Presynaptic function of Kainate receptors

Pathway network for the Presynaptic function of Kainate receptors SuperPath

Sources:

Reactome
QIAGEN

Pathways in the Presynaptic function of Kainate receptors SuperPath

#	Name	Source	Genes
1	Presynaptic function of Kainate receptors	Reactome	GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIK3 PLCB1 PLCB2 PLCB3 (see all 21) (see less)
2	Class B/2 (Secretin family receptors)	Reactome	ADCYAP1 ADCYAP1R1 ADGRE1 ADGRE2 ADGRE3 ADGRE5 ADM ADM2 CALCA CALCB CALCR CALCRL CD55 CRH CRHBP CRHR1 CRHR2 DHH FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GCG GCGR GHRH GHRHR GIP GIPR GLP1R GLP2R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 IAPP IHH PTCH1 PTCH2 PTH PTH1R PTH2 PTH2R PTHLH RAMP1 RAMP2 RAMP3 SCT SCTR SHH SMO UCN UCN2 UCN3 VIP VIPR1 VIPR2 WNT1 WNT10A WNT10B WNT11 WNT16 WNT2 WNT2B WNT3 WNT3A WNT4 WNT5A WNT6 WNT7A WNT7B WNT8A WNT8B WNT9A WNT9B (see all 94) (see less)
3	Glucagon-type ligand receptors	Reactome	ADCYAP1 ADCYAP1R1 GCG GCGR GHRH GHRHR GIP GIPR GLP1R GLP2R GNAS GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 SCT SCTR VIP VIPR1 VIPR2 (see all 33) (see less)
4	Activation of kainate receptors upon glutamate binding	Reactome	CALM1 CALM2 CALM3 DLG1 DLG3 DLG4 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 NCALD PLCB1 PLCB2 PLCB3 (see all 32) (see less)
5	G beta:gamma signalling through PLC beta	Reactome	GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 PLCB1 PLCB2 PLCB3 (see all 20) (see less)
6	G-Protein Signaling through Tubby Protein	QIAGEN	ABL1 ABL2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG2 GNG3 GNG4 INSR JAK2 PLCB1 PLCB2 PLCB3 PLCB4 PLCG1 PLCG2 TUB (see all 19) (see less)
7	Activation of Ca-permeable Kainate Receptor	Reactome	CALM1 CALM2 CALM3 DLG1 DLG3 DLG4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 NCALD (see all 12) (see less)
8	Ionotropic activity of kainate receptors	Reactome	CALM1 CALM2 CALM3 DLG1 DLG3 DLG4 GRIK1 GRIK2 GRIK3 GRIK4 GRIK5 NCALD (see all 12) (see less)
9	Calcitonin-like ligand receptors	Reactome	ADM ADM2 CALCA CALCB CALCR CALCRL IAPP RAMP1 RAMP2 RAMP3 (see all 10) (see less)
10	Activation of Na-permeable kainate receptors	Reactome	GRIK1 GRIK2

