PLK1 signaling events

Pathway network for the PLK1 signaling events SuperPath

Sources:

PubChem
Reactome

Pathways in the PLK1 signaling events SuperPath

#	Name	Source	Genes
1	PLK1 signaling events	PubChem	AURKA BORA BUB1 BUB1B CCNB1 CDC14B CDC20 CDC25B CDC25C CDK1 CENPE CENPU CLSPN ECT2 ERCC6L FBXO5 FZR1 GOLGA2 GORASP1 INCENP KIF20A KIF2A KIZ MAD2L1BP NDC80 NINL NUDC ODF2 PAK1 PLK1 PPP1CB PPP1R12A PPP2CA PPP2R1A PRC1 PTPA RAB1A RHOA ROCK2 SGO1 SPC24 STAG2 TPT1 TPX2 TUBG1 WEE1 (see all 46) (see less)
2	Phosphorylation of Emi1	Reactome	CCNB1 CDC20 CDK1 FBXO5 FZR1 PLK1 (see all 6) (see less)
3	Mitotic Metaphase/Anaphase Transition	Reactome	FBXO5 PLK1

Gene overlap in member pathways for PLK1 signaling events SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FBXO5	F-Box Protein 5	Protein Coding	3
2	PLK1	Polo Like Kinase 1	Protein Coding	3
3	FZR1	Fizzy And Cell Division Cycle 20 Related 1	Protein Coding	2
4	CDC20	Cell Division Cycle 20	Protein Coding	2
5	CDK1	Cyclin Dependent Kinase 1	Protein Coding	2
6	CCNB1	Cyclin B1	Protein Coding	2
7	SPC24	SPC24 Component Of NDC80 Kinetochore Complex	Protein Coding	1
8	KIZ	Kizuna Centrosomal Protein	Protein Coding	1
9	CDC14B	Cell Division Cycle 14B	Protein Coding	1
10	ROCK2	Rho Associated Coiled-Coil Containing Protein Kinase 2	Protein Coding	1
11	TPT1	Tumor Protein, Translationally-Controlled 1	Protein Coding	1
12	MAD2L1BP	MAD2L1 Binding Protein	Protein Coding	1
13	NDC80	NDC80 Kinetochore Complex Component	Protein Coding	1
14	ECT2	Epithelial Cell Transforming 2	Protein Coding	1
15	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	1
16	CENPU	Centromere Protein U	Protein Coding	1
17	KIF20A	Kinesin Family Member 20A	Protein Coding	1
18	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
19	TPX2	TPX2 Microtubule Nucleation Factor	Protein Coding	1
20	AURKA	Aurora Kinase A	Protein Coding	1
21	BORA	BORA Aurora Kinase A Activator	Protein Coding	1
22	CDC25B	Cell Division Cycle 25B	Protein Coding	1
23	ERCC6L	ERCC Excision Repair 6 Like, Spindle Assembly Checkpoint Helicase	Protein Coding	1
24	NUDC	Nuclear Distribution C, Dynein Complex Regulator	Protein Coding	1
25	SGO1	Shugoshin 1	Protein Coding	1
26	BUB1B	BUB1 Mitotic Checkpoint Serine/Threonine Kinase B	Protein Coding	1
27	BUB1	BUB1 Mitotic Checkpoint Serine/Threonine Kinase	Protein Coding	1
28	INCENP	Inner Centromere Protein	Protein Coding	1
29	PRC1	Protein Regulator Of Cytokinesis 1	Protein Coding	1
30	CDC25C	Cell Division Cycle 25C	Protein Coding	1
31	PPP1R12A	Protein Phosphatase 1 Regulatory Subunit 12A	Protein Coding	1
32	PPP1CB	Protein Phosphatase 1 Catalytic Subunit Beta	Protein Coding	1
33	CLSPN	Claspin	Protein Coding	1
34	STAG2	STAG2 Cohesin Complex Component	Protein Coding	1
35	KIF2A	Kinesin Family Member 2A	Protein Coding	1
36	CENPE	Centromere Protein E	Protein Coding	1
37	WEE1	WEE1 G2 Checkpoint Kinase	Protein Coding	1
38	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
39	RHOA	Ras Homolog Family Member A	Protein Coding	1
40	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
41	TUBG1	Tubulin Gamma 1	Protein Coding	1
42	NINL	Ninein Like	Protein Coding	1
43	ODF2	Outer Dense Fiber Of Sperm Tails 2	Protein Coding	1
44	RAB1A	RAB1A, Member RAS Oncogene Family	Protein Coding	1
45	GOLGA2	Golgin A2	Protein Coding	1
46	GORASP1	Golgi Reassembly Stacking Protein 1	Protein Coding	1

