Pre-NOTCH Expression and Processing

Pathway network for the Pre-NOTCH Expression and Processing SuperPath

Sources:

Reactome

Pathways in the Pre-NOTCH Expression and Processing SuperPath

#	Name	Source	Genes
1	Pre-NOTCH Expression and Processing	Reactome	AGO1 AGO2 AGO3 AGO4 ATP2A1 ATP2A2 ATP2A3 B4GALT1 CCND1 CREBBP E2F1 E2F3 ELANE ELF3 EP300 FURIN H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 JUN KAT2A KAT2B LFNG MAML1 MAML2 MAML3 MAMLD1 MFNG MOV10 NOTCH1 NOTCH2 NOTCH2NLA NOTCH2NLB NOTCH2NLC NOTCH3 NOTCH4 POFUT1 POGLUT1 PRKCI RAB6A RBPJ RFNG RUNX1 SEL1L SIRT6 SNW1 ST3GAL3 ST3GAL4 ST3GAL6 TFDP1 TFDP2 TMED2 TNRC6A TNRC6B TNRC6C TP53 (see all 112) (see less)
2	Signaling by NOTCH	Reactome	ACTA2 ADAM10 ADAM17 ADRM1 AGO1 AGO2 AGO3 AGO4 AKT1 APH1A APH1B ARRB1 ARRB2 ATP2A1 ATP2A2 ATP2A3 B4GALT1 CCNC CCND1 CDK8 CNTN1 CREB1 CREBBP CUL1 DLGAP5 DLK1 DLL1 DLL4 DNER DTX1 DTX2 DTX4 E2F1 E2F3 EGF EGFR ELANE ELF3 EP300 FABP7 FBXW7 FCER2 FLT4 FURIN H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HDAC1 HDAC10 HDAC11 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HES1 HES5 HEY1 HEY2 HEYL HIF1A IKZF1 ITCH JAG1 JAG2 JUN KAT2A KAT2B LFNG MAML1 MAML2 MAML3 MAMLD1 MDK MFNG MIB1 MIB2 MOV10 MYC NBEA NCOR1 NCOR2 NCSTN NEURL1 NEURL1B NOTCH1 NOTCH2 NOTCH2NLA NOTCH2NLB NOTCH2NLC NOTCH3 NOTCH4 NUMB PBX1 PLXND1 POFUT1 POGLUT1 PRKCI PSEN1 PSEN2 PSENEN PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTCRA RAB6A RBPJ RBX1 RFNG RPS27A RUNX1 SEL1L SEM1 SIRT6 SKP1 SMAD3 SNW1 ST3GAL3 ST3GAL4 ST3GAL6 STAT1 TACC3 TBL1X TBL1XR1 TFDP1 TFDP2 TLE1 TLE2 TLE3 TLE4 TMED2 TNRC6A TNRC6B TNRC6C TP53 UBA52 UBB UBC WWC1 WWP2 YBX1 YWHAZ (see all 228) (see less)
3	Pre-NOTCH Transcription and Translation	Reactome	AGO1 AGO2 AGO3 AGO4 CCND1 CREBBP E2F1 E2F3 ELANE ELF3 EP300 H2AB1 H2AC14 H2AC18 H2AC19 H2AC20 H2AC4 H2AC6 H2AC7 H2AC8 H2AJ H2AX H2AZ2 H2BC1 H2BC10 H2BC11 H2BC12 H2BC12L H2BC13 H2BC14 H2BC15 H2BC17 H2BC21 H2BC26 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 H3-3A H3-3B H3C1 H3C10 H3C11 H3C12 H3C13 H3C14 H3C15 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 JUN KAT2A KAT2B MAML1 MAML2 MAML3 MAMLD1 MOV10 NOTCH1 NOTCH2 NOTCH2NLA NOTCH2NLB NOTCH2NLC NOTCH3 NOTCH4 PRKCI RBPJ RUNX1 SIRT6 SNW1 TFDP1 TFDP2 TNRC6A TNRC6B TNRC6C TP53 (see all 96) (see less)
4	Pre-NOTCH Processing in Golgi	Reactome	ATP2A1 ATP2A2 ATP2A3 B4GALT1 FURIN LFNG MFNG NOTCH1 NOTCH2 NOTCH3 NOTCH4 RAB6A RFNG SEL1L ST3GAL3 ST3GAL4 ST3GAL6 TMED2 (see all 18) (see less)
5	Pre-NOTCH Processing in the Endoplasmic Reticulum	Reactome	NOTCH1 NOTCH2 NOTCH3 NOTCH4 POFUT1 POGLUT1 (see all 6) (see less)
6	Defective LFNG causes SCDO3	Reactome	LFNG NOTCH1 NOTCH2 NOTCH3 NOTCH4
7	Expression of NOTCH2NL genes	Reactome	ELANE NOTCH2NLA NOTCH2NLB NOTCH2NLC

