Prostaglandin and leukotriene metabolism in senescence

No Pathway Network information available for Prostaglandin and leukotriene metabolism in senescence

Pathways in the Prostaglandin and leukotriene metabolism in senescence SuperPath

#	Name	Source	Genes
1	Prostaglandin and leukotriene metabolism in senescence	WikiPathways	ALOX12 ALOX15 ALOX15B ALOX5 ALOX5AP CYSLTR1 GNAI1 GNAQ GNAS HRAS IGFBP5 LTA4H LTC4S MAPK11 PLA2G4A PTGDS PTGER1 PTGER2 PTGER3 PTGER4 PTGES PTGIS PTGS1 PTGS2 RB1 SIRT1 TBXAS1 (see all 27) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
2	CYSLTR1	Cysteinyl Leukotriene Receptor 1	Protein Coding	1
3	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
4	PTGDS	Prostaglandin D2 Synthase	Protein Coding	1
5	PTGES	Prostaglandin E Synthase	Protein Coding	1
6	TBXAS1	Thromboxane A Synthase 1	Protein Coding	1
7	RB1	RB Transcriptional Corepressor 1	Protein Coding	1
8	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	1
9	PTGS1	Prostaglandin-Endoperoxide Synthase 1	Protein Coding	1
10	PTGIS	Prostaglandin I2 Synthase	Protein Coding	1
11	PTGER4	Prostaglandin E Receptor 4	Protein Coding	1
12	PTGER3	Prostaglandin E Receptor 3	Protein Coding	1
13	PTGER2	Prostaglandin E Receptor 2	Protein Coding	1
14	PTGER1	Prostaglandin E Receptor 1	Protein Coding	1
15	MAPK11	Mitogen-Activated Protein Kinase 11	Protein Coding	1
16	LTC4S	Leukotriene C4 Synthase	Protein Coding	1
17	LTA4H	Leukotriene A4 Hydrolase	Protein Coding	1
18	IGFBP5	Insulin Like Growth Factor Binding Protein 5	Protein Coding	1
19	GNAS	GNAS Complex Locus	Protein Coding	1
20	GNAQ	G Protein Subunit Alpha Q	Protein Coding	1
21	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
22	ALOX15B	Arachidonate 15-Lipoxygenase Type B	Protein Coding	1
23	ALOX15	Arachidonate 15-Lipoxygenase	Protein Coding	1
24	ALOX5AP	Arachidonate 5-Lipoxygenase Activating Protein	Protein Coding	1
25	ALOX5	Arachidonate 5-Lipoxygenase	Protein Coding	1
26	ALOX12	Arachidonate 12-Lipoxygenase, 12S Type	Protein Coding	1
27	SIRT1	Sirtuin 1	Protein Coding	1

