Pleural mesothelioma

No Pathway Network information available for Pleural mesothelioma

Pathways in the Pleural mesothelioma SuperPath

#	Name	Source	Genes
1	Pleural mesothelioma	WikiPathways	ACTA1 ACTA2 ACTB ACTC1 ACTG1 ACTG2 ADAMTS1 ADAMTSL4-AS1 AGER AJUBA AKT1 AKT1S1 AKT2 AKT3 AMOT ANGPT1 ANGPT2 ANGPT4 APC AREG ASXL1 ATF2 ATF3 ATG13 ATM AXIN1 BAG2 BAK1 BAP1 BARD1 BAX BBC3 BCL2 BDNF BECN1 BMI1 BRCA1 BTC BTRC BUB1B-PAK6 CASP1 CCL2 CCL4 CCL5 CCN2 CCND1 CCND2 CCND3 CCNE1 CD274 CD44 CD47 CDH1 CDH8 CDK2 CDK4 CDK7 CDKN1A CDKN2A CER1 CHD8 CIT COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 CREB1 CSF1 CSF1R CSF2 CSF3 CSNK1A1 CSNK1A1L CSNK1E CSNK2A1 CSNK2A2 CSNK2A3 CSNK2B CTBP1 CTBP2 CTHRC1 CTNNA1 CTNNA2 CTNNA3 CTNNB1 CUL1 CXCL1 CXCL10 CXCL12 CXCL5 CXXC4 CYCS DDIT3 DEPTOR DKK1 DKK2 DKK4 DSC3 DVL1 DVL2 DVL3 E2F1 EED EFNA1 EFNA2 EFNA3 EFNA4 EFNA5 EGF EGFR EIF4B EIF4EBP1 EIF4G1 ELK1 EPHA2 EZH2 FABP4 FGF1 FGF10 FGF11 FGF12 FGF13 FGF14 FGF17 FGF18 FGF19 FGF2 FGF20 FGF21 FGF22 FGF23 FGF3 FGF4 FGF5 FGF6 FGF7 FGF8 FGF9 FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT3LG FLT4 FN1 FOSL1 FOXM1 FOXO1 FRAT1 FRAT2 FZD1 FZD10 FZD2 FZD3 FZD5 FZD6 FZD7 FZD8 FZD9 GABPA GRB2 GSK3B HBEGF HCFC1 HGF HIF1A HMGB1 HMGN1 HRAS IDO1 IGF1 IGF1R IGF2 IL10 IL1B IL34 IL6 INS INSR ITGA1 ITGA2 ITGA3 ITGA4 ITGA6 ITGAV ITGB1 ITGB2 ITGB3 ITGB4 ITPR3 JAK1 JUN KDM6A KDR KIF23 KIT KITLG KMT2C KREMEN1 LAMA1 LAMA2 LAMA3 LAMA4 LAMA5 LAMB1 LAMB2 LAMB3 LAMC1 LAMC2 LAMC3 LATS1 LATS2 LEF1 LGALS9 LIMD1 LIN28B LRP5 LRP6 MAD1L1 MAD2L1 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAP3K1 MAP3K10 MAP3K11 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K9 MAP4K1 MAP4K2 MAP4K3 MAP4K4 MAPK1 MAPK10 MAPK14 MAPK3 MAPK7 MAPK8 MAPK9 MAPKAPK2 MAX MCU MDK MDM2 MDM4 MEF2D MET MINK1 MKNK1 MKNK2 MLST8 MMP14 MMP2 MMP3 MMP9 MOB1A MOB1B MST1 MTOR MYC NDRG1 NF2 NFKB1 NGF NGFR NLRP3 NOTUM NTF3 NTF4 NTRK1 NTRK2 OGT PAK1 PAK2 PAK3 PAK4 PAK5 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PDK1 PGF PHC1 PIGF PIK3CA PIK3CB PIK3CD PIK3CG PLAU PLCB4 PODXL PORCN PPARGC1A PRB1 PRKAB2 PRKAG2 PRSS23 PTEN PTK2 RAF1 RASSF1 RASSF2 RASSF3 RASSF4 RASSF5 RASSF6 RASSF7 RB1CC1 RBBP4 RHEB RING1 RNF2 ROR1 ROR2 RPS6 RPS6KA1 RPS6KA3 RPS6KA5 RPS6KB1 RPS6KB2 RPTOR RYK SAV1 SELE SENP2 SERPINF1 SETD2 SETD5 SETDB1 SFRP1 SFRP2 SFRP4 SFRP5 SHC1 SLC2A1 SLC3A2 SLC7A5 SOS1 SOST SOX17 SP1 SPARC SRC STAT1 STK3 SUZ12 TCF7 TCF7L1 TCF7L2 TEAD1 TEAD2 TEAD3 TEAD4 TEK TELO2 TERT TGFA TGFB1 TNIK TNNT1 TP53 TRAF2 TSC1 TSC2 TTI1 UHRF1 ULK1 ULK2 VEGFA VEGFB VEGFC VEGFD VGLL4 WDR5 WIF1 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT5B WNT6 WNT7A WNT7B WWC1 WWTR1 YAP1 YY1 (see all 409) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	OGT	O-Linked N-Acetylglucosamine (GlcNAc) Transferase	Protein Coding	1
2	PIGF	Phosphatidylinositol Glycan Anchor Biosynthesis Class F	Protein Coding	1
3	EFNA2	Ephrin A2	Protein Coding	1
4	CDH1	Cadherin 1	Protein Coding	1
5	FGF19	Fibroblast Growth Factor 19	Protein Coding	1
6	TELO2	Telomere Maintenance 2	Protein Coding	1
7	SETDB1	SET Domain Bifurcated Histone Lysine Methyltransferase 1	Protein Coding	1
8	RB1CC1	RB1 Inducible Coiled-Coil 1	Protein Coding	1
9	RASSF2	Ras Association Domain Family Member 2	Protein Coding	1
10	ULK2	Unc-51 Like Autophagy Activating Kinase 2	Protein Coding	1
11	CD47	CD47 Molecule	Protein Coding	1
12	CD44	CD44 Molecule (IN Blood Group)	Protein Coding	1
13	ADAMTS1	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 1	Protein Coding	1
14	KIF23	Kinesin Family Member 23	Protein Coding	1
15	MAP4K4	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4	Protein Coding	1
16	RPS6KA5	Ribosomal Protein S6 Kinase A5	Protein Coding	1
17	LATS1	Large Tumor Suppressor Kinase 1	Protein Coding	1
18	CCNE1	Cyclin E1	Protein Coding	1
19	WNT3A	Wnt Family Member 3A	Protein Coding	1
20	CCND3	Cyclin D3	Protein Coding	1
21	CCND2	Cyclin D2	Protein Coding	1
22	FGF17	Fibroblast Growth Factor 17	Protein Coding	1
23	FGF18	Fibroblast Growth Factor 18	Protein Coding	1
24	EED	Embryonic Ectoderm Development	Protein Coding	1
25	BECN1	Beclin 1	Protein Coding	1
26	MKNK1	MAPK Interacting Serine/Threonine Kinase 1	Protein Coding	1
27	AJUBA	Ajuba LIM Protein	Protein Coding	1
28	TEAD2	TEA Domain Transcription Factor 2	Protein Coding	1
29	CUL1	Cullin 1	Protein Coding	1
30	AKT1S1	AKT1 Substrate 1	Protein Coding	1
31	KREMEN1	Kringle Containing Transmembrane Protein 1	Protein Coding	1
32	RASSF4	Ras Association Domain Family Member 4	Protein Coding	1
33	MAD1L1	Mitotic Arrest Deficient 1 Like 1	Protein Coding	1
34	RASSF5	Ras Association Domain Family Member 5	Protein Coding	1
35	TCF7L1	Transcription Factor 7 Like 1	Protein Coding	1
36	CASP1	Caspase 1	Protein Coding	1
37	FZD8	Frizzled Class Receptor 8	Protein Coding	1
38	FZD6	Frizzled Class Receptor 6	Protein Coding	1
39	BAP1	BRCA1 Associated Deubiquitinase 1	Protein Coding	1
40	AXIN1	Axin 1	Protein Coding	1
41	SLC7A5	Solute Carrier Family 7 Member 5	Protein Coding	1
42	WNT5B	Wnt Family Member 5B	Protein Coding	1
43	FGF23	Fibroblast Growth Factor 23	Protein Coding	1
44	WNT10A	Wnt Family Member 10A	Protein Coding	1
45	PDGFD	Platelet Derived Growth Factor D	Protein Coding	1
46	YY1	YY1 Transcription Factor	Protein Coding	1
47	WNT2B	Wnt Family Member 2B	Protein Coding	1
48	WNT11	Wnt Family Member 11	Protein Coding	1
49	WNT10B	Wnt Family Member 10B	Protein Coding	1
50	WNT7A	Wnt Family Member 7A	Protein Coding	1
51	WNT5A	Wnt Family Member 5A	Protein Coding	1
52	WNT3	Wnt Family Member 3	Protein Coding	1
53	WNT2	Wnt Family Member 2	Protein Coding	1
54	WNT1	Wnt Family Member 1	Protein Coding	1
55	VEGFC	Vascular Endothelial Growth Factor C	Protein Coding	1
56	VEGFB	Vascular Endothelial Growth Factor B	Protein Coding	1
57	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
58	KDM6A	Lysine Demethylase 6A	Protein Coding	1
59	TSC2	TSC Complex Subunit 2	Protein Coding	1
60	TSC1	TSC Complex Subunit 1	Protein Coding	1
61	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
62	TP53	Tumor Protein P53	Protein Coding	1
63	TNNT1	Troponin T1, Slow Skeletal Type	Protein Coding	1
64	ACTG1	Actin Gamma 1	Protein Coding	1
65	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
66	TGFA	Transforming Growth Factor Alpha	Protein Coding	1
67	TERT	Telomerase Reverse Transcriptase	Protein Coding	1
68	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	1
69	TEAD1	TEA Domain Transcription Factor 1	Protein Coding	1
70	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	1
71	TCF7L2	Transcription Factor 7 Like 2	Protein Coding	1
72	TCF7	Transcription Factor 7	Protein Coding	1
73	BTC	Betacellulin	Protein Coding	1
74	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
75	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
76	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
77	SPARC	Secreted Protein Acidic And Cysteine Rich	Protein Coding	1
78	SP1	Sp1 Transcription Factor	Protein Coding	1
79	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
80	SLC3A2	Solute Carrier Family 3 Member 2	Protein Coding	1
81	SLC2A1	Solute Carrier Family 2 Member 1	Protein Coding	1
82	PORCN	Porcupine O-Acyltransferase	Protein Coding	1
83	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	1
84	SHC1	SHC Adaptor Protein 1	Protein Coding	1
85	SOX17	SRY-Box Transcription Factor 17	Protein Coding	1
86	SFRP5	Secreted Frizzled Related Protein 5	Protein Coding	1
87	SFRP4	Secreted Frizzled Related Protein 4	Protein Coding	1
88	SFRP2	Secreted Frizzled Related Protein 2	Protein Coding	1
89	SFRP1	Secreted Frizzled Related Protein 1	Protein Coding	1
90	SELE	Selectin E	Protein Coding	1
91	CXCL12	C-X-C Motif Chemokine Ligand 12	Protein Coding	1
92	CXCL5	C-X-C Motif Chemokine Ligand 5	Protein Coding	1
93	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	1
94	CCL4	C-C Motif Chemokine Ligand 4	Protein Coding	1
95	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	1
96	BDNF	Brain Derived Neurotrophic Factor	Protein Coding	1
97	RYK	Receptor Like Tyrosine Kinase	Protein Coding	1
98	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	1
99	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	1
100	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
101	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
102	RPS6	Ribosomal Protein S6	Protein Coding	1
103	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	1
104	ACTB	Actin Beta	Protein Coding	1
105	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
106	CCND1	Cyclin D1	Protein Coding	1
107	SENP2	SUMO Specific Peptidase 2	Protein Coding	1
108	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
109	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
110	KMT2C	Lysine Methyltransferase 2C	Protein Coding	1
111	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	1
112	BARD1	BRCA1 Associated RING Domain 1	Protein Coding	1
113	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
114	BAK1	BCL2 Antagonist/Killer 1	Protein Coding	1
115	CHD8	Chromodomain Helicase DNA Binding Protein 8	Protein Coding	1
116	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	1
117	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
118	PTEN	Phosphatase And Tensin Homolog	Protein Coding	1
119	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
120	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	1
121	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	1
122	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	1
123	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
124	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
125	PDGFC	Platelet Derived Growth Factor C	Protein Coding	1
126	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
127	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
128	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
129	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	1
130	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
131	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
132	SETD5	SET Domain Containing 5	Protein Coding	1
133	WNT4	Wnt Family Member 4	Protein Coding	1
134	CYCS	Cytochrome C, Somatic	Protein Coding	1
135	PODXL	Podocalyxin Like	Protein Coding	1
136	PLCB4	Phospholipase C Beta 4	Protein Coding	1
137	PLAU	Plasminogen Activator, Urokinase	Protein Coding	1
138	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	1
139	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
140	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
141	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
142	PGF	Placental Growth Factor	Protein Coding	1
143	SERPINF1	Serpin Family F Member 1	Protein Coding	1
144	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
145	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
146	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
147	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	1
148	PRKAG2	Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 2	Protein Coding	1
149	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
150	SOST	Sclerostin	Protein Coding	1
151	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
152	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
