Prolactin Signaling

Pathway network for the Prolactin Signaling SuperPath

Sources:

QIAGEN
WikiPathways
PharmGKB
GeneGo (Thomson Reuters)
Reactome

Pathways in the Prolactin Signaling SuperPath

#	Name	Source	Genes
1	Prolactin Signaling	QIAGEN	ARAF BRAF CEBPB CREBBP CSN2 EP300 FYN GRB2 HRAS IRS1 JAK2 JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 MRAS MYC NMI NR3C1 NRAS PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PRL PRLR RAF1 RRAS RRAS2 SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SOS1 SOS2 SP1 STAT1 STAT3 STAT5A STAT5B TCF7 (see all 73) (see less)
2	PI3K Signaling in B-Lymphocyte	QIAGEN	ABL1 AKT1 AKT2 AKT3 ATF1 ATF2 ATF3 ATF4 ATF5 ATF6 ATF7 BCL10 BLK BLNK BTK CALM1 CALM2 CALM3 CAMK2A CAMK2B CAMK2D CAMK2G CARD10 CBL CD180 CD19 CD40 CD79A CD79B CD81 CHUK CR2 CREB1 CREB3 CREB3L4 DAPP1 ELK1 FCGR2B FOS FOXO3 FYN HRAS IKBKB IKBKE IKBKG IL4 IL4R IRS1 IRS2 ITPR1 ITPR2 ITPR3 JUN KRAS LYN MALT1 MAP2K1 MAP2K2 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 MRAS NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA NFKBIB NFKBIE NRAS PDPK1 PIK3AP1 PIK3C2A PIK3C2B PIK3C2G PIK3C3 PIK3R1 PIK3R3 PLCB1 PLCB2 PLCB3 PLCB4 PLCG1 PLCG2 PLEKHA1 PLEKHA2 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCB PRKCI PRKCZ PTEN PTPRC RAC1 RAF1 RRAS RRAS2 SPP1 SYK TEC TLR4 VAV1 VAV2 VAV3 (see all 118) (see less)
3	Glioblastoma Multiforme	QIAGEN	AKT1 AKT2 AKT3 APC ARAF AXIN1 BRAF CCND1 CCNE1 CCNE2 CDC42 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CTNNB1 DIRAS3 E2F1 E2F2 E2F3 E2F4 E2F5 EGF EGFR FOXO1 FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GRB2 GSK3B HRAS IGF1 IGF1R IGF2 ITPR1 ITPR2 ITPR3 KRAS LEF1 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK3 MAPK6 MDM2 MGMT MRAS MTOR MYC NF1 NF2 NRAS PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PRKCD PTEN RAC1 RAF1 RB1 RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 RPS6KB1 RRAS RRAS2 SOS1 SOS2 SRC TCF3 TCF4 TP53 TSC1 TSC2 (see all 111) (see less)
4	ErbB signaling pathway	WikiPathways	ABL1 ABL2 AKT1 AKT2 AKT3 ARAF AREG BAD BCL2L11 BRAF BTC BUB1B-PAK6 CAMK2A CAMK2B CAMK2D CAMK2G CBL CBLB CCND1 CDKN1A CDKN1B CRK CRKL EGF EGFR EIF4EBP1 ELK1 ERBB2 ERBB3 ERBB4 EREG FOXO1 GAB1 GRB2 GSK3B HBEGF HRAS JUN KRAS MAP2K1 MAP2K2 MAP2K4 MAP2K7 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MDM2 MTOR MYC NCK1 NCK2 NRAS NRG1 NRG2 NRG3 NRG4 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PRKCA PRKCB PRKCG PTK2 RAF1 RPS6KB1 RPS6KB2 SHC1 SHC2 SHC3 SHC4 SOS1 SOS2 SRC STAT5A STAT5B TGFA TP53 (see all 91) (see less)
5	EGFR tyrosine kinase inhibitor resistance	WikiPathways	AKT1 AKT2 AKT3 ARAF AXL BAD BAX BCL2 BCL2L1 BCL2L11 BRAF CCND1 EGF EGFR EIF4E EIF4E2 EIF4EBP1 ERBB2 ERBB3 FGF2 FGFR2 FGFR3 FOXO3 GAB1 GAS6 GRB2 GSK3B HGF HRAS IGF1 IGF1R IL6 IL6R JAK1 JAK2 KDR KRAS MAP2K1 MAP2K2 MAPK1 MAPK3 MET MRAS MTOR MYC NF1 NRAS NRG1 NRG2 PDGFA PDGFB PDGFC PDGFD PDGFRA PDGFRB PDPK1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PRKCA PRKCB PRKCG PTEN RAF1 RPS6 RPS6KB1 RPS6KB2 RRAS RRAS2 SHC1 SHC2 SHC3 SHC4 SOS1 SOS2 SRC STAT3 TGFA VEGFA (see all 84) (see less)
6	Glioblastoma signaling pathways	WikiPathways	AKT1 AKT2 AKT3 ARAF ATM BRAF BRCA1 BRCA2 CBL CCND1 CCND2 CCNE1 CDK2 CDK4 CDK6 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C E2F1 EGFR EP300 ERBB2 ERBB3 ERRFI1 FGFR1 FGFR2 FOXO1 FOXO3 FOXO4 GAB1 GRB2 HRAS IGF1R IRS1 KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAPK1 MAPK3 MDM2 MDM4 MET MSH6 NF1 NRAS PDGFRA PDGFRB PDPK1 PIK3C2A PIK3C2B PIK3C2G PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCG PRKCH PRKCI PRKCQ PRKCZ PTEN RAF1 RB1 SPRY2 SRC TP53 TSC1 TSC2 (see all 82) (see less)
7	ErbB2-ErbB3 Heterodimers	QIAGEN	AKT1 ARAF BAD BCL2 BRAF CCND1 CDKN1B E2F1 E2F2 E2F3 E2F4 E2F5 ELK1 ERBB2 ERBB3 ETV4 FOS FOXO3 GRB2 GSK3A GSK3B HRAS ITPR1 ITPR2 ITPR3 JAK1 JAK2 JAK3 JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK12 MAPK3 MAPK6 MAPK7 MRAS MYC NRAS NRG1 NRG2 NRG3 PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTEN RAF1 RPS6KB1 RRAS RRAS2 SOS1 SOS2 SP1 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B STAT6 (see all 81) (see less)
8	IL-2 Pathway	QIAGEN	AKT1 CHUK ELK1 FOS GRB2 HRAS IKBKB IKBKE IKBKG IL2 IL2RA IL2RB IL2RG JAK1 JAK3 JUN KRAS LCK MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK6 MAPK7 MAPK8 MAPK9 MRAS MYC NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NFKBIA NFKBIB NFKBIE NRAS PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 PPP3CA PPP3CB PPP3CC PPP3R1 PPP3R2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PTEN RAF1 RRAS RRAS2 SOS1 SOS2 STAT5A STAT5B SYK (see all 79) (see less)
9	TREM1 Pathway	QIAGEN	AKT1 ARAF BAD BAX BID BRAF CBL CHUK CYCS ELK1 FOS GRB2 HRAS IKBKB IKBKE IKBKG IL1A IL1B IL1R1 IL1R2 IRAK1 IRAK2 IRAK3 IRAK4 JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MRAS MYD88 NFAT5 NFATC1 NFATC2 NFATC3 NFATC4 NFKB1 NRAS PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 RAF1 RRAS RRAS2 SOS1 SOS2 SYK TLR1 TLR10 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TRAF6 TREM1 TYROBP (see all 78) (see less)
10	ErbB Family Pathway	QIAGEN	AKT1 ARAF AREG BRAF BTC CDC42 EGF EGFR ELK1 ERBB2 ERBB3 ERBB4 EREG FOS FOXO1 GRB2 GSK3B HBEGF HRAS JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K6 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK6 MAPK7 MAPK8 MAPK9 MRAS MTOR NCK1 NCK2 NRAS NRG1 NRG2 NRG3 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 RAF1 RPS6KB1 RRAS RRAS2 SOS1 SOS2 TGFA (see all 76) (see less)
11	LPS Stimulated MAPK Signaling	QIAGEN	ATF1 ATF2 ATF4 CD14 CDC42 CHUK CREB1 CREB3 CREB3L4 ELK1 FOS HRAS IKBKB IKBKE IKBKG JUN KRAS LBP MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K6 MAP3K14 MAP3K4 MAP3K5 MAP3K7 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MRAS NFKB1 NFKBIA NFKBIB NFKBIE NRAS PAK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 RAC1 RAF1 RRAS RRAS2 SRF TLR4 (see all 75) (see less)
12	PACAP Signaling	QIAGEN	ADCY1 ADCY2 ADCY3 ADCYAP1R1 ATF1 ATF4 CREB1 CREB3 CREB3L4 CREBBP FOS GNAS ITPR1 ITPR2 ITPR3 MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAP3K1 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K14 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAP3K6 MAP3K7 MAP3K8 MAP3K9 MAPK1 MAPK3 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCZ1 PRKACA PRKACB PRKACG PRKAR1A PRKAR1B PRKAR2A PRKAR2B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 (see all 67) (see less)
13	EGFR Inhibitor Pathway, Pharmacodynamics	PharmGKB	AKT1 AKT2 AKT3 AREG BTC CAMK1 CAMK1D CAMK1G CAMK2A CAMK2B CAMK2D CAMK2G EGF EGFR ELK1 ERBB2 ERBB3 ERBB4 EREG FOS GRB2 HBEGF HRAS JAK1 JUN KRAS MAP2K1 MAP2K7 MAP3K1 MAPK1 MAPK3 MAPK8 MRAS MYC NFKB1 NFKB2 NRAS NRG1 NRG2 NRG3 PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PRKCA PRKCB PRKCG RAF1 RELA RRAS SHC1 SHC2 SHC3 SOS1 SP1 STAT1 STAT2 STAT3 STAT4 STAT5A STAT5B TGFA (see all 67) (see less)
14	HMGB1 Pathway	QIAGEN	AKT1 AKT2 AKT3 CDC42 DIRAS3 ELK1 FOS HAT1 HMGB1 HRAS IFNG IFNGR1 IFNGR2 IL1A IL1B IL1R1 IL1R2 JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 MOK MRAS NFKB1 NRAS PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 RAC1 RHOA RHOB RHOC RHOD RHOG RHOH RND2 RND3 RRAS RRAS2 SP1 TLR4 TNF TNFRSF1A (see all 62) (see less)
15	Development Prolactin receptor signaling	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 BCL2 BCL2L1 CBL CCND1 CEBPB CREBBP CSH1 CSH2 CSN2 EP300 FYN GH1 GRB2 HRAS IRF1 IRS1 JAK2 JUN MAP2K1 MAP2K2 MAPK1 MAPK3 MYC NEK3 NFKB1 NMI NR3C1 OAS1 PAEPP1 PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PLCG1 PLCG2 PRKCD PRL PRLR PTPN11 RAC1 RAF1 RELA RHOA SHC1 SOCS1 SOCS3 SOS1 SOS2 SP1 SRC STAT1 STAT3 STAT5A STAT5B TEC VAV1 VAV2 (see all 61) (see less)
16	ErbB4 Pathway	QIAGEN	ADAM17 AKT1 APH1A APH1B ARAF BRAF ERBB2 ERBB4 GRB2 HRAS KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 MRAS NCSTN NRAS NRG1 NRG2 NRG3 PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 PSEN1 PSEN2 PSENEN RAF1 RRAS RRAS2 SOS1 SOS2 (see all 60) (see less)
17	Growth Hormone Signaling	QIAGEN	CEBPB CEBPD ELK1 GH1 GH2 GHR IGF1 IGF1R IGF2 IRS1 JAK2 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK4 MAPK6 MAPK7 MAPK8 MAPK9 PDPK1 PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KA6 SLC2A4 SOCS1 SOCS2 SOCS3 SOCS4 SOCS5 SRF STAT1 STAT3 STAT5A STAT5B (see all 58) (see less)
18	Thrombopoietin Pathway	QIAGEN	FOS GRB2 HRAS JAK2 JUN KRAS MAP2K1 MAP2K2 MAP2K3 MAP2K4 MAP2K5 MAP2K6 MAPK1 MAPK12 MAPK3 MAPK6 MAPK7 MPL MRAS NRAS PIK3R1 PIK3R2 PIK3R3 PIK3R4 PIK3R5 PLCG1 PLCG2 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH RAF1 RASA1 RRAS RRAS2 SOS1 STAT1 STAT3 STAT5A STAT5B (see all 42) (see less)
19	UVC-Induced MAPK Signaling	QIAGEN	ARAF ATR BRAF EGFR FOS HRAS JUN KRAS MAP2K1 MAP2K2 MAPK1 MAPK10 MAPK11 MAPK12 MAPK13 MAPK14 MAPK3 MAPK8 MAPK9 MRAS NRAS PRKCA PRKCB PRKCD PRKCE PRKCG PRKCH PRKCI PRKCQ PRKCZ PRKD1 PRKD3 RAF1 RRAS RRAS2 SMPD1 SMPD2 SMPD3 SRC TP53 (see all 40) (see less)
20	Estrogen-stimulated signaling through PRKCZ	Reactome	HRAS KRAS MAPK1 NRAS PDPK1 PRKCZ (see all 6) (see less)
21	TCA cycle nutrient use and invasiveness of ovarian cancer	WikiPathways	EGFR JAK1 MAPK1 MAPK3 STAT3

