Proteolysis Putative SUMO-1 pathway

No Pathway Network information available for Proteolysis Putative SUMO-1 pathway

Pathways in the Proteolysis Putative SUMO-1 pathway SuperPath

#	Name	Source	Genes
1	Proteolysis Putative SUMO-1 pathway	GeneGo (Thomson Reuters)	CBX4 DAXX FAS HSF1 HSF2 JUN MDM2 MYB NFKB1 NFKB2 NFKBIA NR3C1 PIAS1 PIAS2 PML RANBP2 RANGAP1 REL RELA RELB SAE1 SENP1 SP100 SP3 SUMO1 TOP2A TOP2B TP53 UBA2 UBA52 UBB UBC UBE2E3 UBE2I (see all 34) (see less)
2	DNA damage Role of SUMO in p53 regulation	GeneGo (Thomson Reuters)	AKT1 AKT2 AKT3 CHEK2 CREBBP DAXX EP300 MDM2 PIAS1 PIAS2 PML RANBP2 SAE1 SUMO1 TP53 UBA2 UBA52 UBB UBC UBE2I (see all 20) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	DAXX	Death Domain Associated Protein	Protein Coding	2
2	MDM2	MDM2 Proto-Oncogene	Protein Coding	2
3	PML	PML Nuclear Body Scaffold	Protein Coding	2
4	RANBP2	RAN Binding Protein 2	Protein Coding	2
5	TP53	Tumor Protein P53	Protein Coding	2
6	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
7	UBB	Ubiquitin B	Protein Coding	2
8	UBC	Ubiquitin C	Protein Coding	2
9	UBE2I	Ubiquitin Conjugating Enzyme E2 I	Protein Coding	2
10	SUMO1	Small Ubiquitin Like Modifier 1	Protein Coding	2
11	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	2
12	PIAS2	Protein Inhibitor Of Activated STAT 2	Protein Coding	2
13	UBA2	Ubiquitin Like Modifier Activating Enzyme 2	Protein Coding	2
14	SAE1	SUMO1 Activating Enzyme Subunit 1	Protein Coding	2
15	FAS	Fas Cell Surface Death Receptor	Protein Coding	1
16	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	1
17	HSF1	Heat Shock Transcription Factor 1	Protein Coding	1
18	HSF2	Heat Shock Transcription Factor 2	Protein Coding	1
19	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
20	MYB	MYB Proto-Oncogene, Transcription Factor	Protein Coding	1
21	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
22	NFKB2	Nuclear Factor Kappa B Subunit 2	Protein Coding	1
23	NFKBIA	NFKB Inhibitor Alpha	Protein Coding	1
24	RANGAP1	Ran GTPase Activating Protein 1	Protein Coding	1
25	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
26	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
27	RELB	RELB Proto-Oncogene, NF-KB Subunit	Protein Coding	1
28	SP3	Sp3 Transcription Factor	Protein Coding	1
29	SP100	SP100 Nuclear Antigen	Protein Coding	1
30	TOP2A	DNA Topoisomerase II Alpha	Protein Coding	1
31	TOP2B	DNA Topoisomerase II Beta	Protein Coding	1
32	CBX4	Chromobox 4	Protein Coding	1
33	UBE2E3	Ubiquitin Conjugating Enzyme E2 E3	Protein Coding	1
34	SENP1	SUMO Specific Peptidase 1	Protein Coding	1
35	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
36	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
37	CREBBP	CREB Binding Lysine Acetyltransferase	Protein Coding	1
38	EP300	EP300 Lysine Acetyltransferase	Protein Coding	1
39	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
40	CHEK2	Checkpoint Kinase 2	Protein Coding	1

