Protein-protein interactions at synapses

Pathway network for the Protein-protein interactions at synapses SuperPath

Sources:

Reactome

Pathways in the Protein-protein interactions at synapses SuperPath

#	Name	Source	Genes
1	Protein-protein interactions at synapses	Reactome	APBA1 APBA2 APBA3 BEGAIN CASK DLG1 DLG2 DLG3 DLG4 DLGAP1 DLGAP3 DLGAP4 EPB41 EPB41L1 EPB41L2 EPB41L3 EPB41L5 GRIA1 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRM1 GRM5 HOMER1 HOMER2 HOMER3 IL1RAP IL1RAPL1 IL1RAPL2 LIN7A LIN7B LIN7C LRFN1 LRFN2 LRFN3 LRFN4 LRRC4B LRRTM1 LRRTM2 LRRTM3 LRRTM4 NLGN1 NLGN2 NLGN3 NLGN4X NLGN4Y NRXN1 NRXN2 NRXN3 NTRK3 PDLIM5 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRS RTN3 SHANK1 SHANK2 SIPA1L1 SLITRK1 SLITRK2 SLITRK3 SLITRK4 SLITRK5 SLITRK6 STX1A STXBP1 SYT1 SYT10 SYT12 SYT2 SYT7 SYT9 (see all 82) (see less)
2	Neurexins and neuroligins	Reactome	APBA1 APBA2 APBA3 BEGAIN CASK DLG2 DLG3 DLG4 DLGAP1 DLGAP3 DLGAP4 EPB41 EPB41L1 EPB41L2 EPB41L3 EPB41L5 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRM1 GRM5 HOMER1 HOMER2 HOMER3 LIN7A LIN7B LIN7C LRRTM1 LRRTM2 LRRTM3 LRRTM4 NLGN1 NLGN2 NLGN3 NLGN4X NLGN4Y NRXN1 NRXN2 NRXN3 PDLIM5 SHANK1 SHANK2 SIPA1L1 STX1A STXBP1 SYT1 SYT10 SYT12 SYT2 SYT7 SYT9 (see all 53) (see less)
3	Receptor-type tyrosine-protein phosphatases	Reactome	IL1RAP IL1RAPL1 IL1RAPL2 LRRC4B NTRK3 PPFIA1 PPFIA2 PPFIA3 PPFIA4 PPFIBP1 PPFIBP2 PTPRD PTPRF PTPRS SLITRK1 SLITRK2 SLITRK3 SLITRK4 SLITRK5 SLITRK6 (see all 20) (see less)
4	Synaptic adhesion-like molecules	Reactome	DLG1 DLG3 DLG4 GRIA1 GRIA3 GRIA4 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D LRFN1 LRFN2 LRFN3 LRFN4 PTPRD PTPRF PTPRS RTN3 (see all 19) (see less)

