Protein ubiquitination

No Pathway Network information available for Protein ubiquitination

Pathways in the Protein ubiquitination SuperPath

#	Name	Source	Genes
1	Protein ubiquitination	Reactome	CDC34 CDC73 CTR9 DERL1 H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 HLA-A HLTF LEO1 OTULIN PAF1 PCNA PEX10 PEX12 PEX13 PEX14 PEX2 PEX5 PRKDC RAD18 RNF144A RNF152 RNF181 RNF20 RNF40 RPS27A RRAGA RTF1 SELENOS SHPRH SKIC8 TMEM129 UBA1 UBA52 UBA6 UBB UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J2 UBE2K UBE2L3 UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2V2 UBE2W UBE2Z UCHL3 USP5 USP7 USP9X VCP WAC (see all 78) (see less)
2	E3 ubiquitin ligases ubiquitinate target proteins	Reactome	CDC73 CTR9 DERL1 H2BC1 H2BC10 H2BC11 H2BC12 H2BC13 H2BC14 H2BC15 H2BC17 H2BC3 H2BC4 H2BC5 H2BC6 H2BC7 H2BC8 H2BC9 HLA-A HLTF LEO1 PAF1 PCNA PEX10 PEX12 PEX13 PEX14 PEX2 PEX5 PRKDC RAD18 RNF144A RNF152 RNF181 RNF20 RNF40 RPS27A RRAGA RTF1 SELENOS SHPRH SKIC8 TMEM129 UBA52 UBB UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2J2 UBE2L3 UBE2N UBE2V2 VCP WAC (see all 58) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RRAGA	Ras Related GTP Binding A	Protein Coding	2
2	UBE2J2	Ubiquitin Conjugating Enzyme E2 J2	Protein Coding	2
3	LEO1	LEO1 Component Of Paf1/RNA Polymerase II Complex	Protein Coding	2
4	RNF152	Ring Finger Protein 152	Protein Coding	2
5	RTF1	RTF1 Homolog, Paf1/RNA Polymerase II Complex Component	Protein Coding	2
6	H2BC1	H2B Clustered Histone 1	Protein Coding	2
7	SHPRH	SNF2 Histone Linker PHD RING Helicase	Protein Coding	2
8	H2BC5	H2B Clustered Histone 5	Protein Coding	2
9	H2BC3	H2B Clustered Histone 3	Protein Coding	2
10	HLA-A	Major Histocompatibility Complex, Class I, A	Protein Coding	2
11	PCNA	Proliferating Cell Nuclear Antigen	Protein Coding	2
12	RNF181	Ring Finger Protein 181	Protein Coding	2
13	WAC	WW Domain Containing Adaptor With Coiled-Coil	Protein Coding	2
14	PEX10	Peroxisomal Biogenesis Factor 10	Protein Coding	2
15	PEX12	Peroxisomal Biogenesis Factor 12	Protein Coding	2
16	PEX13	Peroxisomal Biogenesis Factor 13	Protein Coding	2
17	PEX14	Peroxisomal Biogenesis Factor 14	Protein Coding	2
18	PAF1	PAF1 Component Of Paf1/RNA Polymerase II Complex	Protein Coding	2
19	SELENOS	Selenoprotein S	Protein Coding	2
20	PRKDC	Protein Kinase, DNA-Activated, Catalytic Subunit	Protein Coding	2
21	RNF20	Ring Finger Protein 20	Protein Coding	2
22	RAD18	RAD18 E3 Ubiquitin Protein Ligase	Protein Coding	2
23	PEX2	Peroxisomal Biogenesis Factor 2	Protein Coding	2
24	PEX5	Peroxisomal Biogenesis Factor 5	Protein Coding	2
25	RPS27A	Ribosomal Protein S27a	Protein Coding	2
26	HLTF	Helicase Like Transcription Factor	Protein Coding	2
27	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
28	UBB	Ubiquitin B	Protein Coding	2
29	UBC	Ubiquitin C	Protein Coding	2
30	UBE2A	Ubiquitin Conjugating Enzyme E2 A	Protein Coding	2
