Platinum Pathway, Pharmacokinetics/Pharmacodynamics

No Pathway Network information available for Platinum Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Platinum Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Platinum Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCC2 ABCG2 ATP7A ATP7B ERCC1 ERCC2 ERCC3 ERCC4 ERCC6 GSTM1 GSTP1 GSTT1 HMGB1 MLH1 MPO MSH2 MSH6 MT1A MT2A NQO1 PMS2 POLB POLH POLM REV3L SLC31A1 SMARCA1 SOD1 XPA (see all 29) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	REV3L	REV3 Like, DNA Directed Polymerase Zeta Catalytic Subunit	Protein Coding	1
2	XPA	XPA, DNA Damage Recognition And Repair Factor	Protein Coding	1
3	SMARCA1	SNF2 Related Chromatin Remodeling ATPase 1	Protein Coding	1
4	SOD1	Superoxide Dismutase 1	Protein Coding	1
5	MLH1	MutL Homolog 1	Protein Coding	1
6	PMS2	PMS1 Homolog 2, Mismatch Repair System Component	Protein Coding	1
7	ATP7B	ATPase Copper Transporting Beta	Protein Coding	1
8	POLB	DNA Polymerase Beta	Protein Coding	1
9	POLH	DNA Polymerase Eta	Protein Coding	1
10	MSH2	MutS Homolog 2	Protein Coding	1
11	MT1A	Metallothionein 1A	Protein Coding	1
12	MT2A	Metallothionein 2A	Protein Coding	1
13	HMGB1	High Mobility Group Box 1	Protein Coding	1
14	ERCC1	ERCC Excision Repair 1, Endonuclease Non-Catalytic Subunit	Protein Coding	1
15	ERCC2	ERCC Excision Repair 2, TFIIH Core Complex Helicase Subunit	Protein Coding	1
16	ERCC3	ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit	Protein Coding	1
17	ERCC4	ERCC Excision Repair 4, Endonuclease Catalytic Subunit	Protein Coding	1
18	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	1
19	POLM	DNA Polymerase Mu	Protein Coding	1
20	SLC31A1	Solute Carrier Family 31 Member 1	Protein Coding	1
21	MPO	Myeloperoxidase	Protein Coding	1
22	GSTM1	Glutathione S-Transferase Mu 1	Protein Coding	1
23	GSTP1	Glutathione S-Transferase Pi 1	Protein Coding	1
24	GSTT1	Glutathione S-Transferase Theta 1	Protein Coding	1
25	MSH6	MutS Homolog 6	Protein Coding	1
26	NQO1	NAD(P)H Quinone Dehydrogenase 1	Protein Coding	1
27	ATP7A	ATPase Copper Transporting Alpha	Protein Coding	1
28	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	1
29	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	1