Gene overlap in member pathways for Presynaptic function of Kainate receptors SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GNB5	G Protein Subunit Beta 5	Protein Coding	6
2	GNB1	G Protein Subunit Beta 1	Protein Coding	6
3	GNB2	G Protein Subunit Beta 2	Protein Coding	6
4	GNB3	G Protein Subunit Beta 3	Protein Coding	6
5	GNG3	G Protein Subunit Gamma 3	Protein Coding	6
6	GNG4	G Protein Subunit Gamma 4	Protein Coding	6
7	GNG2	G Protein Subunit Gamma 2	Protein Coding	6
8	GNB4	G Protein Subunit Beta 4	Protein Coding	6
9	GNG5	G Protein Subunit Gamma 5	Protein Coding	5
10	GNG7	G Protein Subunit Gamma 7	Protein Coding	5
11	GNG10	G Protein Subunit Gamma 10	Protein Coding	5
12	GNG11	G Protein Subunit Gamma 11	Protein Coding	5
13	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	5
14	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	5
15	GNG13	G Protein Subunit Gamma 13	Protein Coding	5
16	GNG12	G Protein Subunit Gamma 12	Protein Coding	5
17	GNG8	G Protein Subunit Gamma 8	Protein Coding	5
18	PLCB1	Phospholipase C Beta 1	Protein Coding	4
19	GRIK3	Glutamate Ionotropic Receptor Kainate Type Subunit 3	Protein Coding	4
20	PLCB2	Phospholipase C Beta 2	Protein Coding	4
21	PLCB3	Phospholipase C Beta 3	Protein Coding	4
22	GRIK1	Glutamate Ionotropic Receptor Kainate Type Subunit 1	Protein Coding	4
23	GRIK2	Glutamate Ionotropic Receptor Kainate Type Subunit 2	Protein Coding	4
24	DLG1	Discs Large MAGUK Scaffold Protein 1	Protein Coding	3
25	DLG3	Discs Large MAGUK Scaffold Protein 3	Protein Coding	3
26	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	3
27	GRIK4	Glutamate Ionotropic Receptor Kainate Type Subunit 4	Protein Coding	3
28	GRIK5	Glutamate Ionotropic Receptor Kainate Type Subunit 5	Protein Coding	3
29	CALM1	Calmodulin 1	Protein Coding	3
30	CALM2	Calmodulin 2	Protein Coding	3
31	CALM3	Calmodulin 3	Protein Coding	3
32	NCALD	Neurocalcin Delta	Protein Coding	3
33	CALCRL	Calcitonin Receptor Like Receptor	Protein Coding	2
34	RAMP2	Receptor Activity Modifying Protein 2	Protein Coding	2
35	RAMP1	Receptor Activity Modifying Protein 1	Protein Coding	2
36	RAMP3	Receptor Activity Modifying Protein 3	Protein Coding	2
37	ADCYAP1	Adenylate Cyclase Activating Polypeptide 1	Protein Coding	2
38	ADCYAP1R1	ADCYAP Receptor Type I	Protein Coding	2
39	ADM	Adrenomedullin	Protein Coding	2
40	GCG	Glucagon	Protein Coding	2
41	GCGR	Glucagon Receptor	Protein Coding	2
42	GHRH	Growth Hormone Releasing Hormone	Protein Coding	2
43	GHRHR	Growth Hormone Releasing Hormone Receptor	Protein Coding	2
44	GIP	Gastric Inhibitory Polypeptide	Protein Coding	2
45	GIPR	Gastric Inhibitory Polypeptide Receptor	Protein Coding	2
46	GLP1R	Glucagon Like Peptide 1 Receptor	Protein Coding	2
47	GNAS	GNAS Complex Locus	Protein Coding	2
48	IAPP	Islet Amyloid Polypeptide	Protein Coding	2
49	SCT	Secretin	Protein Coding	2
50	SCTR	Secretin Receptor	Protein Coding	2
51	VIP	Vasoactive Intestinal Peptide	Protein Coding	2
52	VIPR1	Vasoactive Intestinal Peptide Receptor 1	Protein Coding	2
53	VIPR2	Vasoactive Intestinal Peptide Receptor 2	Protein Coding	2
54	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	2
55	CALCB	Calcitonin Related Polypeptide Beta	Protein Coding	2
56	CALCR	Calcitonin Receptor	Protein Coding	2
