Pluripotent stem cell differentiation pathway

No Pathway Network information available for Pluripotent stem cell differentiation pathway

Pathways in the Pluripotent stem cell differentiation pathway SuperPath

#	Name	Source	Genes
1	Pluripotent stem cell differentiation pathway	WikiPathways	ALK BMP4 CNTF CSF1 CSF1R CXCR1 DKK1 EGF EPO FGF1 FGF10 FGF2 FGF4 FGF8 FLT3LG FST GDF5 HGF IGF1 IL11 IL3 IL6 IL6R INHBA INS KIT KITLG LEFTY1 NODAL NOG NOTCH1 NT5E NTF4 PDGFA PDGFB SHH TF TGFB1 TGFB3 TNFSF11 TPO VEGFA WNT1 WNT2 WNT2B WNT3A WNT5A WNT7B (see all 48) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NOG	Noggin	Protein Coding	1
2	WNT3A	Wnt Family Member 3A	Protein Coding	1
3	TNFSF11	TNF Superfamily Member 11	Protein Coding	1
4	GDF5	Growth Differentiation Factor 5	Protein Coding	1
5	WNT2B	Wnt Family Member 2B	Protein Coding	1
6	WNT5A	Wnt Family Member 5A	Protein Coding	1
7	WNT2	Wnt Family Member 2	Protein Coding	1
8	WNT1	Wnt Family Member 1	Protein Coding	1
9	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
10	TPO	Thyroid Peroxidase	Protein Coding	1
11	TGFB3	Transforming Growth Factor Beta 3	Protein Coding	1
12	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	1
13	TF	Transferrin	Protein Coding	1
14	BMP4	Bone Morphogenetic Protein 4	Protein Coding	1
15	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
16	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	1
17	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	1
18	NTF4	Neurotrophin 4	Protein Coding	1
19	NT5E	5''-Nucleotidase Ecto	Protein Coding	1
20	NOTCH1	Notch Receptor 1	Protein Coding	1
21	NODAL	Nodal Growth Differentiation Factor	Protein Coding	1
22	KITLG	KIT Ligand	Protein Coding	1
23	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
24	INS	Insulin	Protein Coding	1
25	INHBA	Inhibin Subunit Beta A	Protein Coding	1
26	IL11	Interleukin 11	Protein Coding	1
27	CXCR1	C-X-C Motif Chemokine Receptor 1	Protein Coding	1
28	IL6R	Interleukin 6 Receptor	Protein Coding	1
29	IL6	Interleukin 6	Protein Coding	1
30	IL3	Interleukin 3	Protein Coding	1
31	IGF1	Insulin Like Growth Factor 1	Protein Coding	1
32	HGF	Hepatocyte Growth Factor	Protein Coding	1
33	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	1
34	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
35	FGF10	Fibroblast Growth Factor 10	Protein Coding	1
36	FGF8	Fibroblast Growth Factor 8	Protein Coding	1
37	FGF4	Fibroblast Growth Factor 4	Protein Coding	1
38	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
39	FGF1	Fibroblast Growth Factor 1	Protein Coding	1
40	EPO	Erythropoietin	Protein Coding	1
41	EGF	Epidermal Growth Factor	Protein Coding	1
42	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
43	CSF1	Colony Stimulating Factor 1	Protein Coding	1
44	CNTF	Ciliary Neurotrophic Factor	Protein Coding	1
45	FST	Follistatin	Protein Coding	1
46	LEFTY1	Left-Right Determination Factor 1	Protein Coding	1
47	WNT7B	Wnt Family Member 7B	Protein Coding	1
48	FLT3LG	Fms Related Receptor Tyrosine Kinase 3 Ligand	Protein Coding	1