Disorders associated with Platinum Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mismatch repair cancer syndrome 1	Enrichment	MLH1, MSH2, MSH6, PMS2	10.55
2	Xeroderma pigmentosum, variant type	Enrichment	ERCC2, ERCC3, ERCC4, POLH, XPA	10.54
3	Ovarian cancer	Enrichment	ERCC2, ERCC3, ERCC4, MSH2, MSH6, PMS2, XPA	8.86
4	Lynch syndrome 1	Enrichment	MLH1, MSH2, MSH6, PMS2	8.46
5	Lynch syndrome	Enrichment	MLH1, MSH2, MSH6, PMS2	7.65
6	Lynch syndrome 4	Enrichment	MSH2, MSH6, PMS2	7.45
7	Xeroderma pigmentosum-cockayne syndrome complex	Enrichment	ERCC2, ERCC3, ERCC4	7.06
8	Endometrial cancer	Enrichment	MLH1, MSH2, MSH6, PMS2	7.01
9	Cerebrooculofacioskeletal syndrome 1	Enrichment	ERCC1, ERCC2, ERCC6	6.76
10	Colorectal cancer	Enrichment	MLH1, MSH2, MSH6, PMS2, REV3L	5.99
11	Gastric cancer	Enrichment	MLH1, MSH2, MSH6, PMS2	5.71
12	Muir-torre syndrome	Enrichment	MLH1, MSH2	5.36
13	Rhabdomyosarcoma	Enrichment	MSH2, MSH6, PMS2	5.32
14	Hereditary breast ovarian cancer syndrome	Enrichment	MLH1, MSH2, MSH6, PMS2	5.27
15	Inherited cancer-predisposing syndrome	Enrichment	ERCC3, MLH1, MSH2, MSH6, PMS2	5.10
16	Breast cancer	Enrichment	MLH1, MSH2, MSH6, PMS2	4.73
17	Cockayne syndrome a	Enrichment	ERCC4, ERCC6	4.36
18	Cockayne syndrome b	Enrichment	ERCC1, ERCC6	4.18
19	Cockayne syndrome	Enrichment	ERCC4, ERCC6	4.04
20	Hereditary breast carcinoma	Enrichment	MLH1, MSH2, MSH6	3.96
21	Trichothiodystrophy	Enrichment	ERCC2, ERCC3	3.80
22	Familial colorectal cancer	Enrichment	MLH1, MSH2	3.71
23	Uterine corpus cancer	Enrichment	MSH2, MSH6	3.62
24	Hepatoblastoma	Enrichment	ERCC2, MSH2	3.04
25	Lung cancer	Enrichment	ERCC6, MLH1	2.68
26	Wolff syndrome	Enrichment	ATP7B	2.67
27	Neuronopathy, distal hereditary motor, x-linked	Enrichment	ATP7A	2.67
28	Cerebrooculofacioskeletal syndrome 4	Enrichment	ERCC1	2.67
29	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.67
30	Xeroderma pigmentosum, complementation group b	Enrichment	ERCC3	2.67
31	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	2.67
32	Neurodegeneration and seizures due to copper transport defect	Enrichment	SLC31A1	2.67
33	Lynch syndrome 2	Enrichment	MLH1	2.67
34	Xeroderma pigmentosum, complementation group d	Enrichment	ERCC2	2.67
35	Occipital horn syndrome	Enrichment	ATP7A	2.67
36	Trichothiodystrophy 2, photosensitive	Enrichment	ERCC3	2.67
37	Xeroderma pigmentosum group b	Enrichment	ERCC3	2.67
38	Xfe progeroid syndrome	Enrichment	ERCC4	2.67
39	Cerebrooculofacioskeletal syndrome 2	Enrichment	ERCC2	2.67
40	Blood group, junior system	Enrichment	ABCG2	2.67
41	Mismatch repair cancer syndrome 2	Enrichment	MSH2	2.67
42	Mismatch repair cancer syndrome 4	Enrichment	PMS2	2.67
43	Rectal benign neoplasm	Enrichment	MSH2	2.67
44	Intellectual disability, wolff type	Enrichment	ATP7B	2.67
45	Pituitary cancer	Enrichment	PMS2	2.67
46	Ascending colon cancer	Enrichment	MSH2	2.67
47	Ovarian cyst	Enrichment	MSH2	2.67
48	Xeroderma pigmentosum group d	Enrichment	ERCC2	2.67
49	Burkitt lymphoma	Enrichment	PMS2	2.37
50	Xeroderma pigmentosum, complementation group f	Enrichment	ERCC4	2.37
51	Xeroderma pigmentosum, complementation group a	Enrichment	XPA	2.37
52	Developmental and epileptic encephalopathy 93	Enrichment	ATP7B	2.37
53	Deafness, autosomal recessive 109	Enrichment	ATP7B	2.37
54	Fanconi anemia, complementation group q	Enrichment	ERCC4	2.37
55	Kala-azar 2	Enrichment	GSTP1	2.37
56	Xeroderma pigmentosum group f	Enrichment	ERCC4	2.37
57	Spastic tetraplegia and axial hypotonia, progressive	Enrichment	SOD1	2.37
58	Mismatch repair cancer syndrome 3	Enrichment	MSH6	2.37
59	Cockayne syndrome type 3	Enrichment	ERCC6	2.37
60	Spastic ataxia	Enrichment	ATP7B, ERCC4	2.25
61	Dubin-johnson syndrome	Enrichment	ABCC2	2.19