Gene overlap in member pathways for Pre-NOTCH Expression and Processing SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NOTCH1	Notch Receptor 1	Protein Coding	6
2	NOTCH2	Notch Receptor 2	Protein Coding	6
3	NOTCH3	Notch Receptor 3	Protein Coding	6
4	NOTCH4	Notch Receptor 4	Protein Coding	6
5	NOTCH2NLC	Notch 2 N-Terminal Like C	Protein Coding	4
6	NOTCH2NLB	Notch 2 N-Terminal Like B	Protein Coding	4
7	ELANE	Elastase, Neutrophil Expressed	Protein Coding	4
8	NOTCH2NLA	Notch 2 N-Terminal Like A	Protein Coding	4
9	LFNG	LFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	4
10	MAMLD1	Mastermind Like Domain Containing 1	Protein Coding	3
11	ST3GAL6	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6	Protein Coding	3
12	TMED2	Transmembrane P24 Trafficking Protein 2	Protein Coding	3
13	H4C16	H4 Histone 16	Protein Coding	3
14	H3C14	H3 Clustered Histone 14	Protein Coding	3
15	H2BC26	H2B Clustered Histone 26	Protein Coding	3
16	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	3
17	E2F1	E2F Transcription Factor 1	Protein Coding	3
18	E2F3	E2F Transcription Factor 3	Protein Coding	3
19	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	3
20	AGO4	Argonaute RISC Component 4	Protein Coding	3
21	ELF3	E74 Like ETS Transcription Factor 3	Protein Coding	3
22	EP300	EP300 Lysine Acetyltransferase	Protein Coding	3
23	SNW1	SNW Domain Containing 1	Protein Coding	3
24	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	3
25	POFUT1	Protein O-Fucosyltransferase 1	Protein Coding	3
26	H2BC1	H2B Clustered Histone 1	Protein Coding	3
27	KAT2A	Lysine Acetyltransferase 2A	Protein Coding	3
28	AGO1	Argonaute RISC Component 1	Protein Coding	3
29	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	3
30	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	3
31	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	3
32	H2AC8	H2A Clustered Histone 8	Protein Coding	3
33	H2AC7	H2A Clustered Histone 7	Protein Coding	3
34	H2AX	H2A.X Variant Histone	Protein Coding	3
35	H2BC5	H2B Clustered Histone 5	Protein Coding	3
36	H2BC3	H2B Clustered Histone 3	Protein Coding	3
37	H3-3A	H3.3 Histone A	Protein Coding	3
38	H3-3B	H3.3 Histone B	Protein Coding	3
39	H3C15	H3 Clustered Histone 15	Protein Coding	3
40	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	3
41	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	3
42	MFNG	MFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	3
43	MOV10	Mov10 RNA Helicase	Protein Coding	3
44	H2AB1	H2A.B Variant Histone 1	Protein Coding	3
45	ATP2A1	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 1	Protein Coding	3
46	ATP2A2	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2	Protein Coding	3
47	ATP2A3	ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 3	Protein Coding	3
48	FURIN	Furin, Paired Basic Amino Acid Cleaving Enzyme	Protein Coding	3
49	SIRT6	Sirtuin 6	Protein Coding	3
50	H2BC12L	H2B Clustered Histone 12 Like	Protein Coding	3
51	H4C15	H4 Clustered Histone 15	Protein Coding	3
52	MAML3	Mastermind Like Transcriptional Coactivator 3	Protein Coding	3
53	H2AJ	H2A.J Histone	Protein Coding	3
54	PRKCI	Protein Kinase C Iota	Protein Coding	3
55	POGLUT1	Protein O-Glucosyltransferase 1	Protein Coding	3
56	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	3
57	RAB6A	RAB6A, Member RAS Oncogene Family	Protein Coding	3
58	CCND1	Cyclin D1	Protein Coding	3
59	RFNG	RFNG O-Fucosylpeptide 3-Beta-N-Acetylglucosaminyltransferase	Protein Coding	3
60	SEL1L	SEL1L Adaptor Subunit Of SYVN1 Ubiquitin Ligase	Protein Coding	3
61	ST3GAL4	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4	Protein Coding	3
62	ST3GAL3	ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3	Protein Coding	3
63	H3C13	H3 Clustered Histone 13	Protein Coding	3
64	TFDP1	Transcription Factor Dp-1	Protein Coding	3
65	TFDP2	Transcription Factor Dp-2	Protein Coding	3
66	TP53	Tumor Protein P53	Protein Coding	3
67	H2AC19	H2A Clustered Histone 19	Protein Coding	3
68	H4C9	H4 Clustered Histone 9	Protein Coding	3
69	H2AC14	H2A Clustered Histone 14	Protein Coding	3
70	H2AC6	H2A Clustered Histone 6	Protein Coding	3
71	H2AC4	H2A Clustered Histone 4	Protein Coding	3
72	H2AC18	H2A Clustered Histone 18	Protein Coding	3
73	H2AC20	H2A Clustered Histone 20	Protein Coding	3
74	H2BC8	H2B Clustered Histone 8	Protein Coding	3
75	H2BC13	H2B Clustered Histone 13	Protein Coding	3
76	H2BC15	H2B Clustered Histone 15	Protein Coding	3
77	H2BC14	H2B Clustered Histone 14	Protein Coding	3
78	H2BC7	H2B Clustered Histone 7	Protein Coding	3
79	H2BC6	H2B Clustered Histone 6	Protein Coding	3
80	H2BC9	H2B Clustered Histone 9	Protein Coding	3
81	H2BC10	H2B Clustered Histone 10	Protein Coding	3
82	H2BC4	H2B Clustered Histone 4	Protein Coding	3
83	H2BC17	H2B Clustered Histone 17	Protein Coding	3
84	H2BC21	H2B Clustered Histone 21	Protein Coding	3
85	H3C1	H3 Clustered Histone 1	Protein Coding	3
86	H3C4	H3 Clustered Histone 4	Protein Coding	3
87	H3C3	H3 Clustered Histone 3	Protein Coding	3
88	H3C6	H3 Clustered Histone 6	Protein Coding	3
89	H3C11	H3 Clustered Histone 11	Protein Coding	3
90	H3C8	H3 Clustered Histone 8	Protein Coding	3
91	H3C12	H3 Clustered Histone 12	Protein Coding	3
92	H3C10	H3 Clustered Histone 10	Protein Coding	3
93	H3C2	H3 Clustered Histone 2	Protein Coding	3
94	H4C1	H4 Clustered Histone 1	Protein Coding	3
95	H4C4	H4 Clustered Histone 4	Protein Coding	3
96	H4C6	H4 Clustered Histone 6	Protein Coding	3
97	H4C12	H4 Clustered Histone 12	Protein Coding	3
98	H4C11	H4 Clustered Histone 11	Protein Coding	3
99	H4C3	H4 Clustered Histone 3	Protein Coding	3
100	H4C8	H4 Clustered Histone 8	Protein Coding	3
101	H4C2	H4 Clustered Histone 2	Protein Coding	3
102	H4C5	H4 Clustered Histone 5	Protein Coding	3
103	H4C13	H4 Clustered Histone 13	Protein Coding	3
104	H4C14	H4 Clustered Histone 14	Protein Coding	3
105	MAML2	Mastermind Like Transcriptional Coactivator 2	Protein Coding	3
106	H2BC12	H2B Clustered Histone 12	Protein Coding	3
107	RUNX1	RUNX Family Transcription Factor 1	Protein Coding	3
108	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	3
109	H3C7	H3 Clustered Histone 7	Protein Coding	3
110	H2BC11	H2B Clustered Histone 11	Protein Coding	3
111	H2AZ2	H2A.Z Variant Histone 2	Protein Coding	3
112	MAML1	Mastermind Like Transcriptional Coactivator 1	Protein Coding	3
113	HDAC6	Histone Deacetylase 6	Protein Coding	1
114	HDAC5	Histone Deacetylase 5	Protein Coding	1
115	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