Gene overlap in member pathways for Prolactin Signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	21
2	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	20
3	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	18
4	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	18
5	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	17
6	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	17
7	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	17
8	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	17
9	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	16
10	PLCG1	Phospholipase C Gamma 1	Protein Coding	16
11	PLCG2	Phospholipase C Gamma 2	Protein Coding	16
12	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	16
13	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	15
14	PRKCB	Protein Kinase C Beta	Protein Coding	15
15	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	14
16	PRKCA	Protein Kinase C Alpha	Protein Coding	14
17	PRKCG	Protein Kinase C Gamma	Protein Coding	14
18	RRAS	RAS Related	Protein Coding	14
19	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	13
20	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	13
21	PRKCD	Protein Kinase C Delta	Protein Coding	13
22	RRAS2	RAS Related 2	Protein Coding	13
23	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	13
24	MAP2K3	Mitogen-Activated Protein Kinase Kinase 3	Protein Coding	12
25	MAP2K4	Mitogen-Activated Protein Kinase Kinase 4	Protein Coding	12
26	MAP2K6	Mitogen-Activated Protein Kinase Kinase 6	Protein Coding	12
27	MAPK12	Mitogen-Activated Protein Kinase 12	Protein Coding	12
28	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	12
29	PRKCZ	Protein Kinase C Zeta	Protein Coding	12
30	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	12
31	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	11
32	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	11
33	PDPK1	3-Phosphoinositide Dependent Protein Kinase 1	Protein Coding	11
34	PIK3R4	Phosphoinositide-3-Kinase Regulatory Subunit 4	Protein Coding	11
35	PRKCH	Protein Kinase C Eta	Protein Coding	11
36	PRKCI	Protein Kinase C Iota	Protein Coding	11
37	FOS	Fos Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	11
38	ARAF	A-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	10
39	BRAF	B-Raf Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	10
40	MAP2K5	Mitogen-Activated Protein Kinase Kinase 5	Protein Coding	10
41	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	10
42	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	10
43	MAPK13	Mitogen-Activated Protein Kinase 13	Protein Coding	10
44	MAPK14	Mitogen-Activated Protein Kinase 14	Protein Coding	10
45	MAPK6	Mitogen-Activated Protein Kinase 6	Protein Coding	10
46	PRKCE	Protein Kinase C Epsilon	Protein Coding	10
47	PRKCQ	Protein Kinase C Theta	Protein Coding	10
48	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	10
49	ELK1	ETS Transcription Factor ELK1	Protein Coding	10
50	MAPK7	Mitogen-Activated Protein Kinase 7	Protein Coding	9
51	PRKD1	Protein Kinase D1	Protein Coding	9
52	PRKD3	Protein Kinase D3	Protein Coding	9
53	MYC	MYC Proto-Oncogene, BHLH Transcription Factor	Protein Coding	8
54	STAT3	Signal Transducer And Activator Of Transcription 3	Protein Coding	8
55	STAT5A	Signal Transducer And Activator Of Transcription 5A	Protein Coding	8
56	STAT5B	Signal Transducer And Activator Of Transcription 5B	Protein Coding	8
57	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	8
58	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	8
59	EGFR	Epidermal Growth Factor Receptor	Protein Coding	8
60	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	7
61	ERBB2	Erb-B2 Receptor Tyrosine Kinase 2	Protein Coding	7
62	JAK2	Janus Kinase 2	Protein Coding	6
63	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	6
64	PTEN	Phosphatase And Tensin Homolog	Protein Coding	6
65	CCND1	Cyclin D1	Protein Coding	6
66	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	6
67	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	6
68	NRG1	Neuregulin 1	Protein Coding	6
69	ERBB3	Erb-B2 Receptor Tyrosine Kinase 3	Protein Coding	6
70	NRG2	Neuregulin 2	Protein Coding	6
71	IRS1	Insulin Receptor Substrate 1	Protein Coding	5
72	MAPK4	Mitogen-Activated Protein Kinase 4	Protein Coding	5
73	SP1	Sp1 Transcription Factor	Protein Coding	5
74	CBL	Cbl Proto-Oncogene	Protein Coding	5
75	RAC1	Rac Family Small GTPase 1	Protein Coding	5
76	EGF	Epidermal Growth Factor	Protein Coding	5
77	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	5
78	RPS6KB1	Ribosomal Protein S6 Kinase B1	Protein Coding	5
79	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	5
80	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	5
81	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	5
82	NRG3	Neuregulin 3	Protein Coding	5
83	JAK1	Janus Kinase 1	Protein Coding	5
84	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	4
85	FOXO3	Forkhead Box O3	Protein Coding	4
86	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	4
87	IKBKE	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Epsilon	Protein Coding	4
88	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	4
89	ITPR1	Inositol 1,4,5-Trisphosphate Receptor Type 1	Protein Coding	4
90	ITPR2	Inositol 1,4,5-Trisphosphate Receptor Type 2	Protein Coding	4
91	ITPR3	Inositol 1,4,5-Trisphosphate Receptor Type 3	Protein Coding	4
92	PLCB1	Phospholipase C Beta 1	Protein Coding	4
93	PLCB2	Phospholipase C Beta 2	Protein Coding	4
94	PLCB3	Phospholipase C Beta 3	Protein Coding	4
95	PLCB4	Phospholipase C Beta 4	Protein Coding	4
96	TLR4	Toll Like Receptor 4	Protein Coding	4
97	CDC42	Cell Division Cycle 42	Protein Coding	4
98	CDKN1B	Cyclin Dependent Kinase Inhibitor 1B	Protein Coding	4
99	FOXO1	Forkhead Box O1	Protein Coding	4
100	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	4
101	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	4
102	TP53	Tumor Protein P53	Protein Coding	4
103	TGFA	Transforming Growth Factor Alpha	Protein Coding	4
104	SHC1	SHC Adaptor Protein 1	Protein Coding	4
105	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	4
106	ERBB4	Erb-B2 Receptor Tyrosine Kinase 4	Protein Coding	4
107	CEBPB	CCAAT Enhancer Binding Protein Beta	Protein Coding	3
108	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	3
109	EP300	EP300 Lysine Acetyltransferase	Protein Coding	3
110	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	3
111	SOCS1	Suppressor Of Cytokine Signaling 1	Protein Coding	3
112	SOCS3	Suppressor Of Cytokine Signaling 3	Protein Coding	3
113	ATF1	Activating Transcription Factor 1	Protein Coding	3
114	ATF4	Activating Transcription Factor 4	Protein Coding	3
115	CAMK2A	Calcium/Calmodulin Dependent Protein Kinase II Alpha	Protein Coding	3
116	CAMK2B	Calcium/Calmodulin Dependent Protein Kinase II Beta	Protein Coding	3
117	CAMK2D	Calcium/Calmodulin Dependent Protein Kinase II Delta	Protein Coding	3
118	CAMK2G	Calcium/Calmodulin Dependent Protein Kinase II Gamma	Protein Coding	3
119	CREB1	CAMP Responsive Element Binding Protein 1	Protein Coding	3
120	CREB3	CAMP Responsive Element Binding Protein 3	Protein Coding	3
121	CREB3L4	CAMP Responsive Element Binding Protein 3 Like 4	Protein Coding	3
122	NFAT5	Nuclear Factor Of Activated T Cells 5	Protein Coding	3
123	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	3
124	NFATC2	Nuclear Factor Of Activated T Cells 2	Protein Coding	3
125	NFATC3	Nuclear Factor Of Activated T Cells 3	Protein Coding	3
126	NFATC4	Nuclear Factor Of Activated T Cells 4	Protein Coding	3
127	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	3
128	NFKBIB	NFKB Inhibitor Beta	Protein Coding	3
129	NFKBIE	NFKB Inhibitor Epsilon	Protein Coding	3
130	SYK	Spleen Associated Tyrosine Kinase	Protein Coding	3
131	RHOA	Ras Homolog Family Member A	Protein Coding	3
132	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	3
133	E2F1	E2F Transcription Factor 1	Protein Coding	3
134	IGF1	Insulin Like Growth Factor 1	Protein Coding	3
135	MDM2	MDM2 Proto-Oncogene	Protein Coding	3
136	NF1	Neurofibromin 1	Protein Coding	3
137	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	3
138	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	3
139	PLCD1	Phospholipase C Delta 1	Protein Coding	3
140	PLCD3	Phospholipase C Delta 3	Protein Coding	3
141	PLCD4	Phospholipase C Delta 4	Protein Coding	3
142	PLCE1	Phospholipase C Epsilon 1	Protein Coding	3
143	PLCZ1	Phospholipase C Zeta 1	Protein Coding	3
144	BTC	Betacellulin	Protein Coding	3
145	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	3
146	AREG	Amphiregulin	Protein Coding	3
147	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	3
148	EREG	Epiregulin	Protein Coding	3
149	HBEGF	Heparin Binding EGF Like Growth Factor	Protein Coding	3
150	SHC3	SHC Adaptor Protein 3	Protein Coding	3
151	SHC2	SHC Adaptor Protein 2	Protein Coding	3
152	BCL2	BCL2 Apoptosis Regulator	Protein Coding	3
153	CSN2	Casein Beta	Protein Coding	2
154	NMI	N-Myc And STAT Interactor	Protein Coding	2
155	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	2
156	PRL	Prolactin	Protein Coding	2
157	PRLR	Prolactin Receptor	Protein Coding	2
158	SOCS2	Suppressor Of Cytokine Signaling 2	Protein Coding	2
159	SOCS4	Suppressor Of Cytokine Signaling 4	Protein Coding	2
160	SOCS5	Suppressor Of Cytokine Signaling 5	Protein Coding	2
161	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	2
162	ATF2	Activating Transcription Factor 2	Protein Coding	2
163	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	2
164	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	2
165	PIK3C2G	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Gamma	Protein Coding	2
166	PPP3CA	Protein Phosphatase 3 Catalytic Subunit Alpha	Protein Coding	2
167	PPP3CB	Protein Phosphatase 3 Catalytic Subunit Beta	Protein Coding	2
168	PPP3CC	Protein Phosphatase 3 Catalytic Subunit Gamma	Protein Coding	2
169	PPP3R1	Protein Phosphatase 3 Regulatory Subunit B, Alpha	Protein Coding	2
170	PPP3R2	Protein Phosphatase 3 Regulatory Subunit B, Beta	Protein Coding	2
171	TEC	Tec Protein Tyrosine Kinase	Protein Coding	2
172	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
173	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	2
174	RHOB	Ras Homolog Family Member B	Protein Coding	2
175	RHOC	Ras Homolog Family Member C	Protein Coding	2
176	RHOD	Ras Homolog Family Member D	Protein Coding	2
177	RND3	Rho Family GTPase 3	Protein Coding	2
178	RHOG	Ras Homolog Family Member G	Protein Coding	2
179	RHOH	Ras Homolog Family Member H	Protein Coding	2
180	DIRAS3	DIRAS Family GTPase 3	Protein Coding	2
181	RND2	Rho Family GTPase 2	Protein Coding	2
182	CCNE1	Cyclin E1	Protein Coding	2
183	CDK2	Cyclin Dependent Kinase 2	Protein Coding	2
184	CDK4	Cyclin Dependent Kinase 4	Protein Coding	2
185	CDK6	Cyclin Dependent Kinase 6	Protein Coding	2
186	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	2
187	E2F2	E2F Transcription Factor 2	Protein Coding	2
188	E2F3	E2F Transcription Factor 3	Protein Coding	2
189	E2F4	E2F Transcription Factor 4	Protein Coding	2
190	E2F5	E2F Transcription Factor 5	Protein Coding	2
191	IGF2	Insulin Like Growth Factor 2	Protein Coding	2
192	PDGFA	Platelet Derived Growth Factor Subunit A	Protein Coding	2
193	PDGFB	Platelet Derived Growth Factor Subunit B	Protein Coding	2
194	PDGFC	Platelet Derived Growth Factor C	Protein Coding	2
195	RB1	RB Transcriptional Corepressor 1	Protein Coding	2
196	PDGFD	Platelet Derived Growth Factor D	Protein Coding	2
197	TSC1	TSC Complex Subunit 1	Protein Coding	2
198	TSC2	TSC Complex Subunit 2	Protein Coding	2
199	NCK2	NCK Adaptor Protein 2	Protein Coding	2
200	RPS6KB2	Ribosomal Protein S6 Kinase B2	Protein Coding	2
201	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	2
202	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	2