Disorders associated with PLK1 signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1, BUB1B	3.51
2	Oocyte/zygote/embryo maturation arrest 14	Enrichment	CDC20	3.35
3	Developmental and epileptic encephalopathy 109	Enrichment	FZR1	3.35
4	Colorectal cancer	Enrichment	AURKA, BUB1, BUB1B	2.50
5	Holoprosencephaly 13, x-linked	Enrichment	STAG2	2.47
6	Cortical dysplasia, complex, with other brain malformations 3	Enrichment	KIF2A	2.47
7	Premature chromatid separation trait	Enrichment	BUB1B	2.47
8	Cardiomyopathy, familial restrictive, 6	Enrichment	KIF20A	2.47
9	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	2.47
10	Mullegama-klein-martinez syndrome	Enrichment	STAG2	2.47
11	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.47
12	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.47
13	Developmental delay with hypotonia, myopathy, and brain abnormalities	Enrichment	GOLGA2	2.47
14	Microcephaly 13, primary, autosomal recessive	Enrichment	CENPE	2.47
15	Xq25 microduplication syndrome	Enrichment	STAG2	2.47
16	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.47
17	Noonan syndrome-like disorder with loose anagen hair 2	Enrichment	PPP1CB	2.47
18	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.47
19	Microcephaly 30, primary, autosomal recessive	Enrichment	BUB1	2.47
20	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.47
21	Encephalopathy, acute, infection-induced 10	Enrichment	TPT1	2.17
22	Cortical dysplasia, complex, with other brain malformations 4	Enrichment	TUBG1	2.17
23	Genitourinary and/or brain malformation syndrome	Enrichment	PPP1R12A	2.17
24	Noonan syndrome-like disorder with loose anagen hair	Enrichment	PPP1CB	2.17
25	Chronic atrial and intestinal dysrhythmia	Enrichment	SGO1	2.17
26	Houge-janssens syndrome 3	Enrichment	PPP2CA	2.17
27	Retinitis pigmentosa 69	Enrichment	KIZ	1.99
28	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B	1.77
29	Chromosome 15q11.2 deletion syndrome	Enrichment	TUBG1	1.77
30	Hemihyperplasia, isolated	Enrichment	RHOA	1.70
31	Familial isolated restrictive cardiomyopathy	Enrichment	KIF20A	1.63
32	Undetermined early-onset epileptic encephalopathy	Enrichment	FZR1	1.61
33	Seckel syndrome	Enrichment	CENPE	1.33
34	Dandy-walker syndrome	Enrichment	PPP1CB	1.25
35	Alobar holoprosencephaly	Enrichment	STAG2	1.25
36	Neuromuscular disease	Enrichment	GOLGA2	1.23
37	Semilobar holoprosencephaly	Enrichment	STAG2	1.23
38	Lissencephaly	Enrichment	TUBG1	1.16
39	Noonan syndrome 1	Enrichment	PPP1CB	1.12
40	Rasopathy	Enrichment	PPP1CB	1.07
41	Primary autosomal recessive microcephaly	Enrichment	CENPE	0.99
42	Nephronophthisis	Enrichment	INCENP	0.97
43	Body mass index quantitative trait locus 11	Enrichment	NUDC	0.81
44	Myeloma, multiple	Enrichment	AURKA	0.76
45	Ovarian cancer	Enrichment	BUB1B	0.54
46	Complex neurodevelopmental disorder	Enrichment	PPP2CA	0.46
47	Retinitis pigmentosa	Enrichment	KIZ	0.29
48	Hereditary retinal dystrophy	Enrichment	KIZ	0.20
49	Fundus dystrophy	Enrichment	KIZ	0.20

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PLK1 signaling events

Pathway Network for PLK1 signaling events

Pathway network for the PLK1 signaling events SuperPath

Member Pathways for PLK1 signaling events

Pathways in the PLK1 signaling events SuperPath

Gene overlap in member pathways for PLK1 signaling events SuperPath

Associated Genes for PLK1 signaling events

Associated Disorders for PLK1 signaling events

Disorders associated with PLK1 signaling events SuperPath

STRING Interaction Network for PLK1 signaling events

Sources for PLK1 signaling events