57	ADM2	Adrenomedullin 2	Protein Coding	2
58	GLP2R	Glucagon Like Peptide 2 Receptor	Protein Coding	2
59	FZD10	Frizzled Class Receptor 10	Protein Coding	1
60	PTH2	Parathyroid Hormone 2	Protein Coding	1
61	UCN3	Urocortin 3	Protein Coding	1
62	CRH	Corticotropin Releasing Hormone	Protein Coding	1
63	CRHBP	Corticotropin Releasing Hormone Binding Protein	Protein Coding	1
64	CRHR1	Corticotropin Releasing Hormone Receptor 1	Protein Coding	1
65	CRHR2	Corticotropin Releasing Hormone Receptor 2	Protein Coding	1
66	CD55	CD55 Molecule (Cromer Blood Group)	Protein Coding	1
67	ADGRE1	Adhesion G Protein-Coupled Receptor E1	Protein Coding	1
68	FZD2	Frizzled Class Receptor 2	Protein Coding	1
69	ADGRE2	Adhesion G Protein-Coupled Receptor E2	Protein Coding	1
70	IHH	Indian Hedgehog Signaling Molecule	Protein Coding	1
71	DHH	Desert Hedgehog Signaling Molecule	Protein Coding	1
72	WNT16	Wnt Family Member 16	Protein Coding	1
73	WNT4	Wnt Family Member 4	Protein Coding	1
74	PTCH1	Patched 1	Protein Coding	1
75	PTH	Parathyroid Hormone	Protein Coding	1
76	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	1
77	PTH1R	Parathyroid Hormone 1 Receptor	Protein Coding	1
78	PTH2R	Parathyroid Hormone 2 Receptor	Protein Coding	1
79	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	1
80	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	1
81	UCN	Urocortin	Protein Coding	1
82	WNT1	Wnt Family Member 1	Protein Coding	1
83	WNT2	Wnt Family Member 2	Protein Coding	1
84	WNT3	Wnt Family Member 3	Protein Coding	1
85	WNT5A	Wnt Family Member 5A	Protein Coding	1
86	WNT6	Wnt Family Member 6	Protein Coding	1
87	WNT7A	Wnt Family Member 7A	Protein Coding	1
88	WNT7B	Wnt Family Member 7B	Protein Coding	1
89	WNT8A	Wnt Family Member 8A	Protein Coding	1
90	WNT8B	Wnt Family Member 8B	Protein Coding	1
91	WNT10B	Wnt Family Member 10B	Protein Coding	1
92	WNT11	Wnt Family Member 11	Protein Coding	1
93	WNT2B	Wnt Family Member 2B	Protein Coding	1
94	WNT9A	Wnt Family Member 9A	Protein Coding	1
95	WNT9B	Wnt Family Member 9B	Protein Coding	1
96	FZD5	Frizzled Class Receptor 5	Protein Coding	1
97	FZD3	Frizzled Class Receptor 3	Protein Coding	1
98	WNT10A	Wnt Family Member 10A	Protein Coding	1
99	FZD1	Frizzled Class Receptor 1	Protein Coding	1
100	FZD4	Frizzled Class Receptor 4	Protein Coding	1
101	FZD6	Frizzled Class Receptor 6	Protein Coding	1
102	FZD7	Frizzled Class Receptor 7	Protein Coding	1
103	FZD8	Frizzled Class Receptor 8	Protein Coding	1
104	FZD9	Frizzled Class Receptor 9	Protein Coding	1
105	ADGRE3	Adhesion G Protein-Coupled Receptor E3	Protein Coding	1
106	PTCH2	Patched 2	Protein Coding	1
107	WNT3A	Wnt Family Member 3A	Protein Coding	1
108	UCN2	Urocortin 2	Protein Coding	1
109	ADGRE5	Adhesion G Protein-Coupled Receptor E5	Protein Coding	1
110	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
111	ABL2	ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase	Protein Coding	1
112	INSR	Insulin Receptor	Protein Coding	1
113	JAK2	Janus Kinase 2	Protein Coding	1
114	PLCB4	Phospholipase C Beta 4	Protein Coding	1
115	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
116	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
117	TUB	TUB Bipartite Transcription Factor	Protein Coding	1

