Postsynaptic nicotinic acetylcholine receptors

Pathway network for the Postsynaptic nicotinic acetylcholine receptors SuperPath

Sources:

Reactome

Pathways in the Postsynaptic nicotinic acetylcholine receptors SuperPath

#	Name	Source	Genes
1	Postsynaptic nicotinic acetylcholine receptors	Reactome	CHRFAM7A CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG (see all 15) (see less)
2	Acetylcholine binding and downstream events	Reactome	CHRFAM7A CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG (see all 15) (see less)
3	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Reactome	CHRFAM7A CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNA7 CHRNA9 CHRNB2 CHRNB3 CHRNB4 (see all 12) (see less)
4	Presynaptic nicotinic acetylcholine receptors	Reactome	CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 CHRNB3 CHRNB4 CHRND CHRNE CHRNG (see all 12) (see less)
5	Highly calcium permeable nicotinic acetylcholine receptors	Reactome	CHRNA1 CHRNA2 CHRNA3 CHRNA4 CHRNA5 CHRNA6 CHRNB2 CHRNB3 CHRNB4 (see all 9) (see less)
6	Highly sodium permeable postsynaptic acetylcholine nicotinic receptors	Reactome	CHRNA3 CHRNA4 CHRNB2 CHRNB4 CHRND CHRNE CHRNG (see all 7) (see less)

Gene overlap in member pathways for Postsynaptic nicotinic acetylcholine receptors SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CHRNA3	Cholinergic Receptor Nicotinic Alpha 3 Subunit	Protein Coding	6
2	CHRNA4	Cholinergic Receptor Nicotinic Alpha 4 Subunit	Protein Coding	6
3	CHRNB2	Cholinergic Receptor Nicotinic Beta 2 Subunit	Protein Coding	6
4	CHRNB4	Cholinergic Receptor Nicotinic Beta 4 Subunit	Protein Coding	6
5	CHRNA1	Cholinergic Receptor Nicotinic Alpha 1 Subunit	Protein Coding	5
6	CHRNA2	Cholinergic Receptor Nicotinic Alpha 2 Subunit	Protein Coding	5
7	CHRNA5	Cholinergic Receptor Nicotinic Alpha 5 Subunit	Protein Coding	5
8	CHRNB3	Cholinergic Receptor Nicotinic Beta 3 Subunit	Protein Coding	5
9	CHRNA6	Cholinergic Receptor Nicotinic Alpha 6 Subunit	Protein Coding	5
10	CHRND	Cholinergic Receptor Nicotinic Delta Subunit	Protein Coding	4
11	CHRNE	Cholinergic Receptor Nicotinic Epsilon Subunit	Protein Coding	4
12	CHRNG	Cholinergic Receptor Nicotinic Gamma Subunit	Protein Coding	4
13	CHRNA7	Cholinergic Receptor Nicotinic Alpha 7 Subunit	Protein Coding	3
14	CHRNA9	Cholinergic Receptor Nicotinic Alpha 9 Subunit	Protein Coding	3
15	CHRFAM7A	CHRNA7 (Exons 5-10) And FAM7A (Exons A-E) Fusion	Protein Coding	3

Disorders associated with Postsynaptic nicotinic acetylcholine receptors SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Myasthenic syndrome, congenital, 1b, fast-channel	Enrichment	CHRNA1, CHRND, CHRNE	8.67
2	Autosomal dominant sleep-related hypermotor epilepsy	Enrichment	CHRNA2, CHRNA4, CHRNB2	8.15
3	Myasthenic syndrome, congenital, 1a, slow-channel	Enrichment	CHRNA1, CHRND, CHRNE	7.73
4	Multiple pterygium syndrome, lethal type	Enrichment	CHRNA1, CHRND, CHRNG	7.53
5	Postsynaptic congenital myasthenic syndromes	Enrichment	CHRNA1, CHRND, CHRNE	6.94
6	Smoking as a quantitative trait locus 3	Enrichment	CHRNA3, CHRNA5	6.41
7	Epilepsy, nocturnal frontal lobe, 1	Enrichment	CHRNA4, CHRNB2	6.16
8	Autosomal dominant nocturnal frontal lobe epilepsy	Enrichment	CHRNA4, CHRNB2	5.86
9	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CHRNA3, CHRNA4, CHRNB4	5.59
10	Frontotemporal dementia 1	Enrichment	CHRNA4, CHRNB4	4.90
11	Congenital myasthenic syndrome	Enrichment	CHRNA1, CHRNE	4.19
12	Centronuclear myopathy	Enrichment	CHRNA1, CHRND	3.83
13	Fetal akinesia deformation sequence 1	Enrichment	CHRND, CHRNG	3.82
14	Distal arthrogryposis	Enrichment	CHRND, CHRNG	3.71
15	Bladder dysfunction, autonomic, with impaired pupillary reflex and secondary cakut	Enrichment	CHRNA3	3.29
16	Myasthenic syndrome, congenital, 3a, slow-channel	Enrichment	CHRND	3.29
17	Myasthenic syndrome, congenital, 3c, associated with acetylcholine receptor deficiency	Enrichment	CHRND	3.29
18	Epilepsy, nocturnal frontal lobe, 3	Enrichment	CHRNB2	3.29
19	Myasthenic syndrome, congenital, 3b, fast-channel	Enrichment	CHRND	3.29
20	Epilepsy, nocturnal frontal lobe, 4	Enrichment	CHRNA2	3.18
21	Multiple pterygium syndrome, escobar variant	Enrichment	CHRNG	2.81
22	Chromosome 15q13.3 deletion syndrome	Enrichment	CHRNA7	2.75
23	Tobacco addiction	Enrichment	CHRNA4	2.69
24	Contractures, pterygia, and spondylocarpotarsal fusion syndrome 1b	Enrichment	CHRNG	2.69
25	Myasthenic syndrome, congenital, 4a, slow-channel	Enrichment	CHRNE	2.59
26	Myasthenic syndrome, congenital, 4b, fast-channel	Enrichment	CHRNE	2.59
27	Rheumatoid arthritis	Enrichment	CHRNG	2.33
28	Myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency	Enrichment	CHRNE	2.29
29	Pulmonary disease, chronic obstructive	Enrichment	CHRNB4	2.17
30	Scoliosis	Enrichment	CHRNG	1.91
31	Congenital myopathy	Enrichment	CHRNA1	1.90
32	Peripheral nervous system disease	Enrichment	CHRNG	1.79
33	Neuropathy	Enrichment	CHRNG	1.79
34	Hydrops fetalis, nonimmune	Enrichment	CHRNA1	1.77
35	Non-immune hydrops fetalis	Enrichment	CHRNA1	1.69
36	Autism	Enrichment	CHRNA1	1.33

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Postsynaptic nicotinic acetylcholine receptors

Pathway Network for Postsynaptic nicotinic acetylcholine receptors

Pathway network for the Postsynaptic nicotinic acetylcholine receptors SuperPath

Member Pathways for Postsynaptic nicotinic acetylcholine receptors

Pathways in the Postsynaptic nicotinic acetylcholine receptors SuperPath

Gene overlap in member pathways for Postsynaptic nicotinic acetylcholine receptors SuperPath

Associated Genes for Postsynaptic nicotinic acetylcholine receptors

Associated Disorders for Postsynaptic nicotinic acetylcholine receptors

Disorders associated with Postsynaptic nicotinic acetylcholine receptors SuperPath

STRING Interaction Network for Postsynaptic nicotinic acetylcholine receptors

Sources for Postsynaptic nicotinic acetylcholine receptors