Disorders associated with Pluripotent stem cell differentiation pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Osteoporosis, juvenile	Enrichment	DKK1, WNT1, WNT3A	7.38
2	Proximal symphalangism	Enrichment	GDF5, NOG	4.91
3	Septopreoptic holoprosencephaly	Enrichment	FGF8, NODAL, SHH	4.74
4	Midline interhemispheric variant of holoprosencephaly	Enrichment	FGF8, NODAL, SHH	4.74
5	Microform holoprosencephaly	Enrichment	FGF8, NODAL, SHH	4.65
6	Lobar holoprosencephaly	Enrichment	FGF8, NODAL, SHH	4.65
7	Alobar holoprosencephaly	Enrichment	FGF8, NODAL, SHH	4.56
8	Semilobar holoprosencephaly	Enrichment	FGF8, NODAL, SHH	4.49
9	Multiple synostoses syndrome	Enrichment	GDF5, NOG	4.14
10	Type 1 diabetes mellitus	Enrichment	IL6, INS	3.74
11	Testicular germ cell tumor	Enrichment	KIT, KITLG	3.74
12	Macs syndrome	Enrichment	SHH, WNT7B	2.65
13	Holoprosencephaly 3	Enrichment	SHH	2.45
14	Chiari malformation type i	Enrichment	DKK1	2.45
15	Calcification of joints and arteries	Enrichment	NT5E	2.45
16	Stapes ankylosis with broad thumbs and toes	Enrichment	NOG	2.45
17	Tarsal-carpal coalition syndrome	Enrichment	NOG	2.45
18	Hypomagnesemia 4, renal	Enrichment	EGF	2.45
19	Angel-shaped phalangoepiphyseal dysplasia	Enrichment	GDF5	2.45
20	Deafness, autosomal recessive 39	Enrichment	HGF	2.45
21	Mastocytosis, cutaneous	Enrichment	KIT	2.45
22	Brachydactyly, type b2	Enrichment	NOG	2.45
23	Neuroblastoma 3	Enrichment	ALK	2.45
24	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.45
25	Hyperpigmentation with or without hypopigmentation, familial progressive	Enrichment	KITLG	2.45
26	Microphthalmia/coloboma 5	Enrichment	SHH	2.45
27	Symphalangism, proximal, 1a	Enrichment	NOG	2.45
28	Multiple synostoses syndrome 1	Enrichment	NOG	2.45
29	Microvascular complications of diabetes 2	Enrichment	EPO	2.45
30	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	2.45
31	Atransferrinemia	Enrichment	TF	2.45
32	Heterotaxy, visceral, 5, autosomal	Enrichment	NODAL	2.45
33	Diarrhea 9	Enrichment	WNT2B	2.45
34	Microphthalmia, syndromic 6	Enrichment	BMP4	2.45
35	Orofacial cleft 11	Enrichment	BMP4	2.45
36	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	2.45
37	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.45
38	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.45
39	Ovary adenocarcinoma	Enrichment	INHBA	2.45
40	Skin/hair/eye pigmentation, variation in, 7	Enrichment	KITLG	2.45
41	Glaucoma 1, open angle, o	Enrichment	NTF4	2.45
42	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.45
43	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.45
44	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.45
45	Hypogonadotropic hypogonadism 6 with or without anosmia	Enrichment	FGF8	2.45
46	Erythrocytosis, familial, 5	Enrichment	EPO	2.45
47	Loeys-dietz syndrome 5	Enrichment	TGFB3	2.45
48	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	2.45
49	Chronic mast cell leukemia	Enrichment	KIT	2.45
50	Deafness, autosomal dominant 69	Enrichment	KITLG	2.45
51	Csf1r-related disorder	Enrichment	CSF1R	2.45
52	Immunodeficiency 125	Enrichment	FLT3LG	2.45
53	Short-rib thoracic dysplasia 22 without polydactyly	Enrichment	FGF4	2.45
54	Isolated bone marrow mastocytosis	Enrichment	KIT	2.45
55	Smoldering systemic mastocytosis	Enrichment	KIT	2.45
56	Alk-positive anaplastic large cell lymphoma	Enrichment	ALK	2.45
57	Mastocytosis	Enrichment	KIT	2.45
58	Familial progressive hyperpigmentation	Enrichment	KITLG	2.45
59	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	2.45
60	Cutaneous mastocytoma	Enrichment	KIT	2.45
61	Typical urticaria pigmentosa	Enrichment	KIT	2.45
62	Nodular urticaria pigmentosa	Enrichment	KIT	2.45
63	Alk-positive large b-cell lymphoma	Enrichment	ALK	2.45
64	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	2.45
65	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	2.45
66	Acute mast cell leukemia	Enrichment	KIT	2.45
67	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.45
68	Familial progressive hyper- and hypopigmentation	Enrichment	KITLG	2.45