203	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
204	NCK1	NCK Adaptor Protein 1	Protein Coding	2
205	EIF4EBP1	Eukaryotic Translation Initiation Factor 4E Binding Protein 1	Protein Coding	2
206	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	2
207	BCL2L11	BCL2 Like 11	Protein Coding	2
208	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	2
209	SHC4	SHC Adaptor Protein 4	Protein Coding	2
210	BCL2L1	BCL2 Like 1	Protein Coding	2
211	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	2
212	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	2
213	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	2
214	PIK3CG	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma	Protein Coding	2
215	JAK3	Janus Kinase 3	Protein Coding	2
216	STAT2	Signal Transducer And Activator Of Transcription 2	Protein Coding	2
217	STAT4	Signal Transducer And Activator Of Transcription 4	Protein Coding	2
218	IL1A	Interleukin 1 Alpha	Protein Coding	2
219	IL1B	Interleukin 1 Beta	Protein Coding	2
220	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	2
221	IL1R2	Interleukin 1 Receptor Type 2	Protein Coding	2
222	MAP3K14	Mitogen-Activated Protein Kinase Kinase Kinase 14	Protein Coding	2
223	MAP3K4	Mitogen-Activated Protein Kinase Kinase Kinase 4	Protein Coding	2
224	MAP3K5	Mitogen-Activated Protein Kinase Kinase Kinase 5	Protein Coding	2
225	MAP3K7	Mitogen-Activated Protein Kinase Kinase Kinase 7	Protein Coding	2
226	SRF	Serum Response Factor	Protein Coding	2
227	MAP3K1	Mitogen-Activated Protein Kinase Kinase Kinase 1	Protein Coding	2
228	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	2
229	GH1	Growth Hormone 1	Protein Coding	2
230	TCF7	Transcription Factor 7	Protein Coding	1
231	ATF3	Activating Transcription Factor 3	Protein Coding	1
232	ATF5	Activating Transcription Factor 5	Protein Coding	1
233	ATF6	Activating Transcription Factor 6	Protein Coding	1
234	ATF7	Activating Transcription Factor 7	Protein Coding	1
235	BCL10	BCL10 Immune Signaling Adaptor	Protein Coding	1
236	BLK	BLK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
237	BLNK	B Cell Linker	Protein Coding	1
238	BTK	Bruton Tyrosine Kinase	Protein Coding	1
239	CALM1	Calmodulin 1	Protein Coding	1
240	CALM2	Calmodulin 2	Protein Coding	1
241	CALM3	Calmodulin 3	Protein Coding	1
242	CARD10	Caspase Recruitment Domain Family Member 10	Protein Coding	1
243	CD19	CD19 Molecule	Protein Coding	1
244	CD79A	CD79a Molecule	Protein Coding	1
245	CD79B	CD79b Molecule	Protein Coding	1
246	CD81	CD81 Molecule	Protein Coding	1
247	CR2	Complement C3d Receptor 2	Protein Coding	1
248	DAPP1	Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides 1	Protein Coding	1
249	FCGR2B	Fc Gamma Receptor IIb	Protein Coding	1
250	IL4	Interleukin 4	Protein Coding	1
251	IL4R	Interleukin 4 Receptor	Protein Coding	1
252	IRS2	Insulin Receptor Substrate 2	Protein Coding	1
253	CD180	CD180 Molecule	Protein Coding	1
254	LYN	LYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
255	MALT1	MALT1 Paracaspase	Protein Coding	1
256	PIK3AP1	Phosphoinositide-3-Kinase Adaptor Protein 1	Protein Coding	1
257	PIK3C3	Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3	Protein Coding	1
258	PLEKHA1	Pleckstrin Homology Domain Containing A1	Protein Coding	1
259	PLEKHA2	Pleckstrin Homology Domain Containing A2	Protein Coding	1
260	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	1
261	SPP1	Secreted Phosphoprotein 1	Protein Coding	1
262	CD40	CD40 Molecule	Protein Coding	1
263	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	1
264	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
265	AXIN1	Axin 1	Protein Coding	1
266	CCNE2	Cyclin E2	Protein Coding	1
267	CTNNB1	Catenin Beta 1	Protein Coding	1
268	FZD1	Frizzled Class Receptor 1	Protein Coding	1
269	FZD10	Frizzled Class Receptor 10	Protein Coding	1
270	FZD2	Frizzled Class Receptor 2	Protein Coding	1
271	FZD3	Frizzled Class Receptor 3	Protein Coding	1
272	FZD4	Frizzled Class Receptor 4	Protein Coding	1
273	FZD5	Frizzled Class Receptor 5	Protein Coding	1
274	FZD6	Frizzled Class Receptor 6	Protein Coding	1
275	FZD7	Frizzled Class Receptor 7	Protein Coding	1
276	FZD8	Frizzled Class Receptor 8	Protein Coding	1
277	FZD9	Frizzled Class Receptor 9	Protein Coding	1
278	LEF1	Lymphoid Enhancer Binding Factor 1	Protein Coding	1
279	MGMT	O-6-Methylguanine-DNA Methyltransferase	Protein Coding	1
280	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	1
281	TCF3	Transcription Factor 3	Protein Coding	1
282	TCF4	Transcription Factor 4	Protein Coding	1
283	CBLB	Cbl Proto-Oncogene B	Protein Coding	1
284	PTK2	Protein Tyrosine Kinase 2	Protein Coding	1
285	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
286	CRK	CRK Proto-Oncogene, Adaptor Protein	Protein Coding	1
287	NRG4	Neuregulin 4	Protein Coding	1
288	BUB1B-PAK6	BUB1B-PAK6 Readthrough	Protein Coding	1
289	ABL2	ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase	Protein Coding	1
290	VEGFA	Vascular Endothelial Growth Factor A	Protein Coding	1
291	RPS6	Ribosomal Protein S6	Protein Coding	1
292	AXL	AXL Receptor Tyrosine Kinase	Protein Coding	1
293	KDR	Kinase Insert Domain Receptor	Protein Coding	1
294	IL6R	Interleukin 6 Receptor	Protein Coding	1
295	IL6	Interleukin 6	Protein Coding	1
296	HGF	Hepatocyte Growth Factor	Protein Coding	1
297	GAS6	Growth Arrest Specific 6	Protein Coding	1
298	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
299	FGF2	Fibroblast Growth Factor 2	Protein Coding	1
300	EIF4E	Eukaryotic Translation Initiation Factor 4E	Protein Coding	1
301	EIF4E2	Eukaryotic Translation Initiation Factor 4E Family Member 2	Protein Coding	1
302	CCND2	Cyclin D2	Protein Coding	1
303	BRCA2	BRCA2 DNA Repair Associated	Protein Coding	1
304	BRCA1	BRCA1 DNA Repair Associated	Protein Coding	1
305	ERRFI1	ERBB Receptor Feedback Inhibitor 1	Protein Coding	1
306	ATM	ATM Serine/Threonine Kinase	Protein Coding	1
307	MDM4	MDM4 Regulator Of P53	Protein Coding	1
308	MSH6	MutS Homolog 6	Protein Coding	1
309	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
310	CDKN2C	Cyclin Dependent Kinase Inhibitor 2C	Protein Coding	1
311	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	1
312	SPRY2	Sprouty RTK Signaling Antagonist 2	Protein Coding	1
313	FOXO4	Forkhead Box O4	Protein Coding	1
314	ETV4	ETS Variant Transcription Factor 4	Protein Coding	1
315	GSK3A	Glycogen Synthase Kinase 3 Alpha	Protein Coding	1
316	STAT6	Signal Transducer And Activator Of Transcription 6	Protein Coding	1
317	IL2	Interleukin 2	Protein Coding	1
318	IL2RA	Interleukin 2 Receptor Subunit Alpha	Protein Coding	1
319	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	1
320	IL2RG	Interleukin 2 Receptor Subunit Gamma	Protein Coding	1
321	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
322	BID	BH3 Interacting Domain Death Agonist	Protein Coding	1
323	CYCS	Cytochrome C, Somatic	Protein Coding	1
324	IRAK1	Interleukin 1 Receptor Associated Kinase 1	Protein Coding	1
325	IRAK2	Interleukin 1 Receptor Associated Kinase 2	Protein Coding	1
326	IRAK3	Interleukin 1 Receptor Associated Kinase 3	Protein Coding	1
327	IRAK4	Interleukin 1 Receptor Associated Kinase 4	Protein Coding	1
328	MYD88	MYD88 Innate Immune Signal Transduction Adaptor	Protein Coding	1
329	TLR1	Toll Like Receptor 1	Protein Coding	1
330	TLR10	Toll Like Receptor 10	Protein Coding	1
331	TLR2	Toll Like Receptor 2	Protein Coding	1
332	TLR3	Toll Like Receptor 3	Protein Coding	1
333	TLR5	Toll Like Receptor 5	Protein Coding	1
334	TLR6	Toll Like Receptor 6	Protein Coding	1
335	TLR7	Toll Like Receptor 7	Protein Coding	1
336	TLR8	Toll Like Receptor 8	Protein Coding	1
337	TLR9	Toll Like Receptor 9	Protein Coding	1
338	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
339	TREM1	Triggering Receptor Expressed On Myeloid Cells 1	Protein Coding	1
340	TYROBP	Transmembrane Immune Signaling Adaptor TYROBP	Protein Coding	1
341	CD14	CD14 Molecule	Protein Coding	1
342	LBP	Lipopolysaccharide Binding Protein	Protein Coding	1
343	ADCY1	Adenylate Cyclase 1	Protein Coding	1
344	ADCY2	Adenylate Cyclase 2	Protein Coding	1
345	ADCY3	Adenylate Cyclase 3	Protein Coding	1
346	ADCYAP1R1	ADCYAP Receptor Type I	Protein Coding	1
347	GNAS	GNAS Complex Locus	Protein Coding	1
348	MAP3K10	Mitogen-Activated Protein Kinase Kinase Kinase 10	Protein Coding	1
349	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
350	MAP3K12	Mitogen-Activated Protein Kinase Kinase Kinase 12	Protein Coding	1
351	MAP3K13	Mitogen-Activated Protein Kinase Kinase Kinase 13	Protein Coding	1
352	MAP3K2	Mitogen-Activated Protein Kinase Kinase Kinase 2	Protein Coding	1
353	MAP3K3	Mitogen-Activated Protein Kinase Kinase Kinase 3	Protein Coding	1
354	MAP3K6	Mitogen-Activated Protein Kinase Kinase Kinase 6	Protein Coding	1
355	MAP3K8	Mitogen-Activated Protein Kinase Kinase Kinase 8	Protein Coding	1
356	MAP3K9	Mitogen-Activated Protein Kinase Kinase Kinase 9	Protein Coding	1
357	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
358	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
359	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
360	PRKAR1A	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Alpha	Protein Coding	1
361	PRKAR1B	Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta	Protein Coding	1
362	PRKAR2A	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Alpha	Protein Coding	1
363	PRKAR2B	Protein Kinase CAMP-Dependent Type II Regulatory Subunit Beta	Protein Coding	1
364	CAMK1G	Calcium/Calmodulin Dependent Protein Kinase IG	Protein Coding	1
365	CAMK1	Calcium/Calmodulin Dependent Protein Kinase I	Protein Coding	1
366	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
367	CAMK1D	Calcium/Calmodulin Dependent Protein Kinase ID	Protein Coding	1
368	HAT1	Histone Acetyltransferase 1	Protein Coding	1
369	HMGB1	High Mobility Group Box 1	Protein Coding	1
370	IFNG	Interferon Gamma	Protein Coding	1
371	IFNGR1	Interferon Gamma Receptor 1	Protein Coding	1
372	IFNGR2	Interferon Gamma Receptor 2	Protein Coding	1
373	MOK	MOK Protein Kinase	Protein Coding	1
374	TNF	Tumor Necrosis Factor	Protein Coding	1
375	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	1
376	CSH1	Chorionic Somatomammotropin Hormone 1	Protein Coding	1
377	CSH2	Chorionic Somatomammotropin Hormone 2	Protein Coding	1
378	IRF1	Interferon Regulatory Factor 1	Protein Coding	1
379	NEK3	NIMA Related Kinase 3	Protein Coding	1
380	OAS1	2''-5''-Oligoadenylate Synthetase 1	Protein Coding	1
381	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
382	PAEPP1	Progestagen Associated Endometrial Protein Pseudogene 1	Pseudogene	1
383	ADAM17	ADAM Metallopeptidase Domain 17	Protein Coding	1
384	APH1A	Aph-1A Gamma-Secretase Subunit	Protein Coding	1
385	NCSTN	Nicastrin	Protein Coding	1
386	PSENEN	Presenilin Enhancer, Gamma-Secretase Subunit	Protein Coding	1
387	PSEN1	Presenilin 1	Protein Coding	1
388	PSEN2	Presenilin 2	Protein Coding	1
389	APH1B	Aph-1B Gamma-Secretase Subunit	Protein Coding	1
390	CEBPD	CCAAT Enhancer Binding Protein Delta	Protein Coding	1
391	GH2	Growth Hormone 2	Protein Coding	1
392	GHR	Growth Hormone Receptor	Protein Coding	1
393	RPS6KA1	Ribosomal Protein S6 Kinase A1	Protein Coding	1
394	RPS6KA2	Ribosomal Protein S6 Kinase A2	Protein Coding	1
395	RPS6KA3	Ribosomal Protein S6 Kinase A3	Protein Coding	1
396	RPS6KA4	Ribosomal Protein S6 Kinase A4	Protein Coding	1
397	RPS6KA6	Ribosomal Protein S6 Kinase A6	Protein Coding	1
398	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	1
399	MPL	MPL Proto-Oncogene, Thrombopoietin Receptor	Protein Coding	1
400	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
401	ATR	ATR Checkpoint Kinase	Protein Coding	1
402	SMPD1	Sphingomyelin Phosphodiesterase 1	Protein Coding	1
403	SMPD2	Sphingomyelin Phosphodiesterase 2	Protein Coding	1
404	SMPD3	Sphingomyelin Phosphodiesterase 3	Protein Coding	1

