PPAR signaling pathway

Pathway network for the PPAR signaling pathway SuperPath

Sources:

WikiPathways

Pathways in the PPAR signaling pathway SuperPath

#	Name	Source	Genes
1	PPAR signaling pathway	WikiPathways	ACAA1 ACADL ACADM ACOX1 ACOX2 ACOX3 ACSBG1 ACSBG2 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 ADIPOQ ANGPTL4 APOA1 APOA2 APOA5 APOC3 AQP7 CD36 CPT1A CPT1B CPT1C CPT2 CYP27A1 CYP4A11 CYP7A1 CYP8B1 DBI EHHADH FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 FADS2 GK2 GK3 HMGCS2 ILK LPL ME1 MMP1 NR1H3 OLR1 PCK1 PCK2 PDPK1 PLIN1 PLTP PPARA PPARD PPARG RXRA RXRB RXRG SCD SCP2 SLC27A1 SLC27A2 SLC27A4 SLC27A5 SLC27A6 SORBS1 UCP1 (see all 68) (see less)
2	Fatty acid transporters	WikiPathways	ACSBG1 ACSBG2 ACSL1 ACSL3 ACSL4 ACSL5 ACSL6 CD36 DBI FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7 FABP9 SLC27A4 (see all 18) (see less)
3	FABP4 in ovarian cancer	WikiPathways	FABP4

Gene overlap in member pathways for PPAR signaling pathway SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FABP4	Fatty Acid Binding Protein 4	Protein Coding	3
2	ACSBG2	Acyl-CoA Synthetase Bubblegum Family Member 2	Protein Coding	2
3	ACSBG1	Acyl-CoA Synthetase Bubblegum Family Member 1	Protein Coding	2
4	ACSL3	Acyl-CoA Synthetase Long Chain Family Member 3	Protein Coding	2
5	CD36	CD36 Molecule (CD36 Blood Group)	Protein Coding	2
6	ACSL5	Acyl-CoA Synthetase Long Chain Family Member 5	Protein Coding	2
7	ACSL6	Acyl-CoA Synthetase Long Chain Family Member 6	Protein Coding	2
8	ACSL4	Acyl-CoA Synthetase Long Chain Family Member 4	Protein Coding	2
9	ACSL1	Acyl-CoA Synthetase Long Chain Family Member 1	Protein Coding	2
10	FABP7	Fatty Acid Binding Protein 7	Protein Coding	2
11	FABP5	Fatty Acid Binding Protein 5	Protein Coding	2
12	FABP3	Fatty Acid Binding Protein 3	Protein Coding	2
13	FABP2	Fatty Acid Binding Protein 2	Protein Coding	2
14	FABP1	Fatty Acid Binding Protein 1	Protein Coding	2
15	DBI	Diazepam Binding Inhibitor, Acyl-CoA Binding Protein	Protein Coding	2
16	SLC27A4	Solute Carrier Family 27 Member 4	Protein Coding	2
17	FABP6	Fatty Acid Binding Protein 6	Protein Coding	2
18	ACAA1	Acetyl-CoA Acyltransferase 1	Protein Coding	1
19	GK2	Glycerol Kinase 2	Protein Coding	1
20	SLC27A5	Solute Carrier Family 27 Member 5	Protein Coding	1
21	FADS2	Fatty Acid Desaturase 2	Protein Coding	1
22	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	1
23	ACOX3	Acyl-CoA Oxidase 3, Pristanoyl	Protein Coding	1
24	ACOX2	Acyl-CoA Oxidase 2	Protein Coding	1
25	UCP1	Uncoupling Protein 1	Protein Coding	1