116	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	1
117	CDK8	Cyclin Dependent Kinase 8	Protein Coding	1
118	IKZF1	IKAROS Family Zinc Finger 1	Protein Coding	1
119	TACC3	Transforming Acidic Coiled-Coil Containing Protein 3	Protein Coding	1
120	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	1
121	WWP2	WW Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	1
122	DTX2	Deltex E3 Ubiquitin Ligase 2	Protein Coding	1
123	CNTN1	Contactin 1	Protein Coding	1
124	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	1
125	MIB2	MIB E3 Ubiquitin Protein Ligase 2	Protein Coding	1
126	PTCRA	Pre T Cell Antigen Receptor Alpha	Protein Coding	1
127	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
128	DTX1	Deltex E3 Ubiquitin Ligase 1	Protein Coding	1
129	EGF	Epidermal Growth Factor	Protein Coding	1
130	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
131	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
132	FABP7	Fatty Acid Binding Protein 7	Protein Coding	1
133	FCER2	Fc Epsilon Receptor II	Protein Coding	1
134	PLXND1	Plexin D1	Protein Coding	1
135	DTX4	Deltex E3 Ubiquitin Ligase 4	Protein Coding	1
136	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	1
137	WWC1	WW And C2 Domain Containing 1	Protein Coding	1
138	NCSTN	Nicastrin	Protein Coding	1
139	HEY1	Hes Related Family BHLH Transcription Factor With YRPW Motif 1	Protein Coding	1
140	HEY2	Hes Related Family BHLH Transcription Factor With YRPW Motif 2	Protein Coding	1
141	HEYL	Hes Related Family BHLH Transcription Factor With YRPW Motif Like	Protein Coding	1
142	NBEA	Neurobeachin	Protein Coding	1
143	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
144	HDAC1	Histone Deacetylase 1	Protein Coding	1
145	HDAC2	Histone Deacetylase 2	Protein Coding	1
146	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	1
147	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
148	JAG2	Jagged Canonical Notch Ligand 2	Protein Coding	1
149	HES5	Hes Family BHLH Transcription Factor 5	Protein Coding	1
150	ARRB1	Arrestin Beta 1	Protein Coding	1
151	SMAD3	SMAD Family Member 3	Protein Coding	1
152	ARRB2	Arrestin Beta 2	Protein Coding	1
153	MDK	Midkine	Protein Coding	1
154	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
155	YBX1	Y-Box Binding Protein 1	Protein Coding	1
156	PBX1	PBX Homeobox 1	Protein Coding	1
157	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	1
158	HDAC7	Histone Deacetylase 7	Protein Coding	1
159	NEURL1B	Neuralized E3 Ubiquitin Protein Ligase 1B	Protein Coding	1
160	DLL4	Delta Like Canonical Notch Ligand 4	Protein Coding	1
161	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	1
162	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	1
163	HDAC8	Histone Deacetylase 8	Protein Coding	1
164	PSEN1	Presenilin 1	Protein Coding	1
165	PSEN2	Presenilin 2	Protein Coding	1
166	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	1
167	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	1
168	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	1
169	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	1
170	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	1
171	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	1
172	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	1
173	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	1
174	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	1
175	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	1
176	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	1
177	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	1
178	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	1
179	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	1
180	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	1
181	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	1
182	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	1
183	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	1
184	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	1
185	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	1
186	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	1
187	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	1
188	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	1
189	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	1
190	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	1
191	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	1
192	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	1
193	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	1
194	MIB1	MIB E3 Ubiquitin Protein Ligase 1	Protein Coding	1
195	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
196	RPS27A	Ribosomal Protein S27a	Protein Coding	1
197	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	1
198	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	1
199	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
200	TBL1X	Transducin Beta Like 1 X-Linked	Protein Coding	1
201	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	1
202	TLE2	TLE Family Member 2, Transcriptional Corepressor	Protein Coding	1
203	TLE3	TLE Family Member 3, Transcriptional Corepressor	Protein Coding	1
204	TLE4	TLE Family Member 4, Transcriptional Corepressor	Protein Coding	1
205	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
206	UBB	Ubiquitin B	Protein Coding	1
207	UBC	Ubiquitin C	Protein Coding	1
208	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1
209	TBL1XR1	TBL1X/Y Related 1	Protein Coding	1
210	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	1
211	HDAC11	Histone Deacetylase 11	Protein Coding	1
212	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	1
213	ITCH	Itchy E3 Ubiquitin Protein Ligase	Protein Coding	1
214	HDAC10	Histone Deacetylase 10	Protein Coding	1
215	CUL1	Cullin 1	Protein Coding	1
216	NUMB	NUMB Endocytic Adaptor Protein	Protein Coding	1
217	DLK1	Delta Like Non-Canonical Notch Ligand 1	Protein Coding	1
218	HDAC3	Histone Deacetylase 3	Protein Coding	1
219	CCNC	Cyclin C	Protein Coding	1
220	NEURL1	Neuralized E3 Ubiquitin Protein Ligase 1	Protein Coding	1
221	DNER	Delta/Notch Like EGF Repeat Containing	Protein Coding	1
222	NCOR1	Nuclear Receptor Corepressor 1	Protein Coding	1
223	NCOR2	Nuclear Receptor Corepressor 2	Protein Coding	1
224	HDAC9	Histone Deacetylase 9	Protein Coding	1
225	HDAC4	Histone Deacetylase 4	Protein Coding	1
226	DLGAP5	DLG Associated Protein 5	Protein Coding	1
227	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	1
228	RBX1	Ring-Box 1	Protein Coding	1

