Posttranslational regulation of adherens junction stability and dissassembly

No Pathway Network information available for Posttranslational regulation of adherens junction stability and dissassembly

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

Disorders associated with Posttranslational regulation of adherens junction stability and dissassembly SuperPath

according to GeneCards Suite gene sharing
#DisorderTypeGenesScore
1Colorectal cancerEnrichmentCDH1, CTNNA1, CTNNB1, IGF2, MET, RET, SRC7.68
2Congenital central hypoventilation syndromeEnrichmentBDNF, GDNF, RET5.46
3Renal agenesis, bilateralEnrichmentGFRA1, RET, ROBO15.46
4Lip and oral cavity carcinomaEnrichmentABL1, EGFR, HRAS5.05
5Blepharocheilodontic syndrome 1EnrichmentCDH1, CTNND14.91
6Childhood hepatocellular carcinomaEnrichmentCTNNB1, MET4.91
7Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variantEnrichmentCDH2, DSP, JUP4.83
8Ovarian cancerEnrichmentCDH1, CTNNB1, EGFR, MET, RET4.56
9Epidermolysis bullosa, lethal acantholyticEnrichmentDSP, JUP4.44
10Hepatocellular carcinomaEnrichmentCTNNB1, MET, RET4.21
11Diffuse gastric and lobular breast cancer syndromeEnrichmentCDH1, CTNNA14.14
12Inherited cancer-predisposing syndromeEnrichmentCDH1, CTNNA1, EGFR, MET, RET4.00
13Bladder cancerEnrichmentCTNNB1, EGFR, HRAS3.85
14Cleft lip with or without cleft palateEnrichmentCDH1, CTNND13.74
15Adult hepatocellular carcinomaEnrichmentCTNNB1, EGF3.36
16Lung non-small cell carcinomaEnrichmentEGFR, HRAS3.18
17Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variantEnrichmentDSP, JUP3.10
18Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variantEnrichmentDSP, JUP3.10
19Heart diseaseEnrichmentABL1, CREBBP2.96
20Corpus callosum, agenesis ofEnrichmentCDH2, CREBBP2.90
21Isolated corpus callosum agenesisEnrichmentCDH2, CREBBP2.90
22Intellectual disability-hypoplastic corpus callosum-preauricular tag syndromeEnrichmentCDH2, CREBBP2.90
23Arrhythmogenic right ventricular cardiomyopathyEnrichmentDSP, JUP2.85
24Arteriovenous malformations of the brainEnrichmentCDH2, EGFR2.70
25Multiple endocrine neoplasia, type iibEnrichmentRET2.45
26Nystagmus 8, congenital, autosomal recessiveEnrichmentROBO12.45
27Arrhythmogenic right ventricular dysplasia, familial, 12EnrichmentJUP2.45
28Hypomagnesemia 4, renalEnrichmentEGF2.45
29Macular dystrophy, patterned, 2EnrichmentCTNNA12.45
30Charcot-marie-tooth disease, dominant intermediate bEnrichmentDNM22.45
31Naxos diseaseEnrichmentJUP2.45
32Developmental and epileptic encephalopathy 58EnrichmentNTRK22.45
33Charcot-marie-tooth disease, axonal, type 2bEnrichmentRAB7A2.45
34Charcot-marie-tooth disease type 2bEnrichmentRAB7A2.45
35Osteofibrous dysplasiaEnrichmentMET2.45
36Agenesis of corpus callosum, cardiac, ocular, and genital syndromeEnrichmentCDH22.45
37Renal hypodysplasia/aplasia 4EnrichmentGFRA12.45
38Alzheimer disease 18EnrichmentADAM102.45
39Deafness, autosomal recessive 97EnrichmentMET2.45
40Autism 9EnrichmentMET2.45
41Arrhythmogenic right ventricular dysplasia, familial, 14EnrichmentCDH22.45
42Coronary heart disease 6EnrichmentMMP32.45
43Lethal congenital contracture syndrome 5EnrichmentDNM22.45
44Reticulate acropigmentation of kitamuraEnrichmentADAM102.45
45Hirschsprung disease 3EnrichmentGDNF2.45
46Obesity, hyperphagia, and developmental delayEnrichmentNTRK22.45
47Thrombocytopenia 6EnrichmentSRC2.45
