Presenilin action in Notch and Wnt signaling

No Pathway Network information available for Presenilin action in Notch and Wnt signaling

Pathways in the Presenilin action in Notch and Wnt signaling SuperPath

#	Name	Source	Genes
1	Presenilin action in Notch and Wnt signaling	PubChem	ADAM10 APC APH1A APH1B AXIN1 BTRC CCND1 CREBBP CSNK1A1 CSNK2A1 CTBP1 CTNNB1 DKK1 DKK2 DLL1 DTX1 DVL1 FBXW11 FOS FRAT1 FZD1 GSK3B HDAC1 HNF1A JUN KREMEN2 LRP6 MAP3K7 MAPK1 MAPK3 MYC NCSTN NEDD4 NKD1 NLK NOTCH1 PPARD PPP2R5D PSEN1 PSENEN RBPJ TAB1 TLE1 TLE5 WIF1 WNT1 (see all 46) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DTX1	Deltex E3 Ubiquitin Ligase 1	Protein Coding	1
2	FRAT1	FRAT Regulator Of Wnt Signaling Pathway 1	Protein Coding	1
3	NKD1	NKD Inhibitor Of Wnt Signaling Pathway 1	Protein Coding	1
4	DKK2	Dickkopf Wnt Signaling Pathway Inhibitor 2	Protein Coding	1
5	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	1
6	KREMEN2	Kringle Containing Transmembrane Protein 2	Protein Coding	1
7	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	1
8	WNT1	Wnt Family Member 1	Protein Coding	1
9	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
10	FZD1	Frizzled Class Receptor 1	Protein Coding	1
11	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
12	FBXW11	F-Box And WD Repeat Domain Containing 11	Protein Coding	1
13	TAB1	TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1	Protein Coding	1
14	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
15	NLK	Nemo Like Kinase	Protein Coding	1
16	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	1
17	WIF1	Wnt Inhibitory Factor 1	Protein Coding	1
18	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
19	LRP6	LDL Receptor Related Protein 6	Protein Coding	1
20	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
21	TLE5	TLE Family Member 5, Transcriptional Modulator	Protein Coding	1
22	CSNK1A1	Casein Kinase 1 Alpha 1	Protein Coding	1
23	AXIN1	Axin 1	Protein Coding	1
24	DLL1	Delta Like Canonical Notch Ligand 1	Protein Coding	1
25	NOTCH1	Notch Receptor 1	Protein Coding	1
26	CCND1	Cyclin D1	Protein Coding	1
27	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
28	NEDD4	NEDD4 E3 Ubiquitin Protein Ligase	Protein Coding	1
29	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
30	PPARD	Peroxisome Proliferator Activated Receptor Delta	Protein Coding	1
31	PSEN1	Presenilin 1	Protein Coding	1
32	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	1
33	CTNNB1	Catenin Beta 1	Protein Coding	1
34	CTBP1	C-Terminal Binding Protein 1	Protein Coding	1
35	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
36	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
37	ADAM10	ADAM Metallopeptidase Domain 10	Protein Coding	1
38	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	1
39	NCSTN	Nicastrin	Protein Coding	1
40	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
41	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
42	PPP2R5D	Protein Phosphatase 2 Regulatory Subunit B''Delta	Protein Coding	1
43	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	1
44	HDAC1	Histone Deacetylase 1	Protein Coding	1
45	HNF1A	HNF1 Homeobox A	Protein Coding	1
46	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1

