyskinesia 3 with or without generalized epilepsy	Enrichment	KCNMA1	1.71
139	Patent foramen ovale	Enrichment	PTPN11	1.65
140	Focal segmental glomerulosclerosis	Enrichment	TRPC6	1.63
141	Cleft palate, isolated	Enrichment	GNB1	1.63
142	Carney complex variant	Enrichment	PDE11A	1.59
143	Idiopathic achalasia	Enrichment	NOS1	1.59
144	Noonan syndrome 1	Enrichment	PTPN11	1.55
145	Scoliosis	Enrichment	PTPN11	1.53
146	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.52
147	Congenital stationary night blindness	Enrichment	GNB3	1.50
148	Alzheimer disease 2	Enrichment	NOS3	1.49
149	Convulsions, familial infantile, with paroxysmal choreoathetosis	Enrichment	PDE2A	1.49
150	Pre-eclampsia	Enrichment	NOS3	1.49
151	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.49
152	Rasopathy	Enrichment	PTPN11	1.49
153	Autism spectrum disorder	Enrichment	GNB1, KCNMA1, PTPN11	1.47
154	Fetal akinesia deformation sequence 1	Enrichment	ATP2B3	1.43
155	Non-immune hydrops fetalis	Enrichment	PTPN11	1.42
156	Moyamoya disease 1	Enrichment	GUCY1A1	1.42
157	Lung cancer	Enrichment	PPP2R1B	1.40
158	Genetic steroid-resistant nephrotic syndrome	Enrichment	TRPC6	1.40
159	Distal arthrogryposis	Enrichment	ATP2B3	1.37
160	Paroxysmal dystonia	Enrichment	PDE2A	1.35
161	Microcephaly	Enrichment	ATP2B3, GNB1, PTPN11	1.34
162	Complex neurodevelopmental disorder	Enrichment	ATP2B1, GNB2, PPP2CA	1.33
163	Dystonia	Enrichment	GNB1	1.32
164	Nephrotic syndrome	Enrichment	TRPC6	1.30
165	Choreatic disease	Enrichment	PDE2A	1.29
166	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.28
167	Cerebral palsy	Enrichment	GNB1	1.27
168	Thrombocytopenia	Enrichment	PTPN11	1.23
169	Stroke, ischemic	Enrichment	NOS3	1.20
170	Body mass index quantitative trait locus 11	Enrichment	GNAS	1.17
171	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	1.17
172	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.17
173	Autism	Enrichment	ATP2B1	1.14
174	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ATP2B2	1.06
175	Breast cancer	Enrichment	GNG3	1.00
176	Alzheimer disease, familial, 1	Enrichment	NOS3	0.98
177	Congenital nervous system abnormality	Enrichment	GNB5	0.86
178	Nervous system disease	Enrichment	GNB5	0.86
179	Malaria	Enrichment	NOS2	0.86
180	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	0.81
181	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	PRKG1	0.60
182	Schizophrenia	Enrichment	PDE11A	0.50
183	Primary ovarian insufficiency	Enrichment	NOS3	0.50

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Platelet homeostasis

Pathway Network for Platelet homeostasis

Pathway network for the Platelet homeostasis SuperPath

Member Pathways for Platelet homeostasis

Pathways in the Platelet homeostasis SuperPath

Gene overlap in member pathways for Platelet homeostasis SuperPath

Associated Genes for Platelet homeostasis

Associated Disorders for Platelet homeostasis

Disorders associated with Platelet homeostasis SuperPath

STRING Interaction Network for Platelet homeostasis

Sources for Platelet homeostasis