Post-translational modification: synthesis of GPI-anchored proteins

Pathway network for the Post-translational modification: synthesis of GPI-anchored proteins SuperPath

Sources:

Reactome

Pathways in the Post-translational modification: synthesis of GPI-anchored proteins SuperPath

#	Name	Source	Genes
1	Post-translational modification: synthesis of GPI-anchored proteins	Reactome	ALPG ALPI ALPL ART3 ART4 BST1 CD109 CD52 CEACAM5 CEACAM7 CNTN3 CNTN4 CNTN5 CPM DPM1 DPM2 DPM3 FCGR3B FOLR2 GP2 GPAA1 GPIHBP1 GPLD1 IZUMO1R LSAMP LY6D LY6E LY6G6C LY6G6D LY6H LY6K LYPD1 LYPD2 LYPD3 LYPD4 LYPD5 LYPD6B LYPD8 MDGA1 MDGA2 MELTF MSLN NEGR1 NRN1 NRN1L NTM NTNG1 NTNG2 OPCML OTOA PGAP1 PIGA PIGB PIGC PIGF PIGG PIGH PIGK PIGL PIGM PIGN PIGO PIGP PIGQ PIGS PIGT PIGU PIGV PIGW PIGX PIGY PIGZ PLAUR PLET1 PRND PRSS21 PRSS41 PSCA RAET1G RAET1L RECK RTN4RL1 RTN4RL2 SPACA4 SPRN TECTA TECTB TEX101 THY1 ULBP2 VNN1 VNN2 XPNPEP2 (see all 93) (see less)
2	Synthesis of glycosylphosphatidylinositol (GPI)	Reactome	DPM2 PIGA PIGB PIGC PIGF PIGG PIGH PIGL PIGM PIGN PIGO PIGP PIGQ PIGV PIGW PIGX PIGY PIGZ (see all 18) (see less)
3	Attachment of GPI anchor to uPAR	Reactome	GPAA1 PGAP1 PIGK PIGS PIGT PIGU PLAUR (see all 7) (see less)

