Propranolol Pathway, Pharmacokinetics

No Pathway Network information available for Propranolol Pathway, Pharmacokinetics

#	Name	Source	Genes
1	Propranolol Pathway, Pharmacokinetics	PharmGKB	ALDH2 CYP1A2 CYP2D6 MAOA SULT1A3 UGT1A10 UGT1A9 UGT2B4 UGT2B7 (see all 9) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	UGT2B4	UDP Glucuronosyltransferase Family 2 Member B4	Protein Coding	1
2	UGT2B7	UDP Glucuronosyltransferase Family 2 Member B7	Protein Coding	1
3	ALDH2	Aldehyde Dehydrogenase 2 Family Member	Protein Coding	1
4	SULT1A3	Sulfotransferase Family 1A Member 3	Protein Coding	1
5	UGT1A10	UDP Glucuronosyltransferase Family 1 Member A10	Protein Coding	1
6	UGT1A9	UDP Glucuronosyltransferase Family 1 Member A9	Protein Coding	1
7	MAOA	Monoamine Oxidase A	Protein Coding	1
8	CYP1A2	Cytochrome P450 Family 1 Subfamily A Member 2	Protein Coding	1
9	CYP2D6	Cytochrome P450 Family 2 Subfamily D Member 6 (Gene/Pseudogene)	Protein Coding	1

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Crigler-najjar syndrome, type i	Enrichment	UGT1A10, UGT1A9	4.76
2	Hyperbilirubinemia, transient familial neonatal	Enrichment	UGT1A10, UGT1A9	4.76
3	Bilirubin, serum level of, quantitative trait locus 1	Enrichment	UGT1A10, UGT1A9	4.76
4	Crigler-najjar syndrome, type ii	Enrichment	UGT1A10, UGT1A9	4.76
5	Gilbert syndrome	Enrichment	UGT1A10, UGT1A9	4.67
6	Bilirubin metabolic disorder	Enrichment	UGT1A10, UGT1A9	4.67
7	Brunner syndrome	Enrichment	MAOA	3.18
8	Alcohol sensitivity, acute	Enrichment	ALDH2	3.18
9	Drug metabolism, poor, cyp2d6-related	Enrichment	CYP2D6	3.18
10	Amed syndrome, digenic	Enrichment	ALDH2	2.88
11	Alcohol dependence	Enrichment	ALDH2	2.40

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Propranolol Pathway, Pharmacokinetics