Disorders associated with Pre-NOTCH Expression and Processing SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Spondylocostal dysostosis	Direct
2	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12, H4C1, H4C9	6.46
3	Keratoacanthoma	Enrichment	NOTCH1, NOTCH2	6.31
4	Dowling-degos disease	Enrichment	POFUT1, POGLUT1	6.01
5	Glioma susceptibility 1	Enrichment	H3-3A, H3C1, TP53	4.73
6	Tessadori-bicknell-van haaften neurodevelopmental syndrome 1	Enrichment	H4C1, H4C3	4.30
7	Tessadori-bicknell-van haaften neurodevelopmental syndrome 2	Enrichment	H4C1, H4C11	4.30
8	Bryant-li-bhoj neurodevelopmental syndrome 2	Enrichment	H3-3A, H3-3B	4.30
9	Tessadori-bicknell-van haaften neurodevelopmental syndrome 3	Enrichment	H4C1, H4C5	3.83
10	Adams-oliver syndrome	Enrichment	DLL4, NOTCH1, RBPJ	3.81
11	Complex neurodevelopmental disorder	Enrichment	AGO1, AGO2, H4C3, H4C5, H4C9, TNRC6B	3.61
12	Neuronal intranuclear inclusion disease	Enrichment	NOTCH2NLC	3.53
13	Oculopharyngodistal myopathy 3	Enrichment	NOTCH2NLC	3.53
14	Myeloma, multiple	Enrichment	CCND1, CREBBP, H3C1, HDAC4, NCOR2, TP53	3.47
15	Hajdu-cheney syndrome	Enrichment	NOTCH2	3.35
16	Alagille syndrome 2	Enrichment	NOTCH2	3.35
17	Lateral meningocele syndrome	Enrichment	NOTCH3	3.35
18	Dowling-degos disease 4	Enrichment	POGLUT1	3.35
19	Muscular dystrophy, limb-girdle, autosomal recessive 21	Enrichment	POGLUT1	3.35
20	Dowling-degos disease 2	Enrichment	POFUT1	3.35
21	Myofibromatosis, infantile, 2	Enrichment	NOTCH3	3.35
22	Autosomal recessive limb-girdle muscular dystrophy type 2z	Enrichment	POGLUT1	3.35
23	Transient cerebral ischemia	Enrichment	NOTCH3	3.35
24	Cerebral arteriopathy, autosomal recessive, with subcortical infarcts and leukoencephalopathy 1	Enrichment	NOTCH3	3.35
25	Cyclic neutropenia	Enrichment	ELANE	3.23
26	Neutropenia, severe congenital, x-linked	Enrichment	ELANE	3.23
27	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.14
28	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.14
29	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	3.08
30	Neonatal inflammatory skin and bowel disease	Enrichment	ADAM17, EGFR	3.08
31	Tetralogy of fallot	Enrichment	FLT4, HEY2, JAG1, NOTCH1	3.06
32	Neutropenia, severe congenital, 1, autosomal dominant	Enrichment	ELANE	3.05
33	Tremor, hereditary essential, 6	Enrichment	NOTCH2NLC	3.05
34	Adams-oliver syndrome 5	Enrichment	NOTCH1	3.05
35	Infantile myofibromatosis	Enrichment	NOTCH3	3.05
36	Lipodystrophy, familial partial, type 1	Enrichment	NOTCH3	3.05
37	Depressive disorder	Enrichment	NOTCH3	3.05
38	Migraine without aura	Enrichment	NOTCH3	2.88
39	Spondylocostal dysostosis 3, autosomal recessive	Enrichment	LFNG	2.88
40	Congenital disorder of glycosylation, type iid	Enrichment	B4GALT1	2.88
41	Intellectual developmental disorder, autosomal recessive 12	Enrichment	ST3GAL3	2.88
42	Combined low ldl and fibrinogen	Enrichment	B4GALT1	2.88
43	Neurodevelopmental disorder with poor growth, absent speech, progressive ataxia, and dysmorphic facies	Enrichment	SEL1L	2.88
44	Rhabdomyolysis 2	Enrichment	ATP2A2	2.88
45	St3gal3-cdg	Enrichment	ST3GAL3	2.88
46	Autosomal dominant severe congenital neutropenia	Enrichment	ELANE	2.83
47	Lung cancer susceptibility 3	Enrichment	ACTA2, EGFR, TP53	2.83
48	Cerebrovascular disease	Enrichment	NOTCH3	2.75
49	Oculopharyngodistal myopathy 1	Enrichment	NOTCH2NLC	2.69
50	Neutropenia	Enrichment	ELANE	2.69
51	Leukemia, chronic lymphocytic	Enrichment	CCND1, TP53	2.67
52	Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1	Enrichment	NOTCH3	2.66
53	Vascular dementia	Enrichment	NOTCH3	2.66
54	Gliosarcoma	Enrichment	EGFR, TACC3, TP53	2.65
55	Acrokeratosis verruciformis	Enrichment	ATP2A2	2.58
56	Brody disease	Enrichment	ATP2A1	2.58
57	Developmental and epileptic encephalopathy 15	Enrichment	ST3GAL3	2.58
58	Neurodevelopmental disorder with hypotonia, poor growth, dysmorphic facies, and agammaglobulinemia	Enrichment	SEL1L	2.58
59	Giant cell glioblastoma	Enrichment	EGFR, TACC3, TP53	2.57
60	Hypoplastic left heart syndrome	Enrichment	NOTCH1	2.45
61	Diffuse large b-cell lymphoma	Enrichment	CREBBP, TBL1XR1, TP53	2.43
62	Darier-white disease	Enrichment	ATP2A2	2.40