153	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
154	ROR2	Receptor Tyrosine Kinase Like Orphan Receptor 2	Protein Coding	1
155	ROR1	Receptor Tyrosine Kinase Like Orphan Receptor 1	Protein Coding	1
156	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
157	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	1
158	NTF4	Neurotrophin 4	Protein Coding	1
159	NTF3	Neurotrophin 3	Protein Coding	1
160	NGFR	Nerve Growth Factor Receptor	Protein Coding	1
161	NGF	Nerve Growth Factor	Protein Coding	1
162	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
163	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	1
164	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
165	ATF3	Activating Transcription Factor 3	Protein Coding	1
166	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
167	MST1	Macrophage Stimulating 1	Protein Coding	1
168	MMP14	Matrix Metallopeptidase 14	Protein Coding	1
169	MMP9	Matrix Metallopeptidase 9	Protein Coding	1
170	MMP3	Matrix Metallopeptidase 3	Protein Coding	1
171	MMP2	Matrix Metallopeptidase 2	Protein Coding	1
172	MAP3K9	Mitogen-Activated Protein Kinase Kinase Kinase 9	Protein Coding	1
173	KITLG	KIT Ligand	Protein Coding	1
174	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
175	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	1
176	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	1
177	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
178	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	1
179	MEF2D	Myocyte Enhancer Factor 2D	Protein Coding	1
180	MDM4	MDM4 Regulator Of P53	Protein Coding	1
181	MDM2	MDM2 Proto-Oncogene	Protein Coding	1
182	MDK	Midkine	Protein Coding	1
183	MAX	MYC Associated Transcriptional Regulator X	Protein Coding	1
184	MAD2L1	Mitotic Arrest Deficient 2 Like 1	Protein Coding	1
185	LRP5	LDL Receptor Related Protein 5	Protein Coding	1
186	LRP6	LDL Receptor Related Protein 6	Protein Coding	1
187	LGALS9	Galectin 9	Protein Coding	1
188	LAMC2	Laminin Subunit Gamma 2	Protein Coding	1
189	LAMC1	Laminin Subunit Gamma 1	Protein Coding	1
190	LAMB3	Laminin Subunit Beta 3	Protein Coding	1
191	LAMB2	Laminin Subunit Beta 2	Protein Coding	1
192	LAMB1	Laminin Subunit Beta 1	Protein Coding	1
193	LAMA4	Laminin Subunit Alpha 4	Protein Coding	1
194	LAMA3	Laminin Subunit Alpha 3	Protein Coding	1
195	LAMA2	Laminin Subunit Alpha 2	Protein Coding	1
196	LIN28B	Lin-28 RNA Binding Posttranscriptional Regulator B	Protein Coding	1
197	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
198	KDR	Kinase Insert Domain Receptor	Protein Coding	1
199	AREG	Amphiregulin	Protein Coding	1
200	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
201	JAK1	Janus Kinase 1	Protein Coding	1
202	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	1
203	ITGB4	Integrin Subunit Beta 4	Protein Coding	1
204	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
205	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
206	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
207	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
208	ITGA4	Integrin Subunit Alpha 4	Protein Coding	1
209	ITGA3	Integrin Subunit Alpha 3	Protein Coding	1
210	ITGA2	Integrin Subunit Alpha 2	Protein Coding	1
211	ITGA1	Integrin Subunit Alpha 1	Protein Coding	1
212	ITGA6	Integrin Subunit Alpha 6	Protein Coding	1
213	INSR	Insulin Receptor	Protein Coding	1
214	INS	Insulin	Protein Coding	1
215	CXCL10	C-X-C Motif Chemokine Ligand 10	Protein Coding	1
216	IDO1	Indoleamine 2,3-Dioxygenase 1	Protein Coding	1
217	IL10	Interleukin 10	Protein Coding	1
218	IL6	Interleukin 6	Protein Coding	1
219	IL1B	Interleukin 1 Beta	Protein Coding	1
220	IGF2	Insulin Like Growth Factor 2	Protein Coding	1
221	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
222	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
223	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
224	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
225	HMGN1	High Mobility Group Nucleosome Binding Domain 1	Protein Coding	1
226	HMGB1	High Mobility Group Box 1	Protein Coding	1
227	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
228	HGF	Hepatocyte Growth Factor	Protein Coding	1
229	HCFC1	Host Cell Factor C1	Protein Coding	1
230	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
231	CXCL1	C-X-C Motif Chemokine Ligand 1	Protein Coding	1
232	UHRF1	Ubiquitin Like With PHD And Ring Finger Domains 1	Protein Coding	1
233	CD274	CD274 Molecule	Protein Coding	1
234	CTNNA3	Catenin Alpha 3	Protein Coding	1
235	SETD2	SET Domain Containing 2, Histone Lysine Methyltransferase	Protein Coding	1
236	ANGPT2	Angiopoietin 2	Protein Coding	1
237	LAMA1	Laminin Subunit Alpha 1	Protein Coding	1
238	ANGPT1	Angiopoietin 1	Protein Coding	1
239	RASSF3	Ras Association Domain Family Member 3	Protein Coding	1
240	BBC3	BCL2 Binding Component 3	Protein Coding	1
241	LATS2	Large Tumor Suppressor Kinase 2	Protein Coding	1
242	FGF21	Fibroblast Growth Factor 21	Protein Coding	1
243	WWTR1	WW Domain Containing Transcription Regulator 1	Protein Coding	1
244	FZD2	Frizzled Class Receptor 2	Protein Coding	1
245	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	1
246	SUZ12	SUZ12 Polycomb Repressive Complex 2 Subunit	Protein Coding	1
247	FN1	Fibronectin 1	Protein Coding	1
248	WWC1	WW And C2 Domain Containing 1	Protein Coding	1
249	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	1
250	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	1
251	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	1
252	FOXO1	Forkhead Box O1	Protein Coding	1
253	FOXM1	Forkhead Box M1	Protein Coding	1
254	TNIK	TRAF2 And NCK Interacting Kinase	Protein Coding	1
255	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
256	VEGFD	Vascular Endothelial Growth Factor D	Protein Coding	1
257	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
258	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
259	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
260	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
261	FGF14	Fibroblast Growth Factor 14	Protein Coding	1
262	FGF13	Fibroblast Growth Factor 13	Protein Coding	1
263	FGF12	Fibroblast Growth Factor 12	Protein Coding	1
264	FGF10	Fibroblast Growth Factor 10	Protein Coding	1
265	FGF9	Fibroblast Growth Factor 9	Protein Coding	1
266	FGF8	Fibroblast Growth Factor 8	Protein Coding	1
267	FGF7	Fibroblast Growth Factor 7	Protein Coding	1
268	FGF6	Fibroblast Growth Factor 6	Protein Coding	1
269	FGF5	Fibroblast Growth Factor 5	Protein Coding	1
270	FGF4	Fibroblast Growth Factor 4	Protein Coding	1
271	FGF3	Fibroblast Growth Factor 3	Protein Coding	1
272	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
273	FGF1	Fibroblast Growth Factor 1	Protein Coding	1
274	FABP4	Fatty Acid Binding Protein 4	Protein Coding	1
275	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	1
276	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
277	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
278	EIF4G1	Eukaryotic Translation Initiation Factor 4 Gamma 1	Protein Coding	1
279	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	1
280	EPHA2	EPH Receptor A2	Protein Coding	1
281	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
282	EGF	Epidermal Growth Factor	Protein Coding	1
283	EFNA5	Ephrin A5	Protein Coding	1
284	EFNA1	Ephrin A1	Protein Coding	1
285	PHC1	Polyhomeotic Homolog 1	Protein Coding	1
286	E2F1	E2F Transcription Factor 1	Protein Coding	1
287	DVL3	Dishevelled Segment Polarity Protein 3	Protein Coding	1
288	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
289	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	1
290	DSC3	Desmocollin 3	Protein Coding	1
291	AGER	Advanced Glycosylation End-Product Specific Receptor	Protein Coding	1
292	ASXL1	ASXL Transcriptional Regulator 1	Protein Coding	1
293	DDIT3	DNA Damage Inducible Transcript 3	Protein Coding	1
294	AMOT	Angiomotin	Protein Coding	1
295	CTNNB1	Catenin Beta 1	Protein Coding	1
296	CTNNA2	Catenin Alpha 2	Protein Coding	1
297	CTNNA1	Catenin Alpha 1	Protein Coding	1
298	CCN2	Cellular Communication Network Factor 2	Protein Coding	1
299	CTBP2	C-Terminal Binding Protein 2	Protein Coding	1
300	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
301	NOTUM	Notum, Palmitoleoyl-Protein Carboxylesterase	Protein Coding	1
302	IL34	Interleukin 34	Protein Coding	1
303	CSNK2B	Casein Kinase 2 Beta	Protein Coding	1
304	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	1
305	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
306	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
307	CSF3	Colony Stimulating Factor 3	Protein Coding	1
308	CSF2	Colony Stimulating Factor 2	Protein Coding	1
309	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
310	CSF1	Colony Stimulating Factor 1	Protein Coding	1
311	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	1
312	ATF2	Activating Transcription Factor 2	Protein Coding	1
313	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
314	COL4A6	Collagen Type IV Alpha 6 Chain	Protein Coding	1
315	COL4A5	Collagen Type IV Alpha 5 Chain	Protein Coding	1
316	COL4A4	Collagen Type IV Alpha 4 Chain	Protein Coding	1
317	COL4A3	Collagen Type IV Alpha 3 Chain	Protein Coding	1
318	COL4A2	Collagen Type IV Alpha 2 Chain	Protein Coding	1
319	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	1
320	CTHRC1	Collagen Triple Helix Repeat Containing 1	Protein Coding	1
321	NLRP3	NLR Family Pyrin Domain Containing 3	Protein Coding	1
322	WIF1	Wnt Inhibitory Factor 1	Protein Coding	1
323	RASSF1	Ras Association Domain Family Member 1	Protein Coding	1
324	CIT	Citron Rho-Interacting Serine/Threonine Kinase	Protein Coding	1
325	PRSS23	Serine Protease 23	Protein Coding	1
326	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
327	YAP1	Yes1 Associated Transcriptional Regulator	Protein Coding	1
328	NDRG1	N-Myc Downstream Regulated 1	Protein Coding	1
329	LAMC3	Laminin Subunit Gamma 3	Protein Coding	1
330	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
331	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	1
332	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	1
333	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
334	CDK2	Cyclin Dependent Kinase 2	Protein Coding	1
335	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
336	EIF4B	Eukaryotic Translation Initiation Factor 4B	Protein Coding	1
337	EFNA4	Ephrin A4	Protein Coding	1
338	EFNA3	Ephrin A3	Protein Coding	1
339	DVL2	Dishevelled Segment Polarity Protein 2	Protein Coding	1
340	RASSF6	Ras Association Domain Family Member 6	Protein Coding	1
341	ATG13	Autophagy Related 13	Protein Coding	1
342	VGLL4	Vestigial Like Family Member 4	Protein Coding	1
343	TTI1	TELO2 Interacting Protein 1	Protein Coding	1
344	BAG2	BAG Cochaperone 2	Protein Coding	1
345	CER1	Cerberus 1, DAN Family BMP Antagonist	Protein Coding	1
346	MOB1B	MOB Kinase Activator 1B	Protein Coding	1
347	MAP3K6	Mitogen-Activated Protein Kinase Kinase Kinase 6	Protein Coding	1
348	MCU	Mitochondrial Calcium Uniporter	Protein Coding	1
349	LIMD1	LIM Domain Containing 1	Protein Coding	1
350	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
351	MAP4K3	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3	Protein Coding	1