26	SCP2	Sterol Carrier Protein 2	Protein Coding	1
27	SCD	Stearoyl-CoA Desaturase	Protein Coding	1
28	RXRG	Retinoid X Receptor Gamma	Protein Coding	1
29	RXRB	Retinoid X Receptor Beta	Protein Coding	1
30	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
31	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	1
32	PPARD	Peroxisome Proliferator Activated Receptor Delta	Protein Coding	1
33	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	1
34	PLTP	Phospholipid Transfer Protein	Protein Coding	1
35	PLIN1	Perilipin 1	Protein Coding	1
36	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	1
37	ANGPTL4	Angiopoietin Like 4	Protein Coding	1
38	PCK2	Phosphoenolpyruvate Carboxykinase 2, Mitochondrial	Protein Coding	1
39	PCK1	Phosphoenolpyruvate Carboxykinase 1	Protein Coding	1
40	ACOX1	Acyl-CoA Oxidase 1	Protein Coding	1
41	OLR1	Oxidized Low Density Lipoprotein Receptor 1	Protein Coding	1
42	MMP1	Matrix Metallopeptidase 1	Protein Coding	1
43	ME1	Malic Enzyme 1	Protein Coding	1
44	LPL	Lipoprotein Lipase	Protein Coding	1
45	AQP7	Aquaporin 7	Protein Coding	1
46	ILK	Integrin Linked Kinase	Protein Coding	1
47	APOC3	Apolipoprotein C3	Protein Coding	1
48	ACADM	Acyl-CoA Dehydrogenase Medium Chain	Protein Coding	1
49	APOA2	Apolipoprotein A2	Protein Coding	1
50	APOA1	Apolipoprotein A1	Protein Coding	1
51	ACADL	Acyl-CoA Dehydrogenase Long Chain	Protein Coding	1
52	HMGCS2	3-Hydroxy-3-Methylglutaryl-CoA Synthase 2	Protein Coding	1
53	SLC27A6	Solute Carrier Family 27 Member 6	Protein Coding	1
54	EHHADH	Enoyl-CoA Hydratase And 3-Hydroxyacyl CoA Dehydrogenase	Protein Coding	1
55	CYP27A1	Cytochrome P450 Family 27 Subfamily A Member 1	Protein Coding	1
56	CYP8B1	Cytochrome P450 Family 8 Subfamily B Member 1	Protein Coding	1
57	CYP7A1	Cytochrome P450 Family 7 Subfamily A Member 1	Protein Coding	1
58	CYP4A11	Cytochrome P450 Family 4 Subfamily A Member 11	Protein Coding	1
59	CPT2	Carnitine Palmitoyltransferase 2	Protein Coding	1
60	CPT1B	Carnitine Palmitoyltransferase 1B	Protein Coding	1
61	CPT1A	Carnitine Palmitoyltransferase 1A	Protein Coding	1
62	CPT1C	Carnitine Palmitoyltransferase 1C	Protein Coding	1
63	APOA5	Apolipoprotein A5	Protein Coding	1
64	SLC27A2	Solute Carrier Family 27 Member 2	Protein Coding	1
65	NR1H3	Nuclear Receptor Subfamily 1 Group H Member 3	Protein Coding	1
66	SORBS1	Sorbin And SH3 Domain Containing 1	Protein Coding	1
67	SLC27A1	Solute Carrier Family 27 Member 1	Protein Coding	1
68	GK3	Glycerol Kinase 3	Protein Coding	1
69	FABP9	Fatty Acid Binding Protein 9	Protein Coding	1

