PPAR-alpha pathway

No Pathway Network information available for PPAR-alpha pathway

Pathways in the PPAR-alpha pathway SuperPath

#	Name	Source	Genes
1	PPAR-alpha pathway	WikiPathways	ACAA1 ACADM APOA1 APOA2 APOA5 APOC3 CCND1 CDK1 CDK4 CPT1A CPT2 CYP4A11 CYP7A1 CYP8B1 DBI EHHADH FABP1 KLK15 MYC NR1H3 PLTP PPARA RXRA SCP2 SLC27A1 UGT1A9 (see all 26) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACAA1	Acetyl-CoA Acyltransferase 1	Protein Coding	1
2	CDK1	Cyclin Dependent Kinase 1	Protein Coding	1
3	SCP2	Sterol Carrier Protein 2	Protein Coding	1
4	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
5	CCND1	Cyclin D1	Protein Coding	1
6	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	1
7	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	1
8	PLTP	Phospholipid Transfer Protein	Protein Coding	1
9	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
10	APOC3	Apolipoprotein C3	Protein Coding	1
11	ACADM	Acyl-CoA Dehydrogenase Medium Chain	Protein Coding	1
12	APOA2	Apolipoprotein A2	Protein Coding	1
13	APOA1	Apolipoprotein A1	Protein Coding	1
14	FABP1	Fatty Acid Binding Protein 1	Protein Coding	1
15	EHHADH	Enoyl-CoA Hydratase And 3-Hydroxyacyl CoA Dehydrogenase	Protein Coding	1
16	DBI	Diazepam Binding Inhibitor, Acyl-CoA Binding Protein	Protein Coding	1
17	CYP8B1	Cytochrome P450 Family 8 Subfamily B Member 1	Protein Coding	1
18	CYP7A1	Cytochrome P450 Family 7 Subfamily A Member 1	Protein Coding	1
19	CYP4A11	Cytochrome P450 Family 4 Subfamily A Member 11	Protein Coding	1
20	CPT2	Carnitine Palmitoyltransferase 2	Protein Coding	1
21	CPT1A	Carnitine Palmitoyltransferase 1A	Protein Coding	1
22	APOA5	Apolipoprotein A5	Protein Coding	1
23	CDK4	Cyclin Dependent Kinase 4	Protein Coding	1
24	NR1H3	Nuclear Receptor Subfamily 1 Group H Member 3	Protein Coding	1
25	KLK15	Kallikrein Related Peptidase 15	Protein Coding	1
26	SLC27A1	Solute Carrier Family 27 Member 1	Protein Coding	1

Disorders associated with PPAR-alpha pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.72
2	Acyl-coa dehydrogenase, medium-chain, deficiency of	Enrichment	ACADM	2.72
3	Fanconi renotubular syndrome 3	Enrichment	EHHADH	2.72
4	Familial apolipoprotein a5 deficiency	Enrichment	APOA5	2.72
5	Apolipoprotein c-iii deficiency	Enrichment	APOC3	2.72
6	Leukoencephalopathy with dystonia and motor neuropathy	Enrichment	SCP2	2.72
7	Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency	Enrichment	CYP7A1	2.72
8	Medium-chain acyl-coenzyme a dehydrogenase deficiency	Enrichment	ACADM	2.72
9	Aapoaii amyloidosis	Enrichment	APOA2	2.72
10	Burkitt lymphoma	Enrichment	MYC	2.42
11	Hyperlipoproteinemia, type v	Enrichment	APOA5	2.42
12	Carnitine palmitoyltransferase ii deficiency, infantile	Enrichment	CPT2	2.42
13	Carnitine palmitoyltransferase ii deficiency, lethal neonatal	Enrichment	CPT2	2.42
14	Carnitine palmitoyltransferase i deficiency	Enrichment	CPT1A	2.42
15	Carnitine palmitoyltransferase ii deficiency, myopathic, stress-induced	Enrichment	CPT2	2.42
16	Encephalopathy, acute, infection-induced 4	Enrichment	CPT2	2.42
17	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	2.42
18	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	2.42
19	Acute necrotizing encephalopathy of childhood	Enrichment	CPT2	2.42
20	Myeloma, multiple	Enrichment	CCND1, RXRA	2.29
21	Hyperalphalipoproteinemia 1	Enrichment	APOC3	2.24
22	D-bifunctional protein deficiency	Enrichment	EHHADH	2.24
23	Hypoalphalipoproteinemia, primary, 2	Enrichment	APOA1	2.24
24	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	2.24
25	Dedifferentiated liposarcoma	Enrichment	CDK4	2.24
26	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	2.24
27	Well-differentiated liposarcoma	Enrichment	CDK4	2.24
28	Hypertriglyceridemia 1	Enrichment	APOA5	2.12
29	Hypoalphalipoproteinemia, primary, 1	Enrichment	APOA1	2.12
30	Mantle cell lymphoma	Enrichment	CCND1	2.12
31	Hydrocephalus, congenital, 2, with or without brain or eye anomalies	Enrichment	ACADM	2.12
32	Coronary artery anomaly	Enrichment	APOC3	2.12
33	Primary fanconi renotubular syndrome	Enrichment	EHHADH	2.12
34	Amyloidosis, hereditary systemic 2	Enrichment	APOA1	2.02
35	Von hippel-lindau syndrome	Enrichment	CCND1	2.02
36	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.72
37	Crigler-najjar syndrome, type i	Enrichment	UGT1A9	1.72
38	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A9	1.72
39	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A9	1.72
40	Crigler-najjar syndrome, type ii	Enrichment	UGT1A9	1.72
41	Gilbert syndrome	Enrichment	UGT1A9	1.68
42	Bilirubin metabolic disorder	Enrichment	UGT1A9	1.68
43	Hypercholesterolemia, familial, 1	Enrichment	APOA2	1.61
44	Multiple sclerosis	Enrichment	NR1H3	1.58
45	Familial hypercholesterolemia	Enrichment	APOA2	1.55
46	Melanoma, cutaneous malignant 1	Enrichment	CDK4	1.49
47	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.36
48	Gastric cancer	Enrichment	CDK4	1.10
49	Colorectal cancer	Enrichment	CCND1	0.81
50	Congenital nervous system abnormality	Enrichment	CPT2	0.73
51	Nervous system disease	Enrichment	CPT2	0.73
52	Inherited cancer-predisposing syndrome	Enrichment	CDK4	0.65

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PPAR-alpha pathway

Pathway Network for PPAR-alpha pathway

Member Pathways for PPAR-alpha pathway

Pathways in the PPAR-alpha pathway SuperPath

Associated Genes for PPAR-alpha pathway

Associated Disorders for PPAR-alpha pathway

Disorders associated with PPAR-alpha pathway SuperPath

STRING Interaction Network for PPAR-alpha pathway

Sources for PPAR-alpha pathway