Disorders associated with Proteolysis Putative SUMO-1 pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Li-fraumeni syndrome	Enrichment	CHEK2, MDM2, TP53	7.26
2	Li-fraumeni syndrome 1	Enrichment	CHEK2, TP53	5.69
3	Sarcoma	Enrichment	CHEK2, TP53	5.69
4	Diffuse large b-cell lymphoma	Enrichment	CHEK2, CREBBP, TP53	5.58
5	Osteogenic sarcoma	Enrichment	CHEK2, TP53	5.21
6	Bone osteosarcoma	Enrichment	CHEK2, TP53	5.21
7	Colorectal cancer	Enrichment	AKT1, CHEK2, EP300, TP53	5.15
8	Nasopharyngeal carcinoma	Enrichment	NFKBIA, TP53	4.74
9	Rubinstein-taybi syndrome 1	Enrichment	CREBBP, EP300	4.51
10	Chromosome 16p13.3 deletion syndrome, proximal	Enrichment	CREBBP, EP300	4.51
11	Breast adenocarcinoma	Enrichment	AKT1, TP53	4.51
12	Hereditary breast carcinoma	Enrichment	AKT1, CHEK2, TP53	4.46
13	Common variable immunodeficiency	Enrichment	NFKB1, NFKB2	3.90
14	Breast cancer	Enrichment	AKT1, CHEK2, TP53	3.76
15	Rare genetic intellectual disability	Enrichment	CREBBP, EP300	3.67
16	Primary hyperaldosteronism	Enrichment	NR3C1, TP53	3.66
17	Ovarian cancer	Enrichment	AKT1, CHEK2, TP53	3.38
18	Tooth agenesis	Enrichment	RANBP2, SUMO1	3.33
19	Pancreatic cancer	Enrichment	CHEK2, TP53	3.22
20	Gliosarcoma	Enrichment	NFKBIA, TP53	3.15
21	Giant cell glioblastoma	Enrichment	NFKBIA, TP53	3.09
22	Prostate cancer	Enrichment	CHEK2, TP53	3.09
23	Proteus syndrome	Enrichment	AKT1	2.83
24	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.83
25	Accelerated tumor formation	Enrichment	MDM2	2.83
26	Lessel-kubisch syndrome	Enrichment	MDM2	2.83
27	Bone marrow failure syndrome 5	Enrichment	TP53	2.83
28	Orofacial cleft 10	Enrichment	SUMO1	2.83
29	Papilloma of choroid plexus	Enrichment	TP53	2.83
30	Basal cell carcinoma 7	Enrichment	TP53	2.83
31	Anaplastic thyroid carcinoma	Enrichment	TP53	2.83
32	Tumor predisposition syndrome 4	Enrichment	CHEK2	2.83
33	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.83
34	Cowden syndrome 6	Enrichment	AKT1	2.83
35	Ductal carcinoma in situ	Enrichment	TP53	2.83
36	Menke-hennekam syndrome 1	Enrichment	CREBBP	2.83
37	Leiomyosarcoma	Enrichment	CHEK2	2.83
38	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.83
39	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.83
40	Rubinstein-taybi syndrome due to 16p13.3 microdeletion	Enrichment	CREBBP	2.83
41	Capillary hemangioma	Enrichment	AKT3	2.83
42	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.83
43	Choroid plexus cancer	Enrichment	TP53	2.83
44	Menke-hennekam syndrome	Enrichment	CREBBP	2.83
45	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.83
46	Familial acute necrotizing encephalopathy	Enrichment	RANBP2	2.83
47	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.83
48	Gastric cancer	Enrichment	CHEK2, TP53	2.75
49	B-cell immunodeficiency, distal limb anomalies, and urogenital malformations	Enrichment	TOP2B	2.60
50	Glucocorticoid resistance, generalized	Enrichment	NR3C1	2.60
51	Immunodeficiency 92	Enrichment	REL	2.60
52	Deficiency in anterior pituitary function - variable immunodeficiency syndrome	Enrichment	NFKB2	2.60
53	Immunodeficiency 53	Enrichment	RELB	2.60
54	Hereditary breast ovarian cancer syndrome	Enrichment	CHEK2, TP53	2.53
55	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.53
56	Thumb deformity	Enrichment	CREBBP	2.53
57	Cervical cancer	Enrichment	TP53	2.53
58	Lymphoma, hodgkin, classic	Enrichment	TP53	2.53
59	Congenital heart defects, multiple types, 3	Enrichment	CHEK2	2.53