63	Breast adenocarcinoma	Enrichment	AKT1, TP53	2.39
64	Stroke, ischemic	Enrichment	NOTCH3	2.35
65	Migraine with or without aura 1	Enrichment	NOTCH3	2.31
66	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.31
67	Squamous cell carcinoma, head and neck	Enrichment	EGFR, TP53	2.25
68	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	2.25
69	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	IKZF1, TP53	2.25
70	Aortic valve disease 1	Enrichment	NOTCH1	2.24
71	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	2.21
72	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2, HEY2, NOTCH1, SMAD3	2.21
73	Autoinflammatory disease	Enrichment	ELANE	2.15
74	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	2.15
75	Bone marrow failure syndrome 5	Enrichment	TP53	2.15
76	Papilloma of choroid plexus	Enrichment	TP53	2.15
77	Basal cell carcinoma 7	Enrichment	TP53	2.15
78	Hypospadias 2, x-linked	Enrichment	MAMLD1	2.15
79	Anaplastic thyroid carcinoma	Enrichment	TP53	2.15
80	Ductal carcinoma in situ	Enrichment	TP53	2.15
81	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	2.15
82	Bryant-li-bhoj neurodevelopmental syndrome 1	Enrichment	H3-3A	2.15
83	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.15
84	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.15
85	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.15
86	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.15
87	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.15
88	Choroid plexus cancer	Enrichment	TP53	2.15
89	Menke-hennekam syndrome	Enrichment	CREBBP	2.15
90	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.15
91	Lethal brain and heart developmental defects	Enrichment	SIRT6	2.15
92	46,xy ovotesticular disorder of sex development	Enrichment	MAMLD1	2.15
93	Spondylocostal dysostosis, autosomal recessive	Enrichment	LFNG	2.10
94	Adult hepatocellular carcinoma	Enrichment	EGF, TP53	2.03
95	Auditory neuropathy	Enrichment	NOTCH3	1.94
96	Connective tissue disease	Enrichment	NOTCH1	1.85
97	Adrenocortical carcinoma, hereditary	Enrichment	TP53	1.85
98	Storage pool platelet disease	Enrichment	RUNX1	1.85
99	Thumb deformity	Enrichment	CREBBP	1.85
100	Cervical cancer	Enrichment	TP53	1.85
101	Premature ovarian failure 3	Enrichment	AGO2	1.85
102	Lymphoma, hodgkin, classic	Enrichment	TP53	1.85
103	Adams-oliver syndrome 3	Enrichment	RBPJ	1.85
104	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	1.85
105	Menke-hennekam syndrome 2	Enrichment	EP300	1.85
106	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	1.85
107	Congenital fibrosarcoma	Enrichment	TP53	1.85
108	Li-fraumeni syndrome 1	Enrichment	TP53	1.85
109	Sarcoma	Enrichment	TP53	1.85
110	Cervix carcinoma	Enrichment	TP53	1.85
111	Hodgkin's lymphoma	Enrichment	TP53	1.85
112	Posterior hypospadias	Enrichment	MAMLD1	1.85
113	X-linked myotubular myopathy-abnormal genitalia syndrome	Enrichment	MAMLD1	1.85
114	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	1.85
115	Tafro syndrome	Enrichment	RUNX1	1.85
116	Colorectal cancer	Enrichment	AKT1, CCND1, EP300, FBXW7, TP53	1.81
117	Lip and oral cavity carcinoma	Enrichment	EGFR, TP53	1.78
118	Proteus syndrome	Enrichment	AKT1	1.77
119	Chondrodysplasia with platyspondyly, distinctive brachydactyly, hydrocephaly, and microphthalmia	Enrichment	HDAC6	1.77
120	Hypothyroidism, congenital, nongoitrous, 8	Enrichment	TBL1X	1.77
121	Hypomagnesemia 4, renal	Enrichment	EGF	1.77
122	Acne inversa, familial, 1	Enrichment	NCSTN	1.77
123	Memory quantitative trait locus	Enrichment	WWC1	1.77
124	Congenital myopathy 12	Enrichment	CNTN1	1.77
125	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	1.77
126	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	1.77
127	Adams-oliver syndrome 6	Enrichment	DLL4	1.77
128	Chromosome 2q37 deletion syndrome	Enrichment	HDAC4	1.77
129	Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay	Enrichment	PBX1	1.77
130	Auriculocondylar syndrome 4	Enrichment	HDAC9	1.77
131	Cornelia de lange syndrome 5	Enrichment	HDAC8	1.77
132	Stankiewicz-isidor syndrome	Enrichment	PSMD12	1.77
133	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	1.77
