Prostaglandin synthesis and regulation

Pathway network for the Prostaglandin synthesis and regulation SuperPath

Sources:

WikiPathways
PharmGKB
Reactome

Pathways in the Prostaglandin synthesis and regulation SuperPath

#	Name	Source	Genes
1	Prostaglandin synthesis and regulation	WikiPathways	ABCC4 AKR1C1 AKR1C2 AKR1C3 ANXA1 ANXA2 ANXA3 ANXA4 ANXA5 ANXA6 CBR1 CYP11A1 EDN1 EDNRA EDNRB HPGD HPGDS HSD11B1 HSD11B2 MITF PLA2G4A PPARG PPARGC1A PPARGC1B PRL PTGDR PTGDS PTGER1 PTGER2 PTGER3 PTGER4 PTGES PTGFR PTGFRN PTGIR PTGIS PTGS1 PTGS2 S100A10 S100A6 SCGB1A1 SOX9 TBXA2R TBXAS1 (see all 44) (see less)
2	Ibuprofen Pathway, Pharmacodynamics	PharmGKB	AKR1B1 AKR1C3 CNR1 CNR2 FAAH HPGDS NOS1 NOS2 NOS3 PLA2G2A PLA2G4A PTGDR PTGDR2 PTGDS PTGER1 PTGER2 PTGER3 PTGER4 PTGES PTGES2 PTGES3 PTGFR PTGIR PTGIS PTGS1 PTGS2 TBXA2R TBXAS1 (see all 28) (see less)
3	Eicosanoid metabolism via cyclooxygenases (COX)	WikiPathways	HPGD PPARG PTGIS TBXAS1
4	Defective TBXAS1 causes GHDD	Reactome	TBXAS1

Gene overlap in member pathways for Prostaglandin synthesis and regulation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	TBXAS1	Thromboxane A Synthase 1	Protein Coding	4
2	PTGIS	Prostaglandin I2 Synthase	Protein Coding	3
3	PTGDS	Prostaglandin D2 Synthase	Protein Coding	2
4	PTGES	Prostaglandin E Synthase	Protein Coding	2
5	AKR1C3	Aldo-Keto Reductase Family 1 Member C3	Protein Coding	2
6	TBXA2R	Thromboxane A2 Receptor	Protein Coding	2
7	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	2
8	PTGS1	Prostaglandin-Endoperoxide Synthase 1	Protein Coding	2
9	PTGIR	Prostaglandin I2 Receptor	Protein Coding	2
10	PTGFR	Prostaglandin F Receptor	Protein Coding	2
11	PTGER4	Prostaglandin E Receptor 4	Protein Coding	2
12	PTGER3	Prostaglandin E Receptor 3	Protein Coding	2
13	PTGER2	Prostaglandin E Receptor 2	Protein Coding	2
14	PTGER1	Prostaglandin E Receptor 1	Protein Coding	2
15	PTGDR	Prostaglandin D2 Receptor	Protein Coding	2
16	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	2
17	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	2
18	HPGD	15-Hydroxyprostaglandin Dehydrogenase	Protein Coding	2
19	HPGDS	Hematopoietic Prostaglandin D Synthase	Protein Coding	2
20	CBR1	Carbonyl Reductase 1	Protein Coding	1
21	SCGB1A1	Secretoglobin Family 1A Member 1	Protein Coding	1
22	SOX9	SRY-Box Transcription Factor 9	Protein Coding	1
23	S100A10	S100 Calcium Binding Protein A10	Protein Coding	1
24	S100A6	S100 Calcium Binding Protein A6	Protein Coding	1
25	PRL	Prolactin	Protein Coding	1
26	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	1
27	HSD11B2	Hydroxysteroid 11-Beta Dehydrogenase 2	Protein Coding	1
28	HSD11B1	Hydroxysteroid 11-Beta Dehydrogenase 1	Protein Coding	1
29	ANXA6	Annexin A6	Protein Coding	1
30	ANXA5	Annexin A5	Protein Coding	1
31	ANXA4	Annexin A4	Protein Coding	1
32	ANXA3	Annexin A3	Protein Coding	1
33	ANXA2	Annexin A2	Protein Coding	1
34	ANXA1	Annexin A1	Protein Coding	1
35	EDNRB	Endothelin Receptor Type B	Protein Coding	1
36	EDNRA	Endothelin Receptor Type A	Protein Coding	1
37	EDN1	Endothelin 1	Protein Coding	1
38	AKR1C2	Aldo-Keto Reductase Family 1 Member C2	Protein Coding	1
39	AKR1C1	Aldo-Keto Reductase Family 1 Member C1	Protein Coding	1
40	CYP11A1	Cytochrome P450 Family 11 Subfamily A Member 1	Protein Coding	1
41	PPARGC1B	PPARG Coactivator 1 Beta	Protein Coding	1
42	PPARGC1A	PPARG Coactivator 1 Alpha	Protein Coding	1
43	ABCC4	ATP Binding Cassette Subfamily C Member 4 (PEL Blood Group)	Protein Coding	1
44	PTGFRN	Prostaglandin F2 Receptor Inhibitor	Protein Coding	1
45	FAAH	Fatty Acid Amide Hydrolase	Protein Coding	1
46	PTGES2	Prostaglandin E Synthase 2	Protein Coding	1
47	NOS1	Nitric Oxide Synthase 1	Protein Coding	1
48	NOS3	Nitric Oxide Synthase 3	Protein Coding	1
49	AKR1B1	Aldo-Keto Reductase Family 1 Member B	Protein Coding	1
50	PLA2G2A	Phospholipase A2 Group IIA	Protein Coding	1
51	CNR1	Cannabinoid Receptor 1	Protein Coding	1
52	CNR2	Cannabinoid Receptor 2	Protein Coding	1
53	PTGDR2	Prostaglandin D2 Receptor 2	Protein Coding	1
54	PTGES3	Prostaglandin E Synthase 3	Protein Coding	1
55	NOS2	Nitric Oxide Synthase 2	Protein Coding	1

