Proteolysis_Putative ubiquitin pathway

No Pathway Network information available for Proteolysis_Putative ubiquitin pathway

Pathways in the Proteolysis_Putative ubiquitin pathway SuperPath

#	Name	Source	Genes
1	Proteolysis_Putative ubiquitin pathway	GeneGo (Thomson Reuters)	ATXN3 BTRC CUL1 FBXW11 FBXW7 GPR37 HSPA14 HSPA1A HSPA1B HSPA1L HSPA2 HSPA4 HSPA5 HSPA6 HSPA7 HSPA8 HSPA9 PRKN RBX1 SEPTIN5 SKP1 SKP2 SNCAIP STUB1 TRAF6 UBA1 UBA52 UBB UBC UBE2D1 UBE2E1 UBE2L3 UBE2L6 UBE2N UBE2V1 (see all 35) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	GPR37	G Protein-Coupled Receptor 37	Protein Coding	1
2	HSPA1A	Heat Shock Protein Family A (Hsp70) Member 1A	Protein Coding	1
3	HSPA1B	Heat Shock Protein Family A (Hsp70) Member 1B	Protein Coding	1
4	HSPA1L	Heat Shock Protein Family A (Hsp70) Member 1 Like	Protein Coding	1
5	HSPA2	Heat Shock Protein Family A (Hsp70) Member 2	Protein Coding	1
6	HSPA4	Heat Shock Protein Family A (Hsp70) Member 4	Protein Coding	1
7	HSPA5	Heat Shock Protein Family A (Hsp70) Member 5	Protein Coding	1
8	HSPA6	Heat Shock Protein Family A (Hsp70) Member 6	Protein Coding	1
9	HSPA7	Heat Shock Protein Family A (Hsp70) Member 7 (Pseudogene)	Pseudogene	1
10	HSPA8	Heat Shock Protein Family A (Hsp70) Member 8	Protein Coding	1
11	HSPA9	Heat Shock Protein Family A (Hsp70) Member 9	Protein Coding	1
12	ATXN3	Ataxin 3	Protein Coding	1
13	PRKN	Parkin RBR E3 Ubiquitin Protein Ligase	Protein Coding	1
14	SEPTIN5	Septin 5	Protein Coding	1
15	SKP1	S-Phase Kinase Associated Protein 1	Protein Coding	1
16	SKP2	S-Phase Kinase Associated Protein 2	Protein Coding	1
17	TRAF6	TNF Receptor Associated Factor 6	Protein Coding	1
18	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
19	UBB	Ubiquitin B	Protein Coding	1
20	UBC	Ubiquitin C	Protein Coding	1
21	UBA1	Ubiquitin Like Modifier Activating Enzyme 1	Protein Coding	1
22	UBE2D1	Ubiquitin Conjugating Enzyme E2 D1	Protein Coding	1
23	UBE2E1	Ubiquitin Conjugating Enzyme E2 E1	Protein Coding	1
24	UBE2L3	Ubiquitin Conjugating Enzyme E2 L3	Protein Coding	1
25	UBE2N	Ubiquitin Conjugating Enzyme E2 N	Protein Coding	1
26	UBE2V1	Ubiquitin Conjugating Enzyme E2 V1	Protein Coding	1
27	CUL1	Cullin 1	Protein Coding	1
28	BTRC	Beta-Transducin Repeat Containing E3 Ubiquitin Protein Ligase	Protein Coding	1
29	UBE2L6	Ubiquitin Conjugating Enzyme E2 L6	Protein Coding	1
30	SNCAIP	Synuclein Alpha Interacting Protein	Protein Coding	1
31	RBX1	Ring-Box 1	Protein Coding	1
32	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	1
33	FBXW11	F-Box And WD Repeat Domain Containing 11	Protein Coding	1
34	HSPA14	Heat Shock Protein Family A (Hsp70) Member 14	Protein Coding	1
35	FBXW7	F-Box And WD Repeat Domain Containing 7	Protein Coding	1

Disorders associated with Proteolysis_Putative ubiquitin pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Parkinson's disease	Enrichment	ATXN3, PRKN	2.97
2	Parkinson disease, late-onset	Enrichment	ATXN3, PRKN	2.76
3	Leprosy 2	Enrichment	PRKN	2.59
4	Even-plus syndrome	Enrichment	HSPA9	2.59
5	Anemia, sideroblastic, 4	Enrichment	HSPA9	2.59
6	Neurodevelopmental, jaw, eye, and digital syndrome	Enrichment	FBXW11	2.59
7	Developmental delay, hypotonia, and impaired language	Enrichment	FBXW7	2.59
8	Parkinson disease 12	Enrichment	PRKN	2.29
9	Vexas syndrome	Enrichment	UBA1	2.29
10	Spinocerebellar ataxia 48	Enrichment	STUB1	2.29
11	Spinal muscular atrophy, x-linked 2	Enrichment	UBA1	2.29
12	Autosomal recessive sideroblastic anemia	Enrichment	HSPA9	2.29
13	Submucosal cleft palate	Enrichment	UBB	2.29
14	Cleft hard palate	Enrichment	UBB	2.29
15	Uvula, bifid	Enrichment	UBB	2.11
16	Cleft soft palate	Enrichment	UBB	2.11
17	Complex hereditary spastic paraplegia	Enrichment	PRKN	1.99
18	Ectodermal dysplasia 10a, hypohidrotic/hair/nail type, autosomal dominant	Enrichment	TRAF6	1.89
19	Parkinson disease 2, autosomal recessive juvenile	Enrichment	PRKN	1.89
20	Pervasive developmental disorder	Enrichment	FBXW7	1.89
21	Parkin type of early-onset parkinson disease	Enrichment	PRKN	1.89
22	Rare pervasive developmental disorder	Enrichment	FBXW7	1.89
23	Machado-joseph disease	Enrichment	ATXN3	1.81
24	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.81
25	Isolated split hand-split foot malformation	Enrichment	BTRC	1.69
26	Early-onset parkinson's disease	Enrichment	PRKN	1.52
27	Lung cancer susceptibility 3	Enrichment	PRKN	1.45
28	Lung cancer	Enrichment	PRKN	1.10
29	Systemic lupus erythematosus	Enrichment	UBE2L3	1.02
30	Schizophrenia	Enrichment	PRKN	0.85
31	Autism	Enrichment	PRKN	0.77
32	Colorectal cancer	Enrichment	FBXW7	0.69
33	Ovarian cancer	Enrichment	PRKN	0.64
34	Autism spectrum disorder	Enrichment	PRKN	0.61
35	Complex neurodevelopmental disorder	Enrichment	FBXW11	0.56

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Proteolysis_Putative ubiquitin pathway

Pathway Network for Proteolysis_Putative ubiquitin pathway

Member Pathways for Proteolysis_Putative ubiquitin pathway

Pathways in the Proteolysis_Putative ubiquitin pathway SuperPath

Associated Genes for Proteolysis_Putative ubiquitin pathway

Associated Disorders for Proteolysis_Putative ubiquitin pathway

Disorders associated with Proteolysis_Putative ubiquitin pathway SuperPath

STRING Interaction Network for Proteolysis_Putative ubiquitin pathway

Sources for Proteolysis_Putative ubiquitin pathway