69	Plaque-form urticaria pigmentosa	Enrichment	KIT	2.45
70	Interstitial lung disease specific to childhood	Enrichment	FGF10	2.45
71	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	2.45
72	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.45
73	Testis seminoma	Enrichment	KIT	2.45
74	Camurati-engelmann disease 1	Enrichment	TGFB1	2.15
75	Pulmonary hypoplasia, primary	Enrichment	FGF10	2.15
76	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	2.15
77	Piebald trait	Enrichment	KIT	2.15
78	Multiple synostoses syndrome 2	Enrichment	GDF5	2.15
79	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.15
80	Solitary median maxillary central incisor	Enrichment	SHH	2.15
81	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.15
82	Maturity-onset diabetes of the young, type 10	Enrichment	INS	2.15
83	Osteopetrosis, autosomal recessive 2	Enrichment	TNFSF11	2.15
84	Brachydactyly, type a1, c	Enrichment	GDF5	2.15
85	Symphalangism, proximal, 1b	Enrichment	GDF5	2.15
86	Waardenburg syndrome, type 2f	Enrichment	KITLG	2.15
87	Hyperproinsulinemia	Enrichment	INS	2.15
88	Diamond-blackfan anemia-like	Enrichment	EPO	2.15
89	Inflammatory bowel disease, immunodeficiency, and encephalopathy	Enrichment	TGFB1	2.15
90	Thyroid dyshormonogenesis 2a	Enrichment	TPO	2.15
91	Camurati-engelmann disease	Enrichment	TGFB1	2.15
92	Diabetes mellitus, permanent neonatal, 4	Enrichment	INS	2.15
93	Loeys-dietz syndrome 4	Enrichment	TGFB3	2.15
94	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.15
95	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	2.15
96	Isolated radial hemimelia	Enrichment	SHH	2.15
97	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1, TGFB3	1.98
98	Brachydactyly, type a1	Enrichment	GDF5	1.98
99	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10	1.98
100	Brachydactyly, type c	Enrichment	GDF5	1.98
101	Type 1 diabetes mellitus 2	Enrichment	INS	1.98
102	Acromesomelic dysplasia 2a	Enrichment	GDF5	1.98
103	Acromesomelic dysplasia 2c	Enrichment	GDF5	1.98
104	Acromesomelic dysplasia 2b	Enrichment	GDF5	1.98
105	Syndactyly, type iv	Enrichment	SHH	1.98
106	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	1.98
107	Microphthalmia, syndromic 9	Enrichment	WNT7B	1.98
108	Testicular germ cell cancer	Enrichment	KIT	1.98
109	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	1.98
110	Keratoacanthoma	Enrichment	NOTCH1	1.98
111	Kaposi sarcoma	Enrichment	IL6	1.85
112	Brachydactyly, type a2	Enrichment	GDF5	1.85
113	Polydactyly, preaxial ii	Enrichment	SHH	1.85
114	Robinow syndrome, autosomal dominant 1	Enrichment	WNT5A	1.85
115	Schizencephaly	Enrichment	SHH	1.85
116	Neonatal diabetes mellitus	Enrichment	INS	1.85
117	Orofacial cleft	Enrichment	FST	1.85
118	Autosomal dominant robinow syndrome	Enrichment	WNT5A	1.85
119	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	KIT	1.85
120	Autosomal recessive osteopetrosis	Enrichment	TNFSF11	1.85
121	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	1.85
122	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.85
123	Orofacial clefting syndrome	Enrichment	FST	1.85
124	Arrhythmogenic right ventricular dysplasia, familial, 1	Enrichment	TGFB3	1.76
125	Robinow syndrome, autosomal recessive 1	Enrichment	WNT5A	1.76
126	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.76
127	Insulin-like growth factor i	Enrichment	IGF1	1.76
128	Acute myeloid leukemia with maturation	Enrichment	KIT	1.76
129	Holoprosencephaly	Enrichment	FGF8	1.76
130	Arrhythmogenic right ventricular dysplasia 1	Enrichment	TGFB3	1.76
131	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	KIT	1.76
132	Holoprosencephaly 1	Enrichment	FGF8	1.68
133	Anterior segment dysgenesis 5	Enrichment	BMP4	1.68
134	Inflammatory bowel disease 25, autosomal recessive	Enrichment	TGFB1	1.68
135	Inflammatory myofibroblastic tumor	Enrichment	ALK	1.68
136	Autosomal recessive robinow syndrome	Enrichment	WNT5A	1.68
137	Familial thyroid dyshormonogenesis	Enrichment	TPO	1.68
138	Diarrhea	Enrichment	WNT2B	1.68
139	Il10-related early-onset inflammatory bowel disease	Enrichment	TGFB1	1.68
