Prion disease pathway

No Pathway Network information available for Prion disease pathway

Pathways in the Prion disease pathway SuperPath

#	Name	Source	Genes
1	Prion disease pathway	WikiPathways	BATF BCL11A BCL2 CASP12 CASP3 CHD2 CTCF EBF1 ELK1 EP300 FGFR1 FYN HSP90B1 HSPA5 IRF4 MAPK1 MAPK3 MEF2C NCAM1 NFKB1 PAX5 PDIA3 POU2F2 PRNP PTK2 RAD21 RFX5 RXRA SMC3 SPI1 STAT3 TBP (see all 32) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RFX5	Regulatory Factor X5	Protein Coding	1
2	SMC3	Structural Maintenance Of Chromosomes 3	Protein Coding	1
3	CASP3	Caspase 3	Protein Coding	1
4	HSP90B1	Heat Shock Protein 90 Beta Family Member 1	Protein Coding	1
5	TBP	TATA-Box Binding Protein	Protein Coding	1
6	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	1
7	SPI1	Spi-1 Proto-Oncogene	Protein Coding	1
8	RXRA	Retinoid X Receptor Alpha	Protein Coding	1
9	BCL2	BCL2 Apoptosis Regulator	Protein Coding	1
10	RAD21	RAD21 Cohesin Complex Component	Protein Coding	1
11	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
12	PRNP	Prion Protein (Kanno Blood Group)	Protein Coding	1
13	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
14	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
15	POU2F2	POU Class 2 Homeobox 2	Protein Coding	1
16	BCL11A	BCL11 Transcription Factor A	Protein Coding	1
17	PAX5	Paired Box 5	Protein Coding	1
18	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
19	NCAM1	Neural Cell Adhesion Molecule 1	Protein Coding	1
20	MEF2C	Myocyte Enhancer Factor 2C	Protein Coding	1
21	IRF4	Interferon Regulatory Factor 4	Protein Coding	1
22	HSPA5	Heat Shock Protein Family A (Hsp70) Member 5	Protein Coding	1
23	PDIA3	Protein Disulfide Isomerase Family A Member 3	Protein Coding	1
24	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
25	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
26	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
27	EBF1	EBF Transcription Factor 1	Protein Coding	1
28	CHD2	Chromodomain Helicase DNA Binding Protein 2	Protein Coding	1
29	CTCF	CCCTC-Binding Factor	Protein Coding	1
30	CASP12	Caspase 12 (Gene/Pseudogene)	Protein Coding	1
31	BATF	Basic Leucine Zipper ATF-Like Transcription Factor	Protein Coding	1
32	ELK1	ETS Transcription Factor ELK1	Protein Coding	1