Gene overlap in member pathways for Protein-protein interactions at synapses SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DLG3	Discs Large MAGUK Scaffold Protein 3	Protein Coding	3
2	DLG4	Discs Large MAGUK Scaffold Protein 4	Protein Coding	3
3	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	3
4	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	3
5	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	3
6	GRIN2C	Glutamate Ionotropic Receptor NMDA Type Subunit 2C	Protein Coding	3
7	GRIN2D	Glutamate Ionotropic Receptor NMDA Type Subunit 2D	Protein Coding	3
8	PTPRD	Protein Tyrosine Phosphatase Receptor Type D	Protein Coding	3
9	PTPRF	Protein Tyrosine Phosphatase Receptor Type F	Protein Coding	3
10	PTPRS	Protein Tyrosine Phosphatase Receptor Type S	Protein Coding	3
11	RTN3	Reticulon 3	Protein Coding	2
12	PDLIM5	PDZ And LIM Domain 5	Protein Coding	2
13	IL1RAPL1	Interleukin 1 Receptor Accessory Protein Like 1	Protein Coding	2
14	SLITRK1	SLIT And NTRK Like Family Member 1	Protein Coding	2
15	SYT2	Synaptotagmin 2	Protein Coding	2
16	SLITRK4	SLIT And NTRK Like Family Member 4	Protein Coding	2
17	SYT9	Synaptotagmin 9	Protein Coding	2
18	DLG1	Discs Large MAGUK Scaffold Protein 1	Protein Coding	2
19	DLG2	Discs Large MAGUK Scaffold Protein 2	Protein Coding	2
20	EPB41	Erythrocyte Membrane Protein Band 4.1	Protein Coding	2
21	EPB41L1	Erythrocyte Membrane Protein Band 4.1 Like 1	Protein Coding	2
22	EPB41L2	Erythrocyte Membrane Protein Band 4.1 Like 2	Protein Coding	2
23	NLGN4Y	Neuroligin 4 Y-Linked	Protein Coding	2
24	DLGAP4	DLG Associated Protein 4	Protein Coding	2
25	SLITRK3	SLIT And NTRK Like Family Member 3	Protein Coding	2
26	NLGN1	Neuroligin 1	Protein Coding	2
27	SHANK2	SH3 And Multiple Ankyrin Repeat Domains 2	Protein Coding	2
28	EPB41L3	Erythrocyte Membrane Protein Band 4.1 Like 3	Protein Coding	2
29	SIPA1L1	Signal Induced Proliferation Associated 1 Like 1	Protein Coding	2
30	LRRTM2	Leucine Rich Repeat Transmembrane Neuronal 2	Protein Coding	2
31	SLITRK5	SLIT And NTRK Like Family Member 5	Protein Coding	2
32	IL1RAPL2	Interleukin 1 Receptor Accessory Protein Like 2	Protein Coding	2
33	GRIA1	Glutamate Ionotropic Receptor AMPA Type Subunit 1	Protein Coding	2
34	GRIA3	Glutamate Ionotropic Receptor AMPA Type Subunit 3	Protein Coding	2
35	GRIA4	Glutamate Ionotropic Receptor AMPA Type Subunit 4	Protein Coding	2
36	GRM1	Glutamate Metabotropic Receptor 1	Protein Coding	2
37	GRM5	Glutamate Metabotropic Receptor 5	Protein Coding	2
38	APBA1	Amyloid Beta Precursor Protein Binding Family A Member 1	Protein Coding	2
39	APBA2	Amyloid Beta Precursor Protein Binding Family A Member 2	Protein Coding	2
40	SYT10	Synaptotagmin 10	Protein Coding	2
41	LRRTM1	Leucine Rich Repeat Transmembrane Neuronal 1	Protein Coding	2
42	LRRTM3	Leucine Rich Repeat Transmembrane Neuronal 3	Protein Coding	2
43	IL1RAP	Interleukin 1 Receptor Accessory Protein	Protein Coding	2
44	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	2
45	SHANK1	SH3 And Multiple Ankyrin Repeat Domains 1	Protein Coding	2
46	NLGN3	Neuroligin 3	Protein Coding	2
47	LIN7C	Lin-7 Cell Polarity Scaffold C	Protein Coding	2
48	LRFN2	Leucine Rich Repeat And Fibronectin Type III Domain Containing 2	Protein Coding	2
49	NLGN4X	Neuroligin 4 X-Linked	Protein Coding	2
50	NLGN2	Neuroligin 2	Protein Coding	2
51	BEGAIN	Brain Enriched Guanylate Kinase Associated	Protein Coding	2
52	LRFN1	Leucine Rich Repeat And Fibronectin Type III Domain Containing 1	Protein Coding	2
53	EPB41L5	Erythrocyte Membrane Protein Band 4.1 Like 5	Protein Coding	2
54	DLGAP3	DLG Associated Protein 3	Protein Coding	2
55	LIN7B	Lin-7 Cell Polarity Scaffold B	Protein Coding	2
56	STX1A	Syntaxin 1A	Protein Coding	2
57	STXBP1	Syntaxin Binding Protein 1	Protein Coding	2
58	SYT1	Synaptotagmin 1	Protein Coding	2
59	LRFN4	Leucine Rich Repeat And Fibronectin Type III Domain Containing 4	Protein Coding	2
60	LRFN3	Leucine Rich Repeat And Fibronectin Type III Domain Containing 3	Protein Coding	2
61	LRRTM4	Leucine Rich Repeat Transmembrane Neuronal 4	Protein Coding	2
62	SLITRK6	SLIT And NTRK Like Family Member 6	Protein Coding	2
63	SLITRK2	SLIT And NTRK Like Family Member 2	Protein Coding	2
64	PPFIBP2	PPFIB Scaffold Protein 2	Protein Coding	2
65	PPFIBP1	PPFIB Scaffold Protein 1	Protein Coding	2
66	PPFIA4	PPFI Scaffold Protein A4	Protein Coding	2
67	PPFIA2	PPFI Scaffold Protein A2	Protein Coding	2
68	PPFIA1	PPFI Scaffold Protein A1	Protein Coding	2
69	PPFIA3	PPFI Scaffold Protein A3	Protein Coding	2
70	CASK	Calcium/Calmodulin Dependent Serine Protein Kinase	Protein Coding	2
71	LIN7A	Lin-7 Cell Polarity Scaffold A	Protein Coding	2
72	SYT7	Synaptotagmin 7	Protein Coding	2
73	SYT12	Synaptotagmin 12	Protein Coding	2
74	DLGAP1	DLG Associated Protein 1	Protein Coding	2
75	NRXN3	Neurexin 3	Protein Coding	2
76	NRXN1	Neurexin 1	Protein Coding	2
77	NRXN2	Neurexin 2	Protein Coding	2
78	LRRC4B	Leucine Rich Repeat Containing 4B	Protein Coding	2
79	HOMER3	Homer Scaffold Protein 3	Protein Coding	2
80	HOMER2	Homer Scaffold Protein 2	Protein Coding	2
81	HOMER1	Homer Scaffold Protein 1	Protein Coding	2
82	APBA3	Amyloid Beta Precursor Protein Binding Family A Member 3	Protein Coding	2