134	Neurodevelopmental disorder with or without early-onset generalized epilepsy	Enrichment	NBEA	1.77
135	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	1.77
136	Alzheimer disease 18	Enrichment	ADAM10	1.77
137	Autoimmune disease, multisystem, with facial dysmorphism	Enrichment	ITCH	1.77
138	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	1.77
139	Immunodeficiency 31a	Enrichment	STAT1	1.77
140	Cowden syndrome 6	Enrichment	AKT1	1.77
141	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	1.77
142	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	1.77
143	Immunodeficiency 31b	Enrichment	STAT1	1.77
144	Acne inversa, familial, 3	Enrichment	PSEN1	1.77
145	Congenital heart defects, multiple types, 7	Enrichment	FLT4	1.77
146	Muscular dystrophy, limb-girdle, autosomal recessive 27	Enrichment	JAG2	1.77
147	Immunodeficiency, common variable, 13	Enrichment	IKZF1	1.77
148	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	1.77
149	Neurodevelopmental disorder with central hypotonia and dysmorphic facies	Enrichment	HDAC4	1.77
150	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	1.77
151	Combined immunodeficiency due to dimerization defective ikaros mutation	Enrichment	IKZF1	1.77
152	Immunodeficiency 126	Enrichment	PTCRA	1.77
153	Syndromic multisystem autoimmune disease due to itch deficiency	Enrichment	ITCH	1.77
154	Early-onset combined immunodeficiency with low ig due to dominant negative ikaros mutation	Enrichment	IKZF1	1.77
155	Pash syndrome	Enrichment	NCSTN	1.77
156	Huntington's disease-like	Enrichment	PSEN2	1.77
157	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	1.77
158	Platelet disorder, familial, with associated myeloid malignancy	Enrichment	RUNX1	1.68
159	Osteogenic sarcoma	Enrichment	TP53	1.68
160	Nasopharyngeal carcinoma	Enrichment	TP53	1.68
161	Tethered spinal cord syndrome	Enrichment	CREBBP	1.68
162	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.68
163	Anaplastic astrocytoma	Enrichment	TP53	1.68
164	Squamous cell carcinoma	Enrichment	TP53	1.68
165	Adenocarcinoma	Enrichment	TP53	1.68
166	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.68
167	Bone osteosarcoma	Enrichment	TP53	1.68
168	Lessel-kreienkamp syndrome	Enrichment	AGO2	1.68
169	Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with runx1	Enrichment	RUNX1	1.68
170	Primary ovarian insufficiency	Enrichment	NOTCH2	1.59
171	Small cell cancer of the lung	Enrichment	TP53	1.55
172	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.55
173	Mantle cell lymphoma	Enrichment	CCND1	1.55
174	Lung sarcomatoid carcinoma	Enrichment	TP53	1.55
175	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.55
176	Blood platelet disease	Enrichment	RUNX1	1.55
177	Leukemia, acute myeloid	Enrichment	RUNX1, TP53	1.49
178	Lymphatic malformation 1	Enrichment	FLT4	1.48
179	Burkitt lymphoma	Enrichment	MYC	1.48
180	Intracranial hypertension, idiopathic	Enrichment	FLT4	1.48
181	Ebstein anomaly	Enrichment	CDK8	1.48
182	Alzheimer disease 3	Enrichment	PSEN1	1.48
183	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	1.48
184	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	1.48
185	Pick disease of brain	Enrichment	PSEN1	1.48
186	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	1.48
187	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	1.48
188	Moyamoya disease 5	Enrichment	ACTA2	1.48
189	Syndactyly, type iii	Enrichment	HDAC8	1.48
190	Loeys-dietz syndrome 3	Enrichment	SMAD3	1.48
191	Immunodeficiency 31c	Enrichment	STAT1	1.48
192	Diamond-blackfan anemia-like	Enrichment	IKZF1	1.48
193	Birk-aharoni syndrome	Enrichment	PSMC1	1.48
194	Spondyloepiphyseal dysplasia, nishimura type	Enrichment	WWP2	1.48
195	Cerebellar, ocular, craniofacial, and genital syndrome	Enrichment	NBEA	1.48
196	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	1.48
197	Congenital heart defects, multiple types, 9	Enrichment	PLXND1	1.48
198	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	1.48
199	Wilson-turner syndrome	Enrichment	HDAC8	1.48
200	Left ventricular noncompaction 7	Enrichment	MIB1	1.48
201	Stevens-johnson syndrome	Enrichment	IKZF1	1.48
202	Central precocious puberty	Enrichment	DLK1	1.48
203	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	1.48