352	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	1
353	CSNK1E	Casein Kinase 1 Epsilon	Protein Coding	1
354	CSNK1A1L	Casein Kinase 1 Alpha 1 Like	Protein Coding	1
355	FZD10	Frizzled Class Receptor 10	Protein Coding	1
356	MAP4K1	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1	Protein Coding	1
357	WDR5	WD Repeat Domain 5	Protein Coding	1
358	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
359	BUB1B-PAK6	BUB1B-PAK6 Readthrough	Protein Coding	1
360	CDK7	Cyclin Dependent Kinase 7	Protein Coding	1
361	FZD9	Frizzled Class Receptor 9	Protein Coding	1
362	FZD7	Frizzled Class Receptor 7	Protein Coding	1
363	FZD1	Frizzled Class Receptor 1	Protein Coding	1
364	FOSL1	FOS Like 1, AP-1 Transcription Factor Subunit	Protein Coding	1
365	RASSF7	Ras Association Domain Family Member 7	Protein Coding	1
366	CXXC4	CXXC Finger Protein 4	Protein Coding	1
367	FZD3	Frizzled Class Receptor 3	Protein Coding	1
368	FZD5	Frizzled Class Receptor 5	Protein Coding	1
369	WNT7B	Wnt Family Member 7B	Protein Coding	1
370	WNT6	Wnt Family Member 6	Protein Coding	1
371	TRAF2	TNF Receptor Associated Factor 2	Protein Coding	1
372	TEAD3	TEA Domain Transcription Factor 3	Protein Coding	1
373	TEAD4	TEA Domain Transcription Factor 4	Protein Coding	1
374	STK3	Serine/Threonine Kinase 3	Protein Coding	1
375	DEPTOR	DEP Domain Containing MTOR Interacting Protein	Protein Coding	1
376	MLST8	MTOR Associated Protein MLST8	Protein Coding	1
377	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	1
378	SAV1	Salvador Family WW Domain Containing Protein 1	Protein Coding	1
379	RNF2	Ring Finger Protein 2	Protein Coding	1
380	RING1	Ring Finger Protein 1	Protein Coding	1
381	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	1
382	MAP4K2	Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2	Protein Coding	1
383	ADAMTSL4-AS1	ADAMTSL4 Antisense RNA 1	RNA Gene	1
384	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	1
385	PRKAB2	Protein Kinase AMP-Activated Non-Catalytic Subunit Beta 2	Protein Coding	1
386	PRB1	Proline Rich Protein BstNI Subfamily 1	Protein Coding	1
387	MOB1A	MOB Kinase Activator 1A	Protein Coding	1
388	PDK1	Pyruvate Dehydrogenase Kinase 1	Protein Coding	1
389	WNT16	Wnt Family Member 16	Protein Coding	1
390	ANGPT4	Angiopoietin 4	Protein Coding	1
391	MINK1	Misshapen Like Kinase 1	Protein Coding	1
392	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
393	MAP3K10	Mitogen-Activated Protein Kinase Kinase Kinase 10	Protein Coding	1
394	LAMA5	Laminin Subunit Alpha 5	Protein Coding	1
395	CDH8	Cadherin 8	Protein Coding	1
396	MAPKAPK2	MAPK Activated Protein Kinase 2	Protein Coding	1
397	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
398	MKNK2	MAPK Interacting Serine/Threonine Kinase 2	Protein Coding	1
399	CSNK2A3	Casein Kinase 2 Alpha 3	Protein Coding	1
400	DKK2	Dickkopf Wnt Signaling Pathway Inhibitor 2	Protein Coding	1
401	DKK4	Dickkopf Wnt Signaling Pathway Inhibitor 4	Protein Coding	1
402	FGF22	Fibroblast Growth Factor 22	Protein Coding	1
403	FGF20	Fibroblast Growth Factor 20	Protein Coding	1
404	GABPA	GA Binding Protein Transcription Factor Subunit Alpha	Protein Coding	1
405	FRAT2	FRAT Regulator Of Wnt Signaling Pathway 2	Protein Coding	1
406	FLT3LG	Fms Related Receptor Tyrosine Kinase 3 Ligand	Protein Coding	1
407	FGF11	Fibroblast Growth Factor 11	Protein Coding	1
408	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
409	FRAT1	FRAT Regulator Of Wnt Signaling Pathway 1	Protein Coding	1

Disorders associated with Pleural mesothelioma SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bladder cancer	Enrichment	ATM, BRCA1, CDKN1A, CDKN2A, CTNNA3, CTNNB1, EGFR, FGFR3, HRAS, KDM6A, PIK3CA, PTEN, TERT, TP53, TSC1	10.86
2	Inherited cancer-predisposing syndrome	Enrichment	APC, ATM, BAP1, BARD1, BRCA1, CDH1, CDK4, CDKN2A, CTNNA1, EGFR, EZH2, KIT, MAP4K2, MAX, MET, NF2, PDGFRA, PTEN, TP53, TSC1, TSC2	9.38
3	Colorectal cancer	Enrichment	AKT1, APC, ATM, BAX, BRCA1, CCND1, CDH1, CTNNA1, CTNNB1, FGFR2, FGFR3, FZD3, IGF2, MET, PIK3CA, SRC, TP53	9.12
4	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1, EGF, PIK3CA, TP53, TSC1, TSC2	9.12
5	Ovarian cancer	Enrichment	AKT1, APC, ATM, BARD1, BRCA1, CDH1, CDKN2A, CTNNB1, EGFR, KIT, MAP3K1, MET, NTRK1, PDGFRA, PIK3CA, PTEN, TP53, TSC2	8.96
6	Gastric cancer	Enrichment	APC, ATM, BARD1, BRCA1, CDH1, CDK4, CDKN2A, FGFR2, IL1B, PIK3CA, PTEN, TP53	8.50
7	Meningioma	Enrichment	AKT1, BAP1, NF2, PDGFB, PIK3CA, PTEN, TERT	7.82
8	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, DVL3, FZD2, ROR2, WNT5A	7.61
9	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA, PTEN, RHEB	7.61
10	Autosomal recessive robinow syndrome	Enrichment	DVL1, DVL3, FZD2, ROR2, WNT5A	6.85
11	Hereditary breast carcinoma	Enrichment	AKT1, APC, ATM, BARD1, BRCA1, CDH1, PIK3CA, PTEN, RB1CC1, TP53	6.26
12	Lip and oral cavity carcinoma	Enrichment	CDKN2A, EGFR, HRAS, KIT, PIK3CA, TP53	6.24
13	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, DVL3, FZD2, WNT5A	6.09
14	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	6.09
15	Autosomal dominant robinow syndrome	Enrichment	DVL1, DVL3, FZD2, WNT5A	6.09
16	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB, TSC1, TSC2	6.09
17	Endometrial cancer	Enrichment	ATM, BARD1, BRCA1, CDH1, FGFR2, PIK3CA, PTEN	5.76
18	Breast cancer	Enrichment	AKT1, APC, ATM, BARD1, BRCA1, CDH1, JUN, PIK3CA, PTEN, RB1CC1, SHC1, TP53	5.65
19	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1, MET, PIK3CA, TERT, TP53	5.61
20	Junctional epidermolysis bullosa	Enrichment	ITGA6, ITGB4, LAMA3, LAMB3, LAMC2	5.56
21	Myeloma, multiple	Enrichment	ATM, BAP1, BARD1, CCND1, FGFR3, FLT3, KMT2C, LATS1, TP53, YAP1	5.24
22	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4, LAMA3, LAMB3, LAMC2	4.93
23	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4, LAMA3, LAMB3, LAMC2	4.93
24	Adrenocortical carcinoma	Enrichment	CDKN2A, CTNNB1, TERT, TP53	4.93
25	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA, RB1CC1, TP53	4.93
26	Lung squamous cell carcinoma	Enrichment	CDKN2A, EGFR, FGFR3, PIK3CA	4.93
27	Prostate cancer	Enrichment	ATM, BRCA1, CDH1, MAD1L1, PIK3CA, PTEN, TP53	4.72
28	Hepatoblastoma	Enrichment	APC, BARD1, CTNNB1, FGFR3, TERT, TP53	4.57
29	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10, FGFR2, FGFR3	4.57
30	Osteoporosis, juvenile	Enrichment	DKK1, WNT1, WNT3A	4.57
31	Hamartoma	Enrichment	FGFR3, TSC1, TSC2	4.57
32	Digenic alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	4.57
33	Renal cell carcinoma, nonpapillary	Enrichment	ATM, BAP1, MET, MTOR, SETD2	4.25
34	Kidney disease	Enrichment	COL4A3, COL4A4, COL4A5, LAMB2, TSC1	4.25
35	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1	4.25
36	Gliosarcoma	Enrichment	ATM, EGFR, FGFR1, FGFR3, TP53	4.09
37	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA, TEK	4.04
38	Diffuse gastric and lobular breast cancer syndrome	Enrichment	CDH1, CTNNA1, MAP3K6	3.97
39	Autism spectrum disorder	Enrichment	ASXL1, CHD8, CSNK2A1, CSNK2B, EED, KDM6A, KMT2C, MAP2K1, PTEN, SETD2, SETD5, TSC2	3.97
40	Giant cell glioblastoma	Enrichment	ATM, EGFR, FGFR1, FGFR3, TP53	3.95
41	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA, TEK	3.83
42	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, MAP2K1, PIK3CA	3.64
43	Alport syndrome 3a, autosomal dominant	Enrichment	COL4A3, COL4A4, COL4A5	3.58
44	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, LRP5, PRSS23	3.58
45	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1, DVL3, FZD2	3.58
46	Autosomal dominant alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	3.58
47	Alport syndrome	Enrichment	COL4A3, COL4A4, COL4A5	3.58
48	Primary hypereosinophilic syndrome	Enrichment	FGFR1, PDGFRA, PDGFRB	3.58
49	Nephrotic syndrome	Enrichment	COL4A3, COL4A4, COL4A5, FN1, ITGA3, LAMA5, LAMB2	3.57
50	Tooth agenesis	Enrichment	FGFR1, LRP6, TGFA, WNT10A, WNT10B	3.38
51	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2, TP53	3.29
52	Cowden syndrome 1	Enrichment	EGFR, PIK3CA, PTEN	3.29
53	Epidermolysis bullosa, junctional 1b, severe	Enrichment	LAMA3, LAMB3, LAMC2	3.29
54	Testicular germ cell tumor	Enrichment	FGFR3, KIT, KITLG	3.29
55	Noonan syndrome 1	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1	3.28
56	Lung cancer susceptibility 3	Enrichment	ACTA2, EGFR, FGF10, TP53	3.19
57	Nevus, epidermal	Enrichment	FGFR3, HRAS, PIK3CA	3.06
58	Squamous cell carcinoma, head and neck	Enrichment	EGFR, PTEN, TP53	3.06
59	Renal cell carcinoma, papillary, 1	Enrichment	ATM, MET, MTOR	3.06
60	Noonan syndrome 3	Enrichment	HRAS, RAF1, SOS1	3.06
61	Gallbladder cancer	Enrichment	CTNNB1, PIK3CA, TP53	3.06
62	Pilomyxoid astrocytoma	Enrichment	FGFR1, NTRK2, RAF1	3.06
63	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, FLT3, TP53	3.06
64	Van buchem disease	Enrichment	LRP5, SOST	3.04
65	Cervical cancer	Enrichment	FGFR3, TP53	3.04
66	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	3.04
67	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	3.04
68	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	3.04
69	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	3.04
70	Robinow syndrome, autosomal dominant 3	Enrichment	DVL3, FZD2	3.04
71	Childhood hepatocellular carcinoma	Enrichment	CTNNB1, MET	3.04
72	Split hand-foot malformation	Enrichment	FGFR2, LEF1	3.04
73	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	3.04
74	Ocular melanoma	Enrichment	BAP1, PLCB4	3.04
75	Cervix carcinoma	Enrichment	FGFR3, TP53	3.04
76	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	3.04
77	X-linked diffuse leiomyomatosis-alport syndrome	Enrichment	COL4A5, COL4A6	3.04
78	Malignant peritoneal mesothelioma	Enrichment	LATS1, LATS2	3.04
79	Rasopathy	Enrichment	HRAS, MAP2K1, MAP2K2, RAF1, SOS1	3.02
80	Rhabdomyosarcoma	Enrichment	BRCA1, HRAS, PTEN, TP53	2.95
81	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BARD1, BRCA1, CTNNA1, CTNNA2, PTEN, TP53	2.90
82	Exudative vitreoretinopathy	Enrichment	CTNNB1, LRP5, PRSS23	2.87
83	Melanoma, cutaneous malignant 1	Enrichment	BAP1, CDK4, CDKN2A, TERT	2.85
84	Human immunodeficiency virus type 1	Enrichment	CCL2, CCL5, CXCL12, IL10	2.75
85	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	2.70
86	Non-immune hydrops fetalis	Enrichment	ACTA1, ANGPT2, FLT4, FZD6, HRAS	2.66
87	Arteriovenous malformations of the brain	Enrichment	EGFR, IL6, MAP4K4, NLRP3	2.66
88	Lung cancer	Enrichment	ACTA2, BRCA1, EGFR, MET, PIK3CA	2.60
89	Crouzon syndrome	Enrichment	FGFR2, FGFR3	2.57
90	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	2.57
91	Hematuria, benign familial, 1	Enrichment	COL4A3, COL4A4	2.57
92	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	2.57
93	Weaver syndrome	Enrichment	EZH2, SUZ12	2.57
94	Multicentric osteolysis, nodulosis, and arthropathy	Enrichment	MMP14, MMP2	2.57
95	Anus, imperforate	Enrichment	CTNNB1, MAP4K4	2.57
96	Desmoid tumor	Enrichment	APC, CTNNB1	2.57
97	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	2.57
98	Dedifferentiated liposarcoma	Enrichment	CDK4, MDM2	2.57
99	Testicular germ cell cancer	Enrichment	FGFR3, KIT	2.57
100	Adenocarcinoma	Enrichment	ATM, TP53	2.57
101	Spermatocytoma	Enrichment	FGFR3, HRAS	2.57