Disorders associated with Presynaptic function of Kainate receptors SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	7.53
2	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	5.67
3	Cerebral visual impairment	Enrichment	GNB1, GRIK2	5.27
4	Pseudohypoparathyroidism	Enrichment	GNAS, PTH1R	4.32
5	Brachydactyly, type e1	Enrichment	PTH1R, PTHLH	3.85
6	Osteoporosis, juvenile	Enrichment	WNT1, WNT3A	3.85
7	Neurodevelopmental disorder with impaired language and ataxia and with or without seizures	Enrichment	GRIK2	3.83
8	Intellectual developmental disorder, autosomal recessive 6	Enrichment	GRIK2	3.83
9	Polydactyly, preaxial ii	Enrichment	PTCH1, SHH	3.55
10	Robinow syndrome, autosomal dominant 1	Enrichment	FZD2, WNT5A	3.55
11	Autosomal dominant robinow syndrome	Enrichment	FZD2, WNT5A	3.55
12	Long qt syndrome	Enrichment	CALM1, CALM2	3.48
13	Macs syndrome	Enrichment	PTCH1, SHH, WNT7B	3.47
14	Robinow syndrome, autosomal recessive 1	Enrichment	FZD2, WNT5A	3.33
15	Basal cell nevus syndrome 1	Enrichment	PTCH1, PTCH2	3.15
16	Basal cell carcinoma 1	Enrichment	PTCH1, PTCH2	3.15
17	Autosomal recessive robinow syndrome	Enrichment	FZD2, WNT5A	3.15
18	Long qt syndrome 16	Enrichment	CALM3	3.05
19	Long qt syndrome 15	Enrichment	CALM2	3.05
20	Donohue syndrome	Enrichment	INSR	2.85
21	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	2.85
22	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	2.85
23	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	2.85
24	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	2.85
25	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.85
26	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.85
27	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.85
28	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	2.85
29	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.85
30	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	2.85
31	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.85
32	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	2.85
33	Sick sinus syndrome 4	Enrichment	GNB2	2.85
34	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.85
35	Lymphatic malformation 8	Enrichment	CALCRL	2.83
36	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.75
37	Long qt syndrome 14	Enrichment	CALM1	2.75
38	Intellectual developmental disorder, x-linked 90	Enrichment	DLG3	2.75
39	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	2.75
40	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.61
41	Osseous heteroplasia, progressive	Enrichment	GNAS	2.61
42	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.61
43	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.61
44	Disorders of gnas inactivation	Enrichment	GNAS	2.61
45	Schizophrenia 16	Enrichment	VIPR2	2.61
46	Mahvash disease	Enrichment	GCGR	2.61
47	Isolated growth hormone deficiency, type iv	Enrichment	GHRHR	2.61
48	Monostotic fibrous dysplasia	Enrichment	GNAS	2.61
49	Mazabraud syndrome	Enrichment	GNAS	2.61
50	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	2.58
51	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	2.58
52	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	2.58
53	Dlg4-related synaptopathy	Enrichment	DLG4	2.58
54	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	2.55
55	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	2.55
56	Thrombocythemia 3	Enrichment	JAK2	2.55
57	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	2.55
58	Ocular melanoma	Enrichment	PLCB4	2.55
59	Retinal dystrophy and obesity	Enrichment	TUB	2.55
60	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	2.55
61	Polycythemia	Enrichment	JAK2	2.55
62	Hypereosinophilic syndrome	Enrichment	JAK2	2.55
63	Bone mineral density quantitative trait locus 15	Enrichment	CALCR	2.53
