Proton Pump Inhibitor Pathway, Pharmacodynamics

No Pathway Network information available for Proton Pump Inhibitor Pathway, Pharmacodynamics

Pathways in the Proton Pump Inhibitor Pathway, Pharmacodynamics SuperPath

#	Name	Source	Genes
1	Proton Pump Inhibitor Pathway, Pharmacodynamics	PharmGKB	ADCY1 ADCY2 ADCY3 ADCY4 ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 AKAP1 AKT3 ATP4A ATP4B CASR CCKBR CHRM3 GNAS HRH2 PDE3A PIK3C2A PIK3C2B PIK3R5 PLCB1 PLCB2 PLCB3 PLCB4 PLCD1 PLCD3 PLCD4 PLCE1 PLCG1 PLCG2 PLCH1 PLCH2 PLCL1 PLCL2 PLCZ1 PRKCA PRKCB PRKCG PRKCH PRKCI PRKCZ PRKD1 SSTR2 (see all 45) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	SSTR2	Somatostatin Receptor 2	Protein Coding	1
2	ADCY5	Adenylate Cyclase 5	Protein Coding	1
3	CASR	Calcium Sensing Receptor	Protein Coding	1
4	AKAP1	A-Kinase Anchoring Protein 1	Protein Coding	1
5	CCKBR	Cholecystokinin B Receptor	Protein Coding	1
6	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
7	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
8	PDE3A	Phosphodiesterase 3A	Protein Coding	1
9	HRH2	Histamine Receptor H2	Protein Coding	1
10	PLCL2	Phospholipase C Like 2	Protein Coding	1
11	PLCB1	Phospholipase C Beta 1	Protein Coding	1
12	GNAS	GNAS Complex Locus	Protein Coding	1
13	PIK3C2A	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Alpha	Protein Coding	1
14	PIK3C2B	Phosphatidylinositol-4-Phosphate 3-Kinase Catalytic Subunit Type 2 Beta	Protein Coding	1
15	PLCB2	Phospholipase C Beta 2	Protein Coding	1
16	PLCB3	Phospholipase C Beta 3	Protein Coding	1
17	PLCB4	Phospholipase C Beta 4	Protein Coding	1
18	PLCD1	Phospholipase C Delta 1	Protein Coding	1
19	PLCL1	Phospholipase C Like 1 (Inactive)	Protein Coding	1
20	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
21	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
22	ATP4B	ATPase H+/K+ Transporting Subunit Beta	Protein Coding	1
23	ATP4A	ATPase H+/K+ Transporting Subunit Alpha	Protein Coding	1
24	ADCY1	Adenylate Cyclase 1	Protein Coding	1
25	ADCY6	Adenylate Cyclase 6	Protein Coding	1
26	PRKCA	Protein Kinase C Alpha	Protein Coding	1
27	PRKCB	Protein Kinase C Beta	Protein Coding	1
28	PRKCG	Protein Kinase C Gamma	Protein Coding	1
29	PRKCH	Protein Kinase C Eta	Protein Coding	1
30	PRKCI	Protein Kinase C Iota	Protein Coding	1
31	PRKD1	Protein Kinase D1	Protein Coding	1
32	PRKCZ	Protein Kinase C Zeta	Protein Coding	1
33	ADCY7	Adenylate Cyclase 7	Protein Coding	1
34	CHRM3	Cholinergic Receptor Muscarinic 3	Protein Coding	1
35	ADCY8	Adenylate Cyclase 8	Protein Coding	1
36	ADCY9	Adenylate Cyclase 9	Protein Coding	1
37	ADCY2	Adenylate Cyclase 2	Protein Coding	1
38	ADCY3	Adenylate Cyclase 3	Protein Coding	1
39	PLCZ1	Phospholipase C Zeta 1	Protein Coding	1
40	PIK3R5	Phosphoinositide-3-Kinase Regulatory Subunit 5	Protein Coding	1
41	PLCH2	Phospholipase C Eta 2	Protein Coding	1
42	PLCH1	Phospholipase C Eta 1	Protein Coding	1
43	ADCY4	Adenylate Cyclase 4	Protein Coding	1
44	PLCD3	Phospholipase C Delta 3	Protein Coding	1
45	PLCD4	Phospholipase C Delta 4	Protein Coding	1