102	Well-differentiated liposarcoma	Enrichment	CDK4, MDM2	2.57
103	Leukemia, chronic lymphocytic	Enrichment	ATM, CCND1, TP53	2.55
104	Meningioma, familial	Enrichment	NF2, PDGFB, PTEN	2.43
105	Uterine corpus cancer	Enrichment	ATM, BRCA1, PTEN	2.43
106	Microcephaly	Enrichment	ACTB, ACTG1, ASXL1, COL4A1, CTNNB1, IGF1R, KIF23, MAPK1, PAK3, SLC2A1	2.39
107	Brain small vessel disease 1 with or without ocular anomalies	Enrichment	COL4A1, COL4A2	2.28
108	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	2.28
109	Alport syndrome 2, autosomal recessive	Enrichment	COL4A3, COL4A4	2.28
110	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1, CTNNA1	2.28
111	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA	2.28
112	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, CCND2	2.28
113	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	2.28
114	Mantle cell lymphoma	Enrichment	ATM, CCND1	2.28
115	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	2.28
116	Lung sarcomatoid carcinoma	Enrichment	TERT, TP53	2.28
117	Malignant epithelioid hemangioendothelioma	Enrichment	WWTR1, YAP1	2.28
118	Chronic myelomonocytic leukemia	Enrichment	ASXL1, FLT3	2.28
119	Retinopathy of prematurity	Enrichment	LRP5, PRSS23	2.28
120	Tuberous sclerosis	Enrichment	TSC1, TSC2	2.28
121	Craniopharyngioma	Enrichment	APC, CTNNB1	2.28
122	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3, KIT	2.28
123	Autosomal recessive alport syndrome	Enrichment	COL4A3, COL4A4	2.28
124	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	ASXL1, KIT	2.28
125	Glioma	Enrichment	FGFR2, PTEN	2.28
126	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB, WWTR1	2.28
127	Osteogenesis imperfecta, type iv	Enrichment	SERPINF1, SPARC, WNT1	2.21
128	Nk-cell enteropathy	Enrichment	IGF1R, PIK3CB, SETD5	2.21
129	Pancreatic cancer	Enrichment	ATM, BRCA1, CDKN2A, TP53	2.21
130	Leukemia, acute myeloid	Enrichment	ASXL1, FLT3, KIT, TERT, TP53	2.17
131	Hydrops fetalis, nonimmune	Enrichment	ACTA1, FLT4, FZD6, HRAS	2.14
132	Multiple sclerosis	Enrichment	ITGB4, LAMA5, LAMB1	2.11
133	Osteoporosis	Enrichment	LRP5, SRC, WNT1	2.11
134	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	2.07
135	Rhabdomyosarcoma 2	Enrichment	FOXO1, TP53	2.07
136	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	2.07
137	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B-PAK6, MAD1L1	2.07
138	Acute myeloid leukemia with maturation	Enrichment	FLT3, KIT	2.07
139	Holoprosencephaly	Enrichment	FGF8, FGFR1	2.07
140	Epidermolysis bullosa	Enrichment	ITGA6, LAMB3	2.07
141	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	2.07
142	Coloboma of choroid and retina	Enrichment	ACTG1, FZD5	2.07
143	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3, KIT	2.07
144	Familial porencephaly	Enrichment	COL4A1, COL4A2	2.07
145	Hydrocephalus	Enrichment	FGFR2, FZD3, PDGFRB	2.02
146	Melanoma, uveal	Enrichment	BAP1, PLCB4	1.90
147	Split-hand/foot malformation 1	Enrichment	FGFR2, LEF1	1.90
148	Hemihyperplasia, isolated	Enrichment	IGF2, PIK3CA	1.90
149	Holoprosencephaly 1	Enrichment	FGF8, FGFR1	1.90
150	Type 1 diabetes mellitus	Enrichment	IL6, INS	1.90
151	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6, ITGB4	1.90
152	Hemangioma, capillary infantile	Enrichment	FLT4, KDR	1.90
153	Hemorrhage, intracerebral	Enrichment	COL4A1, COL4A2	1.90
154	Keratoconus	Enrichment	COL4A1, TSC1	1.90
155	Clear cell renal cell carcinoma	Enrichment	ATM, BAP1	1.90
156	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2, ITGB3	1.90
157	Il10-related early-onset inflammatory bowel disease	Enrichment	IL10, TGFB1	1.90
158	46,xy disorder of sex development	Enrichment	FGFR3, INSR	1.90
159	Polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	1.87
160	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	1.87
161	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF17, FGF8, FGFR1	1.80
162	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, MAP4K2	1.76
163	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, PTEN	1.76
164	Gastrointestinal stromal tumor	Enrichment	KIT, PDGFRA	1.76
165	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1, PIK3CA	1.76
166	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NGF, NTRK1	1.76
167	Follicular thyroid carcinoma	Enrichment	HRAS, PTEN	1.76
168	Overgrowth syndrome	Enrichment	CHD8, MTOR	1.76
169	Diffuse large b-cell lymphoma	Enrichment	FOXO1, PTEN, TP53	1.73
170	Craniosynostosis	Enrichment	CTNNA1, FGFR2, FGFR3	1.67
171	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, RAF1	1.65
172	Glioma susceptibility 1	Enrichment	BAP1, TP53	1.65
173	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	1.65
174	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1B-PAK6, MAD1L1	1.65
175	Isolated split hand-split foot malformation	Enrichment	BTRC, WNT10B	1.65
176	Skin disease	Enrichment	ITGB4, LAMB3, LAMC2	1.56
177	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	ASXL1, FLT3	1.55
178	Ventricular septal defect	Enrichment	RPS6KA3, TEK	1.55
179	Colonic benign neoplasm	Enrichment	APC, ATM	1.55
180	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	1.52
181	Brachydactyly, type b1	Enrichment	ROR2	1.52
182	Hypochondroplasia	Enrichment	FGFR3	1.52
183	Chiari malformation type i	Enrichment	DKK1	1.52
184	Macrodactyly	Enrichment	PIK3CA	1.52
185	Proteus syndrome	Enrichment	AKT1	1.52
186	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	1.52
187	Osteoglophonic dysplasia	Enrichment	FGFR1	1.52
188	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	1.52
189	Craniodiaphyseal dysplasia, autosomal dominant	Enrichment	SOST	1.52
190	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	1.52
191	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	1.52
192	Thanatophoric dysplasia, type i	Enrichment	FGFR3	1.52
193	Trigonocephaly 1	Enrichment	FGFR1	1.52
194	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.52
195	Donohue syndrome	Enrichment	INSR	1.52
196	Spinocerebellar ataxia 27a	Enrichment	FGF14	1.52
197	Baraitser-winter syndrome 1	Enrichment	ACTB	1.52
198	Coffin-lowry syndrome	Enrichment	RPS6KA3	1.52
199	Muenke syndrome	Enrichment	FGFR3	1.52
200	Vacterl association with hydrocephalus	Enrichment	PTEN	1.52
201	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	1.52
202	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	1.52
203	Alport syndrome 1, x-linked	Enrichment	COL4A5	1.52
204	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	1.52
205	Exudative vitreoretinopathy 4	Enrichment	LRP5	1.52
206	Sclerosteosis 1	Enrichment	SOST	1.52
207	Kabuki syndrome 2	Enrichment	KDM6A	1.52
208	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	1.52
209	Focal dermal hypoplasia	Enrichment	PORCN	1.52
210	Noonan syndrome 5	Enrichment	RAF1	1.52
211	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	1.52
212	Hypomagnesemia 4, renal	Enrichment	EGF	1.52
213	Cinca syndrome	Enrichment	NLRP3	1.52
214	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	1.52
215	Noonan syndrome 4	Enrichment	SOS1	1.52
216	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	1.52
217	Macular dystrophy, patterned, 2	Enrichment	CTNNA1	1.52
218	Keratoendotheliitis fugax hereditaria	Enrichment	NLRP3	1.52
219	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	1.52
220	Melanoma, cutaneous malignant 3	Enrichment	CDK4	1.52
221	Deafness, autosomal recessive 39	Enrichment	HGF	1.52
222	Mastocytosis, cutaneous	Enrichment	KIT	1.52
223	Stomatin-deficient cryohydrocytosis with neurologic defects	Enrichment	SLC2A1	1.52
224	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	1.52
225	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	1.52
226	Melanoma, uveal 2	Enrichment	BAP1	1.52
227	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	1.52
228	Melorheostosis, isolated	Enrichment	MAP2K1	1.52
229	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	1.52
230	Omodysplasia 2	Enrichment	FZD2	1.52
231	Schwannomatosis, vestibular	Enrichment	NF2	1.52
232	Apert syndrome	Enrichment	FGFR2	1.52
233	Cardiomyopathy, dilated, 1jj	Enrichment	LAMA4	1.52
234	Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or impaired intellectual development	Enrichment	YAP1	1.52
235	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	1.52
236	Hyperpigmentation with or without hypopigmentation, familial progressive	Enrichment	KITLG	1.52
237	Memory quantitative trait locus	Enrichment	WWC1	1.52
238	Familial cold autoinflammatory syndrome 1	Enrichment	NLRP3	1.52
239	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	1.52
240	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	1.52
241	Cowden syndrome 5	Enrichment	PIK3CA	1.52
242	Parkinson disease 18, autosomal dominant	Enrichment	EIF4G1	1.52
243	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	1.52
244	Split-hand/foot malformation 6	Enrichment	WNT10B	1.52
245	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	1.52
246	Nemaline myopathy 5a, autosomal recessive, severe infantile	Enrichment	TNNT1	1.52
247	Tooth agenesis, selective, 7	Enrichment	LRP6	1.52
248	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	1.52
249	You-hoover-fong syndrome	Enrichment	TELO2	1.52
250	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	1.52
251	Caudal duplication anomaly	Enrichment	AXIN1	1.52
252	Lissencephaly 5	Enrichment	LAMB1	1.52
253	Hypogonadotropic hypogonadism 20 with or without anosmia	Enrichment	FGF17	1.52
254	Tooth agenesis, selective, 8	Enrichment	WNT10B	1.52
255	Vesicoureteral reflux 3	Enrichment	SOX17	1.52
256	Microcephaly 11, primary, autosomal recessive	Enrichment	PHC1	1.52
257	Ectodermal dysplasia 13, hair/tooth type	Enrichment	KREMEN1	1.52
258	Intellectual developmental disorder, autosomal dominant 23	Enrichment	SETD5	1.52
259	46,xy sex reversal 6	Enrichment	MAP3K1	1.52
260	Gist-plus syndrome	Enrichment	PDGFRA	1.52
261	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	1.52
262	Accelerated tumor formation	Enrichment	MDM2	1.52
263	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	1.52
264	Arrhythmogenic right ventricular dysplasia, familial, 13	Enrichment	CTNNA3	1.52
265	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	1.52
266	Muckle-wells syndrome	Enrichment	NLRP3	1.52
267	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	1.52
268	Exudative vitreoretinopathy 8	Enrichment	LRP6	1.52
269	Angioedema, hereditary, 5	Enrichment	ANGPT1	1.52
270	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	1.52
271	Luo-schoch-yamamoto syndrome	Enrichment	RNF2	1.52
272	Cerebral cavernous malformations 4	Enrichment	PIK3CA	1.52
273	Pyle disease	Enrichment	SFRP4	1.52
274	Noonan syndrome 13	Enrichment	MAPK1	1.52
275	Deafness, autosomal recessive 108	Enrichment	ROR1	1.52
276	Deafness, autosomal dominant 34, with or without inflammation	Enrichment	NLRP3	1.52
277	Nephrotic syndrome, type 26	Enrichment	LAMA5	1.52
278	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	1.52
279	Neurodevelopmental disorder with microcephaly and movement abnormalities	Enrichment	TTI1	1.52
280	Deafness, x-linked 6	Enrichment	COL4A6	1.52
281	Intellectual developmental disorder, x-linked 110	Enrichment	FGF13	1.52
282	Spinocerebellar ataxia 27b, late-onset	Enrichment	FGF14	1.52