31	UBE2B	Ubiquitin Conjugating Enzyme E2 B	Protein Coding	2
32	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	2
33	UBE2D2	Ubiquitin Conjugating Enzyme E2 D2	Protein Coding	2
34	UBE2D3	Ubiquitin Conjugating Enzyme E2 D3	Protein Coding	2
35	UBE2E1	Ubiquitin Conjugating Enzyme E2 E1	Protein Coding	2
36	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	2
37	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	2
38	UBE2V2	Ubiquitin Conjugating Enzyme E2 V2	Protein Coding	2
39	VCP	Valosin Containing Protein	Protein Coding	2
40	DERL1	Derlin 1	Protein Coding	2
41	CDC73	Cell Division Cycle 73	Protein Coding	2
42	SKIC8	SKI8 Subunit Of Superkiller Complex	Protein Coding	2
43	H2BC8	H2B Clustered Histone 8	Protein Coding	2
44	H2BC13	H2B Clustered Histone 13	Protein Coding	2
45	H2BC15	H2B Clustered Histone 15	Protein Coding	2
46	H2BC14	H2B Clustered Histone 14	Protein Coding	2
47	H2BC7	H2B Clustered Histone 7	Protein Coding	2
48	H2BC6	H2B Clustered Histone 6	Protein Coding	2
49	H2BC9	H2B Clustered Histone 9	Protein Coding	2
50	H2BC10	H2B Clustered Histone 10	Protein Coding	2
51	H2BC4	H2B Clustered Histone 4	Protein Coding	2
52	H2BC17	H2B Clustered Histone 17	Protein Coding	2
53	H2BC12	H2B Clustered Histone 12	Protein Coding	2
54	H2BC11	H2B Clustered Histone 11	Protein Coding	2
55	TMEM129	Transmembrane Protein 129, E3 Ubiquitin Ligase	Protein Coding	2
56	CTR9	CTR9 Component Of Paf1/RNA Polymerase II Complex	Protein Coding	2
57	RNF144A	Ring Finger Protein 144A	Protein Coding	2
58	RNF40	Ring Finger Protein 40	Protein Coding	2
59	UBE2E3	Ubiquitin Conjugating Enzyme E2 E3	Protein Coding	1
60	UBE2C	Ubiquitin Conjugating Enzyme E2 C	Protein Coding	1
61	UBE2S	Ubiquitin Conjugating Enzyme E2 S	Protein Coding	1
62	UBE2T	Ubiquitin Conjugating Enzyme E2 T	Protein Coding	1
63	UBE2K	Ubiquitin Conjugating Enzyme E2 K	Protein Coding	1
64	UBE2R2	Ubiquitin Conjugating Enzyme E2 R2	Protein Coding	1
65	UBA6	Ubiquitin Like Modifier Activating Enzyme 6	Protein Coding	1
66	UBE2W	Ubiquitin Conjugating Enzyme E2 W	Protein Coding	1
67	UBE2Z	Ubiquitin Conjugating Enzyme E2 Z	Protein Coding	1
68	UBA1	Ubiquitin Like Modifier Activating Enzyme 1	Protein Coding	1
69	UBE2G1	Ubiquitin Conjugating Enzyme E2 G1	Protein Coding	1
70	UBE2G2	Ubiquitin Conjugating Enzyme E2 G2	Protein Coding	1
71	UBE2H	Ubiquitin Conjugating Enzyme E2 H	Protein Coding	1
72	UCHL3	Ubiquitin C-Terminal Hydrolase L3	Protein Coding	1
73	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	1
74	USP5	Ubiquitin Specific Peptidase 5	Protein Coding	1
75	USP9X	Ubiquitin Specific Peptidase 9 X-Linked	Protein Coding	1
76	OTULIN	OTU Deubiquitinase With Linear Linkage Specificity	Protein Coding	1
77	UBE2Q2	Ubiquitin Conjugating Enzyme E2 Q2	Protein Coding	1
78	CDC34	Cell Division Cycle 34, Ubiquitin Conjugating Enzyme	Protein Coding	1