Disorders associated with Prolactin Signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Rasopathy	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS2, SOS1, SOS2	16.00
2	Ovarian cancer	Enrichment	AKT1, APC, CDKN1B, CDKN2A, CTNNB1, EGFR, KRAS, PDGFRA, PTEN, RB1, RRAS2, TP53, TSC2	16.00
3	Noonan syndrome and noonan-related syndrome	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, NRAS, RAF1, SOS1	16.00
4	Lung non-small cell carcinoma	Enrichment	BRAF, EGFR, ERBB2, HRAS, KRAS, MAP2K1, NRAS, PIK3CA	16.00
5	Bladder cancer	Enrichment	EGFR, ERBB2, ERBB3, FGFR3, HRAS, KRAS, NF1, PIK3CA, PTEN	16.00
6	Noonan syndrome 1	Enrichment	BRAF, HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, RAF1, RRAS, RRAS2, SOS1, SOS2	16.00
7	Colorectal cancer	Enrichment	AKT1, BAX, BRAF, CCND1, ERBB2, FGFR2, FGFR3, MET, NRAS, PIK3CA, PIK3R1, SRC	11.33
8	Hereditary breast carcinoma	Enrichment	AKT1, ATM, BRCA1, BRCA2, KRAS, MSH6, PIK3CA, PTEN, TP53	10.94
9	Gastric cancer	Enrichment	ATM, BRCA1, BRCA2, CDK4, CDKN2A, ERBB2, FGFR2, KRAS, MSH6, NF1, PIK3CA, PTEN, TP53	10.75
10	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1, EGF, TP53, TSC1, TSC2	10.70
11	Lip and oral cavity carcinoma	Enrichment	BRAF, CDKN2A, EGFR, HRAS, PIK3CA, RB1, TP53	10.63
12	Inherited cancer-predisposing syndrome	Enrichment	ATM, BRCA1, BRCA2, CDK4, CDKN1B, CDKN2A, EGFR, MET, MSH6, NF1, PDGFRA, PTEN, RB1, TP53, TSC1, TSC2	10.61
13	Breast cancer	Enrichment	AKT1, ATM, BRCA1, BRCA2, CDKN2B, KRAS, MSH6, PIK3CA, PTEN, TP53	10.46
14	Rhabdomyosarcoma	Enrichment	BRCA1, BRCA2, CBL, HRAS, MSH6, NF1, PTEN, TP53	10.44
15	Endometrial cancer	Enrichment	ATM, BRCA1, BRCA2, FGFR2, MSH6, PIK3CA, PTEN	10.29
16	Myeloma, multiple	Enrichment	ATM, BRAF, BRCA2, CCND1, CDKN2C, KRAS, NF1, PIK3R2, TP53	10.15
17	Cardiofaciocutaneous syndrome 1	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.07
18	Cardiofaciocutaneous syndrome	Enrichment	BRAF, KRAS, MAP2K1, MAP2K2	10.07
19	Lung cancer susceptibility 3	Enrichment	BRAF, EGFR, ERBB2, KRAS, RB1, TP53	9.87
20	Nevus, epidermal	Enrichment	FGFR3, HRAS, KRAS, NRAS, PIK3CA	9.75
21	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	9.62
22	Prostate cancer	Enrichment	ATM, BRCA1, BRCA2, MSH6, PIK3CA, PTEN, TP53	9.46
23	Lung cancer	Enrichment	BRAF, BRCA1, EGFR, ERBB2, KRAS, MET, PIK3CA	9.14
24	Hereditary breast ovarian cancer syndrome	Enrichment	ATM, BRCA1, BRCA2, KRAS, MSH6, NF1, PTEN, TP53	8.90
25	Noonan syndrome 3	Enrichment	HRAS, KRAS, RAF1, SOS1	8.56
26	Uterine corpus cancer	Enrichment	ATM, BRCA1, BRCA2, MSH6, PTEN	8.49
27	Melanocytic nevus syndrome, congenital	Enrichment	BRAF, HRAS, NRAS, RAF1	8.34
28	Pancreatic cancer	Enrichment	ATM, BRCA1, BRCA2, CDKN2A, KRAS, TP53	8.18
29	Hemimegalencephaly	Enrichment	AKT3, MTOR, PIK3CA, PTEN	8.17
30	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA, TP53	7.73
31	Lung squamous cell carcinoma	Enrichment	CDKN2A, EGFR, KRAS, PIK3CA	7.73
32	Langerhans cell histiocytosis	Enrichment	BRAF, MAP2K1, NRAS	7.62
33	Thyroid cancer, nonmedullary, 2	Enrichment	BRAF, HRAS, NRAS, PTEN	7.39
34	Follicular thyroid carcinoma	Enrichment	BRAF, HRAS, NRAS, PTEN	7.39
35	Multiple endocrine neoplasia, type i	Enrichment	CDKN1A, CDKN1B, CDKN2B, CDKN2C	7.37
36	Gallbladder cancer	Enrichment	BRAF, KRAS, PIK3CA, TP53	7.37
37	Pilomyxoid astrocytoma	Enrichment	BRAF, FGFR1, KRAS, RAF1	7.37
38	Diffuse large b-cell lymphoma	Enrichment	BRAF, BRCA2, FOXO1, PTEN, TP53	7.11
39	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	6.79
40	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	6.76
41	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2, STAT3	6.69
42	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	6.46
43	Juvenile myelomonocytic leukemia	Enrichment	CBL, KRAS, NRAS, RRAS	6.32
44	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	6.31
45	Meningioma	Enrichment	AKT1, PDGFB, PIK3CA, PTEN	6.19
46	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, CCND2, PIK3R2	6.07
47	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, RASA1	6.02
48	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	6.01
49	Autosomal non-syndromic agammaglobulinemia	Enrichment	BLNK, CD79A, CD79B, PIK3R1	5.96
50	Rhabdomyosarcoma 2	Enrichment	FOXO1, NF1, TP53	5.68
51	Primary hypereosinophilic syndrome	Enrichment	FGFR1, PDGFRA, PDGFRB	5.68
52	Focal cortical dysplasia, type ii	Enrichment	MTOR, TSC1, TSC2	5.67
53	Craniopharyngioma	Enrichment	APC, BRAF, CTNNB1	5.67
54	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, TSC1, TSC2	5.67
55	Gliosarcoma	Enrichment	ATM, EGFR, FGFR1, TP53	5.67
56	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, RASA1	5.64
57	Melanoma, cutaneous malignant 1	Enrichment	BRAF, CDK4, CDKN2A, CDKN2B	5.56
58	Giant cell glioblastoma	Enrichment	ATM, EGFR, FGFR1, TP53	5.56
59	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, RASA1	5.49
60	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	5.47
61	Li-fraumeni syndrome	Enrichment	CDKN2A, MDM2, TP53	5.38
62	Cowden syndrome 1	Enrichment	EGFR, PIK3CA, PTEN	5.38
63	Arteriovenous malformations of the brain	Enrichment	BRAF, EGFR, IL6, KRAS	5.31
64	Squamous cell carcinoma, head and neck	Enrichment	EGFR, PTEN, TP53	5.14
65	Adrenocortical carcinoma	Enrichment	CDKN2A, CTNNB1, TP53	4.98
66	Specific learning disability	Enrichment	GHR, MAPK1, RPS6KA3	4.92
67	Cowden syndrome	Enrichment	AKT1, PIK3CA, PTEN	4.76
68	Pulmonic stenosis	Enrichment	BRAF, SOS1	4.72
69	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS, PRKAR1A	4.62
70	Leukemia, chronic lymphocytic	Enrichment	ATM, CCND1, TP53	4.61
71	Melanoma	Enrichment	BRAF, CDKN2A, PTEN	4.61
72	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1, TP53	4.56
73	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG, NFKBIA	4.52
74	Immunodeficiency 33	Enrichment	IKBKG, IRAK4	4.49
75	Transient predisposition to invasive pyogenic bacterial infection	Enrichment	IRAK4, MYD88	4.49
76	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	4.46
77	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.44
78	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	4.44
79	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	4.44
80	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	4.44
81	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	4.44
82	Inflammatory breast carcinoma	Enrichment	BRCA1, BRCA2	4.44
83	Bilateral breast cancer	Enrichment	BRCA1, BRCA2	4.44
84	Pleomorphic rhabdomyosarcoma	Enrichment	NF1, TP53	4.44
85	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	4.42
86	Thyroid cancer, nonmedullary, 1	Enrichment	BRAF, TP53	4.30
87	Lung sarcomatoid carcinoma	Enrichment	KRAS, TP53	4.30
88	Noonan syndrome with multiple lentigines	Enrichment	BRAF, RAF1	4.30
89	Alzheimer disease 4	Enrichment	PSEN1, PSEN2	4.24
90	Breast-ovarian cancer, familial 1	Enrichment	ATM, BRCA1, BRCA2	4.23
91	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.23
92	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	4.23
93	High-grade b-cell lymphoma double-hit/triple-hit	Enrichment	BCL2, MYC	4.23
94	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	4.23
95	Nk-cell enteropathy	Enrichment	AXL, IGF1R, PIK3CB	4.20
96	Melanoma of soft tissue	Enrichment	ATF1, CREB1	4.14
97	Common variable immunodeficiency phenotype due to cd19/cd81 deficiency	Enrichment	CD19, CD81	4.12
98	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	4.12
99	Behcet syndrome	Enrichment	IFNGR1, TLR4, TNFRSF1A	4.08
100	Meningioma, familial	Enrichment	NF2, PDGFB, PTEN	4.08
101	Tethered spinal cord syndrome	Enrichment	BRAF, CREBBP	4.07
102	Lynch syndrome	Enrichment	KRAS, MSH6, PIK3CA	4.04
103	Ataxia-telangiectasia	Enrichment	ATM, BRAF	3.97
104	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	3.97
105	Osteogenic sarcoma	Enrichment	RB1, TP53	3.97
106	Dedifferentiated liposarcoma	Enrichment	CDK4, MDM2	3.97
107	Hamartoma	Enrichment	TSC1, TSC2	3.97
108	Squamous cell carcinoma	Enrichment	RB1, TP53	3.97
109	Adenocarcinoma	Enrichment	ATM, TP53	3.97
110	Bone osteosarcoma	Enrichment	RB1, TP53	3.97
111	Well-differentiated liposarcoma	Enrichment	CDK4, MDM2	3.97
112	Crouzon syndrome	Enrichment	FGFR2, FGFR3	3.95
113	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	3.95
114	Spermatocytoma	Enrichment	FGFR3, HRAS	3.95
115	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL, PTPN11	3.93
116	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, ITPR3	3.90
117	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	3.90
118	Insulin-like growth factor i	Enrichment	IGF1, IGF1R	3.75
119	Myelofibrosis	Enrichment	JAK2, MPL	3.71
120	Essential thrombocythemia	Enrichment	JAK2, MPL	3.71
121	Myeloproliferative neoplasm	Enrichment	CBL, JAK2	3.71
122	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	3.70
123	Desmoid tumor	Enrichment	APC, CTNNB1	3.70
124	Small cell cancer of the lung	Enrichment	RB1, TP53	3.67
125	Polyposis syndrome, hereditary mixed, 1	Enrichment	BRCA1, BRCA2	3.67
126	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2, NF1	3.67
127	Cholangiocarcinoma	Enrichment	BRCA1, BRCA2	3.67
128	Lynch syndrome 4	Enrichment	MSH6, RB1	3.67
129	Mantle cell lymphoma	Enrichment	ATM, CCND1	3.67
130	Tuberous sclerosis	Enrichment	TSC1, TSC2	3.67
131	Embryonal rhabdomyosarcoma	Enrichment	NF1, TP53	3.67
132	Pilocytic astrocytoma	Enrichment	KRAS, NF1	3.67
133	Glioma	Enrichment	FGFR2, PTEN	3.67
134	T-cell acute lymphoblastic leukemia	Enrichment	ABL1, BCL10	3.65
135	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	3.65
136	Lymphoma, non-hodgkin, familial	Enrichment	BRAF, TP53	3.63
137	Multisystem inflammatory syndrome in children	Enrichment	IRAK3, TLR3, TLR6	3.58
138	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL, MAPK1	3.58
139	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	3.53
140	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	3.53
141	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	3.53
142	Primary hyperaldosteronism	Enrichment	BRAF, TP53	3.52
143	Systemic lupus erythematosus	Enrichment	BLK, CR2, FCGR2B, SPP1	3.45
144	Breast-ovarian cancer, familial 2	Enrichment	BRCA1, BRCA2	3.45
145	Acute megakaryocytic leukemia	Enrichment	PTEN, TP53	3.45
146	Noonan syndrome 13	Enrichment	MAPK1	3.43
147	T-cell large granular lymphocyte leukemia	Enrichment	STAT3	3.43
148	Autoimmune disease, multisystem, infantile-onset, 1	Enrichment	STAT3	3.43
149	Stat3-related early-onset multisystem autoimmune disease	Enrichment	STAT3	3.43
150	Chronic lymphoproliferative disorder of natural killer cells	Enrichment	STAT3	3.43
151	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	3.43
152	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	3.43
153	Hirschsprung disease 1	Enrichment	ERBB2, ERBB3, NRG3	3.42
154	Early-onset autosomal dominant alzheimer disease	Enrichment	PSEN1, PSEN2	3.40
155	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B-PAK6, PAK6	3.36
156	Oculoectodermal syndrome	Enrichment	KRAS	3.35
157	Melanosis, neurocutaneous	Enrichment	NRAS	3.35
158	Noonan syndrome 6	Enrichment	NRAS	3.35
159	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	3.35
160	Congenital pulmonary airway malformation	Enrichment	KRAS	3.35
161	Phakomatosis pigmentokeratotica	Enrichment	HRAS	3.35
162	Neurocutaneous melanocytosis	Enrichment	NRAS	3.35
163	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.30
164	Hepatoblastoma	Enrichment	APC, CTNNB1, TP53	3.20
165	Overgrowth syndrome	Enrichment	MTOR, PIK3R1	3.19
166	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, FZD4	3.19
167	Oligoarticular juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	3.16
168	Rheumatoid factor-negative juvenile idiopathic arthritis	Enrichment	IL2RA, IL2RB	3.16