283	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	1.52
284	Intellectual developmental disorder, autosomal dominant 70	Enrichment	SETD2	1.52
285	Venous malformations, multiple cutaneous and mucosal	Enrichment	TEK	1.52
286	Knobloch syndrome 2	Enrichment	PAK2	1.52
287	Cortical dysplasia, complex, with other brain malformations 9	Enrichment	CTNNA2	1.52
288	Lessel-kubisch syndrome	Enrichment	MDM2	1.52
289	Bone marrow failure syndrome 6	Enrichment	MDM4	1.52
290	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.52
291	Bone marrow failure syndrome 5	Enrichment	TP53	1.52
292	Hereditary lymphedema id	Enrichment	VEGFC	1.52
293	Winchester syndrome	Enrichment	MMP14	1.52
294	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	1.52
295	Osteofibrous dysplasia	Enrichment	MET	1.52
296	Diarrhea 9	Enrichment	WNT2B	1.52
297	Graft-versus-host disease	Enrichment	IL10	1.52
298	Papilloma of choroid plexus	Enrichment	TP53	1.52
299	Auriculocondylar syndrome 2a	Enrichment	PLCB4	1.52
300	Basal cell carcinoma 7	Enrichment	TP53	1.52
301	Porencephaly	Enrichment	COL4A1	1.52
302	Imagawa-matsumoto syndrome	Enrichment	SUZ12	1.52
303	Intellectual developmental disorder, x-linked 106	Enrichment	OGT	1.52
304	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	1.52
305	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	1.52
306	Anaplastic thyroid carcinoma	Enrichment	TP53	1.52
307	Developmental and epileptic encephalopathy 90	Enrichment	FGF13	1.52
308	Cardiomyopathy, familial hypertrophic, 6	Enrichment	PRKAG2	1.52
309	Infant-type hemispheric glioma	Enrichment	BRCA1	1.52
310	Lymphatic malformation 4	Enrichment	VEGFC	1.52
311	Intellectual developmental disorder, autosomal recessive 54	Enrichment	TNIK	1.52
312	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	1.52
313	Papillary tumor of the pineal region	Enrichment	PTEN	1.52
314	Uveal coloboma-cleft lip and palate-intellectual disability	Enrichment	YAP1	1.52
315	Glycogen storage disease of heart, lethal congenital	Enrichment	PRKAG2	1.52
316	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	1.52
317	Familial isolated trichomegaly	Enrichment	FGF5	1.52
318	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	1.52
319	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	1.52
320	Deafness, autosomal recessive 97	Enrichment	MET	1.52
321	Microvascular complications of diabetes 1	Enrichment	VEGFA	1.52
322	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.52
323	Skin/hair/eye pigmentation, variation in, 7	Enrichment	KITLG	1.52
324	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	1.52
325	Thrombocytopenia 4	Enrichment	CYCS	1.52
326	Hemifacial myohyperplasia	Enrichment	PIK3CA	1.52
327	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	1.52
328	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	1.52
329	Santos syndrome	Enrichment	WNT7A	1.52
330	Becker nevus syndrome	Enrichment	ACTB	1.52
331	Hypotrichosis and recurrent skin vesicles	Enrichment	DSC3	1.52
332	Melorheostosis	Enrichment	MAP2K1	1.52
333	Dystonia-deafness syndrome 1	Enrichment	ACTB	1.52
334	Autism 9	Enrichment	MET	1.52
335	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	1.52
336	Leopard syndrome 2	Enrichment	RAF1	1.52
337	Coronary heart disease 6	Enrichment	MMP3	1.52
338	Multiple synostoses syndrome 3	Enrichment	FGF9	1.52
339	Glaucoma 1, open angle, o	Enrichment	NTF4	1.52
340	Cortical malformations, occipital	Enrichment	LAMC3	1.52
341	Epilepsy, idiopathic generalized 12	Enrichment	SLC2A1	1.52
342	Immunodeficiency 31a	Enrichment	STAT1	1.52
343	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	1.52
344	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	1.52
345	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	1.52
346	Polydactyly-macrocephaly syndrome	Enrichment	MAX	1.52
347	Cowden syndrome 6	Enrichment	AKT1	1.52
348	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	1.52
349	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	1.52
350	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	1.52
351	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	1.52
352	Microphthalmia/coloboma 11	Enrichment	FZD5	1.52
353	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	1.52
354	Endometrial serous adenocarcinoma	Enrichment	ATM	1.52
355	Immunodeficiency 31b	Enrichment	STAT1	1.52
356	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	1.52
357	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	1.52
358	Glioma susceptibility 2	Enrichment	PTEN	1.52
359	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	1.52
360	Ductal carcinoma in situ	Enrichment	TP53	1.52
361	Kosaki overgrowth syndrome	Enrichment	PDGFRB	1.52
362	Kleefstra syndrome 2	Enrichment	KMT2C	1.52
363	Tumoral calcinosis, hyperphosphatemic, familial, 2	Enrichment	FGF23	1.52
364	Hartsfield syndrome	Enrichment	FGFR1	1.52
365	Congenital heart defects, multiple types, 7	Enrichment	FLT4	1.52
366	Renal hypodysplasia/aplasia 2	Enrichment	FGF20	1.52
367	Thrombocytopenia 6	Enrichment	SRC	1.52
368	Cohen-gibson syndrome	Enrichment	EED	1.52
369	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	1.52
370	Glaucoma 3, primary congenital, e	Enrichment	TEK	1.52
371	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	1.52
372	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	1.52
373	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	1.52
374	Developmental and epileptic encephalopathy 47	Enrichment	FGF12	1.52
375	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	1.52
376	Onychodystrophy, osteodystrophy, impaired intellectual development, and seizures syndrome	Enrichment	PIGF	1.52
377	Nemaline myopathy 5b, autosomal recessive, childhood-onset	Enrichment	TNNT1	1.52
378	Chronic mast cell leukemia	Enrichment	KIT	1.52
379	Autosomal recessive dyskeratosis congenita 4	Enrichment	TERT	1.52
380	Trigonitis	Enrichment	RAF1	1.52
381	Bent bone dysplasia syndrome 2	Enrichment	LAMA5	1.52
382	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	1.52
383	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	1.52
384	Auriculocondylar syndrome 2b	Enrichment	PLCB4	1.52
385	Tufted angioma of skin	Enrichment	KDR	1.52
386	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	1.52
387	Deafness, autosomal dominant 69	Enrichment	KITLG	1.52
388	Luscan-lumish syndrome	Enrichment	SETD2	1.52
389	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	1.52
390	Hereditary hypotrichosis with recurrent skin vesicles	Enrichment	DSC3	1.52
391	Adenoid ameloblastoma	Enrichment	CTNNB1	1.52
392	Arthrogryposis, distal, type 11	Enrichment	MET	1.52
393	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	1.52
394	Baraitser-winter syndrome	Enrichment	ACTB	1.52
395	Rabin-pappas syndrome	Enrichment	SETD2	1.52
396	Cdkn2a cancer predisposition	Enrichment	CDKN2A	1.52
397	Mosaic variegated aneuploidy syndrome 7 with inflammation and tumor predisposition	Enrichment	MAD1L1	1.52
398	Csf1r-related disorder	Enrichment	CSF1R	1.52
399	Immunodeficiency 125	Enrichment	FLT3LG	1.52
400	Col4a1-related disorders	Enrichment	COL4A1	1.52
401	Occipital pachygyria and polymicrogyria	Enrichment	LAMC3	1.52
402	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	1.52
403	Nemaline myopathy 5a	Enrichment	TNNT1	1.52
404	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	1.52
405	Hypospadias	Enrichment	PIK3CA	1.52
406	Bockenheimer syndrome	Enrichment	TEK	1.52
407	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	1.52
408	Lrp5-related primary osteoporosis	Enrichment	LRP5	1.52
409	Capillary hemangioma	Enrichment	AKT3	1.52
410	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	1.52
411	Pulmonary hypertension, primary, 7	Enrichment	SOX17	1.52
412	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	1.52
413	Autoimmune disease, multisystem, infantile-onset, 5	Enrichment	CD274	1.52
414	Breast lobular carcinoma	Enrichment	CDH1	1.52
415	Isolated bone marrow mastocytosis	Enrichment	KIT	1.52
416	B-cell non-hodgkin lymphoma	Enrichment	ATM	1.52
417	Smoldering systemic mastocytosis	Enrichment	KIT	1.52
418	Cerebral cavernous malformations 5	Enrichment	MAP3K3	1.52
419	Choroid plexus cancer	Enrichment	TP53	1.52
420	Rare venous malformation	Enrichment	PIK3CA	1.52
421	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	1.52
422	Col4a1 or col4a2-related cerebral small vessel disease	Enrichment	COL4A1	1.52
423	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	1.52
424	Familial adenomatous polyposis	Enrichment	APC	1.52
425	Zebra body myopathy	Enrichment	ACTA1	1.52
426	Spinocerebellar ataxia type 27b	Enrichment	FGF14	1.52
427	Diaphragmatic eventration	Enrichment	PIK3CA	1.52
428	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	1.52
429	Acoustic neuroma	Enrichment	NF2	1.52
430	Congenital smooth muscle hamartoma	Enrichment	ACTB	1.52
431	X-linked alport syndrome	Enrichment	COL4A5	1.52
432	Mastocytosis	Enrichment	KIT	1.52
433	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	1.52
434	Congenital primary lymphedema of gordon	Enrichment	VEGFC	1.52
435	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	1.52
436	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	1.52
437	Epilepsy with myoclonic absences	Enrichment	SLC2A1	1.52
438	Cryopyrin associated periodic syndrome	Enrichment	NLRP3	1.52
439	Familial progressive hyperpigmentation	Enrichment	KITLG	1.52
440	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	1.52
441	Pleomorphic xanthoastrocytoma	Enrichment	TP53	1.52
442	Rare combined vascular malformation	Enrichment	PIK3CA	1.52
443	Cavernous lymphangioma	Enrichment	PIK3CA	1.52
444	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	1.52
445	Cleft lip	Enrichment	SETD5	1.52
446	Cutaneous mastocytoma	Enrichment	KIT	1.52
447	Familial amyloid nephropathy with urticaria and deafness	Enrichment	NLRP3	1.52
448	Gardner syndrome	Enrichment	APC	1.52
449	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	1.52
450	Typical urticaria pigmentosa	Enrichment	KIT	1.52
451	5q22 microdeletion syndrome	Enrichment	APC	1.52
452	Phakomatosis pigmentokeratotica	Enrichment	HRAS	1.52
453	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	1.52
454	Actin-accumulation myopathy	Enrichment	ACTA1	1.52
455	Attenuated familial adenomatous polyposis	Enrichment	APC	1.52
456	Nodular urticaria pigmentosa	Enrichment	KIT	1.52
457	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	1.52
458	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	1.52
459	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	1.52
460	Verrucous hemangioma	Enrichment	MAP3K3	1.52
461	Lama5-related multisystemic syndrome	Enrichment	LAMA5	1.52
462	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	1.52
463	Acute mast cell leukemia	Enrichment	KIT	1.52
464	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	1.52
465	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	1.52
466	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	1.52
467	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	1.52
468	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	1.52
469	Familial progressive hyper- and hypopigmentation	Enrichment	KITLG	1.52
470	Plaque-form urticaria pigmentosa	Enrichment	KIT	1.52