Gene overlap in member pathways for Post-translational modification: synthesis of GPI-anchored proteins SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PIGK	Phosphatidylinositol Glycan Anchor Biosynthesis Class K	Protein Coding	2
2	PIGU	Phosphatidylinositol Glycan Anchor Biosynthesis Class U	Protein Coding	2
3	PIGN	Phosphatidylinositol Glycan Anchor Biosynthesis Class N	Protein Coding	2
4	PIGW	Phosphatidylinositol Glycan Anchor Biosynthesis Class W	Protein Coding	2
5	PIGP	Phosphatidylinositol Glycan Anchor Biosynthesis Class P	Protein Coding	2
6	PIGT	Phosphatidylinositol Glycan Anchor Biosynthesis Class T	Protein Coding	2
7	PIGA	Phosphatidylinositol Glycan Anchor Biosynthesis Class A	Protein Coding	2
8	PIGC	Phosphatidylinositol Glycan Anchor Biosynthesis Class C	Protein Coding	2
9	PIGF	Phosphatidylinositol Glycan Anchor Biosynthesis Class F	Protein Coding	2
10	PIGH	Phosphatidylinositol Glycan Anchor Biosynthesis Class H	Protein Coding	2
11	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	2
12	PIGG	Phosphatidylinositol Glycan Anchor Biosynthesis Class G (EMM Blood Group)	Protein Coding	2
13	PIGX	Phosphatidylinositol Glycan Anchor Biosynthesis Class X	Protein Coding	2
14	PIGV	Phosphatidylinositol Glycan Anchor Biosynthesis Class V	Protein Coding	2
15	PGAP1	Post-GPI Attachment To Proteins Inositol Deacylase 1	Protein Coding	2
16	PIGZ	Phosphatidylinositol Glycan Anchor Biosynthesis Class Z (Gwada Blood Group)	Protein Coding	2
17	PIGO	Phosphatidylinositol Glycan Anchor Biosynthesis Class O	Protein Coding	2
18	PIGY	Phosphatidylinositol Glycan Anchor Biosynthesis Class Y	Protein Coding	2
19	GPAA1	Glycosylphosphatidylinositol Anchor Attachment 1	Protein Coding	2
20	DPM2	Dolichyl-Phosphate Mannosyltransferase Subunit 2, Regulatory	Protein Coding	2
21	PIGQ	Phosphatidylinositol Glycan Anchor Biosynthesis Class Q	Protein Coding	2
22	PIGM	Phosphatidylinositol Glycan Anchor Biosynthesis Class M	Protein Coding	2
23	PIGS	Phosphatidylinositol Glycan Anchor Biosynthesis Class S	Protein Coding	2
24	PIGL	Phosphatidylinositol Glycan Anchor Biosynthesis Class L	Protein Coding	2
25	PIGB	Phosphatidylinositol Glycan Anchor Biosynthesis Class B	Protein Coding	2
26	MSLN	Mesothelin	Protein Coding	1
27	CD52	CD52 Molecule	Protein Coding	1
28	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	1
29	CEACAM7	CEA Cell Adhesion Molecule 7	Protein Coding	1
30	PRSS21	Serine Protease 21	Protein Coding	1
31	LYPD1	LY6/PLAUR Domain Containing 1	Protein Coding	1
32	NRN1L	Neuritin 1 Like	Protein Coding	1
33	LYPD6B	LY6/PLAUR Domain Containing 6B	Protein Coding	1
34	CD109	CD109 Molecule	Protein Coding	1
35	CPM	Carboxypeptidase M	Protein Coding	1
36	LYPD2	LY6/PLAUR Domain Containing 2	Protein Coding	1
37	OTOA	Otoancorin	Protein Coding	1
38	RTN4RL1	Reticulon 4 Receptor Like 1	Protein Coding	1
39	LYPD4	LY6/PLAUR Domain Containing 4	Protein Coding	1
40	CNTN4	Contactin 4	Protein Coding	1
41	RAET1L	Retinoic Acid Early Transcript 1L	Protein Coding	1