169	Acute promyelocytic leukemia	Enrichment	STAT3, STAT5B	3.15
170	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	3.13
171	Lymphoma, mucosa-associated lymphoid type	Enrichment	BCL10, MALT1	3.13
172	Renal cell carcinoma, papillary, 1	Enrichment	ATM, MET	3.13
173	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	CDKN2A, TP53	3.13
174	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	3.07
175	Costello syndrome	Enrichment	HRAS	3.05
176	Wooly hair nevus	Enrichment	HRAS	3.05
177	Severe combined immunodeficiency	Enrichment	IKBKB, JAK3, LCK	3.04
178	Glioma susceptibility 1	Enrichment	ERBB2, TP53	3.01
179	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFB, PDGFRB	2.98
180	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	STAT3	2.96
181	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	2.96
182	Hyper ige syndrome	Enrichment	STAT3	2.96
183	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	2.96
184	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1B-PAK6, PAK6	2.92
185	Leukemia, acute lymphoblastic 3	Enrichment	JAK2, NF1	2.88
186	Lynch syndrome 1	Enrichment	ATM, MSH6	2.80
187	Familial isolated dilated cardiomyopathy	Enrichment	PSEN1, PSEN2, RAF1	2.78
188	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.75
189	Epidermolytic nevus	Enrichment	HRAS	2.75
190	Exudative vitreoretinopathy	Enrichment	CTNNB1, FZD4	2.74
191	Autosomal dominant non-syndromic intellectual disability	Enrichment	CAMK2A, CAMK2B, ERBB4	2.72
192	Familial colorectal cancer type x	Enrichment	ATM, BRCA2	2.72
193	Autism spectrum disorder	Enrichment	MAP2K1, NF1, PTEN, TCF4, TSC2	2.70
194	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	2.70
195	46,xy partial gonadal dysgenesis	Enrichment	MAP3K1, SOS1	2.68
196	Permanent neonatal diabetes mellitus	Enrichment	STAT3	2.53
197	Pallister-killian syndrome	Enrichment	ARAF	2.53
198	Noonan syndrome 5	Enrichment	RAF1	2.53
199	Melorheostosis, isolated	Enrichment	MAP2K1	2.53
200	Noonan syndrome 7	Enrichment	BRAF	2.53
201	Leopard syndrome 3	Enrichment	BRAF	2.53
202	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.53
203	Seckel syndrome 1	Enrichment	ATR	2.53
204	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	2.53
205	Autoimmune lymphoproliferative syndrome, type iii	Enrichment	PRKCD	2.53
206	Noonan syndrome 11	Enrichment	MRAS	2.53
207	Bone marrow failure syndrome 5	Enrichment	TP53	2.53
208	Papilloma of choroid plexus	Enrichment	TP53	2.53
209	Basal cell carcinoma 7	Enrichment	TP53	2.53
210	Anaplastic thyroid carcinoma	Enrichment	TP53	2.53
211	Lymphangioma	Enrichment	BRAF	2.53
212	Phace association	Enrichment	BRAF	2.53
213	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.53
214	Melorheostosis	Enrichment	MAP2K1	2.53
215	Leopard syndrome 2	Enrichment	RAF1	2.53
216	Cutaneous telangiectasia and cancer syndrome, familial	Enrichment	ATR	2.53
217	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	2.53
218	Ductal carcinoma in situ	Enrichment	TP53	2.53
219	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.53
220	Acid sphingomyelinase deficiency	Enrichment	SMPD1	2.53
221	Thrombocytopenia 6	Enrichment	SRC	2.53
222	Trigonitis	Enrichment	RAF1	2.53
223	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.53
224	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.53
225	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.53
226	Choroid plexus cancer	Enrichment	TP53	2.53
227	Syringocystadenoma papilliferum	Enrichment	BRAF	2.53
228	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.53
229	Ganglioglioma	Enrichment	BRAF	2.53
230	Nongerminomatous germ cell tumor	Enrichment	BRAF	2.53
231	Phace syndrome	Enrichment	BRAF	2.53
232	Familial cutaneous telangiectasia and oropharyngeal predisposition cancer syndrome	Enrichment	ATR	2.53
233	Classic hairy cell leukemia	Enrichment	BRAF	2.53
234	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.53
235	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	2.51
236	Thrombocythemia 2	Enrichment	MPL	2.51
237	Noonan syndrome 4	Enrichment	SOS1	2.51
238	Amegakaryocytic thrombocytopenia, congenital, 1	Enrichment	MPL	2.51
239	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.51
240	Growth hormone insensitivity syndrome with immune dysregulation 2, autosomal dominant	Enrichment	STAT5B	2.51
241	Short syndrome	Enrichment	PIK3R1	2.51
242	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.51
243	Immunodeficiency 31a	Enrichment	STAT1	2.51
244	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.51
245	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.51
246	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.51
247	Immunodeficiency 31b	Enrichment	STAT1	2.51
248	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.51
249	Gorham's disease	Enrichment	RASA1	2.51
250	Renal cell carcinoma, nonpapillary	Enrichment	ATM, MET	2.44
251	Wilms tumor 1	Enrichment	BRAF, BRCA2	2.44
252	Hydrocephalus	Enrichment	FGFR2, PDGFRB	2.44
253	Coffin-lowry syndrome	Enrichment	RPS6KA3	2.37
254	Dermatitis, atopic, 4	Enrichment	SOCS3	2.37
255	Laron syndrome	Enrichment	GHR	2.37
256	Intellectual developmental disorder, x-linked 19	Enrichment	RPS6KA3	2.37
257	Growth hormone insensitivity, partial	Enrichment	GHR	2.37
258	Symptomatic form of coffin-lowry syndrome in female carriers	Enrichment	RPS6KA3	2.37
259	Proteus syndrome	Enrichment	AKT1	2.35
260	Paget disease, extramammary	Enrichment	ERBB2	2.35
261	Acne inversa, familial, 1	Enrichment	NCSTN	2.35
262	Noonan syndrome 9	Enrichment	SOS2	2.35
263	Visceral neuropathy, familial, 2, autosomal recessive	Enrichment	ERBB2	2.35
264	Cardiomyopathy, dilated, 1v	Enrichment	PSEN2	2.35
265	Cardiomyopathy, dilated, 1u	Enrichment	PSEN1	2.35
266	Cowden syndrome 6	Enrichment	AKT1	2.35
267	Amyotrophic lateral sclerosis 19	Enrichment	ERBB4	2.35
268	Acne inversa, familial, 2, with or without dowling-degos disease	Enrichment	PSENEN	2.35
269	Acne inversa, familial, 3	Enrichment	PSEN1	2.35
270	Pash syndrome	Enrichment	NCSTN	2.35
271	Huntington's disease-like	Enrichment	PSEN2	2.35
272	Serous carcinoma of the corpus uteri	Enrichment	ERBB2	2.35
273	Macrodactyly	Enrichment	PIK3CA	2.35
274	Metachondromatosis	Enrichment	PTPN11	2.35
275	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.35
276	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.35
277	Leopard syndrome 1	Enrichment	PTPN11	2.35
278	Cowden syndrome 5	Enrichment	PIK3CA	2.35
279	Multiple fibroadenomas of the breast	Enrichment	PRLR	2.35
280	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.35
281	Transient erythroblastopenia of childhood	Enrichment	TEC	2.35
282	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.35
283	Hyperprolactinemia	Enrichment	PRLR	2.35
284	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.35
285	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.35
286	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.35
287	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	2.35
288	Immunodeficiency 100 with pulmonary alveolar proteinosis and hypogammaglobulinemia	Enrichment	OAS1	2.35
289	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	2.35
290	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.35
291	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	2.35
292	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.35
293	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.35
294	Hypospadias	Enrichment	PIK3CA	2.35
295	Capillary hemangioma	Enrichment	AKT3	2.35
296	Familial hyperprolactinemia	Enrichment	PRLR	2.35
297	Rare venous malformation	Enrichment	PIK3CA	2.35
298	Diaphragmatic eventration	Enrichment	PIK3CA	2.35
299	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.35
300	Menke-hennekam syndrome	Enrichment	CREBBP	2.35
301	Rare combined vascular malformation	Enrichment	PIK3CA	2.35
302	Cavernous lymphangioma	Enrichment	PIK3CA	2.35
303	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.35
304	Infantile-onset pulmonary alveolar proteinosis-hypogammaglobulinemia	Enrichment	OAS1	2.35
305	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	2.35
306	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.35
307	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.35
308	Macrodactyly of toe	Enrichment	PIK3CA	2.35
309	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.35
310	Malignant astrocytoma	Enrichment	PTPN11	2.35
311	Periodic fever, familial, autosomal dominant	Enrichment	TNFRSF1A	2.34
312	Helicobacter pylori infection	Enrichment	IFNGR1	2.34
313	Brachyphalangy, polydactyly, and tibial aplasia/hypoplasia	Enrichment	HMGB1	2.34
314	Immunodeficiency 27a	Enrichment	IFNGR1	2.34
315	Immunodeficiency 69	Enrichment	IFNG	2.34
316	Chronic recurrent multifocal osteomyelitis 3	Enrichment	IL1R1	2.34
317	Immunodeficiency 27b	Enrichment	IFNGR1	2.34
318	Multiple sclerosis 5	Enrichment	TNFRSF1A	2.34
319	Macular degeneration, age-related, 10	Enrichment	TLR4	2.34
320	Tnf receptor-associated periodic fever syndrome	Enrichment	TNFRSF1A	2.34
321	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.34
322	Immunodeficiency 129	Enrichment	RHOH	2.34
323	T-cell immunodeficiency with epidermodysplasia verruciformis	Enrichment	RHOH	2.34
324	Nocarh syndrome	Enrichment	CDC42	2.34
325	Autosomal dominant mendelian susceptibility to mycobacterial diseases due to partial ifngammar2 deficiency	Enrichment	IFNGR2	2.34
326	Dandy-walker syndrome	Enrichment	BRAF, PDGFRB	2.33
327	Anhidrosis, isolated, with normal sweat glands	Enrichment	ITPR2	2.31
328	Acrodysostosis 1 with or without hormone resistance	Enrichment	PRKAR1A	2.31
329	Cardiospondylocarpofacial syndrome	Enrichment	MAP3K7	2.31
330	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.31
331	Carney complex, type 1	Enrichment	PRKAR1A	2.31
332	Osseous heteroplasia, progressive	Enrichment	GNAS	2.31
333	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	2.31
334	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.31
335	46,xy sex reversal 6	Enrichment	MAP3K1	2.31
336	Frontometaphyseal dysplasia 2	Enrichment	MAP3K7	2.31
337	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.31
338	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.31
339	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.31
340	Charcot-marie-tooth disease, demyelinating, type 1j	Enrichment	ITPR3	2.31
341	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.31
342	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.31
343	Myxoma, intracardiac	Enrichment	PRKAR1A	2.31
344	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.31
345	Disorders of gnas inactivation	Enrichment	GNAS	2.31
346	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.31
347	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.31
348	Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy	Enrichment	ITPR3	2.31
349	Immunodeficiency 112	Enrichment	MAP3K14	2.31
350	Prkar1b-related neurodegenerative dementia with intermediate filaments	Enrichment	PRKAR1B	2.31
351	Cerebral cavernous malformations 5	Enrichment	MAP3K3	2.31
352	Monostotic fibrous dysplasia	Enrichment	GNAS	2.31
353	Verrucous hemangioma	Enrichment	MAP3K3	2.31
354	Mazabraud syndrome	Enrichment	GNAS	2.31
355	Nik deficiency	Enrichment	MAP3K14	2.31
356	Erythroleukemia, familial	Enrichment	ERBB3	2.31
357	Hypomagnesemia 4, renal	Enrichment	EGF	2.31
358	Lethal congenital contracture syndrome 2	Enrichment	ERBB3	2.31
359	Pseudo-torch syndrome 3	Enrichment	STAT2	2.31
360	Intellectual developmental disorder, autosomal recessive 63	Enrichment	CAMK2A	2.31
361	Intellectual developmental disorder, autosomal dominant 54	Enrichment	CAMK2B	2.31
362	Disabling pansclerotic morphea of childhood	Enrichment	STAT4	2.31