140	Lung squamous cell carcinoma	Enrichment	ALK	1.68
141	Autosomal dominant secondary polycythemia	Enrichment	EPO	1.68
142	Gastrointestinal stromal tumor	Enrichment	KIT	1.61
143	Waardenburg syndrome, type 2e	Enrichment	KITLG	1.61
144	Adams-oliver syndrome	Enrichment	NOTCH1	1.61
145	Melanocytic nevus syndrome, congenital	Enrichment	ALK	1.55
146	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB	1.55
147	Neuroblastoma	Enrichment	ALK	1.55
148	Permanent neonatal diabetes mellitus	Enrichment	INS	1.55
149	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.55
150	Orofacial cleft 1	Enrichment	FGF10	1.50
151	Inflammatory bowel disease 1	Enrichment	IL6	1.50
152	Loeys-dietz syndrome	Enrichment	TGFB3	1.50
153	Adult hepatocellular carcinoma	Enrichment	EGF	1.50
154	Peters-plus syndrome	Enrichment	BMP4	1.46
155	Stickler syndrome	Enrichment	BMP4	1.46
156	Frontotemporal dementia 1	Enrichment	CSF1R	1.42
157	Meningioma, familial	Enrichment	PDGFB	1.42
158	Diabetes mellitus	Enrichment	INS	1.42
159	Septooptic dysplasia	Enrichment	SHH	1.38
160	Congenital hypothyroidism	Enrichment	TPO	1.38
161	Renal hypodysplasia/aplasia 3	Enrichment	BMP4	1.38
162	Meningioma	Enrichment	PDGFB	1.38
163	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	TGFB3	1.38
164	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	TGFB3	1.38
165	Lip and oral cavity carcinoma	Enrichment	KIT	1.38
166	Aortic valve disease 1	Enrichment	NOTCH1	1.35
167	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.35
168	Alzheimer's disease	Enrichment	CSF1R	1.35
169	Osteoporosis	Enrichment	WNT1	1.31
170	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.31
171	Lung cancer susceptibility 3	Enrichment	FGF10	1.31
172	Cleft lip/palate	Enrichment	BMP4	1.31
173	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	TGFB3	1.31
174	Ovarian cancer	Enrichment	ALK, KIT	1.30
175	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.29
176	Wolff-parkinson-white syndrome	Enrichment	NODAL	1.26
177	Rhabdomyosarcoma	Enrichment	ALK	1.26
178	Alzheimer disease, familial, 1	Enrichment	CSF1R	1.23
179	Heart, malformation of	Enrichment	NODAL	1.21
180	Human immunodeficiency virus type 1	Enrichment	CXCR1	1.21
181	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGF8	1.21
182	Arteriovenous malformations of the brain	Enrichment	IL6	1.19
183	Maturity-onset diabetes of the young	Enrichment	INS	1.16
184	Visceral heterotaxy	Enrichment	NODAL	1.12
185	Microphthalmia	Enrichment	WNT7B	1.12
186	Brittle bone disorder	Enrichment	WNT1	1.11
187	Kallmann syndrome	Enrichment	FGF8	1.11
188	Inherited cancer-predisposing syndrome	Enrichment	ALK, KIT	1.10
189	Tetralogy of fallot	Enrichment	NOTCH1	1.05
190	Differentiated thyroid carcinoma	Enrichment	ALK	1.01
191	Visceral heterotaxy 5	Enrichment	NODAL	0.98
192	Lung cancer	Enrichment	ALK	0.97
193	Cystic fibrosis	Enrichment	TGFB1	0.97
194	Connective tissue disease	Enrichment	NOTCH1	0.97
195	Leukemia, acute myeloid	Enrichment	KIT	0.88
196	Type 2 diabetes mellitus	Enrichment	IL6	0.86
197	Sensorineural hearing loss	Enrichment	HGF	0.80
198	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	KITLG	0.77
199	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	FGF8	0.74
200	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	0.73
201	Autism	Enrichment	SHH	0.65
202	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF	0.57

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pluripotent stem cell differentiation pathway

Pathway Network for Pluripotent stem cell differentiation pathway

Member Pathways for Pluripotent stem cell differentiation pathway

Pathways in the Pluripotent stem cell differentiation pathway SuperPath

Associated Genes for Pluripotent stem cell differentiation pathway

Associated Disorders for Pluripotent stem cell differentiation pathway

Disorders associated with Pluripotent stem cell differentiation pathway SuperPath

STRING Interaction Network for Pluripotent stem cell differentiation pathway

Sources for Pluripotent stem cell differentiation pathway