42	MDGA2	MAM Domain Containing Glycosylphosphatidylinositol Anchor 2	Protein Coding	1
43	SPACA4	Sperm Acrosome Associated 4	Protein Coding	1
44	FCGR3B	Fc Gamma Receptor IIIb	Protein Coding	1
45	NTNG1	Netrin G1	Protein Coding	1
46	FOLR2	Folate Receptor Beta	Protein Coding	1
47	PRND	Prion Like Protein Doppel	Protein Coding	1
48	ALPI	Alkaline Phosphatase, Intestinal	Protein Coding	1
49	ALPL	Alkaline Phosphatase, Biomineralization Associated	Protein Coding	1
50	ALPG	Alkaline Phosphatase, Germ Cell	Protein Coding	1
51	NEGR1	Neuronal Growth Regulator 1	Protein Coding	1
52	MDGA1	MAM Domain Containing Glycosylphosphatidylinositol Anchor 1	Protein Coding	1
53	LYPD3	LY6/PLAUR Domain Containing 3	Protein Coding	1
54	GP2	Glycoprotein 2	Protein Coding	1
55	GPLD1	Glycosylphosphatidylinositol Specific Phospholipase D1	Protein Coding	1
56	LYPD5	LY6/PLAUR Domain Containing 5	Protein Coding	1
57	GPIHBP1	Glycosylphosphatidylinositol Anchored High Density Lipoprotein Binding Protein 1	Protein Coding	1
58	PLET1	Placenta Expressed Transcript 1	Protein Coding	1
59	RTN4RL2	Reticulon 4 Receptor Like 2	Protein Coding	1
60	RAET1G	Retinoic Acid Early Transcript 1G	Protein Coding	1
61	PRSS41	Serine Protease 41	Protein Coding	1
62	IZUMO1R	IZUMO1 Receptor, JUNO	Protein Coding	1
63	LSAMP	Limbic System Associated Membrane Protein	Protein Coding	1
64	LY6E	Lymphocyte Antigen 6 Family Member E	Protein Coding	1
65	LY6H	Lymphocyte Antigen 6 Family Member H	Protein Coding	1
66	ART3	ADP-Ribosyltransferase 3 (Inactive)	Protein Coding	1
67	ART4	ADP-Ribosyltransferase 4 (Inactive) (Dombrock Blood Group)	Protein Coding	1
68	MELTF	Melanotransferrin	Protein Coding	1
69	OPCML	Opioid Binding Protein/Cell Adhesion Molecule Like	Protein Coding	1
70	SPRN	Shadow Of Prion Protein	Protein Coding	1
71	CNTN3	Contactin 3	Protein Coding	1
72	NTM	Neurotrimin	Protein Coding	1
73	NRN1	Neuritin 1	Protein Coding	1
74	CNTN5	Contactin 5	Protein Coding	1
75	DPM3	Dolichyl-Phosphate Mannosyltransferase Subunit 3, Regulatory	Protein Coding	1
76	LY6K	Lymphocyte Antigen 6 Family Member K	Protein Coding	1
77	LY6G6D	Lymphocyte Antigen 6 Family Member G6D	Protein Coding	1
78	LYPD8	LY6/PLAUR Domain Containing 8	Protein Coding	1
79	BST1	Bone Marrow Stromal Cell Antigen 1	Protein Coding	1
80	TECTB	Tectorin Beta	Protein Coding	1
81	TECTA	Tectorin Alpha	Protein Coding	1
82	THY1	Thy-1 Cell Surface Antigen	Protein Coding	1
83	XPNPEP2	X-Prolyl Aminopeptidase 2	Protein Coding	1
84	PSCA	Prostate Stem Cell Antigen	Protein Coding	1
85	ULBP2	UL16 Binding Protein 2	Protein Coding	1
86	LY6G6C	Lymphocyte Antigen 6 Family Member G6C	Protein Coding	1
87	TEX101	Testis Expressed 101	Protein Coding	1
88	RECK	Reversion Inducing Cysteine Rich Protein With Kazal Motifs	Protein Coding	1
89	NTNG2	Netrin G2	Protein Coding	1
90	LY6D	Lymphocyte Antigen 6 Family Member D	Protein Coding	1
91	DPM1	Dolichyl-Phosphate Mannosyltransferase Subunit 1, Catalytic	Protein Coding	1
92	VNN2	Vanin 2	Protein Coding	1
93	VNN1	Vanin 1	Protein Coding	1

