Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics

Pathway network for the Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Sources:

PharmGKB

Pathways in the Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCG2 ABL1 BCR CYP2C8 CYP2D6 CYP3A4 CYP3A5 (see all 8) (see less)
2	Imatinib Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCG2 ABL1 BCR CYP1A1 CYP1B1 CYP2C8 CYP3A4 CYP3A5 CYP4F2 CYP4F3 FMO3 KIT SLC22A1 (see all 14) (see less)
3	Taxane Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCC1 ABCC2 ABCG2 CYP1B1 CYP2C8 CYP3A4 CYP3A5 MAP2 MAP4 MAPT NR1I2 SLCO1B3 (see all 13) (see less)
4	Nilotinib Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCG2 ABL1 BCR CYP2C8 CYP2C9 CYP2D6 CYP3A4 KIT PDGFRA PDGFRB UGT1A1 (see all 12) (see less)
5	In progress: Docetaxel Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCC2 ABCG2 CYP3A4 CYP3A5 SLCO1B3 (see all 6) (see less)
6	Apixaban Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABCG2 CYP3A4 CYP3A5 F10 SULT1A1 (see all 6) (see less)
7	Pimozide Pathway, Pharmacokinetics	PharmGKB	ABCB1 CYP2D6 CYP3A4 CYP3A5 CYP3A7
8	Bosutinib Pathway, Pharmacokinetics/Pharmacodynamics	PharmGKB	ABCB1 ABL1 BCR CYP3A4 SRC
9	Aripiprazole Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCG2 CYP2D6 CYP3A4 CYP3A5
10	Risperidone Pathway, Pharmacokinetics	PharmGKB	ABCB1 ABCG2 CYP2D6 CYP3A4 CYP3A5

Gene overlap in member pathways for Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ABCB1	ATP Binding Cassette Subfamily B Member 1	Protein Coding	10
2	CYP3A4	Cytochrome P450 Family 3 Subfamily A Member 4	Protein Coding	10
3	CYP3A5	Cytochrome P450 Family 3 Subfamily A Member 5	Protein Coding	8
4	ABCG2	ATP Binding Cassette Subfamily G Member 2 (JR Blood Group)	Protein Coding	8
5	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	5
6	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	4
7	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	4
8	CYP2C8	Cytochrome P450 Family 2 Subfamily C Member 8	Protein Coding	4
9	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	2
10	CYP1B1	Cytochrome P450 Family 1 Subfamily B Member 1	Protein Coding	2
11	SLCO1B3	Solute Carrier Organic Anion Transporter Family Member 1B3	Protein Coding	2
12	ABCC2	ATP Binding Cassette Subfamily C Member 2	Protein Coding	2
13	SLC22A1	Solute Carrier Family 22 Member 1	Protein Coding	1
14	CYP4F2	Cytochrome P450 Family 4 Subfamily F Member 2	Protein Coding	1
15	FMO3	Flavin Containing Dimethylaniline Monoxygenase 3	Protein Coding	1
16	CYP4F3	Cytochrome P450 Family 4 Subfamily F Member 3	Protein Coding	1
17	CYP1A1	Cytochrome P450 Family 1 Subfamily A Member 1	Protein Coding	1
18	MAP2	Microtubule Associated Protein 2	Protein Coding	1
19	MAP4	Microtubule Associated Protein 4	Protein Coding	1
20	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
21	NR1I2	Nuclear Receptor Subfamily 1 Group I Member 2	Protein Coding	1
22	ABCC1	ATP Binding Cassette Subfamily C Member 1 (ABCC1 Blood Group)	Protein Coding	1
23	UGT1A1	UDP Glucuronosyltransferase Family 1 Member A1	Protein Coding	1
24	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
25	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
26	CYP2C9	Cytochrome P450 Family 2 Subfamily C Member 9	Protein Coding	1
27	SULT1A1	Sulfotransferase Family 1A Member 1	Protein Coding	1
28	F10	Coagulation Factor X	Protein Coding	1
29	CYP3A7	Cytochrome P450 Family 3 Subfamily A Member 7	Protein Coding	1
30	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1