471	Interstitial lung disease specific to childhood	Enrichment	FGF10	1.52
472	Macrodactyly of toe	Enrichment	PIK3CA	1.52
473	Hereditary cryohydrocytosis with reduced stomatin	Enrichment	SLC2A1	1.52
474	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	1.52
475	Microcystic stromal tumor	Enrichment	CTNNB1	1.52
476	Primary peritoneal carcinoma	Enrichment	BRCA1	1.52
477	Actg2 visceral myopathy	Enrichment	ACTG2	1.52
478	Laminin subunit alpha 2-related muscular dystrophy	Enrichment	LAMA2	1.52
479	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.52
480	Testis seminoma	Enrichment	KIT	1.52
481	Brittle bone disorder	Enrichment	LRP5, SERPINF1, WNT1	1.51
482	Kallmann syndrome	Enrichment	FGF17, FGF8, FGFR1	1.51
483	Precursor t-cell acute lymphoblastic leukemia	Enrichment	CDKN2A, FLT3, MYC	1.51
484	Cat eye syndrome	Enrichment	ACTG1, FZD5	1.46
485	Polymicrogyria	Enrichment	AKT3, SETD5	1.46
486	Melanoma	Enrichment	CDKN2A, PTEN	1.46
487	Type 2 diabetes mellitus	Enrichment	AKT2, IL6, INSR, TCF7L2	1.43
488	Distal arthrogryposis	Enrichment	ACTA1, ACTC1, FZD3, ROR2	1.43
489	Leukemia, acute lymphoblastic	Enrichment	CDKN2A, FLT3	1.38
490	Myelodysplastic syndrome	Enrichment	ASXL1, TP53	1.38
491	Specific learning disability	Enrichment	MAPK1, RPS6KA3	1.38
492	West syndrome	Enrichment	CSNK1E, NTRK2, SLC2A1, TSC2	1.37
493	Differentiated thyroid carcinoma	Enrichment	HRAS, NTRK1, TERT	1.25
494	Microphthalmia/coloboma 12	Enrichment	FZD5, YAP1	1.25
495	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1	1.25
496	Chronic kidney disease	Enrichment	COL4A4, COL4A5	1.25
497	Lymphatic malformation 1	Enrichment	FLT4	1.23
498	Amelogenesis imperfecta, type ia	Enrichment	LAMB3	1.23
499	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	1.23
500	Blepharocheilodontic syndrome 1	Enrichment	CDH1	1.23
501	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.23
502	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.23
503	Burkitt lymphoma	Enrichment	MYC	1.23
504	Blue rubber bleb nevus	Enrichment	TEK	1.23
505	Sveinsson chorioretinal atrophy	Enrichment	TEAD1	1.23
506	Anemia, congenital dyserythropoietic, type iiia	Enrichment	KIF23	1.23
507	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	1.23
508	Fibromatosis, gingival, 1	Enrichment	SOS1	1.23
509	Otodental dysplasia	Enrichment	FGF3	1.23
510	Scoliosis, isolated 1	Enrichment	MAPK7	1.23
511	Tooth agenesis, selective, 4	Enrichment	WNT10A	1.23
512	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.23
513	Camurati-engelmann disease 1	Enrichment	TGFB1	1.23
514	Spondyloepimetaphyseal dysplasia, strudwick type	Enrichment	FN1	1.23
515	Costello syndrome	Enrichment	HRAS	1.23
516	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	1.23
517	Spondylometaphyseal dysplasia, corner fracture type	Enrichment	FN1	1.23
518	Trichomegaly	Enrichment	FGF5	1.23
519	Craniodiaphyseal dysplasia	Enrichment	SOST	1.23
520	Epidermolysis bullosa, junctional 2c, laryngoonychocutaneous	Enrichment	LAMA3	1.23
521	Schopf-schulz-passarge syndrome	Enrichment	WNT10A	1.23
522	Intracranial hypertension, idiopathic	Enrichment	FLT4	1.23
523	Kyphomelic dysplasia	Enrichment	CCN2	1.23
524	Myasthenic syndrome, congenital, 5	Enrichment	LAMB2	1.23
525	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	1.23
526	Bladder exstrophy and epispadias complex	Enrichment	WNT3	1.23
527	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.23
528	Dystonia 9	Enrichment	SLC2A1	1.23
529	Pulmonary hypoplasia, primary	Enrichment	FGF10	1.23
530	Quebec platelet disorder	Enrichment	PLAU	1.23
531	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	1.23
532	Odontoonychodermal dysplasia	Enrichment	WNT10A	1.23
533	Pulmonic stenosis	Enrichment	SOS1	1.23
534	Tetraamelia syndrome 1	Enrichment	WNT3	1.23
535	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.23
536	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	1.23
537	Cardiomyopathy, dilated, 1r	Enrichment	ACTC1	1.23
538	Schwannomatosis 1	Enrichment	NF2	1.23
539	Piebald trait	Enrichment	KIT	1.23
540	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	1.23
541	Aural atresia, congenital	Enrichment	FGFR2	1.23
542	Glut1 deficiency syndrome 1	Enrichment	SLC2A1	1.23
543	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.23
544	Cardiomyopathy, familial hypertrophic, 11	Enrichment	ACTC1	1.23
545	Osteogenesis imperfecta, type xv	Enrichment	WNT1	1.23
546	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	1.23
547	Deafness, congenital, with inner ear agenesis, microtia, and microdontia	Enrichment	FGF3	1.23
548	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.23
549	Lissencephaly 1	Enrichment	LAMB1	1.23
550	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	1.23
551	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.23
552	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	1.23
553	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.23
554	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.23
555	Specific language impairment 5	Enrichment	COL4A4	1.23
556	Pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 1	Enrichment	TERT	1.23
557	Silver-russell syndrome 3	Enrichment	IGF2	1.23
558	Angioma, tufted	Enrichment	KDR	1.23
559	Maturity-onset diabetes of the young, type 10	Enrichment	INS	1.23
560	Moyamoya disease 5	Enrichment	ACTA2	1.23
561	Noonan syndrome 8	Enrichment	PIK3CA	1.23
562	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	1.23
563	Pierson syndrome	Enrichment	LAMB2	1.23
564	Lymphoma, hodgkin, classic	Enrichment	TP53	1.23
565	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.23
566	Atrial septal defect 5	Enrichment	ACTC1	1.23
567	Immunodeficiency 31c	Enrichment	STAT1	1.23
568	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	1.23
569	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	1.23
570	Spondyloepimetaphyseal dysplasia, li-shao-li type	Enrichment	CCN2	1.23
571	Charcot-marie-tooth disease, demyelinating, type 4d	Enrichment	NDRG1	1.23
572	Encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 1	Enrichment	COL4A2	1.23
573	Epidermolysis bullosa, junctional 3b, severe	Enrichment	LAMC2	1.23
574	Epidermolysis bullosa, junctional 3a, intermediate	Enrichment	LAMC2	1.23
575	Gabriele-de vries syndrome	Enrichment	YY1	1.23
576	Waardenburg syndrome, type 2f	Enrichment	KITLG	1.23
577	Hyperproinsulinemia	Enrichment	INS	1.23
578	Nemaline myopathy 5c, autosomal dominant	Enrichment	TNNT1	1.23
579	Epidermolysis bullosa, junctional 2a, intermediate	Enrichment	LAMA3	1.23
580	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	1.23
581	Fanconi anemia, complementation group s	Enrichment	BRCA1	1.23
582	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	1.23
583	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	1.23
584	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	1.23
585	Cebalid syndrome	Enrichment	MTOR	1.23
586	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	1.23
587	Infantile myofibromatosis	Enrichment	PDGFRB	1.23
588	Bohring-opitz syndrome	Enrichment	ASXL1	1.23
589	Intravascular large b-cell lymphoma	Enrichment	BCL2	1.23
590	Retinitis pigmentosa 14	Enrichment	TEAD3	1.23
591	Nephrotic syndrome, type 5, with or without ocular abnormalities	Enrichment	LAMB2	1.23
592	Pancreatic cancer 4	Enrichment	BRCA1	1.23
593	Sclerosteosis	Enrichment	SOST	1.23
594	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	1.23
595	Glucose transporter type 1 deficiency syndrome	Enrichment	SLC2A1	1.23
596	Senior-loken syndrome 7	Enrichment	AKT3	1.23
597	Kleefstra syndrome	Enrichment	KMT2C	1.23
598	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.23
599	Osteogenesis imperfecta, type xvii	Enrichment	SPARC	1.23
600	Papillary renal cell carcinoma	Enrichment	MET	1.23
601	Camurati-engelmann disease	Enrichment	TGFB1	1.23
602	Congenital fibrosarcoma	Enrichment	TP53	1.23
603	Glomerulonephritis	Enrichment	COL4A4	1.23
604	Metaphyseal anadysplasia 2	Enrichment	MMP9	1.23
605	High grade glioma	Enrichment	ATM	1.23
606	Li-fraumeni syndrome 1	Enrichment	TP53	1.23
607	Sarcoma	Enrichment	TP53	1.23
608	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	1.23
609	Pericardial effusion	Enrichment	NLRP3	1.23
610	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	1.23
611	Developmental and epileptic encephalopathy 78	Enrichment	YY1	1.23
612	Melanoma, cutaneous malignant 9	Enrichment	TERT	1.23
613	Periampullary adenoma	Enrichment	APC	1.23
614	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	1.23
615	Immune system disease	Enrichment	PIK3CD	1.23
616	Hodgkin's lymphoma	Enrichment	TP53	1.23
617	Bardet-biedl syndrome 16	Enrichment	AKT3	1.23
618	Insulinoma	Enrichment	YY1	1.23
619	T-cell prolymphocytic leukemia	Enrichment	ATM	1.23
620	Epidermolysis bullosa, junctional 2b, severe	Enrichment	LAMA3	1.23
621	Smith-kingsmore syndrome	Enrichment	MTOR	1.23
622	14q11.2 microduplication syndrome	Enrichment	CHD8	1.23
623	Hereditary lymphedema i	Enrichment	FLT4	1.23
624	Idiopathic interstitial pneumonia	Enrichment	TERT	1.23
625	Inflammatory breast carcinoma	Enrichment	BRCA1	1.23
626	3p25.3 microdeletion syndrome	Enrichment	SETD5	1.23
627	Acute myeloid leukemia without maturation	Enrichment	FLT3	1.23
628	Lymphatic malformation 10	Enrichment	ANGPT2	1.23
629	Kury-isidor syndrome	Enrichment	BAP1	1.23
630	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.23
631	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.23
632	Metaphyseal anadysplasia	Enrichment	MMP9	1.23
633	Peritoneum cancer	Enrichment	BRCA1	1.23
634	Charcot-marie-tooth disease type 4d	Enrichment	NDRG1	1.23
635	Bilateral breast cancer	Enrichment	BRCA1	1.23
636	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	1.23
637	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	1.23
638	Chronic eosinophilic leukemia	Enrichment	PDGFRA	1.23
639	Vacterl with hydrocephalus	Enrichment	PTEN	1.23
640	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	1.23
641	3q26 microduplication syndrome	Enrichment	SETD5	1.23
642	Kleefstra syndrome due to a point mutation	Enrichment	KMT2C	1.23
643	Teratoma	Enrichment	CTNNB1	1.23
644	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	1.23
645	Osteosclerosis	Enrichment	LRP5	1.23
646	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	1.23
647	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.23
648	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	1.23
649	Common variable immunodeficiency 12	Enrichment	NFKB1	1.23
650	Juvenile polyposis of infancy	Enrichment	PTEN	1.23
651	Silver-russell syndrome due to an imprinting defect of 11p15	Enrichment	IGF2	1.23
652	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.23
653	Tafro syndrome	Enrichment	MAP2K2	1.23
654	Oculootodental syndrome	Enrichment	FGF3	1.23
655	Intestinal obstruction	Enrichment	ACTG2	1.23
656	Wooly hair nevus	Enrichment	HRAS	1.23
657	Silver-russell syndrome due to 11p15 microduplication	Enrichment	IGF2	1.23
658	Medulloblastoma	Enrichment	APC, CTNNB1	1.19
659	Cleft lip/palate	Enrichment	CDH1, PDGFRA	1.19
660	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	1.19
661	Isolated macular dystrophy	Enrichment	COL4A5, ITGA4	1.19
662	Primary autosomal recessive microcephaly	Enrichment	ANGPT2, CIT, PHC1	1.15