62	Wilson disease	Enrichment	ATP7B	2.19
63	Trichothiodystrophy 1, photosensitive	Enrichment	ERCC2	2.19
64	De sanctis-cacchione syndrome	Enrichment	ERCC6	2.19
65	Menkes disease	Enrichment	ATP7A	2.19
66	Uv-sensitive syndrome 1	Enrichment	ERCC6	2.19
67	Lynch syndrome 5	Enrichment	MSH6	2.19
68	Breast-ovarian cancer, familial 5	Enrichment	ATP7B	2.19
69	Uv-sensitive syndrome	Enrichment	ERCC6	2.19
70	Premature ovarian failure 11	Enrichment	ERCC6	2.19
71	Cellular ependymoma	Enrichment	MSH2	2.19
72	Tanycytic ependymoma	Enrichment	MSH2	2.19
73	Papillary ependymoma	Enrichment	MSH2	2.19
74	Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities	Enrichment	MSH6	2.19
75	Colon adenocarcinoma	Enrichment	MSH6	2.19
76	Clear cell ependymoma	Enrichment	MSH2	2.19
77	Hutchinson-gilford progeria syndrome	Enrichment	ERCC4	2.07
78	Gaucher disease, type i	Enrichment	MSH6	2.07
79	Myeloperoxidase deficiency	Enrichment	MPO	2.07
80	Macular degeneration, age-related, 5	Enrichment	ERCC6	2.07
81	Craniopharyngioma	Enrichment	ERCC2	2.07
82	Benign ependymoma	Enrichment	MSH2	2.07
83	Moebius syndrome	Enrichment	REV3L	1.97
84	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	SOD1	1.97
85	Breast-ovarian cancer, familial 2	Enrichment	PMS2	1.97
86	Autosomal recessive cerebellar ataxia	Enrichment	ERCC4	1.97
87	Lymphoma	Enrichment	PMS2	1.97
88	Glioblastoma	Enrichment	MSH2	1.97
89	Pseudoxanthoma elasticum	Enrichment	ABCC2	1.89
90	Alzheimer's disease 1	Enrichment	MPO	1.83
91	Motor neuron disease	Enrichment	SOD1	1.83
92	Inflammatory bowel disease 1	Enrichment	ERCC2	1.72
93	Leukemia, acute lymphoblastic 3	Enrichment	ERCC4	1.72
94	Colonic benign neoplasm	Enrichment	MLH1	1.72
95	Hypotrichosis simplex	Enrichment	ERCC2	1.72
96	Amyotrophic lateral sclerosis 1	Enrichment	SOD1	1.67
97	Cardiomyopathy, familial hypertrophic, 9	Enrichment	PMS2	1.63
98	Breast-ovarian cancer, familial 1	Enrichment	MSH2	1.56
99	Alzheimer's disease	Enrichment	MPO	1.56
100	Premature menopause	Enrichment	ERCC1	1.56
101	Corpus callosum, agenesis of	Enrichment	ERCC2	1.50
102	Isolated corpus callosum agenesis	Enrichment	ERCC2	1.50
103	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	ERCC2	1.50
104	Gliosarcoma	Enrichment	MSH2	1.47
105	Alzheimer disease, familial, 1	Enrichment	MPO	1.45
106	Giant cell glioblastoma	Enrichment	MSH2	1.45
107	Diffuse large b-cell lymphoma	Enrichment	PMS2	1.40
108	Leukodystrophy	Enrichment	ERCC2	1.38
109	Hepatocellular carcinoma	Enrichment	PMS2	1.34
110	Cardiomyopathy, dilated, 1g	Enrichment	PMS2	1.34
111	Pancreatic cancer	Enrichment	ERCC4	1.28
112	Bladder cancer	Enrichment	ERCC2	1.22
113	Hirschsprung disease 1	Enrichment	ATP7A	1.22
114	Prostate cancer	Enrichment	MSH6	1.22
115	Fanconi anemia, complementation group a	Enrichment	ERCC4	1.14
116	Non-syndromic x-linked intellectual disability	Enrichment	SMARCA1	1.13
117	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	SOD1	0.93
118	Primary ovarian insufficiency	Enrichment	ERCC1	0.92

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Platinum Pathway, Pharmacokinetics/Pharmacodynamics

Pathway Network for Platinum Pathway, Pharmacokinetics/Pharmacodynamics

Member Pathways for Platinum Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Platinum Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Associated Genes for Platinum Pathway, Pharmacokinetics/Pharmacodynamics

Associated Disorders for Platinum Pathway, Pharmacokinetics/Pharmacodynamics

Disorders associated with Platinum Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

STRING Interaction Network for Platinum Pathway, Pharmacokinetics/Pharmacodynamics

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