Disorders associated with Protein ubiquitination SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Neonatal adrenoleukodystrophy	Enrichment	PEX10, PEX12, PEX13, PEX14, PEX2, PEX5	16.00
2	Peroxisome biogenesis disorder 1b	Enrichment	PEX10, PEX12, PEX13, PEX14, PEX2, PEX5	10.56
3	Zellweger syndrome	Enrichment	PEX10, PEX12, PEX13, PEX14, PEX2, PEX5	10.56
4	Zellweger spectrum disorder	Enrichment	PEX10, PEX2, PEX5	5.39
5	Peroxisome biogenesis disorder 2a	Enrichment	PEX5	2.37
6	Peroxisome biogenesis disorder 3b	Enrichment	PEX12	2.37
7	Parathyroid carcinoma	Enrichment	CDC73	2.37
8	Inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1	Enrichment	VCP	2.37
9	Hyperparathyroidism 2 with jaw tumors	Enrichment	CDC73	2.37
10	Peroxisome biogenesis disorder 3a	Enrichment	PEX12	2.37
11	Intellectual developmental disorder, x-linked, syndromic, nascimento type	Enrichment	UBE2A	2.37
12	Syndromic x-linked intellectual disability nascimento type	Enrichment	UBE2A	2.37
13	Birdshot chorioretinopathy	Enrichment	HLA-A	2.37
14	Peroxisome biogenesis disorder 6a	Enrichment	PEX10	2.37
15	Immunodeficiency 26 with or without neurologic abnormalities	Enrichment	PRKDC	2.37
16	Peroxisome biogenesis disorder 6b	Enrichment	PEX10	2.37
17	Ataxia-telangiectasia-like disorder 2	Enrichment	PCNA	2.37
18	Cdc73-related disorders	Enrichment	CDC73	2.37
19	Frontotemporal dementia and/or amyotrophic lateral sclerosis 6	Enrichment	VCP	2.37
20	Multisystem proteinopathy	Enrichment	VCP	2.37
21	Rhizomelic chondrodysplasia punctata, type 5	Enrichment	PEX5	2.37
22	Adult-onset distal myopathy due to vcp mutation	Enrichment	VCP	2.37
23	Autosomal recessive ataxia due to pex10 deficiency	Enrichment	PEX10	2.37
24	Autosomal recessive ataxia due to pex2 deficiency	Enrichment	PEX2	2.37
25	Intellectual developmental disorder, x-linked 99	Enrichment	USP9X	2.24
26	Fanconi anemia, complementation group t	Enrichment	UBE2T	2.24
27	Immunodeficiency 107 invasive staphylococcus aureus infection	Enrichment	OTULIN	2.24
28	Intellectual developmental disorder, x-linked 99, syndromic, female-restricted	Enrichment	USP9X	2.24
29	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive	Enrichment	OTULIN	2.24
30	Female-restricted syndromic x-linked intellectual disability 99	Enrichment	USP9X	2.24
31	Autoinflammation, panniculitis, and dermatosis syndrome, autosomal dominant	Enrichment	OTULIN	2.24
32	Severe cutaneous adverse reaction	Enrichment	HLA-A	2.07
33	Amyotrophic lateral sclerosis 6 with or without frontotemporal dementia	Enrichment	VCP	2.07
34	Hyperparathyroidism 1	Enrichment	CDC73	2.07
35	Peroxisome biogenesis disorder 11a	Enrichment	PEX13	2.07
36	Peroxisome biogenesis disorder 13a	Enrichment	PEX14	2.07
37	Peroxisome biogenesis disorder 2b	Enrichment	PEX5	2.07
38	Peroxisome biogenesis disorder 11b	Enrichment	PEX13	2.07
39	Desanto-shinawi syndrome	Enrichment	WAC	2.07
40	Submucosal cleft palate	Enrichment	UBB	2.07
41	Desanto-shinawi syndrome due to wac point mutation	Enrichment	WAC	2.07
42	Cleft hard palate	Enrichment	UBB	2.07
43	Spastic paraplegia-paget disease of bone syndrome	Enrichment	VCP	2.07
44	Vexas syndrome	Enrichment	UBA1	1.94
45	Spinal muscular atrophy, x-linked 2	Enrichment	UBA1	1.94
46	Hao-fountain syndrome	Enrichment	USP7	1.94
47	Uvula, bifid	Enrichment	UBB	1.89
48	Cleft soft palate	Enrichment	UBB	1.89
49	Peroxisome biogenesis disorder 5b	Enrichment	PEX2	1.89
50	Peroxisome biogenesis disorder 5a	Enrichment	PEX2	1.89
51	Tessadori-bicknell-van haaften neurodevelopmental syndrome 4	Enrichment	H2BC12	1.89
52	Inclusion body myopathy with paget disease of bone and frontotemporal dementia	Enrichment	VCP	1.89
53	Parathyroid adenoma	Enrichment	CDC73	1.89
54	Familial isolated hyperparathyroidism	Enrichment	CDC73	1.89
55	Rhizomelic chondrodysplasia punctata	Enrichment	PEX5	1.77
56	Craniometaphyseal dysplasia, autosomal dominant	Enrichment	OTULIN	1.77
57	Hyperpigmentation of the skin	Enrichment	USP9X	1.77
58	Dementia, lewy body	Enrichment	VCP	1.67
59	Charcot-marie-tooth disease, axonal, type 2e	Enrichment	VCP	1.67
60	Chondrocalcinosis 2	Enrichment	OTULIN	1.64
61	Peroxisome biogenesis disorder 1a	Enrichment	PEX5	1.60
62	Multiple endocrine neoplasia, type i	Enrichment	CDC73	1.53
63	Progressive non-fluent aphasia	Enrichment	VCP	1.42
64	Behavioral variant of frontotemporal dementia	Enrichment	VCP	1.42
65	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1	Enrichment	VCP	1.38
66	Alzheimer's disease	Enrichment	VCP	1.27
67	Wilms tumor 1	Enrichment	CTR9	1.21
68	Alzheimer disease, familial, 1	Enrichment	VCP	1.15
69	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	VCP	1.11
70	Severe covid-19	Enrichment	HLA-A	0.93
71	Systemic lupus erythematosus	Enrichment	UBE2L3	0.81
72	Hereditary breast carcinoma	Enrichment	CDC73	0.76
73	Fanconi anemia, complementation group a	Enrichment	UBE2T	0.74
74	Non-syndromic x-linked intellectual disability	Enrichment	USP9X	0.73
75	Spastic ataxia	Enrichment	PEX10	0.69
76	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	LEO1	0.67
77	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	VCP	0.66
78	Breast cancer	Enrichment	CDC73	0.56
79	Complex neurodevelopmental disorder	Enrichment	CTR9	0.38
80	Inherited cancer-predisposing syndrome	Enrichment	CDC73	0.36

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Protein ubiquitination

Pathway Network for Protein ubiquitination

Member Pathways for Protein ubiquitination

Pathways in the Protein ubiquitination SuperPath

Associated Genes for Protein ubiquitination

Associated Disorders for Protein ubiquitination

Disorders associated with Protein ubiquitination SuperPath

STRING Interaction Network for Protein ubiquitination

Sources for Protein ubiquitination