60	Menke-hennekam syndrome 2	Enrichment	EP300	2.53
61	Acute myeloid leukemia with kat6a-crebbp fusion	Enrichment	CREBBP	2.53
62	Senior-loken syndrome 7	Enrichment	AKT3	2.53
63	Congenital fibrosarcoma	Enrichment	TP53	2.53
64	Chromosome 19q13.11 deletion syndrome, distal	Enrichment	UBA2	2.53
65	Cervix carcinoma	Enrichment	TP53	2.53
66	Hodgkin's lymphoma	Enrichment	TP53	2.53
67	Bardet-biedl syndrome 16	Enrichment	AKT3	2.53
68	Acute necrotizing encephalopathy of childhood	Enrichment	RANBP2	2.53
69	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.53
70	Submucosal cleft palate	Enrichment	UBB	2.53
71	Cleft hard palate	Enrichment	UBB	2.53
72	Myeloma, multiple	Enrichment	CREBBP, TP53	2.52
73	Aplasia cutis congenita, nonsyndromic	Enrichment	UBA2	2.35
74	Uvula, bifid	Enrichment	UBB	2.35
75	Cleft soft palate	Enrichment	UBB	2.35
76	Ectodermal dysplasia 11b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	2.35
77	Tethered spinal cord syndrome	Enrichment	CREBBP	2.35
78	Dedifferentiated liposarcoma	Enrichment	MDM2	2.35
79	Atypical teratoid rhabdoid tumor	Enrichment	TP53	2.35
80	Anaplastic astrocytoma	Enrichment	TP53	2.35
81	Squamous cell carcinoma	Enrichment	TP53	2.35
82	Adenocarcinoma	Enrichment	TP53	2.35
83	Intraocular pressure quantitative trait locus	Enrichment	CREBBP	2.35
84	Well-differentiated liposarcoma	Enrichment	MDM2	2.35
85	Galactosemia ii	Enrichment	NR3C1	2.30
86	Nephronophthisis-like nephropathy 1	Enrichment	RANGAP1	2.30
87	Ectodermal dysplasia and immunodeficiency 2	Enrichment	NFKBIA	2.30
88	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	2.30
89	Immunodeficiency, common variable, 10	Enrichment	NFKB2	2.30
90	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	2.30
91	Rela fusion-positive ependymoma	Enrichment	RELA	2.30
92	Acute basophilic leukemia	Enrichment	MYB	2.30
93	Ectodermal dysplasia and immune deficiency	Enrichment	NFKBIA	2.30
94	Angiocentric glioma	Enrichment	MYB	2.30
95	Common variable immunodeficiency 12	Enrichment	NFKB1	2.30
96	Ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive	Enrichment	RANBP2	2.23
97	Small cell cancer of the lung	Enrichment	TP53	2.23
98	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	2.23
99	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	2.23
100	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	2.23
101	Lung sarcomatoid carcinoma	Enrichment	TP53	2.23
102	Ectodermal dysplasia	Enrichment	RANBP2	2.23
103	Embryonal rhabdomyosarcoma	Enrichment	TP53	2.23
104	Hemoglobin c disease	Enrichment	CHEK2	2.23
105	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	RANBP2	2.13
106	Rhabdomyosarcoma 2	Enrichment	TP53	2.13
107	Rubinstein-taybi syndrome 2	Enrichment	EP300	2.13
108	Lymphoma	Enrichment	TP53	2.13
109	Aplasia cutis congenita	Enrichment	UBA2	2.13
110	Acute megakaryocytic leukemia	Enrichment	TP53	2.13
111	Autosomal recessive hypohidrotic ectodermal dysplasia syndrome	Enrichment	RANBP2	2.13
112	Hemimegalencephaly	Enrichment	AKT3	2.13
113	Adenoid cystic carcinoma	Enrichment	MYB	2.12
114	Vogt-koyanagi-harada disease	Enrichment	FAS	2.12
115	Wilms tumor 5	Enrichment	CHEK2	2.05
116	Inflammatory myofibroblastic tumor	Enrichment	RANBP2	2.05
117	Adrenocortical carcinoma	Enrichment	TP53	2.05
118	Hypertrichosis	Enrichment	CREBBP	2.05
119	Autoimmune lymphoproliferative syndrome	Enrichment	FAS	2.00
120	Immunodeficiency, common variable, 1	Enrichment	NFKB2	2.00
121	Esophageal cancer	Enrichment	TP53	1.99