64	Complex neurodevelopmental disorder	Enrichment	DLG4, GNB2, GRIK2	2.52
65	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4	2.45
66	Osteoporosis	Enrichment	CALCR, WNT1	2.39
67	Medulloblastoma	Enrichment	PTCH1, PTCH2	2.39
68	Polycythemia vera	Enrichment	JAK2	2.38
69	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK2	2.38
70	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	2.38
71	Septopreoptic holoprosencephaly	Enrichment	PTCH1, SHH	2.33
72	Midline interhemispheric variant of holoprosencephaly	Enrichment	PTCH1, SHH	2.33
73	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.31
74	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.31
75	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.31
76	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.31
77	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	2.28
78	Microform holoprosencephaly	Enrichment	PTCH1, SHH	2.27
79	Lobar holoprosencephaly	Enrichment	PTCH1, SHH	2.27
80	Erythrocytosis, familial, 1	Enrichment	JAK2	2.25
81	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	2.25
82	Budd-chiari syndrome	Enrichment	JAK2	2.25
83	Auriculocondylar syndrome 1	Enrichment	PLCB4	2.25
84	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	2.25
85	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	2.25
86	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1	2.25
87	Familial sick sinus syndrome	Enrichment	GNB2	2.25
88	Alobar holoprosencephaly	Enrichment	PTCH1, SHH	2.22
89	Semilobar holoprosencephaly	Enrichment	PTCH1, SHH	2.17
90	Holoprosencephaly 3	Enrichment	SHH	2.16
91	Vibratory urticaria	Enrichment	ADGRE2	2.16
92	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	2.16
93	Mullerian aplasia and hyperandrogenism	Enrichment	WNT4	2.16
94	46,xy sex reversal 7	Enrichment	DHH	2.16
95	Curry-jones syndrome	Enrichment	SMO	2.16
96	46,xx sex reversal with dysgenesis of kidneys, adrenals, and lungs	Enrichment	WNT4	2.16
97	Schilbach-rott syndrome	Enrichment	PTCH1	2.16
98	Omodysplasia 2	Enrichment	FZD2	2.16
99	Microphthalmia/coloboma 5	Enrichment	SHH	2.16
100	Split-hand/foot malformation 6	Enrichment	WNT10B	2.16
101	Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy	Enrichment	CD55	2.16
102	Blood group, cromer system	Enrichment	CD55	2.16
103	Tooth agenesis, selective, 8	Enrichment	WNT10B	2.16
104	Diarrhea 9	Enrichment	WNT2B	2.16
105	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.16
106	Acrocapitofemoral dysplasia	Enrichment	IHH	2.16
107	Santos syndrome	Enrichment	WNT7A	2.16
108	Brachydactyly, type e2	Enrichment	PTHLH	2.16
109	Microphthalmia/coloboma 11	Enrichment	FZD5	2.16
110	Turner syndrome	Enrichment	PTCH1	2.16
111	Protein-losing enteropathy	Enrichment	CD55	2.16
112	Monosomy 9q22.3	Enrichment	PTCH1	2.16
113	Autosomal dominant preaxial polydactyly-upperback hypertrichosis syndrome	Enrichment	SHH	2.16
114	Myeloproliferative neoplasm	Enrichment	JAK2	2.16
115	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	2.15
116	Mccune-albright syndrome	Enrichment	GNAS	2.14
117	Isolated growth hormone deficiency, type ib	Enrichment	GHRHR	2.14
118	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.14
119	Melanoma, uveal	Enrichment	PLCB4	2.08
120	46,xy disorder of sex development	Enrichment	INSR	2.08
121	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIK2	2.07
122	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	2.01
123	Myelofibrosis	Enrichment	JAK2	2.01
124	Leukemia, chronic myeloid	Enrichment	ABL1	2.01
125	Essential thrombocythemia	Enrichment	JAK2	2.01
126	Moyamoya angiopathy	Enrichment	ABL1	2.01
127	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1	2.01
128	Microphthalmia	Enrichment	PTCH1, WNT7B	2.00