Disorders associated with Prostaglandin synthesis and regulation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Bone disease	Direct
2	Protein-deficiency anemia	Direct
3	Waardenburg syndrome, type 4a	Enrichment	EDNRB, MITF	3.82
4	Waardenburg syndrome	Enrichment	EDNRB, MITF	3.82
5	Waardenburg syndrome, type 2e	Enrichment	EDNRB, MITF	3.67
6	Digital clubbing, isolated congenital	Enrichment	HPGD	3.53
7	Ghosal hematodiaphyseal dysplasia	Enrichment	TBXAS1	3.53
8	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	3.53
9	Hypertension, essential	Enrichment	NOS3, PTGIS	3.26
10	Carotid intimal medial thickness 1	Enrichment	PPARG	3.23
11	Bleeding disorder, platelet-type, 14	Enrichment	TBXAS1	3.23
12	Primary hypertrophic osteoarthropathy	Enrichment	HPGD	3.23
13	Familial partial lipodystrophy	Enrichment	PPARG	3.23
14	Hypertrophic osteoarthropathy, primary, autosomal recessive, 1	Enrichment	HPGD	3.05
15	Currarino syndrome	Enrichment	HPGD	2.93
16	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	2.93
17	Leptin deficiency or dysfunction	Enrichment	PPARG	2.93
18	Congenital generalized lipodystrophy	Enrichment	PPARG	2.93
19	Pyloric stenosis, infantile hypertrophic, 1	Enrichment	NOS1	2.69
20	Asthma-related traits 1	Enrichment	PTGDR	2.69
21	Polysubstance abuse	Enrichment	FAAH	2.69
22	Bleeding disorder, platelet-type, 13	Enrichment	TBXA2R	2.69
23	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	2.69
24	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	2.69
25	Bleeding diathesis due to thromboxane synthesis deficiency	Enrichment	TBXA2R	2.69
26	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	2.69
27	Apparent mineralocorticoid excess	Enrichment	HSD11B2	2.49
28	Heterochromia iridis	Enrichment	MITF	2.49
29	Tietz albinism-deafness syndrome	Enrichment	MITF	2.49
30	Mandibulofacial dysostosis with alopecia	Enrichment	EDNRA	2.49
31	Adrenal insufficiency, congenital, with 46,xy sex reversal, partial or complete	Enrichment	CYP11A1	2.49
32	Auriculocondylar syndrome 3	Enrichment	EDN1	2.49
33	46,xy sex reversal 10	Enrichment	SOX9	2.49
34	46,xx sex reversal 2	Enrichment	SOX9	2.49
35	Coloboma, osteopetrosis, microphthalmia, macrocephaly, albinism, and deafness	Enrichment	MITF	2.49
36	Question mark ears, isolated	Enrichment	EDN1	2.49
37	Inherited isolated adrenal insufficiency due to partial cyp11a1 deficiency	Enrichment	CYP11A1	2.49
38	Gliosarcoma	Enrichment	PPARG	2.33
39	Giant cell glioblastoma	Enrichment	PPARG	2.30
40	Asthma, nasal polyps, and aspirin intolerance	Enrichment	PTGER2	2.21
41	Campomelic dysplasia	Enrichment	SOX9	2.19
42	Aganglionosis, total intestinal	Enrichment	EDNRB	2.19
43	Abcd syndrome	Enrichment	EDNRB	2.19
44	Melanoma, cutaneous malignant 8	Enrichment	MITF	2.19
45	Cortisone reductase deficiency 2	Enrichment	HSD11B1	2.19
46	Cortisone reductase deficiency	Enrichment	HSD11B1	2.19
47	Papillary renal cell carcinoma	Enrichment	MITF	2.19
48	Cic-rearranged sarcoma	Enrichment	AKR1C2	2.19
49	Campomelic dysplasia and related disorders	Enrichment	SOX9	2.19
50	Idiopathic achalasia	Enrichment	NOS1	2.08
51	Differentiated thyroid carcinoma	Enrichment	PPARG	2.07