663	Coloboma of macula	Enrichment	FZD5, YAP1	1.13
664	Corpus callosum, agenesis of	Enrichment	COL4A1, SETD2	1.13
665	Osteogenesis imperfecta, type iii	Enrichment	SERPINF1, WNT1	1.13
666	Isolated corpus callosum agenesis	Enrichment	COL4A1, SETD2	1.13
667	Rare genetic intellectual disability	Enrichment	CHD8, MTOR	1.13
668	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	COL4A1, SETD2	1.13
669	Familial hypertrophic cardiomyopathy	Enrichment	ACTC1, PRKAG2, RAF1	1.12
670	Hypertension	Enrichment	COL4A4, COL4A5	1.08
671	Microform holoprosencephaly	Enrichment	FGF8, FGFR1	1.08
672	Lobar holoprosencephaly	Enrichment	FGF8, FGFR1	1.08
673	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.06
674	Achondroplasia	Enrichment	FGFR3	1.06
675	Type 1 diabetes mellitus 2	Enrichment	INS	1.06
676	Prognathism, mandibular	Enrichment	CSNK2B	1.06
677	Retinal arteries, tortuosity of	Enrichment	COL4A1	1.06
678	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.06
679	Larsen syndrome	Enrichment	FGFR3	1.06
680	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	1.06
681	Mesothelioma, malignant	Enrichment	BAP1	1.06
682	Ataxia-telangiectasia	Enrichment	ATM	1.06
683	Tumoral calcinosis, hyperphosphatemic, familial, 1	Enrichment	FGF23	1.06
684	Bleeding disorder, platelet-type, 16	Enrichment	ITGB3	1.06
685	Hypophosphatemic rickets, autosomal dominant	Enrichment	FGF23	1.06
686	Polycythemia vera	Enrichment	ATM	1.06
687	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.06
688	Methylmalonic aciduria and homocystinuria, cblx type	Enrichment	HCFC1	1.06
689	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	1.06
690	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	1.06
691	Microphthalmia, syndromic 9	Enrichment	WNT7B	1.06
692	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.06
693	Tooth agenesis, selective, 2	Enrichment	WNT10A	1.06
694	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	1.06
695	Glomerulopathy with fibronectin deposits 2	Enrichment	FN1	1.06
696	Nuchal bleb, familial	Enrichment	SOS1	1.06
697	Langerhans cell histiocytosis	Enrichment	MAP2K1	1.06
698	Osteogenic sarcoma	Enrichment	TP53	1.06
699	Glut1 deficiency syndrome 2	Enrichment	SLC2A1	1.06
700	Muscular dystrophy, congenital merosin-deficient, 1a	Enrichment	LAMA2	1.06
701	Nasopharyngeal carcinoma	Enrichment	TP53	1.06
702	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA	1.06
703	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.06
704	Tuberous sclerosis 2	Enrichment	TSC2	1.06
705	Brain small vessel disease 2	Enrichment	COL4A2	1.06
706	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.06
707	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.06
708	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.06
709	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD	1.06
710	Osteogenesis imperfecta, type vi	Enrichment	SERPINF1	1.06
711	Tumor predisposition syndrome 1	Enrichment	BAP1	1.06
712	Microangiopathy and leukoencephalopathy, pontine, autosomal dominant	Enrichment	COL4A1	1.06
713	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.06
714	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	1.06
715	Pilarowski-bjornsson syndrome	Enrichment	COL4A3	1.06
716	Alport syndrome 3b, autosomal recessive	Enrichment	COL4A3	1.06
717	Large congenital melanocytic nevus	Enrichment	HRAS	1.06
718	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1	1.06
719	Koolen-de vries syndrome	Enrichment	ATM	1.06
720	Poretti-boltshauser syndrome	Enrichment	LAMA1	1.06
721	Chromosome 17q23.1-q23.2 deletion syndrome	Enrichment	SLC2A1	1.06
722	Interstitial lung disease	Enrichment	TERT	1.06
723	Nail disease	Enrichment	FZD6	1.06
724	Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps	Enrichment	COL4A1	1.06
725	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.06
726	Anaplastic astrocytoma	Enrichment	TP53	1.06
727	Xanthinuria, type ii	Enrichment	TSC2	1.06
728	Immunodeficiency 14	Enrichment	PIK3CD	1.06
729	Myxoid liposarcoma	Enrichment	DDIT3	1.06
730	Squamous cell carcinoma	Enrichment	TP53	1.06
731	Cellular ependymoma	Enrichment	NF2	1.06
732	Tanycytic ependymoma	Enrichment	NF2	1.06
733	Macrocytic anemia	Enrichment	TERT	1.06
734	Papillary ependymoma	Enrichment	NF2	1.06
735	T-cell acute lymphoblastic leukemia	Enrichment	BAX	1.06
736	Hematuria, benign familial, 2	Enrichment	COL4A3	1.06
737	Familial vesicoureteral reflux	Enrichment	SOX17	1.06
738	Microcephaly 17, primary, autosomal recessive	Enrichment	CIT	1.06
739	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.06
740	Bone osteosarcoma	Enrichment	TP53	1.06
741	Bap1 tumor predisposition syndrome	Enrichment	BAP1	1.06
742	Butterfly-shaped pigment dystrophy	Enrichment	CTNNA1	1.06
743	Atypical juvenile parkinsonism	Enrichment	PODXL	1.06
744	Tetraamelia syndrome	Enrichment	WNT3	1.06
745	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.06
746	Colon adenocarcinoma	Enrichment	APC	1.06
747	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.06
748	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.06
749	Melanoma of soft tissue	Enrichment	CREB1	1.06
750	Spindle cell sarcoma	Enrichment	NF2	1.06
751	Mixed phenotype acute leukemia with t	Enrichment	FLT3	1.06
752	Clear cell ependymoma	Enrichment	NF2	1.06
753	Renal cell carcinoma	Enrichment	MET	1.06
754	Enchondromatosis	Enrichment	HIF1A	1.06
755	Testicular cancer	Enrichment	FGFR3	1.06
756	Keratoacanthoma	Enrichment	PIK3CA	1.06
757	Beckwith-wiedemann syndrome due to imprinting defect of 11p15	Enrichment	IGF2	1.06
758	Apc-associated polyposis conditions	Enrichment	APC	1.06
759	Lama2-related muscular dystrophy	Enrichment	LAMA2	1.06
760	Alzheimer disease, familial, 1	Enrichment	CSF1R, PLAU	1.04
761	Dandy-walker syndrome	Enrichment	PDGFRB, SETD2	1.04
762	Semilobar holoprosencephaly	Enrichment	FGF8, FGFR1	1.00
763	Cerebral palsy	Enrichment	COL4A1, COL4A2, PDGFRB	0.95
764	Kaposi sarcoma	Enrichment	IL6	0.94
765	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	0.94
766	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DVL2	0.94
767	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	WNT10A	0.94
768	Small cell cancer of the lung	Enrichment	TP53	0.94
769	Nemaline myopathy 2	Enrichment	ACTA1	0.94
770	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	0.94
771	Schizencephaly	Enrichment	COL4A1	0.94
772	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	0.94
773	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	0.94
774	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	0.94
775	Auriculocondylar syndrome 1	Enrichment	PLCB4	0.94
776	Glaucoma 3, primary infantile, b	Enrichment	TEK	0.94
777	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	0.94
778	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	0.94
779	Pilomatrixoma	Enrichment	CTNNB1	0.94
780	Retinitis pigmentosa 26	Enrichment	ITGA4	0.94
781	Cholangiocarcinoma	Enrichment	BRCA1	0.94
782	Barrett esophagus	Enrichment	CTHRC1	0.94
783	Aminoacylase 1 deficiency	Enrichment	ACTB	0.94
784	Alazami syndrome	Enrichment	CTNNB1	0.94
785	Enophthalmos	Enrichment	CSNK2B	0.94
786	Multiple synostoses syndrome	Enrichment	FGF9	0.94
787	Syndactyly	Enrichment	CSNK2B	0.94
788	Neonatal diabetes mellitus	Enrichment	INS	0.94
789	Intellectual developmental disorder with autism and macrocephaly	Enrichment	CHD8	0.94
790	Orofacial cleft	Enrichment	LRP6	0.94
791	Ectodermal dysplasia	Enrichment	WNT10A	0.94
792	Ciliary dyskinesia, primary, 22	Enrichment	RASSF1	0.94
793	Cerebrovascular disease	Enrichment	PIK3CA	0.94
794	Embryonal rhabdomyosarcoma	Enrichment	TP53	0.94
795	Noonan syndrome with multiple lentigines	Enrichment	RAF1	0.94
796	Epidermolytic nevus	Enrichment	HRAS	0.94
797	Familial cerebral cavernous malformations	Enrichment	PIK3CA	0.94
798	Knobloch syndrome	Enrichment	PAK2	0.94
799	Eyelid coloboma	Enrichment	FZD5	0.94
800	Silver-russell syndrome due to a point mutation	Enrichment	IGF2	0.94
801	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	0.94
802	Full schwannomatosis	Enrichment	NF2	0.94
803	Intermediate nemaline myopathy	Enrichment	ACTA1	0.94
804	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	0.94
805	Vitreoretinopathy	Enrichment	LRP5	0.94
806	Benign ependymoma	Enrichment	NF2	0.94
807	Orofacial clefting syndrome	Enrichment	LRP6	0.94
808	Rare x-linked non-syndromic sensorineural deafness type dfn	Enrichment	COL4A6	0.94
809	Gingival fibromatosis	Enrichment	SOS1	0.94
810	Hereditary angioedema with normal c1inh not related to f12 or plg variant	Enrichment	ANGPT1	0.94
811	Oculomotor apraxia	Enrichment	ATM	0.94
812	Lens coloboma	Enrichment	FZD5	0.94
813	Macs syndrome	Enrichment	PORCN, WNT7B	0.92
814	Focal segmental glomerulosclerosis	Enrichment	COL4A4, COL4A5	0.92
815	Cataract 6, multiple types	Enrichment	EPHA2	0.85
816	Capillary malformations, congenital	Enrichment	PIK3CA	0.85
817	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	0.85
818	Alzheimer disease 2	Enrichment	PLAU	0.85
819	Kbg syndrome	Enrichment	SETD5	0.85
820	Visceral myopathy 1	Enrichment	ACTG2	0.85
821	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	0.85
822	Von hippel-lindau syndrome	Enrichment	CCND1	0.85
823	Microcephaly 1, primary, autosomal recessive	Enrichment	ANGPT2	0.85
824	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	0.85
825	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PODXL	0.85
826	Norrie disease	Enrichment	PRSS23	0.85
827	Macrocephaly/autism syndrome	Enrichment	PTEN	0.85
828	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	0.85
829	Myasthenic syndrome, congenital, 4a, slow-channel	Enrichment	MINK1	0.85
830	Knobloch syndrome 1	Enrichment	PAK2	0.85
831	Breast-ovarian cancer, familial 2	Enrichment	BRCA1	0.85
832	Familial adenomatous polyposis 1	Enrichment	APC	0.85
833	Cholangitis, primary sclerosing	Enrichment	MST1	0.85
834	Glanzmann thrombasthenia 2	Enrichment	ITGB3	0.85
835	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	LAMA2	0.85
836	Pre-eclampsia	Enrichment	FLT1	0.85
837	Follicular lymphoma	Enrichment	BCL2	0.85
838	Lymphoma	Enrichment	TP53	0.85
839	Congenital ptosis	Enrichment	CHD8	0.85
840	Myasthenic syndrome, congenital, 4b, fast-channel	Enrichment	MINK1	0.85
841	Glioblastoma	Enrichment	ATM	0.85
842	Hemangioma	Enrichment	PTEN	0.85
843	Parkin type of early-onset parkinson disease	Enrichment	PODXL	0.85
844	Aplasia cutis congenita	Enrichment	ITGB4	0.85
845	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	WNT10A	0.85
846	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	0.85
847	Aniridia	Enrichment	EPHA2	0.85
848	Aggressive systemic mastocytosis	Enrichment	ASXL1	0.85
849	Diffuse cutaneous systemic sclerosis	Enrichment	CCN2	0.85
850	Endometrial stromal sarcoma	Enrichment	SUZ12	0.85
851	Severe congenital nemaline myopathy	Enrichment	ACTA1	0.85
852	Idiopathic aplastic anemia	Enrichment	TERT	0.85
853	Dyskeratosis congenita, autosomal dominant 1	Enrichment	TERT	0.78
854	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	0.78
855	Coloboma of optic nerve	Enrichment	FZD5	0.78
856	Kabuki syndrome 1	Enrichment	KDM6A	0.78
857	Weyers acrofacial dysostosis	Enrichment	CTNNB1	0.78
858	Wolf-hirschhorn syndrome	Enrichment	CTBP1	0.78