204	Hereditary lymphedema i	Enrichment	FLT4	1.48
205	17q24.2 microdeletion syndrome	Enrichment	PSMD12	1.48
206	Intellectual developmental disorder with hypotonia and behavioral abnormalities	Enrichment	CDK8	1.48
207	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	PBX1	1.48
208	Renal hypoplasia, bilateral	Enrichment	PBX1	1.48
209	Submucosal cleft palate	Enrichment	UBB	1.48
210	Cleft hard palate	Enrichment	UBB	1.48
211	Von hippel-lindau syndrome	Enrichment	CCND1	1.46
212	Rhabdomyosarcoma 2	Enrichment	TP53	1.46
213	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.46
214	Lymphoma	Enrichment	TP53	1.46
215	Acute megakaryocytic leukemia	Enrichment	TP53	1.46
216	Aggressive systemic mastocytosis	Enrichment	RUNX1	1.46
217	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	RUNX1	1.46
218	Heart, malformation of	Enrichment	CDK8, JAG1	1.44
219	Li-fraumeni syndrome	Enrichment	TP53	1.38
220	Pancytopenia	Enrichment	RUNX1	1.38
221	Adrenocortical carcinoma	Enrichment	TP53	1.38
222	Hypertrichosis	Enrichment	CREBBP	1.38
223	Developmental and epileptic encephalopathy	Enrichment	ST3GAL3	1.33
224	Hepatoblastoma	Enrichment	JAG1, TP53	1.32
225	Esophageal cancer	Enrichment	TP53	1.31
226	Leukemia, chronic myeloid	Enrichment	RUNX1	1.31
227	Essential thrombocythemia	Enrichment	TP53	1.31
228	Gallbladder cancer	Enrichment	TP53	1.31
229	Alagille syndrome 1	Enrichment	JAG1	1.30
230	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.30
231	Uvula, bifid	Enrichment	UBB	1.30
232	Pierpont syndrome	Enrichment	TBL1XR1	1.30
233	Cleft soft palate	Enrichment	UBB	1.30
234	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.30
235	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.30
236	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.30
237	Precocious puberty, central, 2	Enrichment	DLK1	1.30
238	Intellectual developmental disorder, autosomal dominant 41	Enrichment	TBL1XR1	1.30
239	Melanoma of soft tissue	Enrichment	CREB1	1.30
240	Enchondromatosis	Enrichment	HIF1A	1.30
241	Thyroid hemiagenesis	Enrichment	PSMD3	1.30
242	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1, NBEA, YWHAZ	1.29
243	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.26
244	Charge syndrome	Enrichment	EP300	1.21
245	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	1.21
246	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	RUNX1	1.21
247	Primary hyperaldosteronism	Enrichment	TP53	1.21
248	Dowling-degos disease 1	Enrichment	ADAM10	1.18
249	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.18
250	Kagami-ogata syndrome	Enrichment	DLK1	1.18
251	Temple syndrome	Enrichment	DLK1	1.18
252	Aortic aneurysm	Enrichment	SMAD3	1.18
253	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	1.18
254	Genetic central precocious puberty in male	Enrichment	DLK1	1.18
255	Middle aortic syndrome	Enrichment	JAG1	1.18
256	Familial colorectal cancer	Enrichment	TP53	1.16
257	Myelodysplastic syndrome	Enrichment	TP53	1.12
258	Moebius syndrome	Enrichment	PLXND1	1.09
259	Enchondromatosis, multiple, ollier type	Enrichment	HIF1A	1.09
260	Pervasive developmental disorder	Enrichment	FBXW7	1.09
261	Aplasia cutis congenita	Enrichment	DLL4	1.09
262	Dementia	Enrichment	PSEN1	1.09
263	Persistent truncus arteriosus	Enrichment	PLXND1	1.09
264	Rare pervasive developmental disorder	Enrichment	FBXW7	1.09
265	Bladder cancer	Enrichment	EGFR, TP53	1.07
266	Heart disease	Enrichment	CREBBP	1.02
267	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.01
268	Cowden syndrome 1	Enrichment	EGFR	1.01
269	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.01
270	Moyamoya disease 1	Enrichment	ACTA2	1.01
271	Hemangioma, capillary infantile	Enrichment	FLT4	1.01
272	Patent ductus arteriosus	Enrichment	PSMC3	1.01
273	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.01
274	Lung squamous cell carcinoma	Enrichment	EGFR	1.01
275	Breast cancer	Enrichment	JUN, TP53	1.01
276	Lung cancer	Enrichment	ACTA2, EGFR	1.00
277	Polydactyly, postaxial, type a1	Enrichment	EP300	1.00
278	Corpus callosum, agenesis of	Enrichment	CREBBP	1.00
279	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.00
280	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.00