52	Waardenburg syndrome, type 2a	Enrichment	MITF	2.01
53	Hirschsprung disease 2	Enrichment	EDNRB	2.01
54	46,xx sex reversal 1	Enrichment	SOX9	2.01
55	46,xy sex reversal 8	Enrichment	AKR1C2	2.01
56	Alzheimer disease 2	Enrichment	NOS3	1.99
57	Pre-eclampsia	Enrichment	NOS3	1.99
58	Type 2 diabetes mellitus	Enrichment	PPARG	1.91
59	Auriculocondylar syndrome 1	Enrichment	EDN1	1.89
60	Pregnancy loss, recurrent 3	Enrichment	ANXA5	1.89
61	Clear cell papillary renal cell carcinoma	Enrichment	MITF	1.89
62	Body mass index quantitative trait locus 11	Enrichment	PPARG	1.83
63	Nonsyndromic 46,xx testicular disorders/differences of sex development	Enrichment	SOX9	1.79
64	Developmental dysplasia of the hip 1	Enrichment	AKR1C1	1.71
65	Adrenal hyperplasia, congenital, due to 21-hydroxylase deficiency	Enrichment	CYP11A1	1.71
66	Pierre robin syndrome	Enrichment	SOX9	1.71
67	21-hydroxylase-deficient congenital adrenal hyperplasia	Enrichment	CYP11A1	1.71
68	Stroke, ischemic	Enrichment	NOS3	1.69
69	Familial colorectal cancer	Enrichment	PLA2G2A	1.69
70	Waardenburg syndrome, type 1	Enrichment	MITF	1.65
71	Colorectal cancer	Enrichment	PPARG	1.59
72	Rare genetic deafness	Enrichment	EDNRB, MITF	1.57
73	Melanoma	Enrichment	MITF	1.50
74	Alzheimer disease, familial, 1	Enrichment	NOS3	1.46
75	46,xy complete gonadal dysgenesis	Enrichment	SOX9	1.45
76	Lipoid congenital adrenal hyperplasia	Enrichment	CYP11A1	1.35
77	46,xy partial gonadal dysgenesis	Enrichment	SOX9	1.35
78	Malaria	Enrichment	NOS2	1.33
79	Melanoma, cutaneous malignant 1	Enrichment	MITF	1.27
80	Ear malformation	Enrichment	MITF	1.12
81	Hirschsprung disease 1	Enrichment	EDNRB	1.05
82	Cystic fibrosis	Enrichment	EDNRA	1.01
83	Connective tissue disease	Enrichment	SOX9	1.01
84	Non-syndromic genetic deafness	Enrichment	MITF	0.96
85	Primary ovarian insufficiency	Enrichment	NOS3	0.94
86	Nonsyndromic hearing loss	Enrichment	MITF	0.89
87	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MITF	0.81
88	Hereditary breast ovarian cancer syndrome	Enrichment	MITF	0.79
89	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	PPARGC1A	0.76
90	Deafness, autosomal recessive	Enrichment	EDNRB	0.73
91	Autosomal recessive nonsyndromic deafness	Enrichment	EDNRB	0.73
92	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	EDNRB	0.60
93	Inherited cancer-predisposing syndrome	Enrichment	MITF	0.46

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Prostaglandin synthesis and regulation

Pathway Network for Prostaglandin synthesis and regulation

Pathway network for the Prostaglandin synthesis and regulation SuperPath

Member Pathways for Prostaglandin synthesis and regulation

Pathways in the Prostaglandin synthesis and regulation SuperPath

Gene overlap in member pathways for Prostaglandin synthesis and regulation SuperPath

Associated Genes for Prostaglandin synthesis and regulation

Associated Disorders for Prostaglandin synthesis and regulation

Disorders associated with Prostaglandin synthesis and regulation SuperPath

STRING Interaction Network for Prostaglandin synthesis and regulation

Sources for Prostaglandin synthesis and regulation