Disorders associated with Presenilin action in Notch and Wnt signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	4.47
2	Osteoporosis, juvenile	Enrichment	DKK1, WNT1	4.47
3	Desmoid tumor	Enrichment	APC, CTNNB1	4.47
4	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1	4.27
5	Craniopharyngioma	Enrichment	APC, CTNNB1	4.17
6	Adams-oliver syndrome	Enrichment	NOTCH1, RBPJ	3.63
7	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	3.40
8	Medulloblastoma	Enrichment	APC, CTNNB1	3.00
9	Polycystic liver disease	Enrichment	CTNNB1, LRP6	2.83
10	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, LRP6	2.83
11	Breast cancer	Enrichment	APC, HNF1A, JUN	2.68
12	Hepatoblastoma	Enrichment	APC, CTNNB1	2.64
13	Colorectal cancer	Enrichment	APC, CCND1, CTNNB1	2.50
14	Chiari malformation type i	Enrichment	DKK1	2.47
15	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.47
16	Hepatic adenomas, familial	Enrichment	HNF1A	2.47
17	Acne inversa, familial, 1	Enrichment	NCSTN	2.47
18	Tooth agenesis, selective, 7	Enrichment	LRP6	2.47
19	Caudal duplication anomaly	Enrichment	AXIN1	2.47
20	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.47
21	Exudative vitreoretinopathy 8	Enrichment	LRP6	2.47
22	Noonan syndrome 13	Enrichment	MAPK1	2.47
23	Neurodevelopmental, jaw, eye, and digital syndrome	Enrichment	FBXW11	2.47
24	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	2.47
25	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.47
26	Alzheimer disease 18	Enrichment	ADAM10	2.47
27	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.47
28	Reticulate acropigmentation of kitamura	Enrichment	ADAM10	2.47
29	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.47
30	Type 1 diabetes mellitus 20	Enrichment	HNF1A	2.47
31	Acne inversa, familial, 3	Enrichment	PSEN1	2.47
32	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.47
33	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.47
34	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.47
35	Adenoid ameloblastoma	Enrichment	CTNNB1	2.47
36	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.47
37	Familial adenomatous polyposis	Enrichment	APC	2.47
38	Menke-hennekam syndrome	Enrichment	CREBBP	2.47
39	Gardner syndrome	Enrichment	APC	2.47
40	5q22 microdeletion syndrome	Enrichment	APC	2.47
41	Pash syndrome	Enrichment	NCSTN	2.47
42	Attenuated familial adenomatous polyposis	Enrichment	APC	2.47
43	Microcystic stromal tumor	Enrichment	CTNNB1	2.47
44	Ovarian cancer	Enrichment	APC, CTNNB1, HNF1A	2.32
45	Congenital nervous system abnormality	Enrichment	CREBBP, CTNNB1, PSEN1	2.26
46	Nervous system disease	Enrichment	CREBBP, CTNNB1, PSEN1	2.26
47	Burkitt lymphoma	Enrichment	MYC	2.17
48	Thumb deformity	Enrichment	CREBBP	2.17
49	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.17
50	Alzheimer disease 3	Enrichment	PSEN1	2.17
51	Pick disease of brain	Enrichment	PSEN1	2.17
52	Osteogenesis imperfecta, type xv	Enrichment	WNT1	2.17
53	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.17
54	Houge-janssens syndrome 1	Enrichment	PPP2R5D	2.17
55	Adams-oliver syndrome 3	Enrichment	RBPJ	2.17
56	Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome	Enrichment	CTBP1	2.17
57	Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures	Enrichment	DLL1	2.17
58	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.17
59	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.17
60	Periampullary adenoma	Enrichment	APC	2.17
61	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	2.17
62	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.17
63	Hyperinsulinism due to hnf1a deficiency	Enrichment	HNF1A	2.17
64	Teratoma	Enrichment	CTNNB1	2.17
65	Type 2 diabetes mellitus	Enrichment	HNF1A, RBPJ	2.05
66	Alzheimer disease 4	Enrichment	PSEN1	1.99
67	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.99
68	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.99
69	Anus, imperforate	Enrichment	CTNNB1	1.99
70	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.99
71	Keratoderma-ichthyosis-deafness syndrome, autosomal recessive	Enrichment	HNF1A	1.99
72	Tethered spinal cord syndrome	Enrichment	CREBBP	1.99
73	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	MYC	1.99
74	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.99
75	Chromophobe renal cell carcinoma	Enrichment	HNF1A	1.99
76	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.99
77	Colon adenocarcinoma	Enrichment	APC	1.99
78	Keratoacanthoma	Enrichment	NOTCH1	1.99
79	Apc-associated polyposis conditions	Enrichment	APC	1.99
80	Dowling-degos disease 1	Enrichment	ADAM10	1.87
81	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1	1.87
82	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.87
83	Maturity-onset diabetes of the young, type 3	Enrichment	HNF1A	1.87
84	Pilomatrixoma	Enrichment	CTNNB1	1.87
85	Alazami syndrome	Enrichment	CTNNB1	1.87
86	Congenital generalized lipodystrophy	Enrichment	FOS	1.87
87	Mantle cell lymphoma	Enrichment	CCND1	1.87
