Processing of Capped Intronless Pre-mRNA

Pathway network for the Processing of Capped Intronless Pre-mRNA SuperPath

Sources:

Reactome

Pathways in the Processing of Capped Intronless Pre-mRNA SuperPath

#	Name	Source	Genes
1	Processing of Capped Intronless Pre-mRNA	Reactome	CLP1 CPSF1 CPSF2 CPSF3 CPSF4 CPSF6 CPSF7 CSTF1 CSTF2 CSTF2T CSTF3 FIP1L1 LSM10 LSM11 NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG SYMPK WDR33 ZNF473 (see all 29) (see less)
2	RNA Polymerase II Transcription Termination	Reactome	ALYREF CASC3 CDC40 CHTOP CLP1 CPSF1 CPSF2 CPSF3 CPSF4 CPSF6 CPSF7 CSTF1 CSTF2 CSTF2T CSTF3 DDX39A DDX39B DHX38 EIF4A3 FIP1L1 FYTTD1 LSM10 LSM11 LUZP4 MAGOH MAGOHB NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 POLDIP3 RBM8A RNPS1 SARNP SLBP SLU7 SNRPB SNRPD3 SNRPE SNRPF SNRPG SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SYMPK THOC1 THOC2 THOC3 THOC5 THOC6 THOC7 U2AF1 U2AF1L4 U2AF2 UPF3B WDR33 ZC3H11A ZNF473 (see all 67) (see less)
3	mRNA 3'-end processing	Reactome	ALYREF CASC3 CDC40 CHTOP CLP1 CPSF1 CPSF2 CPSF3 CPSF4 CPSF6 CPSF7 CSTF1 CSTF2 CSTF2T CSTF3 DDX39A DDX39B DHX38 EIF4A3 FIP1L1 FYTTD1 LUZP4 MAGOH MAGOHB NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 POLDIP3 RBM8A RNPS1 SARNP SLU7 SRRM1 SRSF1 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF9 SYMPK THOC1 THOC2 THOC3 THOC5 THOC6 THOC7 U2AF1 U2AF1L4 U2AF2 UPF3B WDR33 ZC3H11A (see all 58) (see less)
4	Processing of Intronless Pre-mRNAs	Reactome	CLP1 CPSF1 CPSF2 CPSF3 CPSF4 CPSF6 CPSF7 CSTF1 CSTF2 CSTF2T CSTF3 FIP1L1 NCBP1 NCBP2 NUDT21 PABPN1 PAPOLA PCF11 SYMPK WDR33 (see all 20) (see less)
5	SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	Reactome	LSM10 LSM11 NCBP1 NCBP2 SLBP SNRPB SNRPD3 SNRPE SNRPF SNRPG ZNF473 (see all 11) (see less)
6	SLBP independent Processing of Histone Pre-mRNAs	Reactome	LSM10 LSM11 NCBP1 NCBP2 SNRPB SNRPD3 SNRPE SNRPF SNRPG ZNF473 (see all 10) (see less)
7	Inhibition of Host mRNA Processing and RNA Silencing	Reactome	CPSF4 PABPN1