Disorders associated with Protein-protein interactions at synapses SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	West syndrome	Enrichment	GRIA3, GRIN1, GRIN2B	4.53
2	Autosomal dominant non-syndromic intellectual disability	Enrichment	GRIA1, GRIN1, GRIN2B	4.36
3	Autism spectrum disorder	Enrichment	GRIA1, GRIN2B, NRXN1, SHANK2, STXBP1	3.29
4	Complex neurodevelopmental disorder	Enrichment	DLG4, GRIA4, GRIN2B	3.19
5	Non-syndromic x-linked intellectual disability	Enrichment	CASK, DLG3, IL1RAPL1	2.88
6	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	2.85
7	Breasts and/or nipples, aplasia or hypoplasia of, 1	Enrichment	PTPRF	2.85
8	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.85
9	Breasts and/or nipples, aplasia or hypoplasia of, 2	Enrichment	PTPRF	2.85
10	Intellectual developmental disorder, x-linked, syndromic, wu type	Enrichment	GRIA3	2.85
11	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	2.85
12	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.85
13	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	2.85
14	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	2.85
15	Neurodevelopmental disorder with or without seizures and gait abnormalities	Enrichment	GRIA4	2.85
16	Intellectual developmental disorder, autosomal dominant 67	Enrichment	GRIA1	2.85
17	Intellectual developmental disorder, autosomal recessive 76	Enrichment	GRIA1	2.85
18	Syndromic x-linked intellectual disability 94	Enrichment	GRIA3	2.85
19	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.85
20	Landau-kleffner syndrome	Enrichment	GRIN2A	2.85
21	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	2.85
22	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	2.85
23	Grin2a-related disorders	Enrichment	GRIN2A	2.85
24	Epilepsy	Enrichment	GRIN2A, GRIN2B	2.85
25	Deafness and myopia	Enrichment	SLITRK6	2.83
26	Intellectual developmental disorder, x-linked 21	Enrichment	IL1RAPL1	2.83
27	Intellectual developmental disorder, x-linked 111	Enrichment	SLITRK2	2.83
28	Trichotillomania	Enrichment	SLITRK1	2.83
29	Neurodevelopmental disorder with seizures, microcephaly, and brain abnormalities	Enrichment	PPFIBP1	2.83
30	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A	2.83
31	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A	2.79
32	Early infantile developmental and epileptic encephalopathy	Enrichment	CASK, GRIN1	2.66
33	Autism	Enrichment	NRXN1, STX1A, STXBP1	2.56
34	Intellectual developmental disorder, x-linked 90	Enrichment	DLG3	2.55
35	Bilateral generalized polymicrogyria	Enrichment	GRIN1	2.55
36	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	2.55
37	Developmental and epileptic encephalopathy 46	Enrichment	GRIN2D	2.55
38	Vulto-van silfhout-de vries syndrome	Enrichment	DLG4	2.55
39	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	2.55
40	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	2.55
41	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIA1, GRIN1	2.53
42	Gilles de la tourette syndrome	Enrichment	SLITRK1	2.53
43	Paul-chao neurodevelopmental syndrome	Enrichment	PPFIA3	2.53
44	Congenital mesoblastic nephroma	Enrichment	NTRK3	2.53
45	Fibrosarcoma	Enrichment	NTRK3	2.53
46	Hyperopia, high	Enrichment	NRXN1	2.41
47	Chromosome 20q11-q12 deletion syndrome	Enrichment	EPB41L1	2.41
48	Deafness, autosomal dominant 68	Enrichment	HOMER2	2.41
49	Autism 17	Enrichment	SHANK2	2.41
50	Elliptocytosis 1	Enrichment	EPB41	2.41
51	Spinocerebellar ataxia, autosomal recessive 13	Enrichment	GRM1	2.41
52	Baker-gordon syndrome	Enrichment	SYT1	2.41
53	Pitt-hopkins-like syndrome 2	Enrichment	NRXN1	2.41
54	Autism x-linked 1	Enrichment	NLGN3	2.41
55	Myasthenic syndrome, congenital, 7a, presynaptic, and distal motor neuropathy, autosomal dominant	Enrichment	SYT2	2.41
56	Chromosome 2p16.3 deletion syndrome	Enrichment	NRXN1	2.41
57	Spinocerebellar ataxia 44	Enrichment	GRM1	2.41
58	Autism 20	Enrichment	NLGN1	2.41
59	Nrxn1-related severe neurodevelopmental disorder-motor stereotypies-chronic constipation-sleep-wake cycle disturbance	Enrichment	NRXN1	2.41