88	Dowling-degos disease	Enrichment	PSENEN	1.87
89	Orofacial cleft	Enrichment	LRP6	1.87
90	Autosomal dominant robinow syndrome	Enrichment	DVL1	1.87
91	Orofacial clefting syndrome	Enrichment	LRP6	1.87
92	Clear cell papillary renal cell carcinoma	Enrichment	HNF1A	1.87
93	Myeloma, multiple	Enrichment	CCND1, CREBBP	1.81
94	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	1.77
95	Von hippel-lindau syndrome	Enrichment	CCND1	1.77
96	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1	1.77
97	Familial adenomatous polyposis 1	Enrichment	APC	1.77
98	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1	1.77
99	Histiocytoid hemangioma	Enrichment	FOS	1.77
100	Dementia	Enrichment	PSEN1	1.77
101	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.70
102	Wolf-hirschhorn syndrome	Enrichment	CTBP1	1.70
103	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	PSEN1	1.70
104	Rubinstein-taybi syndrome 1	Enrichment	CREBBP	1.70
105	Type 1 diabetes mellitus	Enrichment	HNF1A	1.70
106	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP	1.70
107	Autosomal recessive robinow syndrome	Enrichment	DVL1	1.70
108	Adrenocortical carcinoma	Enrichment	CTNNB1	1.70
109	Clear cell renal cell carcinoma	Enrichment	HNF1A	1.70
110	Hypertrichosis	Enrichment	CREBBP	1.70
111	Semantic dementia	Enrichment	PSEN1	1.63
112	Gallbladder cancer	Enrichment	CTNNB1	1.63
113	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1	1.63
114	Exudative vitreoretinopathy	Enrichment	CTNNB1	1.57
115	Hypoplastic left heart syndrome	Enrichment	NOTCH1	1.57
116	Isolated split hand-split foot malformation	Enrichment	BTRC	1.57
117	Progressive non-fluent aphasia	Enrichment	PSEN1	1.52
118	Colonic benign neoplasm	Enrichment	APC	1.52
119	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.52
120	Leukemia, chronic lymphocytic	Enrichment	CCND1	1.48
121	Frontotemporal dementia 1	Enrichment	PSEN1	1.44
122	Diabetes mellitus	Enrichment	HNF1A	1.44
123	Specific learning disability	Enrichment	MAPK1	1.44
124	Digeorge syndrome	Enrichment	HNF1A	1.40
125	Aortic valve disease 1	Enrichment	NOTCH1	1.36
126	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.36
127	Alzheimer's disease	Enrichment	PSEN1	1.36
128	Osteoporosis	Enrichment	WNT1	1.33
129	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.33
130	Heart disease	Enrichment	CREBBP	1.33
131	Renal cell carcinoma, nonpapillary	Enrichment	HNF1A	1.30
132	Corpus callosum, agenesis of	Enrichment	CREBBP	1.30
133	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.30
134	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.30
135	Rare genetic intellectual disability	Enrichment	CREBBP	1.30
136	Septopreoptic holoprosencephaly	Enrichment	DLL1	1.30
137	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.30
138	Midline interhemispheric variant of holoprosencephaly	Enrichment	DLL1	1.30
139	Microform holoprosencephaly	Enrichment	DLL1	1.28
140	Lobar holoprosencephaly	Enrichment	DLL1	1.28
141	Alzheimer disease, familial, 1	Enrichment	PSEN1	1.25
142	Alobar holoprosencephaly	Enrichment	DLL1	1.25
143	Heart, malformation of	Enrichment	MAPK1	1.23
144	Semilobar holoprosencephaly	Enrichment	DLL1	1.23
145	Diffuse large b-cell lymphoma	Enrichment	CREBBP	1.20
146	Microcephaly	Enrichment	CTNNB1, MAPK1	1.19
147	Maturity-onset diabetes of the young	Enrichment	HNF1A	1.18
148	Complex neurodevelopmental disorder	Enrichment	CSNK2A1, FBXW11	1.18
149	Tooth agenesis	Enrichment	LRP6	1.14
150	Skin disease	Enrichment	NCSTN	1.14
151	Brittle bone disorder	Enrichment	WNT1	1.12
152	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYC	1.12
153	Scoliosis	Enrichment	CREBBP	1.11
154	Tetralogy of fallot	Enrichment	NOTCH1	1.07
155	Bladder cancer	Enrichment	CTNNB1	1.03
156	Connective tissue disease	Enrichment	NOTCH1	0.99
157	Gastric cancer	Enrichment	APC	0.87
158	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	0.86
159	Hereditary breast carcinoma	Enrichment	APC	0.86
160	Autosomal dominant non-syndromic intellectual disability	Enrichment	DLL1	0.81
161	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1	0.78
162	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PSEN1	0.75
163	Autism	Enrichment	CREBBP	0.66
164	Autism spectrum disorder	Enrichment	CSNK2A1	0.51
165	Inherited cancer-predisposing syndrome	Enrichment	APC	0.44

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Presenilin action in Notch and Wnt signaling

Pathway Network for Presenilin action in Notch and Wnt signaling

Member Pathways for Presenilin action in Notch and Wnt signaling

Pathways in the Presenilin action in Notch and Wnt signaling SuperPath

Associated Genes for Presenilin action in Notch and Wnt signaling

Associated Disorders for Presenilin action in Notch and Wnt signaling

Disorders associated with Presenilin action in Notch and Wnt signaling SuperPath

STRING Interaction Network for Presenilin action in Notch and Wnt signaling

Sources for Presenilin action in Notch and Wnt signaling