Gene overlap in member pathways for Processing of Capped Intronless Pre-mRNA SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NCBP2	Nuclear Cap Binding Protein Subunit 2	Protein Coding	6
2	NCBP1	Nuclear Cap Binding Protein Subunit 1	Protein Coding	6
3	CPSF4	Cleavage And Polyadenylation Specific Factor 4	Protein Coding	5
4	PABPN1	Poly(A) Binding Protein Nuclear 1	Protein Coding	5
5	PAPOLA	Poly(A) Polymerase Alpha	Protein Coding	4
6	CLP1	Cleavage Factor Polyribonucleotide Kinase Subunit 1	Protein Coding	4
7	NUDT21	Nudix Hydrolase 21	Protein Coding	4
8	CPSF6	Cleavage And Polyadenylation Specific Factor 6	Protein Coding	4
9	LSM11	LSM11, U7 Small Nuclear RNA Associated	Protein Coding	4
10	CSTF1	Cleavage Stimulation Factor Subunit 1	Protein Coding	4
11	CSTF2	Cleavage Stimulation Factor Subunit 2	Protein Coding	4
12	CSTF3	Cleavage Stimulation Factor Subunit 3	Protein Coding	4
13	CSTF2T	Cleavage Stimulation Factor Subunit 2 Tau Variant	Protein Coding	4
14	ZNF473	Zinc Finger Protein 473	Protein Coding	4
15	CPSF1	Cleavage And Polyadenylation Specific Factor 1	Protein Coding	4
16	PCF11	PCF11 Cleavage And Polyadenylation Factor Subunit	Protein Coding	4
17	CPSF3	Cleavage And Polyadenylation Specific Factor 3	Protein Coding	4
18	CPSF2	Cleavage And Polyadenylation Specific Factor 2	Protein Coding	4
19	WDR33	WD Repeat Domain 33	Protein Coding	4
20	SNRPB	Small Nuclear Ribonucleoprotein Polypeptides B And B1	Protein Coding	4
21	SNRPD3	Small Nuclear Ribonucleoprotein D3 Polypeptide	Protein Coding	4
22	SNRPE	Small Nuclear Ribonucleoprotein Polypeptide E	Protein Coding	4
23	SNRPF	Small Nuclear Ribonucleoprotein Polypeptide F	Protein Coding	4
24	SNRPG	Small Nuclear Ribonucleoprotein Polypeptide G	Protein Coding	4
25	CPSF7	Cleavage And Polyadenylation Specific Factor 7	Protein Coding	4
26	FIP1L1	Factor Interacting With PAPOLA And CPSF1	Protein Coding	4
27	SYMPK	Symplekin Scaffold Protein	Protein Coding	4
28	LSM10	LSM10, U7 Small Nuclear RNA Associated	Protein Coding	4
29	SLBP	Stem-Loop Histone MRNA Binding Protein	Protein Coding	3
30	ALYREF	Aly/REF Export Factor	Protein Coding	2
31	DDX39A	DExD-Box Helicase 39A	Protein Coding	2
32	SRRM1	Serine And Arginine Repetitive Matrix 1	Protein Coding	2
33	SLU7	Spliceosome Associated SLU7	Protein Coding	2
34	RNPS1	RNA Binding Protein With Serine Rich Domain 1	Protein Coding	2
35	U2AF2	U2 Small Nuclear RNA Auxiliary Factor 2	Protein Coding	2
36	U2AF1L4	U2 Small Nuclear RNA Auxiliary Factor 1 Like 4	Protein Coding	2
37	CASC3	CASC3 Exon Junction Complex Subunit	Protein Coding	2
38	CHTOP	Chromatin Target Of PRMT1	Protein Coding	2
39	MAGOH	Mago Homolog, Exon Junction Complex Subunit	Protein Coding	2
40	LUZP4	Leucine Zipper Protein 4	Protein Coding	2
41	CDC40	Cell Division Cycle 40	Protein Coding	2
42	MAGOHB	Mago Homolog B, Exon Junction Complex Subunit	Protein Coding	2
43	THOC2	THO Complex Subunit 2	Protein Coding	2
44	SRSF1	Serine And Arginine Rich Splicing Factor 1	Protein Coding	2
45	SRSF2	Serine And Arginine Rich Splicing Factor 2	Protein Coding	2
46	SRSF3	Serine And Arginine Rich Splicing Factor 3	Protein Coding	2
47	SRSF4	Serine And Arginine Rich Splicing Factor 4	Protein Coding	2
48	SRSF5	Serine And Arginine Rich Splicing Factor 5	Protein Coding	2
49	SRSF6	Serine And Arginine Rich Splicing Factor 6	Protein Coding	2
50	SRSF7	Serine And Arginine Rich Splicing Factor 7	Protein Coding	2
51	UPF3B	UPF3B Regulator Of Nonsense Mediated MRNA Decay	Protein Coding	2
52	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	2
53	DDX39B	DExD-Box Helicase 39B	Protein Coding	2
54	THOC6	THO Complex Subunit 6	Protein Coding	2
55	THOC7	THO Complex Subunit 7	Protein Coding	2
56	FYTTD1	Forty-Two-Three Domain Containing 1	Protein Coding	2
57	POLDIP3	DNA Polymerase Delta Interacting Protein 3	Protein Coding	2
58	THOC3	THO Complex Subunit 3	Protein Coding	2
59	SARNP	SAP Domain Containing Ribonucleoprotein	Protein Coding	2
60	THOC5	THO Complex Subunit 5	Protein Coding	2
61	SRSF9	Serine And Arginine Rich Splicing Factor 9	Protein Coding	2
62	SRSF11	Serine And Arginine Rich Splicing Factor 11	Protein Coding	2
63	EIF4A3	Eukaryotic Translation Initiation Factor 4A3	Protein Coding	2
64	DHX38	DEAH-Box Helicase 38	Protein Coding	2
65	ZC3H11A	Zinc Finger CCCH-Type Containing 11A	Protein Coding	2
66	RBM8A	RNA Binding Motif Protein 8A	Protein Coding	2
67	THOC1	THO Complex Subunit 1	Protein Coding	2