Disorders associated with Prostaglandin and leukotriene metabolism in senescence SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Lip and oral cavity carcinoma	Enrichment	HRAS, RB1	3.60
2	Bladder cancer	Enrichment	HRAS, RB1	2.82
3	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.70
4	Osseous heteroplasia, progressive	Enrichment	GNAS	2.70
5	Ghosal hematodiaphyseal dysplasia	Enrichment	TBXAS1	2.70
6	Sturge-weber syndrome	Enrichment	GNAQ	2.70
7	Leukotriene c4 synthase deficiency	Enrichment	LTC4S	2.70
8	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.70
9	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.70
10	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.70
11	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.70
12	Disorders of gnas inactivation	Enrichment	GNAS	2.70
13	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.70
14	Trilateral retinoblastoma	Enrichment	RB1	2.70
15	Atherosclerosis	Enrichment	ALOX5	2.70
16	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.70
17	Monostotic fibrous dysplasia	Enrichment	GNAS	2.70
18	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.70
19	Mazabraud syndrome	Enrichment	GNAS	2.70
20	Lung oat cell carcinoma	Enrichment	RB1	2.70
21	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.40
22	Costello syndrome	Enrichment	HRAS	2.40
23	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.40
24	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.40
25	Chromosome 13q14 deletion syndrome	Enrichment	RB1	2.40
26	Bleeding disorder, platelet-type, 14	Enrichment	TBXAS1	2.40
27	Pseudohypoparathyroidism	Enrichment	GNAS	2.40
28	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.40
29	Familial retinoblastoma	Enrichment	RB1	2.40
30	Phakomatosis cesioflammea	Enrichment	GNAQ	2.40
31	Wooly hair nevus	Enrichment	HRAS	2.40
32	Mccune-albright syndrome	Enrichment	GNAS	2.22
33	Retinoblastoma	Enrichment	RB1	2.22
34	Asthma, nasal polyps, and aspirin intolerance	Enrichment	PTGER2	2.22
35	Osteogenic sarcoma	Enrichment	RB1	2.22
36	Woolly hair, autosomal recessive 3	Enrichment	RB1	2.22
37	Hypotrichosis 8	Enrichment	RB1	2.22
38	Large congenital melanocytic nevus	Enrichment	HRAS	2.22
39	Squamous cell carcinoma	Enrichment	RB1	2.22
40	Bone osteosarcoma	Enrichment	RB1	2.22
41	Spermatocytoma	Enrichment	HRAS	2.22
42	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.22
43	Anastomosing haemangioma	Enrichment	GNAQ	2.22
44	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS	2.10
45	Small cell cancer of the lung	Enrichment	RB1	2.10
46	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	2.10
47	Lynch syndrome 4	Enrichment	RB1	2.10
48	Epidermolytic nevus	Enrichment	HRAS	2.10
49	Capillary malformations, congenital	Enrichment	GNAQ	2.00
50	Klippel-trenaunay-weber syndrome	Enrichment	GNAQ	1.92
51	Melanoma, uveal	Enrichment	GNAQ	1.92
52	Nevus, epidermal	Enrichment	HRAS	1.86
53	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS	1.86
54	Noonan syndrome 3	Enrichment	HRAS	1.86
55	Brachydactyly	Enrichment	GNAS	1.86
56	Follicular thyroid carcinoma	Enrichment	HRAS	1.86
57	Melanocytic nevus syndrome, congenital	Enrichment	HRAS	1.80
58	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.80
59	Arteriovenous malformation	Enrichment	HRAS	1.75
60	Primary hyperaldosteronism	Enrichment	GNAS	1.75
61	Stroke, ischemic	Enrichment	ALOX5AP	1.70
62	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.70
63	Asthma	Enrichment	ALOX5	1.66
64	Lung non-small cell carcinoma	Enrichment	HRAS	1.66
65	Lung cancer susceptibility 3	Enrichment	RB1	1.56
66	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS	1.53
67	Rhabdomyosarcoma	Enrichment	HRAS	1.50
68	Hypertension, essential	Enrichment	PTGIS	1.48
69	Noonan syndrome 1	Enrichment	HRAS	1.35
70	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.30
71	Rasopathy	Enrichment	HRAS	1.30
72	Differentiated thyroid carcinoma	Enrichment	HRAS	1.25
73	Non-immune hydrops fetalis	Enrichment	HRAS	1.22
74	Body mass index quantitative trait locus 11	Enrichment	GNAS	1.02
75	Ovarian cancer	Enrichment	RB1	0.74
76	Inherited cancer-predisposing syndrome	Enrichment	RB1	0.63

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Prostaglandin and leukotriene metabolism in senescence

Pathway Network for Prostaglandin and leukotriene metabolism in senescence

Member Pathways for Prostaglandin and leukotriene metabolism in senescence

Pathways in the Prostaglandin and leukotriene metabolism in senescence SuperPath

Associated Genes for Prostaglandin and leukotriene metabolism in senescence

Associated Disorders for Prostaglandin and leukotriene metabolism in senescence

Disorders associated with Prostaglandin and leukotriene metabolism in senescence SuperPath

STRING Interaction Network for Prostaglandin and leukotriene metabolism in senescence

Sources for Prostaglandin and leukotriene metabolism in senescence