48Autosomal recessive congenital nystagmusEnrichmentROBO12.45
49Menke-hennekam syndrome 1EnrichmentCREBBP2.45
50Neurodevelopmental disorder with language delay and seizuresEnrichmentTIAM12.45
51Pituitary hormone deficiency, combined or isolated, 8EnrichmentROBO12.45
52Attention deficit-hyperactivity disorder 8EnrichmentCDH22.45
53Adenoid ameloblastomaEnrichmentCTNNB12.45
54Arthrogryposis, distal, type 11EnrichmentMET2.45
55Neurooculorenal syndromeEnrichmentROBO12.45
56Rubinstein-taybi syndrome due to 16p13.3 microdeletionEnrichmentCREBBP2.45
57Skin fragility-woolly hair-palmoplantar keratoderma syndromeEnrichmentDSP2.45
58Autosomal dominant charcot-marie-tooth disease type 2mEnrichmentDNM22.45
59Breast lobular carcinomaEnrichmentCDH12.45
60Thyroid cancerEnrichmentRET2.45
61Vegetative pyoderma gangrenosumEnrichmentPTPN62.45
62Bullous pyoderma gangrenosumEnrichmentPTPN62.45
63Pustular pyoderma gangrenosumEnrichmentPTPN62.45
64Menke-hennekam syndromeEnrichmentCREBBP2.45
65Phakomatosis pigmentokeratoticaEnrichmentHRAS2.45
66Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndromEnrichmentRAC12.45
67Classic pyoderma gangrenosumEnrichmentPTPN62.45
68Egf-related primary hypomagnesemia with intellectual disabilityEnrichmentEGF2.45
69Microcystic stromal tumorEnrichmentCTNNB12.45
70Gastrointestinal system diseaseEnrichmentRET2.45
71Congenital nystagmusEnrichmentROBO12.45
72Multiple endocrine neoplasiaEnrichmentRET2.45
73Tetralogy of fallotEnrichmentRET, ROBO12.42
74Hirschsprung disease 1EnrichmentGDNF, RET2.33
75Differentiated thyroid carcinomaEnrichmentHRAS, RET2.33
76Lung cancerEnrichmentEGFR, MET2.25
77Costello syndromeEnrichmentHRAS2.15
78Thumb deformityEnrichmentCREBBP2.15
79Osteopathia striata with cranial sclerosisEnrichmentCTNNB12.15
80Arrhythmogenic right ventricular dysplasia, familial, 8EnrichmentDSP2.15
81Silver-russell syndrome 3EnrichmentIGF22.15
82Keratosis palmoplantaris striata iiEnrichmentDSP2.15
83Cardiomyopathy, dilated, with woolly hair, keratoderma, and tooth agenesisEnrichmentDSP2.15
84Blepharocheilodontic syndrome 2EnrichmentCTNND12.15
85Intellectual developmental disorder, autosomal dominant 48EnrichmentRAC12.15
86Congenital heart defects and skeletal malformations syndromeEnrichmentABL12.15
87Acute myeloid leukemia with kat6a-crebbp fusionEnrichmentCREBBP2.15
88Progressive familial heart blockEnrichmentDSP2.15
89Papillary renal cell carcinomaEnrichmentMET2.15
90Cardiomyopathy, dilated, with woolly hair and keratodermaEnrichmentDSP2.15
91Medullary thyroid carcinomaEnrichmentRET2.15
92Juvenile nasopharyngeal angiofibromaEnrichmentCTNNB12.15
93TeratomaEnrichmentCTNNB12.15
94Silver-russell syndrome due to an imprinting defect of 11p15EnrichmentIGF22.15
95Wooly hair nevusEnrichmentHRAS2.15
96Silver-russell syndrome due to 11p15 microduplicationEnrichmentIGF22.15
97MicrocephalyEnrichmentABL1, CTNNB1, IGF1R2.03
98Hereditary breast carcinomaEnrichmentCDH1, RET1.98
99Desmoid disease, hereditaryEnrichmentCTNNB11.98
100Thyroid carcinoma, familial medullaryEnrichmentRET1.98
101Myopathy, centronuclear, x-linkedEnrichmentDNM21.98
102Neurodevelopmental disorder with spastic diplegia and visual defectsEnrichmentCTNNB11.98
103Neutrophilic dermatosis, acute febrileEnrichmentPTPN61.98
104Neonatal nephrocutaneous inflammatory syndromeEnrichmentEGFR1.98
105Anus, imperforateEnrichmentCTNNB11.98
106Erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-igeEnrichmentDSP1.98