Disorders associated with Processing of Capped Intronless Pre-mRNA SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Influenza	Direct
2	Aicardi-goutieres syndrome 8	Enrichment	LSM11	3.13
3	Cerebrocostomandibular syndrome	Enrichment	SNRPB	2.83
4	Hypotrichosis 11	Enrichment	SNRPE	2.83
5	Intellectual developmental disorder, x-linked 113	Enrichment	CSTF2	2.83
6	Pontocerebellar hypoplasia, type 10	Enrichment	CLP1	2.83
7	Neurodevelopmental disorder with microcephaly, hypotonia, nystagmus, and seizures	Enrichment	CPSF3	2.83
8	Neurodevelopmental disorder with hypotonia, microcephaly, and seizures	Enrichment	CPSF3	2.53
9	Myopia 27, autosomal dominant	Enrichment	CPSF1	2.53
10	Chronic eosinophilic leukemia	Enrichment	FIP1L1	2.53
11	Robin sequence with cleft mandible and limb anomalies	Enrichment	EIF4A3	2.37
12	Intellectual developmental disorder, x-linked, syndromic 14	Enrichment	UPF3B	2.37
13	Developmental delay, dysmorphic facies, and brain anomalies	Enrichment	U2AF2	2.37
14	Arthrogryposis multiplex congenita 7, x-linked	Enrichment	THOC2	2.37
15	Pontocerebellar hypoplasia, type 15	Enrichment	CDC40	2.37
16	Retinitis pigmentosa 84	Enrichment	DHX38	2.37
17	Syndromic x-linked intellectual disability 14	Enrichment	UPF3B	2.37
18	Deafness, autosomal dominant 86	Enrichment	THOC1	2.37
19	Pierre robin syndrome	Enrichment	SNRPB	2.35
20	Oculopharyngeal muscular dystrophy 1	Enrichment	PABPN1	2.35
21	Hypotrichosis simplex	Enrichment	SNRPE	2.18
22	Aicardi-goutiares syndrome	Enrichment	LSM11	2.18
23	Primary hypereosinophilic syndrome	Enrichment	FIP1L1	2.13
24	Intellectual developmental disorder, x-linked, syndromic, kumar type	Enrichment	THOC2	2.07
25	Beaulieu-boycott-innes syndrome	Enrichment	THOC6	2.07
26	Neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities	Enrichment	SRSF1	2.07
27	Immunodeficiency 127	Enrichment	THOC2	2.07
28	Intellectual developmental disorder, x-linked, syndromic, lujan-fryns type	Enrichment	UPF3B	1.89
29	Thrombocytopenia-absent radius syndrome	Enrichment	RBM8A	1.89
30	Chronic myelomonocytic leukemia	Enrichment	SRSF2	1.77
31	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	SRSF2	1.77
32	Acute promyelocytic leukemia	Enrichment	FIP1L1	1.72
33	Aggressive systemic mastocytosis	Enrichment	SRSF2	1.67
34	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	SRSF2	1.42
35	Myelodysplastic syndrome	Enrichment	U2AF1	1.34
36	Pontocerebellar hypoplasia	Enrichment	CDC40	1.13
37	Leukodystrophy	Enrichment	U2AF2	1.09
38	Non-syndromic x-linked intellectual disability	Enrichment	UPF3B	0.84
39	Leukemia, acute myeloid	Enrichment	SRSF2	0.80
40	Complex neurodevelopmental disorder	Enrichment	CPSF3	0.77
41	Retinitis pigmentosa	Enrichment	DHX38	0.22
42	Hereditary retinal dystrophy	Enrichment	DHX38	0.15
43	Fundus dystrophy	Enrichment	DHX38	0.15

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Processing of Capped Intronless Pre-mRNA

Pathway Network for Processing of Capped Intronless Pre-mRNA

Pathway network for the Processing of Capped Intronless Pre-mRNA SuperPath

Member Pathways for Processing of Capped Intronless Pre-mRNA

Pathways in the Processing of Capped Intronless Pre-mRNA SuperPath

Gene overlap in member pathways for Processing of Capped Intronless Pre-mRNA SuperPath

Associated Genes for Processing of Capped Intronless Pre-mRNA

Associated Disorders for Processing of Capped Intronless Pre-mRNA

Disorders associated with Processing of Capped Intronless Pre-mRNA SuperPath

STRING Interaction Network for Processing of Capped Intronless Pre-mRNA

Sources for Processing of Capped Intronless Pre-mRNA