60	Myasthenic syndrome, congenital, 7b, presynaptic, autosomal recessive	Enrichment	SYT2	2.41
61	Congenital myasthenic syndrome 7	Enrichment	SYT2	2.41
62	Rare disease with autism	Enrichment	SHANK2	2.41
63	Cask-related intellectual disability	Enrichment	CASK	2.41
64	Chondromyxoid fibroma	Enrichment	GRM1	2.41
65	Pyruvate carboxylase deficiency	Enrichment	LRFN4	2.38
66	Heart defects, congenital, and other congenital anomalies	Enrichment	DLG4	2.38
67	Auditory neuropathy and optic atrophy	Enrichment	GRIN2C	2.38
68	Intellectual developmental disorder, autosomal dominant 62	Enrichment	DLG4	2.38
69	Neurodevelopmental disorder with hypotonia and impaired expressive language and with or without seizures	Enrichment	DLG4	2.38
70	Dlg4-related synaptopathy	Enrichment	DLG4	2.38
71	Acyl-coa dehydrogenase, very long-chain, deficiency of	Enrichment	DLG4	2.25
72	Astigmatism	Enrichment	GRIN2B	2.25
73	Glioma	Enrichment	NTRK3	2.23
74	Microcephaly	Enrichment	CASK, GRIN2B, PPFIBP1, STXBP1	2.18
75	Sleep disorder	Enrichment	GRIN2B	2.16
76	Autism x-linked 2	Enrichment	NLGN4X	2.11
77	Fg syndrome 4	Enrichment	CASK	2.11
78	Syndromic x-linked intellectual disability	Enrichment	CASK	2.11
79	9q33.3q34.11 microdeletion syndrome	Enrichment	STXBP1	2.11
80	Intellectual developmental disorder with microcephaly and pontine and cerebellar hypoplasia	Enrichment	CASK	1.93
81	Syndromic x-linked intellectual disability najm type	Enrichment	CASK	1.93
82	Cerebellar disease	Enrichment	CASK	1.93
83	Developmental and epileptic encephalopathy 4	Enrichment	STXBP1	1.81
84	Hereditary elliptocytosis	Enrichment	EPB41	1.81
85	Nk-cell enteropathy	Enrichment	PTPRS	1.74
86	Dystonia	Enrichment	CASK, GRIA3	1.72
87	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	CASK	1.71
88	Cleft lip/palate	Enrichment	DLG1	1.71
89	Developmental and epileptic encephalopathy	Enrichment	GRIA3, STXBP1	1.70
90	Schizophrenia	Enrichment	DLG2, NRXN1	1.65
91	Craniosynostosis	Enrichment	GRIN2B	1.56
92	Scoliosis	Enrichment	GRIN2B	1.48
93	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	1.46
94	Hypogonadotropic hypogonadism	Enrichment	NLGN3	1.46
95	Body mass index quantitative trait locus 11	Enrichment	GRIA4, NRXN1	1.44
96	Differentiated thyroid carcinoma	Enrichment	NTRK3	1.38
97	Presynaptic congenital myasthenic syndromes	Enrichment	SYT2	1.38
98	Cerebral palsy	Enrichment	GRIN2B	1.27
99	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	NLGN3	1.27
100	Congenital myasthenic syndrome	Enrichment	SYT2	1.27
101	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	CASK	1.22
102	Isolated congenital microcephaly	Enrichment	CASK	1.22
103	Syndromic intellectual disability	Enrichment	SYT1	1.19
104	Williams-beuren syndrome	Enrichment	STX1A	1.12
105	Undetermined early-onset epileptic encephalopathy	Enrichment	GRIN2D	1.12
106	Strabismus	Enrichment	STXBP1	1.00
107	Cystic fibrosis	Enrichment	STX1A	0.93
108	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	SLITRK6	0.91
109	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	HOMER2	0.73
110	Spastic ataxia	Enrichment	STXBP1	0.73
111	Congenital nervous system abnormality	Enrichment	CASK	0.47
112	Nervous system disease	Enrichment	CASK	0.47

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Protein-protein interactions at synapses

Pathway Network for Protein-protein interactions at synapses

Pathway network for the Protein-protein interactions at synapses SuperPath

Member Pathways for Protein-protein interactions at synapses

Pathways in the Protein-protein interactions at synapses SuperPath

Gene overlap in member pathways for Protein-protein interactions at synapses SuperPath

Associated Genes for Protein-protein interactions at synapses

Associated Disorders for Protein-protein interactions at synapses

Disorders associated with Protein-protein interactions at synapses SuperPath

STRING Interaction Network for Protein-protein interactions at synapses

Sources for Protein-protein interactions at synapses