Disorders associated with Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Leukemia, chronic myeloid	Enrichment	ABL1, BCR	5.64
2	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, BCR	5.64
3	Primary hypereosinophilic syndrome	Enrichment	PDGFRA, PDGFRB	5.14
4	Gastrointestinal stromal tumor	Enrichment	KIT, PDGFRA	4.82
5	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, BCR	4.56
6	Lip and oral cavity carcinoma	Enrichment	ABL1, KIT	4.33
7	Colchicine resistance	Enrichment	ABCB1	3.43
8	Encephalopathy, acute transient	Enrichment	ABCB1	3.43
9	Inflammatory bowel disease 13	Enrichment	ABCB1	3.43
10	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	3.43
11	Vitamin d-dependent rickets, type 3	Enrichment	CYP3A4	3.43
12	Thrombocytopenia 6	Enrichment	SRC	3.43
13	Uric acid concentration, serum, quantitative trait locus 1	Enrichment	ABCG2	3.43
14	Blood group, junior system	Enrichment	ABCG2	3.43
15	Drug metabolism, altered, cyp2c8-related	Enrichment	CYP2C8	3.23
16	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	3.13
17	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	3.05
18	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	3.05
19	Mastocytosis, cutaneous	Enrichment	KIT	3.05
20	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	3.05
21	Gist-plus syndrome	Enrichment	PDGFRA	3.05
22	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	3.05
23	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	3.05
24	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	3.05
25	Kosaki overgrowth syndrome	Enrichment	PDGFRB	3.05
26	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	3.05
27	Chronic mast cell leukemia	Enrichment	KIT	3.05
28	Isolated bone marrow mastocytosis	Enrichment	KIT	3.05
29	Smoldering systemic mastocytosis	Enrichment	KIT	3.05
30	Mastocytosis	Enrichment	KIT	3.05
31	Cutaneous mastocytoma	Enrichment	KIT	3.05
32	Typical urticaria pigmentosa	Enrichment	KIT	3.05
33	Nodular urticaria pigmentosa	Enrichment	KIT	3.05
34	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	3.05
35	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	3.05
36	Acute mast cell leukemia	Enrichment	KIT	3.05
37	Plaque-form urticaria pigmentosa	Enrichment	KIT	3.05
38	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	3.05
39	Testis seminoma	Enrichment	KIT	3.05
40	Deafness, autosomal dominant 77	Enrichment	ABCC1	3.02
41	Parkinson-dementia syndrome	Enrichment	MAPT	3.02
42	Supranuclear palsy, progressive, 1	Enrichment	MAPT	3.02
43	Progressive supranuclear palsy	Enrichment	MAPT	3.02
44	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	3.02
45	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	3.02
46	Severe primary trimethylaminuria	Enrichment	FMO3	2.99
47	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	2.96
48	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	2.96
49	Dubin-johnson syndrome	Enrichment	ABCC2	2.88
50	Hyperbilirubinemia, rotor type	Enrichment	SLCO1B3	2.88
51	Factor x deficiency	Enrichment	F10	2.88
52	Congenital factor x deficiency	Enrichment	F10	2.88
53	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	2.83
54	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	2.83
55	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	2.75
56	Piebald trait	Enrichment	KIT	2.75
57	Infantile myofibromatosis	Enrichment	PDGFRB	2.75
58	Chronic eosinophilic leukemia	Enrichment	PDGFRA	2.75
59	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	2.75
60	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	2.75
61	Glaucoma 1, open angle, a	Enrichment	CYP1B1	2.72
62	Pick disease of brain	Enrichment	MAPT	2.72
63	Anterior segment dysgenesis 6	Enrichment	CYP1B1	2.72
64	Primary congenital glaucoma	Enrichment	CYP1B1	2.72
65	Trimethylaminuria	Enrichment	FMO3	2.69
66	Primary trimethylaminuria	Enrichment	FMO3	2.69
67	Myelofibrosis	Enrichment	SRC	2.59
68	Moyamoya angiopathy	Enrichment	ABL1	2.59
69	Pseudoxanthoma elasticum	Enrichment	ABCC2	2.58
70	Coumarin resistance	Enrichment	CYP2C9	2.58
71	Testicular germ cell cancer	Enrichment	KIT	2.58
72	Ovarian cancer	Enrichment	KIT, PDGFRA	2.46
73	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	KIT	2.45
74	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	2.45
75	Glaucoma 3, primary infantile, b	Enrichment	CYP1B1	2.42
76	Epilepsy, idiopathic generalized	Enrichment	ABCB1	2.39
77	Acute myeloid leukemia with maturation	Enrichment	KIT	2.35
78	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	KIT	2.35
79	Juvenile glaucoma	Enrichment	CYP1B1	2.32
80	Dementia	Enrichment	MAPT	2.32
81	Osteoporosis	Enrichment	SRC	2.29
82	Heart disease	Enrichment	ABL1	2.29
83	Testicular germ cell tumor	Enrichment	KIT	2.28
84	Glaucoma, primary open angle	Enrichment	CYP1B1	2.24
85	Anterior segment dysgenesis 5	Enrichment	CYP1B1	2.24
86	Inherited cancer-predisposing syndrome	Enrichment	KIT, PDGFRA	2.24
87	Hypertension, essential	Enrichment	CYP3A5	2.20
88	Glaucoma 3, primary congenital, a	Enrichment	CYP1B1	2.17
89	Semantic dementia	Enrichment	MAPT	2.17
90	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFRB	2.15
91	Progressive non-fluent aphasia	Enrichment	MAPT	2.07
92	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	2.07
93	Crigler-najjar syndrome, type i	Enrichment	UGT1A1	2.05
94	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A1	2.05
95	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A1	2.05
96	Crigler-najjar syndrome, type ii	Enrichment	UGT1A1	2.05
97	Peters-plus syndrome	Enrichment	CYP1B1	2.02
98	Gilbert syndrome	Enrichment	UGT1A1	2.01
99	Bilirubin metabolic disorder	Enrichment	UGT1A1	2.01
100	Frontotemporal dementia 1	Enrichment	MAPT	1.98
101	Cleft lip/palate	Enrichment	PDGFRA	1.91
102	Alzheimer's disease	Enrichment	MAPT	1.91
103	Hydrocephalus	Enrichment	PDGFRB	1.88
104	Anterior segment dysgenesis	Enrichment	CYP1B1	1.85
105	Dandy-walker syndrome	Enrichment	PDGFRB	1.83
106	Alzheimer disease, familial, 1	Enrichment	MAPT	1.79
107	Thrombocytopenia	Enrichment	SRC	1.76
108	Parkinson disease, late-onset	Enrichment	MAPT	1.64
109	Colorectal cancer	Enrichment	SRC	1.50
110	Cerebral palsy	Enrichment	PDGFRB	1.47
111	Leukemia, acute myeloid	Enrichment	KIT	1.46
112	Microcephaly	Enrichment	ABL1	1.35
113	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ABCC1	1.31
114	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT	1.27

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics

Pathway Network for Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics

Pathway network for the Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Member Pathways for Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics

Pathways in the Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Gene overlap in member pathways for Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

Associated Genes for Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics

Associated Disorders for Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics

Disorders associated with Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics SuperPath

STRING Interaction Network for Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics

Sources for Ponatinib Pathway, Pharmacokinetics/Pharmacodynamics