Proline catabolism
Pathways in the Proline catabolism SuperPath
| # | Name | Source | Genes |
|---|---|---|---|
| 1 | Proline catabolism | Reactome | |
| 2 | 4-hydroxyproline degradation | PubChem | |
| 3 | trans-4-hydroxy-L-proline degradation I | PubChem | |
| 4 | L-proline degradation | PubChem | |
| 5 | proline degradation | PubChem |
Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways
| # | Symbol | Description | Category | # Related Pathways |
|---|---|---|---|---|
| 1 | ALDH4A1 | Aldehyde Dehydrogenase 4 Family Member A1 | Protein Coding | 5 |
| 2 | PRODH2 | Proline Dehydrogenase 2 | Protein Coding | 3 |
| 3 | PRODH | Proline Dehydrogenase 1 | Protein Coding | 2 |
| 4 | HOGA1 | 4-Hydroxy-2-Oxoglutarate Aldolase 1 | Protein Coding | 2 |
| 5 | GOT2 | Glutamic-Oxaloacetic Transaminase 2 | Protein Coding | 2 |
Disorders associated with Proline catabolism SuperPath
according to GeneCards Suite gene sharing
| # | Disorder | Type | Genes | Score |
|---|---|---|---|---|
| 1 | Hyperprolinemia, type ii | Enrichment | ALDH4A1 | 3.83 |
| 2 | Hyperprolinemia, type i | Enrichment | PRODH | 3.53 |
| 3 | Schizophrenia 4 | Enrichment | PRODH | 3.53 |
| 4 | Hyperoxaluria, primary, type iii | Enrichment | HOGA1 | 3.53 |
| 5 | Developmental and epileptic encephalopathy 82 | Enrichment | GOT2 | 3.23 |
| 6 | Developmental and epileptic encephalopathy | Enrichment | GOT2 | 1.98 |