Disorders associated with PPAR signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Phosphoenolpyruvate carboxykinase deficiency	Enrichment	PCK1, PCK2	4.13
2	Coronary artery anomaly	Enrichment	APOC3, LPL	3.83
3	Intellectual developmental disorder, x-linked 63	Enrichment	ACSL4	2.88
4	Coronary heart disease 7	Enrichment	CD36	2.88
5	Diarrhea 13	Enrichment	ACSL5	2.88
6	Platelet glycoprotein iv deficiency	Enrichment	CD36	2.88
7	Ichthyosis prematurity syndrome	Enrichment	SLC27A4	2.88
8	Phosphoenolpyruvate carboxykinase deficiency, cytosolic	Enrichment	PCK1	2.30
9	Acyl-coa dehydrogenase, medium-chain, deficiency of	Enrichment	ACADM	2.30
10	Cerebrotendinous xanthomatosis	Enrichment	CYP27A1	2.30
11	Fanconi renotubular syndrome 3	Enrichment	EHHADH	2.30
12	Peroxisomal acyl-coa oxidase deficiency	Enrichment	ACOX1	2.30
13	Bile acid synthesis defect, congenital, 6	Enrichment	ACOX2	2.30
14	Mitchell syndrome	Enrichment	ACOX1	2.30
15	Familial apolipoprotein a5 deficiency	Enrichment	APOA5	2.30
16	Glycerol quantitative trait locus	Enrichment	AQP7	2.30
17	Apolipoprotein c-iii deficiency	Enrichment	APOC3	2.30
18	Plasma triglyceride level quantitative trait locus	Enrichment	ANGPTL4	2.30
19	Leukoencephalopathy with dystonia and motor neuropathy	Enrichment	SCP2	2.30
20	Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency	Enrichment	CYP7A1	2.30
21	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.30
22	Medium-chain acyl-coenzyme a dehydrogenase deficiency	Enrichment	ACADM	2.30
23	Aapoaii amyloidosis	Enrichment	APOA2	2.30
24	Amme complex	Enrichment	ACSL4	2.28
25	Blood platelet disease	Enrichment	CD36	2.28
26	Cerebral malaria	Enrichment	CD36	2.28
27	Hyperlipoproteinemia, type v	Enrichment	APOA5	2.00
28	Hyperlipoproteinemia, type i	Enrichment	LPL	2.00
29	Phosphoenolpyruvate carboxykinase deficiency, mitochondrial	Enrichment	PCK2	2.00
30	Carnitine palmitoyltransferase ii deficiency, infantile	Enrichment	CPT2	2.00
31	Carotid intimal medial thickness 1	Enrichment	PPARG	2.00
32	Carnitine palmitoyltransferase ii deficiency, lethal neonatal	Enrichment	CPT2	2.00
33	Lipase deficiency, combined	Enrichment	LPL	2.00
34	Carnitine palmitoyltransferase i deficiency	Enrichment	CPT1A	2.00
35	Carnitine palmitoyltransferase ii deficiency, myopathic, stress-induced	Enrichment	CPT2	2.00
36	Encephalopathy, acute, infection-induced 4	Enrichment	CPT2	2.00
37	Spastic paraplegia 73, autosomal dominant	Enrichment	CPT1C	2.00
38	3-hydroxy-3-methylglutaryl-coa synthase-2 deficiency	Enrichment	HMGCS2	2.00
39	Recessive dystrophic epidermolysis bullosa	Enrichment	MMP1	2.00
40	Familial lipoprotein lipase deficiency	Enrichment	LPL	2.00
41	Hypoalphalipoproteinemia, primary, 2, intermediate	Enrichment	APOA1	2.00
42	Amyloidosis, hereditary systemic 3	Enrichment	APOA1	2.00
43	Familial partial lipodystrophy	Enrichment	PPARG	2.00
44	Acute necrotizing encephalopathy of childhood	Enrichment	CPT2	2.00
45	Stroke, ischemic	Enrichment	ACSL4	1.88
46	Hyperalphalipoproteinemia 1	Enrichment	APOC3	1.82
47	D-bifunctional protein deficiency	Enrichment	EHHADH	1.82
48	Adiponectin deficiency	Enrichment	ADIPOQ	1.82
49	Lipodystrophy, familial partial, type 4	Enrichment	PLIN1	1.82
50	Hypoalphalipoproteinemia, primary, 2	Enrichment	APOA1	1.82
51	Spastic paraplegia 50, autosomal recessive	Enrichment	APOA1	1.82
52	Autosomal recessive congenital ichthyosis	Enrichment	SLC27A4	1.70
53	Hypertriglyceridemia 1	Enrichment	APOA5	1.70
54	Hypoalphalipoproteinemia, primary, 1	Enrichment	APOA1	1.70
55	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.70
56	Leptin deficiency or dysfunction	Enrichment	PPARG	1.70
57	Congenital generalized lipodystrophy	Enrichment	PPARG	1.70
58	Hydrocephalus, congenital, 2, with or without brain or eye anomalies	Enrichment	ACADM	1.70
59	Primary fanconi renotubular syndrome	Enrichment	EHHADH	1.70
60	Hyperlipidemia, familial combined, 3	Enrichment	LPL	1.61
61	Amyloidosis, hereditary systemic 2	Enrichment	APOA1	1.61
62	Body mass index quantitative trait locus 11	Enrichment	AQP7, PPARG	1.59
63	Malaria	Enrichment	CD36	1.52
64	Non-syndromic x-linked intellectual disability	Enrichment	ACSL4	1.33
65	Hypercholesterolemia, familial, 1	Enrichment	APOA2	1.20
66	Multiple sclerosis	Enrichment	NR1H3	1.17
67	Familial hypercholesterolemia	Enrichment	APOA2	1.14
68	Gliosarcoma	Enrichment	PPARG	1.11
69	Giant cell glioblastoma	Enrichment	PPARG	1.09
70	Cardiomyopathy, dilated, 1a	Enrichment	LPL	1.00
71	Myocardial infarction	Enrichment	OLR1	0.98
72	Differentiated thyroid carcinoma	Enrichment	PPARG	0.87
73	Type 2 diabetes mellitus	Enrichment	PPARG	0.72
74	Myeloma, multiple	Enrichment	RXRA	0.61
75	Colorectal cancer	Enrichment	PPARG	0.45
76	Congenital nervous system abnormality	Enrichment	CPT2	0.38
77	Nervous system disease	Enrichment	CPT2	0.38

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PPAR signaling pathway

Pathway Network for PPAR signaling pathway

Pathway network for the PPAR signaling pathway SuperPath

Member Pathways for PPAR signaling pathway

Pathways in the PPAR signaling pathway SuperPath

Gene overlap in member pathways for PPAR signaling pathway SuperPath

Associated Genes for PPAR signaling pathway

Associated Disorders for PPAR signaling pathway

Disorders associated with PPAR signaling pathway SuperPath

STRING Interaction Network for PPAR signaling pathway

Sources for PPAR signaling pathway