129	Tooth agenesis	Enrichment	WNT10A, WNT10B	2.00
130	Hypothyroidism	Enrichment	GNB1	1.95
131	Cleft lip/palate	Enrichment	DLG1	1.91
132	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	1.90
133	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.90
134	Microcephaly	Enrichment	ABL1, GNB1	1.90
135	Failure of tooth eruption, primary	Enrichment	PTH1R	1.86
136	Hypoparathyroidism, familial isolated, 1	Enrichment	PTH	1.86
137	Tooth agenesis, selective, 4	Enrichment	WNT10A	1.86
138	Metaphyseal chondrodysplasia, jansen type	Enrichment	PTH1R	1.86
139	Pallister-hall-like syndrome	Enrichment	SMO	1.86
140	Schopf-schulz-passarge syndrome	Enrichment	WNT10A	1.86
141	Chondrodysplasia, blomstrand type	Enrichment	PTH1R	1.86
142	Ulna and fibula, absence of, with severe limb deficiency	Enrichment	WNT7A	1.86
143	Bladder exstrophy and epispadias complex	Enrichment	WNT3	1.86
144	Odontoonychodermal dysplasia	Enrichment	WNT10A	1.86
145	46,xy gonadal dysgenesis with minifascicular neuropathy	Enrichment	DHH	1.86
146	Eiken syndrome	Enrichment	PTH1R	1.86
147	Tetraamelia syndrome 1	Enrichment	WNT3	1.86
148	Osteogenesis imperfecta, type xv	Enrichment	WNT1	1.86
149	Solitary median maxillary central incisor	Enrichment	SHH	1.86
150	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	1.86
151	Fibular aplasia or hypoplasia, femoral bowing, and poly-, syn-, and oligodactyly	Enrichment	WNT7A	1.86
152	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	1.86
153	Isolated radial hemimelia	Enrichment	SHH	1.86
154	Commissural facial cleft	Enrichment	PTCH2	1.86
155	Sudden infant death syndrome	Enrichment	CALM2	1.83
156	Leukemia, acute lymphoblastic	Enrichment	GNB1	1.82
157	Myelodysplastic syndrome	Enrichment	GNB1	1.82
158	Lip and oral cavity carcinoma	Enrichment	ABL1	1.78
159	Brachydactyly	Enrichment	GNAS	1.77
160	Hirschsprung disease 1	Enrichment	IHH, SMO	1.77
161	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.71
162	Non-immune hydrops fetalis	Enrichment	CALCRL, FZD6	1.71
163	Heart disease	Enrichment	ABL1	1.71
164	Brachydactyly, type a1	Enrichment	IHH	1.69
165	Syndactyly, type iv	Enrichment	SHH	1.69
166	Mullerian duct aplasia, unilateral renal agenesis, and cervicothoracic somite anomalies	Enrichment	WNT4	1.69
167	Microphthalmia, syndromic 9	Enrichment	WNT7B	1.69
168	Tooth agenesis, selective, 2	Enrichment	WNT10A	1.69
169	Holoprosencephaly 7	Enrichment	PTCH1	1.69
170	Familial isolated hypoparathyroidism	Enrichment	PTH	1.69
171	Nail disease	Enrichment	FZD6	1.69
172	Hypoplastic or aplastic tibia with polydactyly	Enrichment	SHH	1.69
173	Tetraamelia syndrome	Enrichment	WNT3	1.69
174	Mpv17-related mitochondrial dna maintenance defect	Enrichment	UCN	1.69
175	Primary hyperaldosteronism	Enrichment	GNAS	1.66
176	Hypertension, essential	Enrichment	GNB3	1.63
177	Cleft palate, isolated	Enrichment	GNB1	1.63
178	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	WNT10A	1.56
179	Mitochondrial dna depletion syndrome 6	Enrichment	UCN	1.56
180	Schizencephaly	Enrichment	SHH	1.56
181	Charcot-marie-tooth disease, axonal, type 2ee	Enrichment	UCN	1.56
182	Ectodermal dysplasia	Enrichment	WNT10A	1.56
183	Retinopathy of prematurity	Enrichment	FZD4	1.56
184	Eyelid coloboma	Enrichment	FZD5	1.56
185	Primary hyperparathyroidism	Enrichment	PTH	1.56
186	Lens coloboma	Enrichment	FZD5	1.56
187	Attention deficit-hyperactivity disorder	Enrichment	GNB5	1.52
188	Non-syndromic x-linked intellectual disability	Enrichment	DLG3	1.50
189	Congenital stationary night blindness	Enrichment	GNB3	1.50
190	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.50
191	Enchondromatosis, multiple, ollier type	Enrichment	PTH1R	1.47
192	Exudative vitreoretinopathy 1	Enrichment	FZD4	1.47
193	Norrie disease	Enrichment	FZD4	1.47