281	Rhabdomyosarcoma	Enrichment	TP53	0.97
282	Multiple enchondromatosis, maffucci type	Enrichment	HIF1A	0.95
283	Semantic dementia	Enrichment	PSEN1	0.95
284	Left ventricular noncompaction	Enrichment	MIB1, MIB2	0.93
285	Fanconi anemia, complementation group c	Enrichment	HDAC8	0.90
286	Isolated split hand-split foot malformation	Enrichment	SEM1	0.90
287	Cornelia de lange syndrome 1	Enrichment	HDAC8	0.85
288	Loeys-dietz syndrome	Enrichment	SMAD3	0.85
289	Progressive non-fluent aphasia	Enrichment	PSEN1	0.85
290	Cornelia de lange syndrome	Enrichment	HDAC8	0.85
291	Cowden syndrome	Enrichment	AKT1	0.85
292	Familial thoracic aortic aneurysm and dissection	Enrichment	SMAD3	0.85
293	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	0.85
294	Hepatocellular carcinoma	Enrichment	TP53	0.84
295	Diamond-blackfan anemia 1	Enrichment	TP53	0.82
296	Polymicrogyria	Enrichment	PSMC3	0.81
297	Scoliosis	Enrichment	CREBBP	0.80
298	Pancreatic cancer	Enrichment	TP53	0.79
299	Hereditary breast carcinoma	Enrichment	AKT1, TP53	0.77
300	Immune deficiency disease	Enrichment	IKZF1	0.77
301	Frontotemporal dementia 1	Enrichment	PSEN1	0.77
302	Leukemia, acute lymphoblastic	Enrichment	IKZF1	0.77
303	Atrial heart septal defect	Enrichment	HDAC8	0.77
304	Lung non-small cell carcinoma	Enrichment	EGFR	0.77
305	Interatrial communication	Enrichment	HDAC8	0.77
306	Meningioma	Enrichment	AKT1	0.73
307	Prostate cancer	Enrichment	TP53	0.73
308	Diaphragmatic hernia, congenital	Enrichment	CDK8	0.70
309	Acute promyelocytic leukemia	Enrichment	TBL1XR1	0.70
310	Alzheimer's disease	Enrichment	PSEN1	0.70
311	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2	0.65
312	Septopreoptic holoprosencephaly	Enrichment	DLL1	0.65
313	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	0.65
314	Diamond-blackfan anemia	Enrichment	TP53	0.65
315	Hydrocephalus, congenital, 1	Enrichment	CDK8	0.62
316	Microform holoprosencephaly	Enrichment	DLL1	0.62
317	Lobar holoprosencephaly	Enrichment	DLL1	0.62
318	Inherited cancer-predisposing syndrome	Enrichment	RUNX1, TP53	0.62
319	Ovarian cancer	Enrichment	AKT1, EGFR, TP53	0.62
320	Alzheimer disease, familial, 1	Enrichment	PSEN1	0.60
321	Alobar holoprosencephaly	Enrichment	DLL1	0.60
322	Type 2 diabetes mellitus	Enrichment	RBPJ	0.59
323	Patent foramen ovale	Enrichment	PSMC3	0.58
324	Polycystic kidney disease	Enrichment	HDAC8	0.58
325	Semilobar holoprosencephaly	Enrichment	DLL1	0.58
326	Gastric cancer	Enrichment	TP53	0.58
327	Arteriovenous malformations of the brain	Enrichment	EGFR	0.56
328	Ehlers-danlos syndrome	Enrichment	SMAD3	0.56
329	Autism spectrum disorder	Enrichment	NBEA, PBX1, TNRC6B	0.56
330	Thrombocytopenia	Enrichment	RUNX1	0.54
331	Myocardial infarction	Enrichment	PSMA6	0.51
332	Skin disease	Enrichment	NCSTN	0.51
333	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	0.49
334	Hereditary breast ovarian cancer syndrome	Enrichment	TP53	0.49
335	Microcephaly	Enrichment	EP300, HDAC8, PSMC3	0.47
336	Autism	Enrichment	CREBBP, NBEA	0.47
337	Hydrops fetalis, nonimmune	Enrichment	FLT4	0.45
338	Non-immune hydrops fetalis	Enrichment	FLT4	0.39
339	Epilepsy	Enrichment	NBEA	0.31
340	Congenital nervous system abnormality	Enrichment	CREBBP	0.28
341	Nervous system disease	Enrichment	CREBBP	0.28
342	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	0.20
343	Hereditary retinal dystrophy	Enrichment	JAG1	0.00
344	Fundus dystrophy	Enrichment	JAG1	0.00

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pre-NOTCH Expression and Processing

Pathway Network for Pre-NOTCH Expression and Processing

Pathway network for the Pre-NOTCH Expression and Processing SuperPath

Member Pathways for Pre-NOTCH Expression and Processing

Pathways in the Pre-NOTCH Expression and Processing SuperPath

Gene overlap in member pathways for Pre-NOTCH Expression and Processing SuperPath

Associated Genes for Pre-NOTCH Expression and Processing

Associated Disorders for Pre-NOTCH Expression and Processing

Disorders associated with Pre-NOTCH Expression and Processing SuperPath

STRING Interaction Network for Pre-NOTCH Expression and Processing

Sources for Pre-NOTCH Expression and Processing