859	Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndrome	Enrichment	BDNF	0.78
860	Moyamoya disease 1	Enrichment	ACTA2	0.78
861	Anterior segment dysgenesis 5	Enrichment	COL4A1	0.78
862	Kleefstra syndrome 1	Enrichment	KMT2C	0.78
863	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	0.78
864	Intestinal pseudo-obstruction	Enrichment	ACTG2	0.78
865	Immunodeficiency-centromeric instability-facial anomalies syndrome	Enrichment	UHRF1	0.78
866	Diarrhea	Enrichment	WNT2B	0.78
867	Pulmonary fibrosis	Enrichment	TERT	0.78
868	Chronic mucocutaneous candidiasis	Enrichment	STAT1	0.78
869	Limited scleroderma	Enrichment	CCN2	0.78
870	Hoyeraal-hreidarsson syndrome	Enrichment	TERT	0.78
871	Hypertrichosis	Enrichment	ASXL1	0.78
872	Kidney clear cell sarcoma	Enrichment	TERT	0.78
873	Multicystic kidney dysplasia	Enrichment	FZD3	0.78
874	Typical nemaline myopathy	Enrichment	ACTA1	0.78
875	Cleft lip with or without cleft palate	Enrichment	CDH1	0.78
876	Multicystic dysplastic kidney	Enrichment	FZD3	0.78
877	Complex neurodevelopmental disorder	Enrichment	BAP1, CSNK2A1, PAK3, RNF2, SETD5, TCF7L2	0.76
878	Developmental and epileptic encephalopathy 1	Enrichment	CSNK1E, SLC2A1	0.76
879	Thrombocytopenia	Enrichment	CYCS, ITGB3, SRC	0.76
880	Tetralogy of fallot	Enrichment	FLT4, KDR	0.73
881	Esophageal cancer	Enrichment	TP53	0.71
882	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	0.71
883	Glaucoma 3, primary congenital, a	Enrichment	TEK	0.71
884	Silver-russell syndrome 1	Enrichment	IGF2	0.71
885	Myelofibrosis	Enrichment	SRC	0.71
886	Coats disease	Enrichment	PRSS23	0.71
887	Myasthenic syndrome, congenital, 1a, slow-channel	Enrichment	MINK1	0.71
888	Glanzmann thrombasthenia 1	Enrichment	ITGB3	0.71
889	Waardenburg syndrome, type 2e	Enrichment	KITLG	0.71
890	Dyskeratosis congenita, autosomal dominant 2	Enrichment	TERT	0.71
891	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	0.71
892	Polycystic kidney disease 1	Enrichment	TSC2	0.71
893	Essential thrombocythemia	Enrichment	TP53	0.71
894	Megacolon	Enrichment	AKT3	0.71
895	Common variable immunodeficiency	Enrichment	NFKB1	0.71
896	Epidermolysis bullosa simplex	Enrichment	ITGB4	0.71
897	Childhood-onset nemaline myopathy	Enrichment	ACTA1	0.71
898	Paroxysmal dystonia	Enrichment	SLC2A1	0.71
899	Hypophosphatemic rickets	Enrichment	FGF23	0.71
900	Hypertelorism	Enrichment	FGFR2, PIK3CA, RPS6KA3	0.69
901	Familial isolated dilated cardiomyopathy	Enrichment	ACTC1, LAMA4, RAF1	0.67
902	Arthrogryposis, distal, type 1a	Enrichment	MET	0.66
903	Gastroesophageal reflux	Enrichment	RPS6KA3	0.66
904	Renal hypodysplasia/aplasia 1	Enrichment	MAP4K4	0.66
905	Methylmalonic aciduria and homocystinuria, cblc type	Enrichment	HCFC1	0.66
906	Lymphoma, non-hodgkin, familial	Enrichment	TP53	0.66
907	Orthostatic intolerance	Enrichment	RPS6KA3	0.66
908	Ewing sarcoma	Enrichment	BAP1	0.66
909	Lennox-gastaut syndrome	Enrichment	MAPK10	0.66
910	Alternating hemiplegia of childhood	Enrichment	SLC2A1	0.66
911	Congenital muscular dystrophy	Enrichment	LAMA2	0.66
912	Neuroblastoma	Enrichment	LIN28B	0.66
913	Permanent neonatal diabetes mellitus	Enrichment	INS	0.66
914	Early-onset posterior polar cataract	Enrichment	EPHA2	0.66
915	Dilated cardiomyopathy	Enrichment	ACTA1, ACTC1, LAMA2, RAF1	0.65
916	Orofacial cleft 1	Enrichment	FGF10	0.62
917	Rheumatoid arthritis	Enrichment	IL10	0.62
918	Charge syndrome	Enrichment	KDM6A	0.62
919	Inflammatory bowel disease 1	Enrichment	IL6	0.62
920	Myoclonic-atonic epilepsy	Enrichment	SLC2A1	0.62
921	Hypogonadotropic hypogonadism	Enrichment	FGFR1	0.62
922	Congenital central hypoventilation syndrome	Enrichment	BDNF	0.62
923	Primary hyperaldosteronism	Enrichment	TP53	0.62
924	Renal agenesis, bilateral	Enrichment	FGF20	0.62
925	Connective tissue disease	Enrichment	ACTA2, FGFR3	0.60
926	Primary ovarian insufficiency	Enrichment	ADAMTS1, KDR, NTRK1	0.58
927	Lynch syndrome 1	Enrichment	ATM	0.58
928	Meier-gorlin syndrome 1	Enrichment	FGFR2	0.58
929	Peters-plus syndrome	Enrichment	COL4A1	0.58
930	Amelogenesis imperfecta, type ie	Enrichment	LAMB3	0.58
931	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	0.58
932	Aplastic anemia	Enrichment	TERT	0.58
933	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	MINK1	0.58
934	Nemaline myopathy	Enrichment	ACTA1	0.58
935	Autosomal dominant macrothrombocytopenia	Enrichment	ITGB3	0.58
936	Familial colorectal cancer	Enrichment	TP53	0.58
937	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD	0.58
938	Primary bone dysplasia	Enrichment	FGFR3	0.58
939	Cakut	Enrichment	ACTG1, COL4A1	0.56
940	Genetic steroid-resistant nephrotic syndrome	Enrichment	COL4A3, LAMA5	0.56
941	Left ventricular noncompaction	Enrichment	ACTC1, RAF1	0.55
942	Immune deficiency disease	Enrichment	ATM	0.54
943	Frontotemporal dementia 1	Enrichment	CSF1R	0.54
944	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	0.54
945	Osteochondrodysplasia	Enrichment	FGFR3	0.54
946	Diabetes mellitus	Enrichment	INS	0.54
947	Heritable pulmonary arterial hypertension	Enrichment	SOX17	0.54
948	Familial colorectal cancer type x	Enrichment	ATM	0.54
949	Presynaptic congenital myasthenic syndromes	Enrichment	LAMA5	0.54
950	Non-syndromic x-linked intellectual disability	Enrichment	HCFC1, RPS6KA3	0.53
951	Fetal akinesia deformation sequence 1	Enrichment	ACTA1, ROR2	0.51
952	Septooptic dysplasia	Enrichment	FGFR1	0.51
953	Juvenile myelomonocytic leukemia	Enrichment	ASXL1	0.51
954	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	0.51
955	Early-onset parkinson's disease	Enrichment	PODXL	0.51
956	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	CTNNA3	0.51
957	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	CTNNA3	0.51
958	Congenital long qt syndrome	Enrichment	ITPR3	0.51
959	Aortic valve disease 1	Enrichment	SOS1	0.48
960	Neural tube defects	Enrichment	ITGB1	0.48
961	Pulmonary hypertension, primary, 1	Enrichment	SOX17	0.48
962	Alzheimer's disease	Enrichment	CSF1R	0.48
963	Amelogenesis imperfecta	Enrichment	LAMB3	0.48
964	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	0.46
965	Pheochromocytoma	Enrichment	MAX	0.46
966	Periventricular nodular heterotopia	Enrichment	BRCA1	0.46
967	Walker-warburg syndrome	Enrichment	COL4A1	0.46
968	Generalized epilepsy with febrile seizures plus	Enrichment	FGF13	0.46
969	Cataract	Enrichment	EPHA2	0.46
970	Congenital myasthenic syndrome	Enrichment	MINK1	0.46
971	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	CTNNA3	0.46
972	Charcot-marie-tooth disease	Enrichment	LAMA2, NDRG1	0.45
973	Wilms tumor 1	Enrichment	IGF2	0.43
974	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1	0.43
975	Myopia	Enrichment	COL4A4	0.43
976	Anterior segment dysgenesis	Enrichment	COL4A1	0.43
977	Atypical hemolytic-uremic syndrome	Enrichment	COL4A5	0.43
978	Lynch syndrome	Enrichment	PIK3CA	0.43
979	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	0.43
980	Septopreoptic holoprosencephaly	Enrichment	FGF8	0.43
981	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8	0.43
982	Hypertrophic cardiomyopathy	Enrichment	ACTC1, PRKAG2	0.43
983	Creatine phosphokinase, elevated serum	Enrichment	LAMA2	0.41
984	Wolff-parkinson-white syndrome	Enrichment	PRKAG2	0.41
985	Hydrocephalus, congenital, 1	Enrichment	SETD2	0.41
986	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	CTNNA3	0.41
987	Isolated elevated serum creatine phosphokinase levels	Enrichment	LAMA2	0.41
988	Isolated congenital microcephaly	Enrichment	PHC1	0.41
989	Congenital nervous system abnormality	Enrichment	CTNNB1, FGFR3, PTEN, TSC2	0.40
990	Nervous system disease	Enrichment	CTNNB1, FGFR3, PTEN, TSC2	0.40
991	Cleft palate, isolated	Enrichment	SETD5	0.39
992	Interstitial lung disease 2	Enrichment	TERT	0.39
993	Cataract 44	Enrichment	EPHA2	0.39
994	Alobar holoprosencephaly	Enrichment	FGF8	0.39
995	Beckwith-wiedemann syndrome	Enrichment	IGF2	0.37
996	Heart, malformation of	Enrichment	MAPK1	0.37
997	Charcot-marie-tooth disease type 4	Enrichment	NDRG1	0.37
998	Neuromuscular disease	Enrichment	ACTA1	0.37
999	Patent foramen ovale	Enrichment	ACTC1	0.37
1000	Polycystic kidney disease	Enrichment	COL4A4	0.37
1001	Early-onset nuclear cataract	Enrichment	EPHA2	0.37
1002	Behcet syndrome	Enrichment	IL10	0.36
1003	Congenital myopathy	Enrichment	ACTA1	0.36
1004	Dyskeratosis congenita	Enrichment	TERT	0.36
1005	Maturity-onset diabetes of the young	Enrichment	INS	0.34
1006	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1, KITLG	0.33
1007	Lissencephaly	Enrichment	ACTG1	0.32
1008	Centronuclear myopathy	Enrichment	ACTA1	0.32
1009	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	MAX	0.32
1010	Myocardial infarction	Enrichment	ITGB3	0.31
1011	Microphthalmia	Enrichment	WNT7B	0.31
1012	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET, ROR1	0.30
1013	Diamond-blackfan anemia 1	Enrichment	TP53	0.30
1014	Undetermined early-onset epileptic encephalopathy	Enrichment	FGF12, NTRK2	0.30
1015	Parkinson disease, late-onset	Enrichment	EIF4G1	0.28
1016	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.28
1017	Autoinflammatory disease	Enrichment	NLRP3	0.28
1018	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R, PPARGC1A	0.28
1019	Strabismus	Enrichment	SLC2A1	0.25
1020	Severe covid-19	Enrichment	ITGAV	0.23
1021	Long qt syndrome 1	Enrichment	ITPR3	0.22
1022	Long qt syndrome	Enrichment	CTNNA3	0.21
1023	Cystic fibrosis	Enrichment	TGFB1	0.20
1024	Peripheral nervous system disease	Enrichment	NGF	0.20
1025	Neuropathy	Enrichment	NGF	0.20
1026	Autism	Enrichment	CHD8, TCF7L2	0.19
1027	Fanconi anemia, complementation group a	Enrichment	BRCA1	0.18
1028	Diamond-blackfan anemia	Enrichment	TP53	0.18
1029	Non-syndromic genetic deafness	Enrichment	ACTG1	0.18
1030	Rare genetic deafness	Enrichment	ACTG1, COL4A5	0.16
1031	Systemic lupus erythematosus	Enrichment	IL10	0.16
1032	Epilepsy	Enrichment	SLC2A1	0.15
1033	Myopathy	Enrichment	ACTA1	0.15
1034	Benign epilepsy with centrotemporal spikes	Enrichment	SLC2A1	0.15
1035	Nonsyndromic hearing loss	Enrichment	ACTG1	0.14
1036	Centralopathic epilepsy	Enrichment	SLC2A1	0.14
1037	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.13
1038	Sensorineural hearing loss	Enrichment	HGF	0.11
1039	Body mass index quantitative trait locus 11	Enrichment	BDNF	0.11
1040	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B	0.11
1041	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8	0.09
1042	Autosomal recessive non-syndromic intellectual disability	Enrichment	TNIK	0.08
1043	Hereditary retinal dystrophy	Enrichment	CTNNA1, ITGA4, LAMA1, LRP5, PRSS23, TEAD3	0.06
1044	Fundus dystrophy	Enrichment	CTNNA1, ITGA4, LAMA1, LRP5, PRSS23, TEAD3	0.06
1045	Cone-rod dystrophy 2	Enrichment	ITGA4	0.06
1046	Leber plus disease	Enrichment	TEAD3	0.02

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pleural mesothelioma

Pathway Network for Pleural mesothelioma

Member Pathways for Pleural mesothelioma

Pathways in the Pleural mesothelioma SuperPath

Associated Genes for Pleural mesothelioma

Associated Disorders for Pleural mesothelioma

Disorders associated with Pleural mesothelioma SuperPath

STRING Interaction Network for Pleural mesothelioma

Sources for Pleural mesothelioma