194	Robinow syndrome, autosomal dominant 2	Enrichment	FZD2	1.47
195	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.47
196	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	WNT10A	1.47
197	Coloboma of choroid and retina	Enrichment	FZD5	1.47
198	Strabismus	Enrichment	GNB1	1.43
199	Coloboma of optic nerve	Enrichment	FZD5	1.39
200	Renal dysplasia, cystic	Enrichment	WNT9B	1.39
201	Renal hypoplasia	Enrichment	WNT9B	1.39
202	Diarrhea	Enrichment	WNT2B	1.39
203	Multicystic kidney dysplasia	Enrichment	FZD3	1.39
204	Multicystic dysplastic kidney	Enrichment	FZD3	1.39
205	Coats disease	Enrichment	FZD4	1.32
206	Autosomal dominant sleep-related hypermotor epilepsy	Enrichment	CRH	1.32
207	Congenital hydrocephalus	Enrichment	PTCH1	1.32
208	Overgrowth syndrome	Enrichment	PTCH1	1.32
209	Dystonia	Enrichment	GNB1	1.32
210	Cerebral palsy	Enrichment	GNB1	1.27
211	Renal hypodysplasia/aplasia 1	Enrichment	WNT9B	1.27
212	Exudative vitreoretinopathy	Enrichment	FZD4	1.27
213	Isolated split hand-split foot malformation	Enrichment	WNT10B	1.27
214	Leukemia, acute myeloid	Enrichment	JAK2	1.26
215	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	1.25
216	Type 2 diabetes mellitus	Enrichment	INSR	1.24
217	Centralopathic epilepsy	Enrichment	PLCB1	1.23
218	West syndrome	Enrichment	PLCB1	1.22
219	Renal agenesis, bilateral	Enrichment	WNT9B	1.22
220	Cat eye syndrome	Enrichment	FZD5	1.17
221	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1	1.17
222	46,xy complete gonadal dysgenesis	Enrichment	DHH	1.13
223	Primary ovarian insufficiency	Enrichment	JAK2	1.10
224	Septooptic dysplasia	Enrichment	SHH	1.10
225	Meningioma	Enrichment	SMO	1.10
226	Microphthalmia/coloboma 12	Enrichment	FZD5	1.06
227	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.06
228	Chronic kidney disease	Enrichment	WNT9B	1.06
229	Breast cancer	Enrichment	GNG3, PTCH2	1.02
230	Coloboma of macula	Enrichment	FZD5	1.00
231	Polydactyly, postaxial, type a1	Enrichment	PTCH1	1.00
232	Osteogenesis imperfecta, type iii	Enrichment	WNT1	1.00
233	Hydrocephalus	Enrichment	FZD3	1.00
234	Rhabdomyosarcoma	Enrichment	PTCH1	0.98
235	Syndromic intellectual disability	Enrichment	PTH2R	0.95
236	Body mass index quantitative trait locus 11	Enrichment	GNAS	0.94
237	Congenital nervous system abnormality	Enrichment	GNB5	0.86
238	Nervous system disease	Enrichment	GNB5	0.86
239	Autism spectrum disorder	Enrichment	GNB1	0.85
240	Brittle bone disorder	Enrichment	WNT1	0.83
241	Hydrops fetalis, nonimmune	Enrichment	FZD6	0.78
242	Distal arthrogryposis	Enrichment	FZD3	0.60
243	Retinitis pigmentosa	Enrichment	TUB	0.59
244	Hereditary breast ovarian cancer syndrome	Enrichment	PTCH1	0.50
245	Hereditary retinal dystrophy	Enrichment	TUB	0.47
246	Fundus dystrophy	Enrichment	TUB	0.47
247	Autism	Enrichment	SHH	0.40
248	Colorectal cancer	Enrichment	FZD3	0.34
249	Ovarian cancer	Enrichment	PTCH1	0.30
250	Inherited cancer-predisposing syndrome	Enrichment	PTCH1	0.22

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Presynaptic function of Kainate receptors

Pathway Network for Presynaptic function of Kainate receptors

Pathway network for the Presynaptic function of Kainate receptors SuperPath

Member Pathways for Presynaptic function of Kainate receptors

Pathways in the Presynaptic function of Kainate receptors SuperPath

Gene overlap in member pathways for Presynaptic function of Kainate receptors SuperPath

Associated Genes for Presynaptic function of Kainate receptors

Associated Disorders for Presynaptic function of Kainate receptors

Disorders associated with Presynaptic function of Kainate receptors SuperPath

STRING Interaction Network for Presynaptic function of Kainate receptors

Sources for Presynaptic function of Kainate receptors