107Exudative vitreoretinopathy 7EnrichmentCTNNB11.98
108Woolly hair-skin fragility syndromeEnrichmentDSP1.98
109Tethered spinal cord syndromeEnrichmentCREBBP1.98
110Large congenital melanocytic nevusEnrichmentHRAS1.98
111Desmoid tumorEnrichmentCTNNB11.98
112Keratosis palmoplantaris striataEnrichmentDSP1.98
113Gingival overgrowthEnrichmentRET1.98
114T-cell acute lymphoblastic leukemiaEnrichmentABL11.98
115Intraocular pressure quantitative trait locusEnrichmentCREBBP1.98
116SpermatocytomaEnrichmentHRAS1.98
117Butterfly-shaped pigment dystrophyEnrichmentCTNNA11.98
118Growth delay due to insulin-like growth factor i resistanceEnrichmentIGF1R1.98
119Neonatal inflammatory skin and bowel diseaseEnrichmentEGFR1.98
120Renal cell carcinomaEnrichmentMET1.98
121Beckwith-wiedemann syndrome due to imprinting defect of 11p15EnrichmentIGF21.98
122Schimmelpenning-feuerstein-mims syndromeEnrichmentHRAS1.85
123Dowling-degos disease 1EnrichmentADAM101.85
124Polyposis syndrome, hereditary mixed, 1EnrichmentCTNNA11.85
125Amyotrophy, monomelicEnrichmentSLIT11.85
126PilomatrixomaEnrichmentCTNNB11.85
127Alazami syndromeEnrichmentCTNNB11.85
128Central hypoventilation syndrome, congenital, 1EnrichmentRET1.85
129Chronic myelogenous leukemia, bcr-abl1 positiveEnrichmentABL11.85
130CraniopharyngiomaEnrichmentCTNNB11.85
131Epidermolytic nevusEnrichmentHRAS1.85
132Silver-russell syndrome due to a point mutationEnrichmentIGF21.85
133Haddad syndromeEnrichmentRET1.85
134Exudative vitreoretinopathy 1EnrichmentCTNNB11.76
135Multiple endocrine neoplasia, type iiaEnrichmentRET1.76
136Insulin-like growth factor iEnrichmentIGF1R1.76
137Cardiac arrestEnrichmentDSP1.76
138Myopathy, centronuclear, 1EnrichmentDNM21.68
139Cowden syndrome 1EnrichmentEGFR1.68
140Weyers acrofacial dysostosisEnrichmentCTNNB11.68
141Rubinstein-taybi syndrome 1EnrichmentCREBBP1.68
142Hemihyperplasia, isolatedEnrichmentIGF21.68
143Wilms tumor, aniridia, genitourinary anomalies, and impaired intellectual development syndromeEnrichmentBDNF1.68
144Chromosome 16p13.3 deletion syndrome, proximalEnrichmentCREBBP1.68
145Adrenocortical carcinomaEnrichmentCTNNB11.68
146Lung squamous cell carcinomaEnrichmentEGFR1.68
147HypertrichosisEnrichmentCREBBP1.68
148Inherited arrhythmogenic cardiomyopathyEnrichmentDSP1.68
149Sporadic pheochromocytoma/secreting paragangliomaEnrichmentRET1.68
150Nevus, epidermalEnrichmentHRAS1.61
151Thyroid cancer, nonmedullary, 2EnrichmentHRAS1.61
152Silver-russell syndrome 1EnrichmentIGF21.61
153MyelofibrosisEnrichmentSRC1.61
154Squamous cell carcinoma, head and neckEnrichmentEGFR1.61
155Leukemia, chronic myeloidEnrichmentABL11.61
156Renal cell carcinoma, papillary, 1EnrichmentMET1.61
157Noonan syndrome 3EnrichmentHRAS1.61
158Gallbladder cancerEnrichmentCTNNB11.61
159Pilomyxoid astrocytomaEnrichmentNTRK21.61
160Follicular thyroid carcinomaEnrichmentHRAS1.61
161Moyamoya angiopathyEnrichmentABL11.61
162B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)EnrichmentABL11.61
163Arthrogryposis, distal, type 1aEnrichmentMET1.55
164Melanocytic nevus syndrome, congenitalEnrichmentHRAS1.55
165Renal hypodysplasia/aplasia 1EnrichmentRET1.55
166Exudative vitreoretinopathyEnrichmentCTNNB11.55
167HypothyroidismEnrichmentRET1.55
168MyocarditisEnrichmentDSP1.55
169Breast cancerEnrichmentCDH1, RET1.54
170Arrhythmogenic right ventricular dysplasia, familial, 9EnrichmentDSP1.50
171Neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesEnrichmentRAC11.50
172Arteriovenous malformationEnrichmentHRAS1.50
173Familial isolated arrhythmogenic right ventricular dysplasiaEnrichmentDSP1.50
174Dilated cardiomyopathyEnrichmentDSP, JUP1.49
175Myopathy, x-linked, with excessive autophagyEnrichmentHRAS1.46
176Cardiac conduction defectEnrichmentDSP1.38
177Renal hypodysplasia/aplasia 3EnrichmentRET1.38
178Aortic valve disease 1EnrichmentDSP1.35
179Nk-cell enteropathyEnrichmentIGF1R1.35
180OsteoporosisEnrichmentSRC1.31
181MedulloblastomaEnrichmentCTNNB11.31
182PheochromocytomaEnrichmentRET1.31
183Lung cancer susceptibility 3EnrichmentEGFR1.31
184Cleft lip/palateEnrichmentCDH11.31
185Pituitary stalk interruption syndromeEnrichmentROBO11.31
186Renal cell carcinoma, nonpapillaryEnrichmentMET1.29
187Wilms tumor 1EnrichmentIGF21.29
188Rare genetic intellectual disabilityEnrichmentCREBBP1.29
189Noonan syndrome and noonan-related syndromeEnrichmentHRAS1.29
190Congenital nervous system abnormalityEnrichmentCREBBP, CTNNB11.27
191Nervous system diseaseEnrichmentCREBBP, CTNNB11.27
192Wolff-parkinson-white syndromeEnrichmentJUP1.26
193RhabdomyosarcomaEnrichmentHRAS1.26
194GliosarcomaEnrichmentEGFR1.26
195Interstitial lung disease 2EnrichmentDSP1.23
196Polycystic liver diseaseEnrichmentCTNNB11.23
197Giant cell glioblastomaEnrichmentEGFR1.23
198Autosomal dominant polycystic liver diseaseEnrichmentCTNNB11.23
199Beckwith-wiedemann syndromeEnrichmentIGF21.21
200Diffuse large b-cell lymphomaEnrichmentCREBBP1.19
201Macs syndromeEnrichmentRIN21.16
202CraniosynostosisEnrichmentCTNNA11.16
203Cardiomyopathy, dilated, 1aEnrichmentDSP1.14
204Endometrial cancerEnrichmentCDH11.14
205Centronuclear myopathyEnrichmentDNM21.14
206HepatoblastomaEnrichmentCTNNB11.14
207Hereditary paraganglioma-pheochromocytoma syndromesEnrichmentRET1.14
208Cardiomyopathy, dilated, 1gEnrichmentDSP1.12
209Noonan syndrome 1EnrichmentHRAS1.11
210Precursor t-cell acute lymphoblastic leukemiaEnrichmentABL11.11
211ScoliosisEnrichmentCREBBP1.09
212Hydrops fetalis, nonimmuneEnrichmentHRAS1.05
213RasopathyEnrichmentHRAS1.05
214Auditory neuropathyEnrichmentCDH21.05
215Prostate cancerEnrichmentCDH11.01
216Long qt syndrome 1EnrichmentDSP1.00
217Long qt syndromeEnrichmentDSP0.98
218Non-immune hydrops fetalisEnrichmentHRAS0.98
219CakutEnrichmentROBO10.94
220Left ventricular noncompactionEnrichmentDSP0.93
221MyopathyEnrichmentDNM20.88
222Charcot-marie-tooth diseaseEnrichmentDNM20.87
223Type 2 diabetes mellitusEnrichmentPTPN10.86
224Gastric cancerEnrichmentCDH10.85
225West syndromeEnrichmentNTRK20.84
226Sensorineural hearing lossEnrichmentRET0.80
227ThrombocytopeniaEnrichmentSRC0.80
228Body mass index quantitative trait locus 11EnrichmentBDNF0.79
229HypertelorismEnrichmentRET0.77
230Familial isolated dilated cardiomyopathyEnrichmentDSP0.77
231Hereditary breast ovarian cancer syndromeEnrichmentCTNNA10.75
232Myeloma, multipleEnrichmentCREBBP0.74
233Undetermined early-onset epileptic encephalopathyEnrichmentNTRK20.74
234AutismEnrichmentCREBBP0.65
235Rare autosomal recessive non-syndromic sensorineural deafness type dfnbEnrichmentMET0.57
236Complex neurodevelopmental disorderEnrichmentTIAM10.45
237Hereditary retinal dystrophyEnrichmentCTNNA10.19
238Fundus dystrophyEnrichmentCTNNA10.19

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