Disorders associated with Prion disease pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Cornelia de lange syndrome 1	Enrichment	RAD21, SMC3	3.72
2	Cornelia de lange syndrome	Enrichment	RAD21, SMC3	3.72
3	Polydactyly, postaxial, type a1	Enrichment	BCL11A, EP300	3.26
4	Autism spectrum disorder	Enrichment	CHD2, MEF2C, SMC3	2.68
5	Osteoglophonic dysplasia	Enrichment	FGFR1	2.63
6	Fetal hemoglobin quantitative trait locus 5	Enrichment	BCL11A	2.63
7	Trigonocephaly 1	Enrichment	FGFR1	2.63
8	Fatal familial insomnia	Enrichment	PRNP	2.63
9	Cornelia de lange syndrome 3 with or without midline brain defects	Enrichment	SMC3	2.63
10	Skin/hair/eye pigmentation, variation in, 8	Enrichment	IRF4	2.63
11	Gerstmann-straussler disease	Enrichment	PRNP	2.63
12	Kuru	Enrichment	PRNP	2.63
13	Cornelia de lange syndrome 4 with or without midline brain defects	Enrichment	RAD21	2.63
14	Agammaglobulinemia 10, autosomal dominant	Enrichment	SPI1	2.63
15	Noonan syndrome 13	Enrichment	MAPK1	2.63
16	Immunodeficiency 131	Enrichment	IRF4	2.63
17	Spongiform encephalopathy with neuropsychiatric features	Enrichment	PRNP	2.63
18	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	2.63
19	Neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language	Enrichment	MEF2C	2.63
20	Huntington disease-like 1	Enrichment	PRNP	2.63
21	Mungan syndrome	Enrichment	RAD21	2.63
22	Familial alzheimer-like prion disease	Enrichment	PRNP	2.63
23	Ctcf-related disorder	Enrichment	CTCF	2.63
24	Hartsfield syndrome	Enrichment	FGFR1	2.63
25	Prion disease	Enrichment	PRNP	2.63
26	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	2.63
27	Intellectual developmental disorder with persistence of fetal hemoglobin	Enrichment	BCL11A	2.63
28	Bcl11a-related intellectual disability	Enrichment	BCL11A	2.63
29	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	2.63
30	5q14.3 microdeletion syndrome	Enrichment	MEF2C	2.63
31	Agammaglobulinemia	Enrichment	SPI1	2.63
32	Prp systemic amyloidosis	Enrichment	PRNP	2.63
33	Complete atrioventricular septal defect without ventricular hypoplasia	Enrichment	MEF2C	2.63
34	Mhc class ii deficiency 5	Enrichment	RFX5	2.63
35	Inherited human prion disease	Enrichment	PRNP	2.63
36	Whipple disease	Enrichment	IRF4	2.63
37	Mef2c-related disorder	Enrichment	MEF2C	2.63
38	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.63
39	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	2.63
40	Inherited creutzfeldt-jakob disease	Enrichment	PRNP	2.63
41	Spinocerebellar ataxia 17	Enrichment	TBP	2.33
42	Pfeiffer syndrome	Enrichment	FGFR1	2.33
43	Jackson-weiss syndrome	Enrichment	FGFR1	2.33
44	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1	2.33
45	Creutzfeldt-jakob disease	Enrichment	PRNP	2.33
46	Sifrim-hitz-weiss syndrome	Enrichment	CHD2	2.33
47	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.33
48	Menke-hennekam syndrome 2	Enrichment	EP300	2.33
49	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.33
50	Mhc class ii deficiency 3	Enrichment	RFX5	2.33
51	Intellectual developmental disorder, autosomal dominant 21	Enrichment	CTCF	2.33
52	Rosette-forming glioneuronal tumor	Enrichment	FGFR1	2.33
53	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	2.33
54	Common variable immunodeficiency 12	Enrichment	NFKB1	2.33
55	B-lymphoblastic leukemia/lymphoma with t(7;9)(q11.2;p13.2)	Enrichment	PAX5	2.33
56	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.15
57	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	2.15
58	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	2.15
59	Breast implant-associated anaplastic large cell lymphoma	Enrichment	STAT3	2.15
60	Hyper ige syndrome	Enrichment	STAT3	2.15
61	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2	2.15
62	Developmental and epileptic encephalopathy 94	Enrichment	CHD2	2.15
63	Desmoplastic/nodular medulloblastoma	Enrichment	CTCF	2.15
64	Trichorhinophalangeal syndrome, type ii	Enrichment	RAD21	2.03
65	Frontotemporal dementia 2	Enrichment	PRNP	2.03
66	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.03
67	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.93
68	Follicular lymphoma	Enrichment	BCL2	1.93
69	Holoprosencephaly	Enrichment	FGFR1	1.93
70	Hereditary persistence of fetal hemoglobin-sickle cell disease syndrome	Enrichment	BCL11A	1.93
71	Primary hypereosinophilic syndrome	Enrichment	FGFR1	1.93
72	Rubinstein-taybi syndrome 1	Enrichment	EP300	1.85
73	Holoprosencephaly 1	Enrichment	FGFR1	1.85
74	Wiedemann-steiner syndrome	Enrichment	SMC3	1.85
75	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	EP300	1.85
76	Pilomyxoid astrocytoma	Enrichment	FGFR1	1.79
77	Common variable immunodeficiency	Enrichment	NFKB1	1.79
78	Lennox-gastaut syndrome	Enrichment	CHD2	1.73
79	Permanent neonatal diabetes mellitus	Enrichment	STAT3	1.73
80	Charge syndrome	Enrichment	EP300	1.68
81	Leukemia, acute lymphoblastic 3	Enrichment	PAX5	1.68
82	Myoclonic-atonic epilepsy	Enrichment	CHD2	1.68
83	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.68
84	Mhc class ii deficiency	Enrichment	RFX5	1.68
85	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.63
86	Autosomal non-syndromic agammaglobulinemia	Enrichment	SPI1	1.63
87	Mhc class ii deficiency 1	Enrichment	RFX5	1.59
88	Leukemia, acute lymphoblastic	Enrichment	PAX5	1.59
89	Specific learning disability	Enrichment	MAPK1	1.59
90	Septooptic dysplasia	Enrichment	FGFR1	1.55
91	Acute promyelocytic leukemia	Enrichment	STAT3	1.52
92	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.49
93	Microcephaly	Enrichment	EP300, MAPK1	1.47
94	Corpus callosum, agenesis of	Enrichment	BCL11A	1.46
95	Isolated corpus callosum agenesis	Enrichment	BCL11A	1.46
96	Rare genetic intellectual disability	Enrichment	EP300	1.46
97	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	BCL11A	1.46
98	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	BCL11A	1.43
99	Gliosarcoma	Enrichment	FGFR1	1.43
100	Microform holoprosencephaly	Enrichment	FGFR1	1.43
101	Lobar holoprosencephaly	Enrichment	FGFR1	1.43
102	Giant cell glioblastoma	Enrichment	FGFR1	1.40
103	Heart, malformation of	Enrichment	MAPK1	1.38
104	Semilobar holoprosencephaly	Enrichment	FGFR1	1.38
105	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	1.38
106	Diffuse large b-cell lymphoma	Enrichment	STAT3	1.36
107	Parkinson's disease	Enrichment	TBP	1.36
108	Tooth agenesis	Enrichment	FGFR1	1.30
109	Kallmann syndrome	Enrichment	FGFR1	1.28
110	Parkinson disease, late-onset	Enrichment	TBP	1.26
111	Epilepsy	Enrichment	CHD2	1.04
112	Benign epilepsy with centrotemporal spikes	Enrichment	CHD2	1.03
113	Centralopathic epilepsy	Enrichment	CHD2	1.01
114	Myeloma, multiple	Enrichment	RXRA	0.91
115	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MEF2C	0.89
116	Colorectal cancer	Enrichment	EP300	0.73
117	Complex neurodevelopmental disorder	Enrichment	CHD2	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Prion disease pathway

Pathway Network for Prion disease pathway

Member Pathways for Prion disease pathway

Pathways in the Prion disease pathway SuperPath

Associated Genes for Prion disease pathway

Associated Disorders for Prion disease pathway

Disorders associated with Prion disease pathway SuperPath

STRING Interaction Network for Prion disease pathway

Sources for Prion disease pathway