Disorders associated with Post-translational modification: synthesis of GPI-anchored proteins SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hyperphosphatasia with impaired intellectual development syndrome 1	Enrichment	PIGG, PIGL, PIGO, PIGV, PIGW, PIGY	10.37
2	Glycosylphosphatidylinositol biosynthesis defect 1	Enrichment	PIGM, PIGW	5.78
3	Neurodevelopmental disorder with or without hypotonia, seizures, and cerebellar atrophy	Enrichment	PIGG, PIGK	3.86
4	Early infantile developmental and epileptic encephalopathy	Enrichment	PIGP, PIGQ	3.60
5	Paroxysmal nocturnal hemoglobinuria 2	Enrichment	PIGT	3.29
6	Multiple congenital anomalies-hypotonia-seizures syndrome 3	Enrichment	PIGT	3.29
7	Developmental and epileptic encephalopathy 95	Enrichment	PIGS	3.29
8	Neurodevelopmental disorder with dysmorphic features, spasticity, and brain abnormalities	Enrichment	PGAP1	3.29
9	Neurodevelopmental disorder with brain anomalies, seizures, and scoliosis	Enrichment	PIGU	3.29
10	Autosomal recessive spastic paraplegia type 67	Enrichment	PGAP1	3.29
11	Glycosylphosphatidylinositol biosynthesis defect 15	Enrichment	GPAA1	2.99
12	Fryns syndrome	Enrichment	PIGN	2.88
13	Neurodevelopmental disorder with epilepsy and hemochromatosis	Enrichment	PIGA	2.88
14	Coloboma, congenital heart disease, ichthyosiform dermatosis, impaired intellectual development, and ear anomalies syndrome	Enrichment	PIGL	2.88
15	Multiple congenital anomalies-hypotonia-seizures syndrome 2	Enrichment	PIGA	2.88
16	Hyperphosphatasia with impaired intellectual development syndrome 2	Enrichment	PIGO	2.88
17	Congenital disorder of glycosylation, type iu	Enrichment	DPM2	2.88
18	Developmental and epileptic encephalopathy 55	Enrichment	PIGP	2.88
19	Multiple congenital anomalies-hypotonia-seizures syndrome 4	Enrichment	PIGQ	2.88
20	Blood group, emm system	Enrichment	PIGG	2.88
21	Onychodystrophy, osteodystrophy, impaired intellectual development, and seizures syndrome	Enrichment	PIGF	2.88
22	Multiple congenital anomalies-hypotonia-seizures syndrome	Enrichment	PIGN	2.88
23	Paroxysmal nocturnal hemoglobinuria	Enrichment	PIGA	2.88
24	Paroxysmal nocturnal hemoglobinuria 1	Enrichment	PIGA	2.58
25	Hyperphosphatasia with impaired intellectual development syndrome 6	Enrichment	PIGY	2.58
26	Glycosylphosphatidylinositol biosynthesis defect 11	Enrichment	PIGW	2.58
27	Glycosylphosphatidylinositol biosynthesis defect 16	Enrichment	PIGC	2.58
28	Multiple congenital anomalies-hypotonia-seizures syndrome 1	Enrichment	PIGN	2.40
29	Glycosylphosphatidylinositol biosynthesis defect 17	Enrichment	PIGH	2.40
30	Developmental and epileptic encephalopathy 80	Enrichment	PIGB	2.40
31	Angioedema induced by ace inhibitors	Enrichment	XPNPEP2	2.16
32	Muscular dystrophy-dystroglycanopathy , type c, 15	Enrichment	DPM3	2.16
33	Hypophosphatasia, adult	Enrichment	ALPL	2.16
34	Hyperlipoproteinemia, type id	Enrichment	GPIHBP1	2.16
35	Blood group, dombrock system	Enrichment	ART4	2.16
36	Hypophosphatasia, childhood	Enrichment	ALPL	2.16
37	Muscular dystrophy-dystroglycanopathy , type b, 15	Enrichment	DPM3	2.16
38	Deafness, autosomal recessive 22	Enrichment	OTOA	2.16
39	Prenatal benign hypophosphatasia	Enrichment	ALPL	2.16
40	Neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia	Enrichment	NTNG2	2.16
41	Neonatal alloimmune neutropenia	Enrichment	FCGR3B	2.16
42	Alpi-related inflammatory bowel disease	Enrichment	ALPI	2.16
43	Wolf-hirschhorn syndrome	Enrichment	PIGG	2.10
44	Developmental and epileptic encephalopathy 14	Enrichment	PIGA	1.93
45	Hyperlipoproteinemia, type i	Enrichment	GPIHBP1	1.86
46	Alpha-thalassemia/impaired intellectual development syndrome, x-linked	Enrichment	ALPL	1.86
47	Deafness, autosomal recessive 7	Enrichment	OTOA	1.86
48	Hypophosphatasia	Enrichment	ALPL	1.86
49	Familial lipoprotein lipase deficiency	Enrichment	GPIHBP1	1.86
50	Alpha thalassemia-x-linked intellectual disability syndrome	Enrichment	ALPL	1.86
51	Hypophosphatasia, infantile	Enrichment	ALPL	1.69
52	Succinic semialdehyde dehydrogenase deficiency	Enrichment	GPLD1	1.69
53	Deafness, autosomal dominant 12	Enrichment	TECTA	1.69
54	Deafness, autosomal recessive 21	Enrichment	TECTA	1.69
55	Cleft palate, isolated	Enrichment	PIGW	1.65
56	Autosomal recessive non-syndromic intellectual disability	Enrichment	PGAP1	1.53
57	Non-immune hydrops fetalis	Enrichment	PIGC	1.39
58	Developmental and epileptic encephalopathy 36	Enrichment	DPM1	1.39
59	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	CD109	1.39
60	Developmental and epileptic encephalopathy	Enrichment	PIGQ	1.33
61	Meniere disease	Enrichment	TECTA	1.33
62	Epilepsy	Enrichment	PIGQ	1.29
63	Rett syndrome, congenital variant	Enrichment	NTNG1	1.27
64	Optic atrophy plus syndrome	Enrichment	PIGQ	1.25
65	West syndrome	Enrichment	PIGA	1.25
66	Deafness, autosomal recessive	Enrichment	OTOA, TECTA	1.16
67	Autosomal recessive nonsyndromic deafness	Enrichment	OTOA, TECTA	1.15
68	Multiple sclerosis	Enrichment	CD109	1.04
69	Rare genetic deafness	Enrichment	OTOA, TECTA	0.99
70	Mitochondrial disease	Enrichment	PIGY	0.96
71	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	OTOA, TECTA	0.91
72	Brittle bone disorder	Enrichment	ALPL	0.83
73	Complex neurodevelopmental disorder	Enrichment	NTNG1, NTNG2	0.68
74	Non-syndromic genetic deafness	Enrichment	TECTA	0.66
75	Systemic lupus erythematosus	Enrichment	FCGR3B	0.63
76	Myopathy	Enrichment	DPM3	0.62
77	Nonsyndromic hearing loss	Enrichment	TECTA	0.60
78	Sensorineural hearing loss	Enrichment	TECTA	0.55
79	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TECTA	0.52
80	Ovarian cancer	Enrichment	OPCML	0.30
81	Congenital nervous system abnormality	Enrichment	NTNG2	0.28
82	Nervous system disease	Enrichment	NTNG2	0.28

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Post-translational modification: synthesis of GPI-anchored proteins

Pathway Network for Post-translational modification: synthesis of GPI-anchored proteins

Pathway network for the Post-translational modification: synthesis of GPI-anchored proteins SuperPath

Member Pathways for Post-translational modification: synthesis of GPI-anchored proteins

Pathways in the Post-translational modification: synthesis of GPI-anchored proteins SuperPath

Gene overlap in member pathways for Post-translational modification: synthesis of GPI-anchored proteins SuperPath

Associated Genes for Post-translational modification: synthesis of GPI-anchored proteins

Associated Disorders for Post-translational modification: synthesis of GPI-anchored proteins

Disorders associated with Post-translational modification: synthesis of GPI-anchored proteins SuperPath

STRING Interaction Network for Post-translational modification: synthesis of GPI-anchored proteins

Sources for Post-translational modification: synthesis of GPI-anchored proteins