363	Systemic lupus erythematosus 11	Enrichment	STAT4	2.31
364	Immunodeficiency 97 with autoinflammation	Enrichment	PIK3CG	2.31
365	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.31
366	Intellectual developmental disorder, autosomal dominant 53	Enrichment	CAMK2A	2.31
367	Intellectual developmental disorder, autosomal dominant 59	Enrichment	CAMK2G	2.31
368	Egf-related primary hypomagnesemia with intellectual disability	Enrichment	EGF	2.31
369	Scoliosis	Enrichment	CREBBP, PTPN11	2.29
370	Incontinentia pigmenti	Enrichment	IKBKG	2.26
371	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	2.26
372	Fetal encasement syndrome	Enrichment	CHUK	2.26
373	Immunodeficiency 15b	Enrichment	IKBKB	2.26
374	Immunodeficiency 15a	Enrichment	IKBKB	2.26
375	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.26
376	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	2.26
377	Bartsocas-papas syndrome 2	Enrichment	CHUK	2.26
378	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	2.26
379	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	2.25
380	Knobloch syndrome 2	Enrichment	PAK2	2.25
381	Medulloblastoma	Enrichment	APC, CTNNB1	2.25
382	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	2.24
383	Protein-deficiency anemia	Enrichment	NRAS	2.24
384	Leprosy 3	Enrichment	TLR2	2.24
385	Legionnaire disease	Enrichment	TLR5	2.24
386	Immunodeficiency 68	Enrichment	MYD88	2.24
387	Macroglobulinemia, waldenstrom 1	Enrichment	MYD88	2.24
388	Immunodeficiency 83 viral infections	Enrichment	TLR3	2.24
389	Leprosy 5	Enrichment	TLR1	2.24
390	Immunodeficiency 82 with systemic inflammation	Enrichment	SYK	2.24
391	Immunodeficiency 74, covid19-related, x-linked	Enrichment	TLR7	2.24
392	Systemic lupus erythematosus 1	Enrichment	TLR5	2.24
393	X-linked immunodeficiency 74	Enrichment	TLR7	2.24
394	Systemic lupus erythematosus 17	Enrichment	TLR7	2.24
395	Asthma-related traits 5	Enrichment	IRAK3	2.24
396	Thrombocytopenia 4	Enrichment	CYCS	2.24
397	Immunodeficiency 67	Enrichment	IRAK4	2.24
398	Melioidosis	Enrichment	TLR5	2.24
399	Colitis	Enrichment	SYK	2.24
400	Waldenstram macroglobulinemia	Enrichment	MYD88	2.24
401	Inflammatory bowel disease-recurrent sinopulmonary infections syndrome	Enrichment	NFAT5	2.24
402	Type 2 diabetes mellitus	Enrichment	AKT2, IRS1, IRS2	2.24
403	Vacterl association with hydrocephalus	Enrichment	PTEN	2.23
404	Type 1 diabetes mellitus 10	Enrichment	IL2RA	2.23
405	Immunodeficiency 63 with lymphoproliferation and autoimmunity	Enrichment	IL2RB	2.23
406	Developmental and epileptic encephalopathy 91	Enrichment	PPP3CA	2.23
407	Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development	Enrichment	PPP3CA	2.23
408	Papillary tumor of the pineal region	Enrichment	PTEN	2.23
409	Glioma susceptibility 2	Enrichment	PTEN	2.23
410	Immunodeficiency 22	Enrichment	LCK	2.23
411	T-b+ severe combined immunodeficiency due to jak3 deficiency	Enrichment	JAK3	2.23
412	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	2.23
413	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.23
414	Cervical cancer	Enrichment	TP53	2.23
415	Lymphoma, hodgkin, classic	Enrichment	TP53	2.23
416	Noonan syndrome 12	Enrichment	RRAS2	2.23
417	Congenital fibrosarcoma	Enrichment	TP53	2.23
418	Li-fraumeni syndrome 1	Enrichment	TP53	2.23
419	Sarcoma	Enrichment	TP53	2.23
420	Cervix carcinoma	Enrichment	TP53	2.23
421	Hodgkin's lymphoma	Enrichment	TP53	2.23
422	Tafro syndrome	Enrichment	MAP2K2	2.23
423	Hyper-ige syndrome 6, autosomal dominant, with recurrent infections	Enrichment	STAT6	2.22
424	Neuroendocrine tumor	Enrichment	CDKN1B	2.22
425	Hydrops fetalis, nonimmune	Enrichment	HRAS, PTPN11	2.22
426	Palmoplantar keratoderma, punctate type ii	Enrichment	BRCA1	2.22
427	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	2.22
428	Osteoglophonic dysplasia	Enrichment	FGFR1	2.22
429	Trigonocephaly 1	Enrichment	FGFR1	2.22
430	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	2.22
431	Deafness, autosomal recessive 26	Enrichment	GAB1	2.22
432	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	2.22
433	Melanoma, cutaneous malignant 3	Enrichment	CDK4	2.22
434	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	2.22
435	Apert syndrome	Enrichment	FGFR2	2.22
436	Glioma susceptibility 3	Enrichment	BRCA2	2.22
437	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3	Enrichment	CCND2	2.22
438	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	2.22
439	Microcephaly 12, primary, autosomal recessive	Enrichment	CDK6	2.22
440	Iga nephropathy 3	Enrichment	SPRY2	2.22
441	Gist-plus syndrome	Enrichment	PDGFRA	2.22
442	Accelerated tumor formation	Enrichment	MDM2	2.22
443	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	2.22
444	Lessel-kubisch syndrome	Enrichment	MDM2	2.22
445	Bone marrow failure syndrome 6	Enrichment	MDM4	2.22
446	Osteofibrous dysplasia	Enrichment	MET	2.22
447	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.22
448	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	2.22
449	Infant-type hemispheric glioma	Enrichment	BRCA1	2.22
450	Pancreatic cancer 2	Enrichment	BRCA2	2.22
451	Deafness, autosomal recessive 97	Enrichment	MET	2.22
452	Autism 9	Enrichment	MET	2.22
453	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	2.22
454	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	2.22
455	Endometrial serous adenocarcinoma	Enrichment	ATM	2.22
456	Kosaki overgrowth syndrome	Enrichment	PDGFRB	2.22
457	Hartsfield syndrome	Enrichment	FGFR1	2.22
458	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	2.22
459	Trilateral retinoblastoma	Enrichment	RB1	2.22
460	Plexiform neurofibroma	Enrichment	NF1	2.22
461	Arthrogryposis, distal, type 11	Enrichment	MET	2.22
462	Neurofibroma	Enrichment	NF1	2.22
463	Cdkn2a cancer predisposition	Enrichment	CDKN2A	2.22
464	Neurofibromatosis	Enrichment	NF1	2.22
465	Chromosome 17q11.2 deletion syndrome	Enrichment	NF1	2.22
466	B-cell non-hodgkin lymphoma	Enrichment	ATM	2.22
467	Optic nerve glioma	Enrichment	NF1	2.22
468	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.22
469	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	2.22
470	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	2.22
471	Primary peritoneal carcinoma	Enrichment	BRCA1	2.22
472	Lung oat cell carcinoma	Enrichment	RB1	2.22
473	Fibromatosis, gingival, 1	Enrichment	SOS1	2.21
474	Scoliosis, isolated 1	Enrichment	MAPK7	2.21
475	Growth hormone insensitivity syndrome with immune dysregulation 1, autosomal recessive	Enrichment	STAT5B	2.21
476	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.21
477	Thrombocythemia 3	Enrichment	JAK2	2.21
478	Immunodeficiency 31c	Enrichment	STAT1	2.21
479	Polycythemia	Enrichment	JAK2	2.21
480	Congenital amegakaryocytic thrombocytopenia	Enrichment	MPL	2.21
481	Hypereosinophilic syndrome	Enrichment	JAK2	2.21
482	Laron syndrome with immunodeficiency	Enrichment	STAT5B	2.21
483	Hypochondroplasia	Enrichment	FGFR3	2.21
484	Thanatophoric dysplasia, type i	Enrichment	FGFR3	2.21
485	Muenke syndrome	Enrichment	FGFR3	2.21
486	Deafness, autosomal recessive 39	Enrichment	HGF	2.21
487	Basal ganglia calcification, idiopathic, 5	Enrichment	PDGFB	2.21
488	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	2.21
489	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	2.21
490	Autism 19	Enrichment	EIF4E	2.21
491	Microvascular complications of diabetes 1	Enrichment	VEGFA	2.21
492	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	2.21
493	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	2.21
494	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	2.21
495	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	2.21
496	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	2.21
497	Tufted angioma of skin	Enrichment	KDR	2.21
498	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	2.21
499	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	2.21
500	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	2.21
501	Heart, malformation of	Enrichment	MAPK1	2.18
502	Craniosynostosis	Enrichment	FGFR2, FGFR3	2.17
503	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	2.09
504	Omodysplasia 2	Enrichment	FZD2	2.09
505	Schwannomatosis, vestibular	Enrichment	NF2	2.09
506	Caudal duplication anomaly	Enrichment	AXIN1	2.09
507	Ectodermal dysplasia 17 with or without limb malformations	Enrichment	LEF1	2.09
508	Agammaglobulinemia 8b, autosomal recessive	Enrichment	TCF3	2.09
509	Agammaglobulinemia 8a, autosomal dominant	Enrichment	TCF3	2.09
510	Microphthalmia/coloboma 11	Enrichment	FZD5	2.09
511	Corneal dystrophy, fuchs endothelial, 3	Enrichment	TCF4	2.09
512	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.09
513	Adenoid ameloblastoma	Enrichment	CTNNB1	2.09
514	Familial adenomatous polyposis	Enrichment	APC	2.09
515	Acoustic neuroma	Enrichment	NF2	2.09
516	Gardner syndrome	Enrichment	APC	2.09
517	5q22 microdeletion syndrome	Enrichment	APC	2.09
518	Attenuated familial adenomatous polyposis	Enrichment	APC	2.09
519	Microcystic stromal tumor	Enrichment	CTNNB1	2.09
520	Silver-russell syndrome 3	Enrichment	IGF2	2.07
521	Growth hormone deficiency, isolated partial	Enrichment	GHR	2.07
522	Kowarski syndrome	Enrichment	GH1	2.07
523	Short stature due to growth hormone qualitative anomaly	Enrichment	GH1	2.07
524	Growth delay due to insulin-like growth factor type 1 deficiency	Enrichment	IGF1	2.07
525	Silver-russell syndrome due to an imprinting defect of 11p15	Enrichment	IGF2	2.07
526	Silver-russell syndrome due to 11p15 microduplication	Enrichment	IGF2	2.07
527	Immunodeficiency, common variable, 6	Enrichment	CD81	2.06
528	Agammaglobulinemia 3, autosomal recessive	Enrichment	CD79A	2.06
529	Immunodeficiency 89 and autoimmunity	Enrichment	CARD10	2.06
530	Isolated growth hormone deficiency type iii	Enrichment	BTK	2.06
531	Immunodeficiency with hyper-igm, type 3	Enrichment	CD40	2.06
532	Long qt syndrome 16	Enrichment	CALM3	2.06
533	Immunodeficiency 12	Enrichment	MALT1	2.06
534	Achromatopsia 7	Enrichment	ATF6	2.06
535	Immunodeficiency, common variable, 3	Enrichment	CD19	2.06
536	Immunodeficiency 105, severe combined	Enrichment	PTPRC	2.06
537	Autoinflammatory disease, systemic, with vasculitis	Enrichment	LYN	2.06
538	Cd45 deficiency	Enrichment	PTPRC	2.06
539	Sezary's disease	Enrichment	BCL10	2.06
540	Long qt syndrome 15	Enrichment	CALM2	2.06
541	Agammaglobulinemia 3	Enrichment	CD79A	2.06
542	Mucosa-associated lymphoma	Enrichment	BCL10	2.06
543	Niemann-pick disease, type a	Enrichment	SMPD1	2.05
544	Niemann-pick disease, type b	Enrichment	SMPD1	2.05
545	Nasopharyngeal carcinoma	Enrichment	TP53	2.05
546	Ceroid lipofuscinosis, neuronal, 6a	Enrichment	SMPD1	2.05
547	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.05
548	Anaplastic astrocytoma	Enrichment	TP53	2.05
549	Alzheimer disease 3	Enrichment	PSEN1	2.05
550	Pick disease of brain	Enrichment	PSEN1	2.05
551	Inflammatory skin and bowel disease, neonatal, 1	Enrichment	ADAM17	2.05
552	Burkitt lymphoma	Enrichment	MYC	2.05
553	Galactosemia ii	Enrichment	NR3C1	2.05
554	Thumb deformity	Enrichment	CREBBP	2.05
555	Ovarian germ cell cancer	Enrichment	CBL	2.05
556	Roifman-chitayat syndrome	Enrichment	PIK3CD	2.05
557	Noonan syndrome 8	Enrichment	PIK3CA	2.05
558	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.05
559	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	2.05
560	Werner syndrome	Enrichment	PTPN11	2.05
561	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.05
562	Menke-hennekam syndrome 2	Enrichment	EP300	2.05
563	Intravascular large b-cell lymphoma	Enrichment	BCL2	2.05
564	Rela fusion-positive ependymoma	Enrichment	RELA	2.05
565	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.05
