PLK3 signaling events

No Pathway Network information available for PLK3 signaling events

Pathways in the PLK3 signaling events SuperPath

#	Name	Source	Genes
1	PLK3 signaling events	PubChem	ATM CCNE1 CDC25C CHEK2 PLK3 TP53 (see all 6) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PLK3	Polo Like Kinase 3	Protein Coding	1
2	CCNE1	Cyclin E1	Protein Coding	1
3	CDC25C	Cell Division Cycle 25C	Protein Coding	1
4	CHEK2	Checkpoint Kinase 2	Protein Coding	1
5	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
6	TP53	Tumor Protein P53	Protein Coding	1

Disorders associated with PLK3 signaling events SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pancreatic cancer	Enrichment	ATM, CHEK2, TP53	6.96
2	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	6.79
3	Sarcoma	Enrichment	CHEK2, TP53	6.79
4	Prostate cancer	Enrichment	ATM, CHEK2, TP53	6.76
5	Osteogenic sarcoma	Enrichment	CHEK2, TP53	6.31
6	Adenocarcinoma	Enrichment	ATM, TP53	6.31
7	Bone osteosarcoma	Enrichment	CHEK2, TP53	6.31
8	Gastric cancer	Enrichment	ATM, CHEK2, TP53	6.23
9	Hereditary breast carcinoma	Enrichment	ATM, CHEK2, TP53	6.20
10	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, CHEK2, TP53	5.90
11	Li-fraumeni syndrome	Enrichment	CHEK2, TP53	5.61
12	Breast cancer	Enrichment	ATM, CHEK2, TP53	5.49
13	Colorectal cancer	Enrichment	ATM, CHEK2, TP53	5.30
14	Colonic benign neoplasm	Enrichment	ATM, CHEK2	5.23
15	Lynch syndrome 1	Enrichment	ATM, CHEK2	5.14
16	Leukemia, chronic lymphocytic	Enrichment	ATM, TP53	5.14
17	Ovarian cancer	Enrichment	ATM, CHEK2, TP53	5.10
18	Uterine corpus cancer	Enrichment	ATM, CHEK2	5.05
19	Familial colorectal cancer type x	Enrichment	ATM, CHEK2	5.05
20	Breast-ovarian cancer, familial 1	Enrichment	ATM, CHEK2	4.90
21	Inherited cancer-predisposing syndrome	Enrichment	ATM, CHEK2, TP53	4.75
22	Gliosarcoma	Enrichment	ATM, TP53	4.71
23	Giant cell glioblastoma	Enrichment	ATM, TP53	4.66
24	Diffuse large b-cell lymphoma	Enrichment	CHEK2, TP53	4.56
25	Endometrial cancer	Enrichment	ATM, CHEK2	4.47
26	Bladder cancer	Enrichment	ATM, TP53	4.18
27	Myeloma, multiple	Enrichment	ATM, TP53	3.60
28	Bone marrow failure syndrome 5	Enrichment	TP53	3.35
29	Papilloma of choroid plexus	Enrichment	TP53	3.35
30	Basal cell carcinoma 7	Enrichment	TP53	3.35
31	Anaplastic thyroid carcinoma	Enrichment	TP53	3.35
32	Tumor predisposition syndrome 4	Enrichment	CHEK2	3.35
33	Endometrial serous adenocarcinoma	Enrichment	ATM	3.35
34	Ductal carcinoma in situ	Enrichment	TP53	3.35
35	Leiomyosarcoma	Enrichment	CHEK2	3.35
36	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	3.35
37	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	3.35
38	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	3.35
39	B-cell non-hodgkin lymphoma	Enrichment	ATM	3.35
40	Choroid plexus cancer	Enrichment	TP53	3.35
41	Pleomorphic xanthoastrocytoma	Enrichment	TP53	3.35
42	Adrenocortical carcinoma, hereditary	Enrichment	TP53	3.05
43	Cervical cancer	Enrichment	TP53	3.05
44	Lymphoma, hodgkin, classic	Enrichment	TP53	3.05
45	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	3.05
46	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	3.05
