Proteoglycan biosynthesis

No Pathway Network information available for Proteoglycan biosynthesis

Pathways in the Proteoglycan biosynthesis SuperPath

#	Name	Source	Genes
1	Proteoglycan biosynthesis	WikiPathways	B3GALT6 B3GAT3 B4GALT7 BPNT2 CANT1 CHST14 CHST3 CHSY1 CSGALNACT1 EXT1 EXT2 EXTL3 PAPSS2 SLC26A2 SLC35B2 SLC35B3 XYLT1 XYLT2 (see all 18) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SLC35B3	Solute Carrier Family 35 Member B3	Protein Coding	1
2	SLC35B2	Solute Carrier Family 35 Member B2	Protein Coding	1
3	CHST3	Carbohydrate Sulfotransferase 3	Protein Coding	1
4	PAPSS2	3''-Phosphoadenosine 5''-Phosphosulfate Synthase 2	Protein Coding	1
5	XYLT2	Xylosyltransferase 2	Protein Coding	1
6	XYLT1	Xylosyltransferase 1	Protein Coding	1
7	CSGALNACT1	Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1	Protein Coding	1
8	BPNT2	3''(2''), 5''-Bisphosphate Nucleotidase 2	Protein Coding	1
9	B3GAT3	Beta-1,3-Glucuronyltransferase 3	Protein Coding	1
10	CHSY1	Chondroitin Sulfate Synthase 1	Protein Coding	1
11	EXTL3	Exostosin Like Glycosyltransferase 3	Protein Coding	1
12	EXT2	Exostosin Glycosyltransferase 2	Protein Coding	1
13	EXT1	Exostosin Glycosyltransferase 1	Protein Coding	1
14	SLC26A2	Solute Carrier Family 26 Member 2	Protein Coding	1
15	B3GALT6	Beta-1,3-Galactosyltransferase 6	Protein Coding	1
16	CANT1	Calcium Activated Nucleotidase 1	Protein Coding	1
17	CHST14	Carbohydrate Sulfotransferase 14	Protein Coding	1
18	B4GALT7	Beta-1,4-Galactosyltransferase 7	Protein Coding	1

Disorders associated with Proteoglycan biosynthesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Spondyloepiphyseal dysplasia with congenital joint dislocations	Enrichment	B3GALT6, B3GAT3, B4GALT7, CHST3	10.49
2	Multiple joint dislocations, short stature, and craniofacial dysmorphism with or without congenital heart defects	Enrichment	B3GAT3, B4GALT7, CHST3	8.71
3	Larsen-like syndrome b3gat3 type	Enrichment	B3GAT3, B4GALT7, CHST3	8.71
4	Desbuquois dysplasia 1	Enrichment	CANT1, CSGALNACT1, XYLT1	7.41
5	Exostoses, multiple, type i	Enrichment	EXT1, EXT2	5.78
6	Ehlers-danlos syndrome, spondylodysplastic type, 2	Enrichment	B3GALT6, B4GALT7	5.78
7	Pseudoxanthoma elasticum	Enrichment	XYLT1, XYLT2	4.60
8	Chondrosarcoma	Enrichment	EXT1	2.88
9	Diastrophic dysplasia	Enrichment	SLC26A2	2.88
10	Atelosteogenesis, type ii	Enrichment	SLC26A2	2.88
11	Al-gazali syndrome	Enrichment	B3GALT6	2.88
12	Brachyolmia type 4 with mild epiphyseal and metaphyseal changes	Enrichment	PAPSS2	2.88
13	Ehlers-danlos syndrome, spondylodysplastic type, 1	Enrichment	B4GALT7	2.88
14	Epiphyseal dysplasia, multiple, 4	Enrichment	SLC26A2	2.88
15	Chondrodysplasia with joint dislocations, gpapp type	Enrichment	BPNT2	2.88
16	Spondyloepimetaphyseal dysplasia with joint laxity, type 1, with or without fractures	Enrichment	B3GALT6	2.88
17	Leukodystrophy, hypomyelinating, 26, with chondrodysplasia	Enrichment	SLC35B2	2.88
18	Immunoskeletal dysplasia with neurodevelopmental abnormalities	Enrichment	EXTL3	2.88
19	Achondrogenesis, type ib	Enrichment	SLC26A2	2.88
20	Spondyloocular syndrome	Enrichment	XYLT2	2.88
21	Brachyolmia	Enrichment	PAPSS2	2.88
22	Autosomal recessive brachyolmia	Enrichment	PAPSS2	2.88
23	Hereditary multiple osteochondromas	Enrichment	EXT1	2.88
24	Skeletal dysplasia, mild, with joint laxity and advanced bone age	Enrichment	CSGALNACT1	2.88
25	Exostosis	Enrichment	EXT1	2.88
26	Epiphyseal dysplasia, multiple, 7	Enrichment	CANT1	2.88
27	Spondylodysplastic ehlers-danlos syndrome	Enrichment	B4GALT7	2.88
28	Spondyloepimetaphyseal dysplasia with joint laxity	Enrichment	B3GALT6	2.88
29	Hereditary multiple exostoses	Enrichment	EXT1	2.88
30	Xylt1-congenital disorder of glycosylation	Enrichment	XYLT1	2.88
31	Skeletal dysplasia-t-cell immunodeficiency-developmental delay syndrome	Enrichment	EXTL3	2.88
32	Primary bone dysplasia with multiple joint dislocations	Enrichment	SLC35B2	2.88
33	Exostoses, multiple, type ii	Enrichment	EXT2	2.58
34	3mc syndrome 2	Enrichment	SLC26A2	2.58
35	Ehlers-danlos syndrome, musculocontractural type, 1	Enrichment	CHST14	2.58
36	Seizures, scoliosis, and macrocephaly/microcephaly syndrome	Enrichment	EXT2	2.58
37	Temtamy preaxial brachydactyly syndrome	Enrichment	CHSY1	2.58
38	Larsen syndrome	Enrichment	CHST3	2.40
39	Desbuquois dysplasia 2	Enrichment	XYLT1	2.40
40	Multiple epiphyseal dysplasia	Enrichment	CANT1	2.40
41	Musculocontractural ehlers-danlos syndrome	Enrichment	CHST14	2.40
42	Trichorhinophalangeal syndrome, type ii	Enrichment	EXT1	2.28
43	Potocki-shaffer syndrome	Enrichment	EXT2	2.28
44	Ovarian cancer	Enrichment	EXT1, EXT2	2.11
45	Osteochondrodysplasia	Enrichment	SLC26A2	1.84
46	Hepatoblastoma	Enrichment	EXT2	1.56
47	Connective tissue disease	Enrichment	SLC26A2	1.38
48	Inherited cancer-predisposing syndrome	Enrichment	EXT2	0.79

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Proteoglycan biosynthesis

Pathway Network for Proteoglycan biosynthesis

Member Pathways for Proteoglycan biosynthesis

Pathways in the Proteoglycan biosynthesis SuperPath

Associated Genes for Proteoglycan biosynthesis

Associated Disorders for Proteoglycan biosynthesis

Disorders associated with Proteoglycan biosynthesis SuperPath

STRING Interaction Network for Proteoglycan biosynthesis

Sources for Proteoglycan biosynthesis