566	Senior-loken syndrome 7	Enrichment	AKT3	2.05
567	Immune system disease	Enrichment	PIK3CD	2.05
568	Bardet-biedl syndrome 16	Enrichment	AKT3	2.05
569	Immunodeficiency 117	Enrichment	IRF1	2.05
570	Malignant germ cell tumor of ovary	Enrichment	CBL	2.05
571	Common variable immunodeficiency 12	Enrichment	NFKB1	2.05
572	Immunodeficiency 127	Enrichment	TNF	2.04
573	Intermittent hydrarthrosis	Enrichment	TNFRSF1A	2.04
574	Polycythemia vera	Enrichment	JAK2	2.03
575	Nuchal bleb, familial	Enrichment	SOS1	2.03
576	Dyskeratosis congenita, autosomal dominant 6	Enrichment	MPL	2.03
577	Wieacker-wolff syndrome	Enrichment	RASA1	2.03
578	Microcephaly	Enrichment	ABL1, CAMK2B, MAPK1, PAK3	2.03
579	Spinocerebellar ataxia 29	Enrichment	ITPR1	2.01
580	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.01
581	Amelogenesis imperfecta, type ig	Enrichment	PRKAR1A	2.01
582	Histiocytoma, angiomatoid fibrous	Enrichment	CREB1	2.01
583	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.01
584	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.01
585	Spermatogenic failure 17	Enrichment	PLCZ1	2.01
586	Marbach-schaaf neurodevelopmental syndrome	Enrichment	PRKAR1B	2.01
587	Usher syndrome, type iv	Enrichment	PRKAR1A	2.01
588	Acrodysostosis	Enrichment	PRKAR1A	2.01
589	Pseudohypoparathyroidism	Enrichment	GNAS	2.01
590	Body mass index quantitative trait locus 19	Enrichment	ADCY3	2.01
591	Fibrolamellar carcinoma	Enrichment	PRKACA	2.01
592	Ocular melanoma	Enrichment	PLCB4	2.01
593	Ciliary dyskinesia, primary, 18	Enrichment	PRKAR1B	2.01
594	Isolated primary pigmented nodular adrenocortical disease	Enrichment	PRKAR1A	2.01
595	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.01
596	Visceral neuropathy, familial, 1, autosomal recessive	Enrichment	ERBB3	2.01
597	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.01
598	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, MYC	1.99
599	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	1.96
600	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.96
601	Cebalid syndrome	Enrichment	MTOR	1.95
602	Smith-kingsmore syndrome	Enrichment	MTOR	1.95
603	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1	Enrichment	TYROBP	1.94
604	Leprosy 1	Enrichment	TLR6	1.94
605	Congenital dyserythropoietic anemia	Enrichment	IRAK4	1.94
606	Joint contractures, osteochondromas, and b-cell lymphoma	Enrichment	NFATC2	1.94
607	Arthritis	Enrichment	SYK	1.94
608	Immunodeficiency 41 with lymphoproliferation and autoimmunity	Enrichment	IL2RA	1.94
609	Vacterl with hydrocephalus	Enrichment	PTEN	1.94
610	Juvenile polyposis of infancy	Enrichment	PTEN	1.94
611	Congenital generalized lipodystrophy	Enrichment	FOS	1.93
612	Hereditary ataxia	Enrichment	PRKCG	1.93
613	Newborn respiratory distress syndrome	Enrichment	BRAF	1.93
614	Hemangiopericytoma, malignant	Enrichment	STAT6	1.92
615	Multiple endocrine neoplasia, type iv	Enrichment	CDKN1B	1.92
616	Cafe-au-lait spots, multiple	Enrichment	NF1	1.92
617	Melanoma-astrocytoma syndrome	Enrichment	CDKN2A	1.92
618	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	1.92
619	Aural atresia, congenital	Enrichment	FGFR2	1.92
620	Melanoma, cutaneous malignant 2	Enrichment	CDKN2A	1.92
621	Chromosome 13q14 deletion syndrome	Enrichment	RB1	1.92
622	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	1.92
623	Fanconi anemia, complementation group s	Enrichment	BRCA1	1.92
624	Cardiac valvular dysplasia, x-linked	Enrichment	ATM	1.92
625	Chromosome 17q11.2 duplication syndrome, 1.4-mb	Enrichment	NF1	1.92
626	Infantile myofibromatosis	Enrichment	PDGFRB	1.92
627	Pancreatic cancer 4	Enrichment	BRCA1	1.92
628	Childhood hepatocellular carcinoma	Enrichment	MET	1.92
629	Diffuse midline glioma, h3 k27m-mutant	Enrichment	BRCA2	1.92
630	Split hand-foot malformation	Enrichment	FGFR2	1.92
631	Melanoma-pancreatic cancer syndrome	Enrichment	CDKN2A	1.92
632	Papillary renal cell carcinoma	Enrichment	MET	1.92
633	High grade glioma	Enrichment	ATM	1.92
634	Fanconi anemia, complementation group d1	Enrichment	BRCA2	1.92
635	Bardet-biedl syndrome 9	Enrichment	NF1	1.92
636	T-cell prolymphocytic leukemia	Enrichment	ATM	1.92
637	Mismatch repair cancer syndrome 3	Enrichment	MSH6	1.92
638	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.92
639	Peritoneum cancer	Enrichment	BRCA1	1.92
640	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	1.92
641	Chronic eosinophilic leukemia	Enrichment	PDGFRA	1.92
642	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	1.92
643	Familial retinoblastoma	Enrichment	RB1	1.92
644	Neuroendocrine tumor of pancreas	Enrichment	BRCA2	1.92
645	Erythrocytosis, familial, 1	Enrichment	JAK2	1.91
646	Budd-chiari syndrome	Enrichment	JAK2	1.91
647	Gingival fibromatosis	Enrichment	SOS1	1.91
648	Dermatofibrosarcoma protuberans	Enrichment	PDGFB	1.91
649	Angioma, tufted	Enrichment	KDR	1.91
650	Immune thrombocytopenia	Enrichment	SOCS1	1.89
651	Autoinflammatory syndrome, familial, with or without immunodeficiency	Enrichment	SOCS1	1.89
652	Isolated growth hormone deficiency, type ib	Enrichment	GH1	1.89
653	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.89
654	Beckwith-wiedemann syndrome due to imprinting defect of 11p15	Enrichment	IGF2	1.89
655	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.87
656	Autoimmune disease, multisystem, infantile-onset, 3	Enrichment	CBLB	1.87
657	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.87
658	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	1.87
659	Tricuspid valve insufficiency	Enrichment	PTPN11	1.87
660	Keratoacanthoma	Enrichment	PIK3CA	1.87
661	Psoriatic arthritis	Enrichment	TNF	1.86
662	Hepatitis c virus	Enrichment	IFNG	1.86
663	Tuberous sclerosis 2	Enrichment	IFNG	1.86
664	Immunodeficiency 28	Enrichment	IFNGR2	1.86
665	Migraine without aura	Enrichment	TNF	1.86
666	Niemann-pick disease, type c1	Enrichment	SMPD1	1.83
667	Lymphoma	Enrichment	TP53	1.83
668	Niemann-pick disease	Enrichment	SMPD1	1.83
669	Histiocytoid hemangioma	Enrichment	FOS	1.83
670	Mccune-albright syndrome	Enrichment	GNAS	1.83
671	Gillespie syndrome	Enrichment	ITPR1	1.83
672	Nephrotic syndrome, type 3	Enrichment	PLCE1	1.83
673	Frontometaphyseal dysplasia	Enrichment	MAP3K7	1.83
674	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	1.83
675	Immunodeficiency 44	Enrichment	STAT2	1.83
676	Capillary malformations, congenital	Enrichment	RASA1	1.81
677	Ectrodactyly and ectodermal dysplasia without cleft lip/palate	Enrichment	LEF1	1.79
678	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.79
679	Schwannomatosis 1	Enrichment	NF2	1.79
680	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	1.79
681	Periampullary adenoma	Enrichment	APC	1.79
682	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	1.79
683	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.79
684	B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)	Enrichment	TCF3	1.79
685	Teratoma	Enrichment	CTNNB1	1.79
686	B-lymphoblastic leukemia/lymphoma with t(17;19)	Enrichment	TCF3	1.79
687	Malaria	Enrichment	FCGR2B, IKBKG	1.77
688	Isolated growth hormone deficiency, type ii	Enrichment	GH1	1.77
689	Anemia, autoimmune hemolytic	Enrichment	SOCS1	1.77
690	Silver-russell syndrome due to a point mutation	Enrichment	IGF2	1.77
691	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	TLR8	1.77
692	Immunodeficiency, common variable, 2	Enrichment	CR2	1.76
693	Isolated growth hormone deficiency, type iii, with agammaglobulinemia	Enrichment	BTK	1.76
694	Agammaglobulinemia 4, autosomal recessive	Enrichment	BLNK	1.76
695	Agammaglobulinemia 6, autosomal recessive	Enrichment	CD79B	1.76
696	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.76
697	Maturity-onset diabetes of the young, type 11	Enrichment	BLK	1.76
698	Immunodeficiency 37	Enrichment	BCL10	1.76
699	Long qt syndrome 14	Enrichment	CALM1	1.76
700	Agammaglobulinemia, x-linked	Enrichment	BTK	1.76
701	Immunodeficiency, common variable, 7	Enrichment	CR2	1.76
702	Agammaglobulinemia 4	Enrichment	BLNK	1.76
703	Agammaglobulinemia 6	Enrichment	CD79B	1.76
704	Immunodeficiency 104, severe combined	Enrichment	PTPRC	1.76
705	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	JAK3	1.76
706	Severe combined immunodeficiency, x-linked	Enrichment	IL2RG	1.76
707	Combined immunodeficiency, x-linked	Enrichment	IL2RG	1.76
708	Laryngeal squamous cell carcinoma	Enrichment	PTEN	1.76
709	Wilms tumor 5	Enrichment	BRAF	1.76
710	Barrett esophagus	Enrichment	ERBB2	1.76
711	Dowling-degos disease	Enrichment	PSENEN	1.76
712	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.76
713	Cerebrovascular disease	Enrichment	PIK3CA	1.75
714	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.75
715	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.74
716	Retinoblastoma	Enrichment	RB1	1.74
717	Watson syndrome	Enrichment	NF1	1.74
718	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	1.74
719	Neurofibromatosis, familial spinal	Enrichment	NF1	1.74
720	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.74
721	Woolly hair, autosomal recessive 3	Enrichment	RB1	1.74
722	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	NF1	1.74
723	Tumor predisposition syndrome 1	Enrichment	BRCA2	1.74
724	Lynch syndrome 5	Enrichment	MSH6	1.74
725	Hypotrichosis 8	Enrichment	RB1	1.74
726	Koolen-de vries syndrome	Enrichment	ATM	1.74
727	Xanthinuria, type ii	Enrichment	TSC2	1.74
728	Brain cancer	Enrichment	NF1	1.74
729	Bap1 tumor predisposition syndrome	Enrichment	BRCA2	1.74
730	Intellectual developmental disorder with dysmorphic facies and behavioral abnormalities	Enrichment	MSH6	1.74
731	Colon adenocarcinoma	Enrichment	MSH6	1.74
732	Renal cell carcinoma	Enrichment	MET	1.74
733	Hepatitis b	Enrichment	IFNGR1	1.74
734	Cerebral malaria	Enrichment	TNF	1.74
735	Klippel-trenaunay-weber syndrome	Enrichment	RASA1	1.73
736	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.73
737	Hemangioma, capillary infantile	Enrichment	RASA1	1.73
738	Basal cell carcinoma 1	Enrichment	RASA1	1.73
739	Chronic mucocutaneous candidiasis	Enrichment	STAT1	1.73
740	Achondroplasia	Enrichment	FGFR3	1.73
741	Larsen syndrome	Enrichment	FGFR3	1.73
742	Testicular germ cell cancer	Enrichment	FGFR3	1.73
743	Testicular cancer	Enrichment	FGFR3	1.73
744	Fanconi anemia, complementation group a	Enrichment	BRCA1, BRCA2	1.72
745	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.71
746	Auriculocondylar syndrome 1	Enrichment	PLCB4	1.71
747	Carney complex variant	Enrichment	PRKAR1A	1.71
748	Spinocerebellar ataxia 15	Enrichment	ITPR1	1.71
749	Arrhythmogenic right ventricular dysplasia, familial, 10	Enrichment	PRKAR1A	1.71
750	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.71
751	Immunodeficiency, common variable, 1	Enrichment	NFKB2	1.71
752	Pediatric systemic lupus erythematosus	Enrichment	STAT4	1.71
753	Thrombocytopenia	Enrichment	PTPN11, SRC	1.71
754	Esophageal cancer	Enrichment	TP53	1.69
755	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.67
756	Dementia	Enrichment	PSEN1	1.66
757	Knobloch syndrome	Enrichment	PAK2	1.65
758	Von hippel-lindau syndrome	Enrichment	CCND1	1.65
759	Rubinstein-taybi syndrome 2	Enrichment	EP300	1.65
760	Follicular lymphoma	Enrichment	BCL2	1.65
761	Aggressive systemic mastocytosis	Enrichment	CBL	1.65
762	Vascular dementia	Enrichment	TNF	1.64
763	Idiopathic aplastic anemia	Enrichment	IFNG	1.64
764	Adenosine deaminase deficiency	Enrichment	JAK3	1.64
765	Cerebral palsy	Enrichment	BRCA2, PDGFRB	1.64
766	Dilated cardiomyopathy	Enrichment	BRAF, RAF1	1.63
767	Lennox-gastaut syndrome	Enrichment	MAPK10	1.63
768	Primary hyperparathyroidism	Enrichment	CDKN1B	1.63
769	Gaucher disease, type i	Enrichment	MSH6	1.62