47	Congenital fibrosarcoma	Enrichment	TP53	3.05
48	High grade glioma	Enrichment	ATM	3.05
49	Cervix carcinoma	Enrichment	TP53	3.05
50	Hodgkin's lymphoma	Enrichment	TP53	3.05
51	T-cell prolymphocytic leukemia	Enrichment	ATM	3.05
52	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	3.05
53	Ataxia-telangiectasia	Enrichment	ATM	2.88
54	Polycythemia vera	Enrichment	ATM	2.88
55	Nasopharyngeal carcinoma	Enrichment	TP53	2.88
56	Koolen-de vries syndrome	Enrichment	ATM	2.88
57	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.88
58	Anaplastic astrocytoma	Enrichment	TP53	2.88
59	Squamous cell carcinoma	Enrichment	TP53	2.88
60	Small cell cancer of the lung	Enrichment	TP53	2.75
61	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.75
62	Mantle cell lymphoma	Enrichment	ATM	2.75
63	Lung sarcomatoid carcinoma	Enrichment	TP53	2.75
64	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.75
65	Hemoglobin c disease	Enrichment	CHEK2	2.75
66	Oculomotor apraxia	Enrichment	ATM	2.75
67	Rhabdomyosarcoma 2	Enrichment	TP53	2.66
68	Lymphoma	Enrichment	TP53	2.66
69	Glioblastoma	Enrichment	ATM	2.66
70	Acute megakaryocytic leukemia	Enrichment	TP53	2.66
71	Wilms tumor 5	Enrichment	CHEK2	2.58
72	Adrenocortical carcinoma	Enrichment	TP53	2.58
73	Clear cell renal cell carcinoma	Enrichment	ATM	2.58
74	Breast adenocarcinoma	Enrichment	TP53	2.58
75	Esophageal cancer	Enrichment	TP53	2.51
76	Squamous cell carcinoma, head and neck	Enrichment	TP53	2.51
77	Renal cell carcinoma, papillary, 1	Enrichment	ATM	2.51
78	Essential thrombocythemia	Enrichment	TP53	2.51
79	Gallbladder cancer	Enrichment	TP53	2.51
80	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	2.51
81	Glioma susceptibility 1	Enrichment	TP53	2.45
82	Lymphoma, non-hodgkin, familial	Enrichment	TP53	2.45
83	Adult hepatocellular carcinoma	Enrichment	TP53	2.40
84	Primary hyperaldosteronism	Enrichment	TP53	2.40
85	Melanoma	Enrichment	CHEK2	2.35
86	Familial colorectal cancer	Enrichment	TP53	2.35
87	Immune deficiency disease	Enrichment	ATM	2.31
88	Myelodysplastic syndrome	Enrichment	TP53	2.31
89	Lip and oral cavity carcinoma	Enrichment	TP53	2.28
90	Nk-cell enteropathy	Enrichment	CHEK2	2.24
91	Lung cancer susceptibility 3	Enrichment	TP53	2.21
92	Renal cell carcinoma, nonpapillary	Enrichment	ATM	2.18
93	Wilms tumor 1	Enrichment	CHEK2	2.18
94	Lynch syndrome	Enrichment	CHEK2	2.18
95	Rhabdomyosarcoma	Enrichment	TP53	2.15
96	Hepatoblastoma	Enrichment	TP53	2.03
97	Hepatocellular carcinoma	Enrichment	TP53	2.01
98	Diamond-blackfan anemia 1	Enrichment	TP53	1.99
99	Lung cancer	Enrichment	CHEK2	1.85
100	Diamond-blackfan anemia	Enrichment	TP53	1.80
101	Leukemia, acute myeloid	Enrichment	TP53	1.76
102	Primary ovarian insufficiency	Enrichment	CHEK2	1.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PLK3 signaling events

Pathway Network for PLK3 signaling events

Member Pathways for PLK3 signaling events

Pathways in the PLK3 signaling events SuperPath

Associated Genes for PLK3 signaling events

Associated Disorders for PLK3 signaling events

Disorders associated with PLK3 signaling events SuperPath

STRING Interaction Network for PLK3 signaling events

Sources for PLK3 signaling events