122	Mitochondrial dna depletion syndrome 4a	Enrichment	RANBP2	1.99
123	Squamous cell carcinoma, head and neck	Enrichment	TP53	1.99
124	Essential thrombocythemia	Enrichment	TP53	1.99
125	Gallbladder cancer	Enrichment	TP53	1.99
126	Megacolon	Enrichment	AKT3	1.99
127	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.99
128	Glioma susceptibility 1	Enrichment	TP53	1.93
129	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.93
130	Mitochondrial dna depletion syndrome 4b	Enrichment	RANBP2	1.93
131	Charge syndrome	Enrichment	EP300	1.88
132	Adult hepatocellular carcinoma	Enrichment	TP53	1.88
133	Colonic benign neoplasm	Enrichment	CHEK2	1.88
134	Cowden syndrome	Enrichment	AKT1	1.88
135	Lynch syndrome 1	Enrichment	CHEK2	1.83
136	Leukemia, chronic lymphocytic	Enrichment	TP53	1.83
137	Polymicrogyria	Enrichment	AKT3	1.83
138	Melanoma	Enrichment	CHEK2	1.83
139	Familial colorectal cancer	Enrichment	TP53	1.83
140	Inherited cancer-predisposing syndrome	Enrichment	CHEK2, TP53	1.80
141	Myelodysplastic syndrome	Enrichment	TP53	1.79
142	Uterine corpus cancer	Enrichment	CHEK2	1.79
143	Familial colorectal cancer type x	Enrichment	CHEK2	1.79
144	Meningioma	Enrichment	AKT1	1.76
145	Lip and oral cavity carcinoma	Enrichment	TP53	1.76
146	Breast-ovarian cancer, familial 1	Enrichment	CHEK2	1.72
147	Acute promyelocytic leukemia	Enrichment	PML	1.72
148	Nk-cell enteropathy	Enrichment	CHEK2	1.72
149	Lung cancer susceptibility 3	Enrichment	TP53	1.69
150	Heart disease	Enrichment	CREBBP	1.69
151	Polydactyly, postaxial, type a1	Enrichment	EP300	1.66
152	Wilms tumor 1	Enrichment	CHEK2	1.66
153	Corpus callosum, agenesis of	Enrichment	CREBBP	1.66
154	Lynch syndrome	Enrichment	CHEK2	1.66
155	Isolated corpus callosum agenesis	Enrichment	CREBBP	1.66
156	Intellectual disability-hypoplastic corpus callosum-preauricular tag syndrome	Enrichment	CREBBP	1.66
157	Rhabdomyosarcoma	Enrichment	TP53	1.63
158	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	1.61
159	Endometrial cancer	Enrichment	CHEK2	1.52
160	Hepatoblastoma	Enrichment	TP53	1.52
161	Hepatocellular carcinoma	Enrichment	TP53	1.50
162	Diamond-blackfan anemia 1	Enrichment	TP53	1.48
163	Scoliosis	Enrichment	CREBBP	1.46
164	Bladder cancer	Enrichment	TP53	1.38
165	Lung cancer	Enrichment	CHEK2	1.34
166	Behcet syndrome	Enrichment	FAS	1.33
167	Nephronophthisis	Enrichment	PIAS1	1.32
168	Diamond-blackfan anemia	Enrichment	TP53	1.29
169	Precursor t-cell acute lymphoblastic leukemia	Enrichment	MYB	1.25
170	Leukemia, acute myeloid	Enrichment	TP53	1.24
171	Type 2 diabetes mellitus	Enrichment	AKT2	1.22
172	Primary ovarian insufficiency	Enrichment	CHEK2	1.08
173	Autism	Enrichment	CREBBP	1.00
174	Congenital nervous system abnormality	Enrichment	CREBBP	0.84
175	Nervous system disease	Enrichment	CREBBP	0.84
176	Microcephaly	Enrichment	EP300	0.78
177	Autism spectrum disorder	Enrichment	TOP2B	0.62

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Proteolysis Putative SUMO-1 pathway

Pathway Network for Proteolysis Putative SUMO-1 pathway

Member Pathways for Proteolysis Putative SUMO-1 pathway

Pathways in the Proteolysis Putative SUMO-1 pathway SuperPath

Associated Genes for Proteolysis Putative SUMO-1 pathway

Associated Disorders for Proteolysis Putative SUMO-1 pathway

Disorders associated with Proteolysis Putative SUMO-1 pathway SuperPath

STRING Interaction Network for Proteolysis Putative SUMO-1 pathway

Sources for Proteolysis Putative SUMO-1 pathway