770	Chordoma	Enrichment	BRCA2	1.62
771	Mismatch repair cancer syndrome 1	Enrichment	MSH6	1.62
772	Middle aortic syndrome	Enrichment	NF1	1.62
773	Oculomotor apraxia	Enrichment	ATM	1.62
774	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.61
775	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.61
776	Anus, imperforate	Enrichment	CTNNB1	1.61
777	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.61
778	Nail disease	Enrichment	FZD6	1.61
779	Cellular ependymoma	Enrichment	NF2	1.61
780	Tanycytic ependymoma	Enrichment	NF2	1.61
781	Papillary ependymoma	Enrichment	NF2	1.61
782	Spindle cell sarcoma	Enrichment	NF2	1.61
783	Clear cell ependymoma	Enrichment	NF2	1.61
784	Apc-associated polyposis conditions	Enrichment	APC	1.61
785	Kaposi sarcoma	Enrichment	IL6	1.61
786	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.61
787	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	1.61
788	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	1.60
789	Mesothelioma, malignant	Enrichment	BCL10	1.59
790	Agammaglobulinemia 1, autosomal recessive	Enrichment	BTK	1.59
791	Systemic lupus erythematosus 9	Enrichment	CR2	1.59
792	Agammaglobulinemia 1	Enrichment	BTK	1.59
793	Cardiomyopathy, familial hypertrophic, 4	Enrichment	BRAF	1.58
794	Inflammatory bowel disease 1	Enrichment	PRKCQ	1.58
795	Ventricular septal defect	Enrichment	BRAF	1.58
796	Patent ductus arteriosus	Enrichment	PTPN11	1.57
797	Hypertrichosis	Enrichment	CREBBP	1.57
798	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ERBB4, PSEN1	1.57
799	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.56
800	Knobloch syndrome 1	Enrichment	PAK2	1.56
801	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.55
802	Autosomal thrombocytopenia with normal platelets	Enrichment	CYCS	1.55
803	Herpes simplex virus encephalitis	Enrichment	TLR3	1.55
804	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	JAK3	1.54
805	Macrocephaly/autism syndrome	Enrichment	PTEN	1.54
806	Hemangioma	Enrichment	PTEN	1.54
807	Primary ovarian insufficiency	Enrichment	JAK2, PRLR	1.54
808	Stroke, ischemic	Enrichment	PRKCH	1.54
809	Familial colorectal cancer	Enrichment	TP53	1.54
810	Melanoma, uveal	Enrichment	PLCB4	1.53
811	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	ITPR1	1.53
812	Silver-russell syndrome 1	Enrichment	IGF2	1.53
813	Long qt syndrome	Enrichment	CALM1, CALM2	1.53
814	Glioblastoma	Enrichment	ATM	1.52
815	Holoprosencephaly	Enrichment	FGFR1	1.52
816	Semantic dementia	Enrichment	PSEN1	1.51
817	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	1.51
818	Megacolon	Enrichment	AKT3	1.51
819	Myelodysplastic syndrome	Enrichment	TP53	1.50
820	Robinow syndrome, autosomal dominant 1	Enrichment	FZD2	1.49
821	Pitt-hopkins syndrome	Enrichment	TCF4	1.49
822	Pilomatrixoma	Enrichment	CTNNB1	1.49
823	Alazami syndrome	Enrichment	CTNNB1	1.49
824	Retinopathy of prematurity	Enrichment	FZD4	1.49
825	Autosomal dominant robinow syndrome	Enrichment	FZD2	1.49
826	Eyelid coloboma	Enrichment	FZD5	1.49
827	Full schwannomatosis	Enrichment	NF2	1.49
828	Benign ependymoma	Enrichment	NF2	1.49
829	Lens coloboma	Enrichment	FZD5	1.49
830	Gastroesophageal reflux	Enrichment	RPS6KA3	1.47
831	Isolated growth hormone deficiency, type ia	Enrichment	GH1	1.47
832	Orthostatic intolerance	Enrichment	RPS6KA3	1.47
833	Brachydactyly	Enrichment	GNAS	1.47
834	Kabuki syndrome 1	Enrichment	BRCA2	1.45
835	Split-hand/foot malformation 1	Enrichment	FGFR2	1.45
836	Holoprosencephaly 1	Enrichment	FGFR1	1.45
837	Keratoconus	Enrichment	TSC1	1.45
838	Clear cell renal cell carcinoma	Enrichment	ATM	1.45
839	Type 1 diabetes mellitus	Enrichment	IL6	1.44
840	Testicular germ cell tumor	Enrichment	FGFR3	1.44
841	46,xy disorder of sex development	Enrichment	FGFR3	1.44
842	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.41
843	Progressive non-fluent aphasia	Enrichment	PSEN1	1.41
844	Behavioral variant of frontotemporal dementia	Enrichment	PSEN1	1.41
845	Hypertelorism	Enrichment	FGFR2, PIK3CA	1.40
846	Aortic valve disease 1	Enrichment	SOS1	1.40
847	Charge syndrome	Enrichment	EP300	1.40
848	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	1.40
849	Robinow syndrome, autosomal recessive 1	Enrichment	FZD2	1.40
850	Norrie disease	Enrichment	FZD4	1.40
851	Familial adenomatous polyposis 1	Enrichment	APC	1.40
852	Cholangitis, primary sclerosing	Enrichment	TCF4	1.40
853	Robinow syndrome, autosomal dominant 2	Enrichment	FZD2	1.40
854	Fuchs' endothelial dystrophy	Enrichment	TCF4	1.40
855	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.40
856	Coloboma of choroid and retina	Enrichment	FZD5	1.40
857	Osteoporosis	Enrichment	SRC	1.39
858	Seckel syndrome	Enrichment	ATR	1.39
859	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.38
860	Gastrointestinal stromal tumor	Enrichment	PDGFRA	1.38
861	Polycystic kidney disease 1	Enrichment	TSC2	1.38
862	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.36
863	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.36
864	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.36
865	Polymicrogyria	Enrichment	AKT3	1.36
866	Aplastic anemia	Enrichment	IFNG	1.35
867	Moyamoya angiopathy	Enrichment	ABL1	1.34
868	Ewing sarcoma	Enrichment	ETV4	1.33
869	Arthrogryposis, distal, type 1a	Enrichment	MET	1.32
870	Frontotemporal dementia 1	Enrichment	PSEN1	1.32
871	Coloboma of optic nerve	Enrichment	FZD5	1.32
872	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.32
873	Autosomal recessive robinow syndrome	Enrichment	FZD2	1.32
874	Multicystic kidney dysplasia	Enrichment	FZD3	1.32
875	Multicystic dysplastic kidney	Enrichment	FZD3	1.32
876	Pectus excavatum	Enrichment	PTPN11	1.32
877	Coronary heart disease 5	Enrichment	IKBKG	1.31
878	Asthma	Enrichment	TNF	1.31
879	West syndrome	Enrichment	PLCB1, TSC2	1.30
880	Rheumatoid arthritis	Enrichment	TLR1	1.30
881	Glaucoma, primary open angle	Enrichment	CARD10	1.29
882	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.29
883	Epicanthus	Enrichment	PTPN11	1.28
884	Congenital long qt syndrome	Enrichment	PTPN11	1.28
885	46,xy complete gonadal dysgenesis	Enrichment	MAP3K1	1.28
886	Neurofibromatosis, type i	Enrichment	NF1	1.27
887	Tracheoesophageal fistula with or without esophageal atresia	Enrichment	BRCA2	1.27
888	Polydactyly	Enrichment	BRCA2	1.27
889	Hypogonadotropic hypogonadism	Enrichment	FGFR1	1.27
890	Colonic benign neoplasm	Enrichment	ATM	1.27
891	Hypercholesterolemia, familial, 1	Enrichment	GHR	1.27
892	Coats disease	Enrichment	FZD4	1.25
893	Alzheimer's disease	Enrichment	PSEN1	1.25
894	Congenital nervous system abnormality	Enrichment	CTNNB1, PTEN, TSC2	1.25
895	Nervous system disease	Enrichment	CTNNB1, PTEN, TSC2	1.25
896	Omenn syndrome	Enrichment	IL2RG	1.25
897	Meier-gorlin syndrome 1	Enrichment	FGFR2	1.23
898	Isolated tracheo-esophageal fistula	Enrichment	BRCA2	1.23
899	Primary bone dysplasia	Enrichment	FGFR3	1.22
900	Heart disease	Enrichment	CREBBP	1.21
901	Immune deficiency disease	Enrichment	SYK	1.21
902	Multiple sclerosis	Enrichment	TNFRSF1A	1.21
903	Combined immunodeficiency	Enrichment	IL2RG	1.21
904	Ichthyosis	Enrichment	IL2RB	1.21
905	Combined t cell and b cell immunodeficiency	Enrichment	IL2RG	1.21
906	Combined t and b cell immunodeficiency	Enrichment	IL2RG	1.21
907	Familial hypercholesterolemia	Enrichment	GHR	1.21
908	Leukemia, acute lymphoblastic	Enrichment	CDKN2A	1.19
909	Polydactyly, postaxial, type a1	Enrichment	EP300	1.18
910	Corpus callosum, agenesis of	Enrichment	CREBBP	1.18
911	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.18
912	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.18
913	Diamond-blackfan anemia 1	Enrichment	TP53	1.18
914	Osteochondrodysplasia	Enrichment	FGFR3	1.18
915	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.17
916	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.16
917	Septooptic dysplasia	Enrichment	FGFR1	1.15
918	Anterior segment dysgenesis	Enrichment	ITPR1	1.14
919	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	1.14
920	Alzheimer disease, familial, 1	Enrichment	PSEN1	1.14
921	Beckwith-wiedemann syndrome	Enrichment	IGF2	1.13
922	Patent foramen ovale	Enrichment	PTPN11	1.11
923	Cat eye syndrome	Enrichment	FZD5	1.10
924	Human immunodeficiency virus type 1	Enrichment	IFNG	1.10
925	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	1.09
926	Pheochromocytoma	Enrichment	NF1	1.09
927	Periventricular nodular heterotopia	Enrichment	BRCA1	1.09
928	Cleft lip/palate	Enrichment	PDGFRA	1.09
929	Achromatopsia	Enrichment	ATF6	1.08
930	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.06
931	Kidney disease	Enrichment	TSC1	1.06
932	Microform holoprosencephaly	Enrichment	FGFR1	1.03
933	Lobar holoprosencephaly	Enrichment	FGFR1	1.03
934	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.03
935	Skin disease	Enrichment	NCSTN	1.03
936	Focal segmental glomerulosclerosis	Enrichment	PLCE1	1.03
937	Left ventricular noncompaction	Enrichment	RAF1	1.01
938	Diamond-blackfan anemia	Enrichment	TP53	1.00
939	Microphthalmia/coloboma 12	Enrichment	FZD5	0.99
940	Stereotypic movement disorder	Enrichment	TCF4	0.99
941	Tooth agenesis	Enrichment	TGFA	0.99
942	Semilobar holoprosencephaly	Enrichment	FGFR1	0.99
943	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	0.99
944	Autoinflammatory disease	Enrichment	TNFRSF1A	0.98
945	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	HGF, MET	0.98
946	Esophageal atresia/tracheoesophageal fistula	Enrichment	BRCA2	0.96
947	Cardiomyopathy, dilated, 1a	Enrichment	NFATC2	0.94
948	Strabismus	Enrichment	PTPN11	0.94
949	Coloboma of macula	Enrichment	FZD5	0.94
950	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	NF1	0.92
951	Kallmann syndrome	Enrichment	FGFR1	0.89
952	Polycystic liver disease	Enrichment	CTNNB1	0.88
953	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	0.88
954	Sudden infant death syndrome	Enrichment	CALM2	0.86
955	Non-syndromic x-linked intellectual disability	Enrichment	RPS6KA3	0.84
956	Tetralogy of fallot	Enrichment	KDR	0.83
957	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	0.81
958	Severe covid-19	Enrichment	JAK3	0.81
959	Dystonia	Enrichment	CAMK2B	0.80
960	Maturity-onset diabetes of the young	Enrichment	BLK	0.79
961	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.75
962	Primary autosomal recessive microcephaly	Enrichment	CDK6	0.75
963	Connective tissue disease	Enrichment	FGFR3	0.74
964	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.74
965	Cakut	Enrichment	ETV4	0.73
966	Centralopathic epilepsy	Enrichment	PLCB1	0.72
967	Nephrotic syndrome	Enrichment	PLCE1	0.72
968	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.65
969	Spastic ataxia	Enrichment	ITPR1	0.64
970	Sensorineural hearing loss	Enrichment	HGF	0.59
971	Autism	Enrichment	CREBBP	0.56
972	Undetermined early-onset epileptic encephalopathy	Enrichment	PPP3CA	0.55
973	Distal arthrogryposis	Enrichment	FZD3	0.53
974	Primary ciliary dyskinesia	Enrichment	PRKAR1B	0.50
975	Cone-rod dystrophy 2	Enrichment	ATF6	0.35
976	Complex neurodevelopmental disorder	Enrichment	PAK3	0.30
977	Hereditary retinal dystrophy	Enrichment	FZD4	0.04
978	Fundus dystrophy	Enrichment	FZD4	0.04

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Prolactin Signaling

Pathway Network for Prolactin Signaling

Pathway network for the Prolactin Signaling SuperPath

Member Pathways for Prolactin Signaling

Pathways in the Prolactin Signaling SuperPath

Gene overlap in member pathways for Prolactin Signaling SuperPath

Associated Genes for Prolactin Signaling

Associated Disorders for Prolactin Signaling

Disorders associated with Prolactin Signaling SuperPath

STRING Interaction Network for Prolactin Signaling

Sources for Prolactin Signaling