Disorders associated with Proton Pump Inhibitor Pathway, Pharmacodynamics SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hypertension and brachydactyly syndrome	Enrichment	PDE3A	2.48
2	Hypocalcemia, autosomal dominant 1	Enrichment	CASR	2.48
3	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.48
4	Hypocalciuric hypercalcemia, familial, type i	Enrichment	CASR	2.48
5	Osseous heteroplasia, progressive	Enrichment	GNAS	2.48
6	Nail disorder, nonsyndromic congenital, 3	Enrichment	PLCD1	2.48
7	Dyskinesia with orofacial involvement, autosomal dominant	Enrichment	ADCY5	2.48
8	Deafness, autosomal recessive 44	Enrichment	ADCY1	2.48
9	Ataxia-oculomotor apraxia 3	Enrichment	PIK3R5	2.48
10	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.48
11	Spondylometaphyseal dysplasia with corneal dystrophy	Enrichment	PLCB3	2.48
12	Neurodevelopmental disorder with hyperkinetic movements and dyskinesia	Enrichment	ADCY5	2.48
13	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.48
14	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	2.48
15	Auriculocondylar syndrome 2a	Enrichment	PLCB4	2.48
16	Oculoskeletodental syndrome	Enrichment	PIK3C2A	2.48
17	Dyskinesia with orofacial involvement, autosomal recessive	Enrichment	ADCY5	2.48
18	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.48
19	Spinocerebellar ataxia 14	Enrichment	PRKCG	2.48
20	Epilepsy, idiopathic generalized 8	Enrichment	CASR	2.48
21	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	2.48
22	Disorders of gnas inactivation	Enrichment	GNAS	2.48
23	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	2.48
24	Congenital heart defects and ectodermal dysplasia	Enrichment	PRKD1	2.48
25	Holoprosencephaly 14	Enrichment	PLCH1	2.48
26	Auriculocondylar syndrome 2b	Enrichment	PLCB4	2.48
27	Capillary hemangioma	Enrichment	AKT3	2.48
28	Hypercalcemia	Enrichment	CASR	2.48
29	Familial hypocalciuric hypercalcemia	Enrichment	CASR	2.48
30	Familial gastric type 1 neuroendocrine tumor	Enrichment	ATP4A	2.48
31	Monostotic fibrous dysplasia	Enrichment	GNAS	2.48
32	Oculocerebrodental syndrome	Enrichment	PIK3C2A	2.48
33	Malignant epithelial tumor of salivary glands	Enrichment	PRKD1	2.48
34	Mazabraud syndrome	Enrichment	GNAS	2.48
35	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.18
36	Hyperparathyroidism, neonatal severe	Enrichment	CASR	2.18
37	Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 2	Enrichment	PIK3R5	2.18
38	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.18
39	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.18
40	Lethal congenital contracture syndrome 8	Enrichment	ADCY6	2.18
41	Spermatogenic failure 17	Enrichment	PLCZ1	2.18
42	Senior-loken syndrome 7	Enrichment	AKT3	2.18
43	Autosomal dominant hypocalcemia	Enrichment	CASR	2.18
44	Pseudohypoparathyroidism	Enrichment	GNAS	2.18
45	Body mass index quantitative trait locus 19	Enrichment	ADCY3	2.18
46	Ocular melanoma	Enrichment	PLCB4	2.18
47	Bardet-biedl syndrome 16	Enrichment	AKT3	2.18
48	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.18
49	Prune belly syndrome	Enrichment	CHRM3	2.00
50	Mccune-albright syndrome	Enrichment	GNAS	2.00
51	Nephrotic syndrome, type 3	Enrichment	PLCE1	2.00
52	Familial isolated hypoparathyroidism	Enrichment	CASR	2.00
53	Parathyroid adenoma	Enrichment	CASR	2.00
54	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.00
55	Hypomyelination neuropathy-arthrogryposis syndrome	Enrichment	ADCY6	2.00
56	Body mass index quantitative trait locus 11	Enrichment	ADCY3, GNAS	1.92
57	Chorea, benign hereditary	Enrichment	ADCY5	1.88
58	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	1.88
59	Auriculocondylar syndrome 1	Enrichment	PLCB4	1.88
60	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.88
61	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.88
62	Developmental and epileptic encephalopathy 12	Enrichment	PLCB1	1.88
63	Hereditary ataxia	Enrichment	PRKCG	1.88
64	Primary hyperparathyroidism	Enrichment	CASR	1.88
65	Hemimegalencephaly	Enrichment	AKT3	1.78
66	Melanoma, uveal	Enrichment	PLCB4	1.70
67	Brachydactyly	Enrichment	GNAS	1.64
68	Megacolon	Enrichment	AKT3	1.64
69	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.58
70	Nephrotic syndrome, type 1	Enrichment	PLCE1	1.53
71	Developmental and epileptic encephalopathy 14	Enrichment	PLCB1	1.53
72	Primary hyperaldosteronism	Enrichment	GNAS	1.53
73	Stroke, ischemic	Enrichment	PRKCH	1.49
74	Polymicrogyria	Enrichment	AKT3	1.49
75	Chromosome 1p36 deletion syndrome	Enrichment	PRKCZ	1.37
76	Pancreatitis, hereditary	Enrichment	CASR	1.26
77	Alobar holoprosencephaly	Enrichment	PLCH1	1.26
78	Focal segmental glomerulosclerosis	Enrichment	PLCE1	1.19
79	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	0.97
80	Benign epilepsy with centrotemporal spikes	Enrichment	PLCB1	0.89
81	Centralopathic epilepsy	Enrichment	PLCB1	0.88
82	Nephrotic syndrome	Enrichment	PLCE1	0.88
83	Hypertrophic cardiomyopathy	Enrichment	CASR	0.88
84	West syndrome	Enrichment	PLCB1	0.87
85	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	ADCY1	0.59

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Proton Pump Inhibitor Pathway, Pharmacodynamics

Pathway Network for Proton Pump Inhibitor Pathway, Pharmacodynamics

Member Pathways for Proton Pump Inhibitor Pathway, Pharmacodynamics

Pathways in the Proton Pump Inhibitor Pathway, Pharmacodynamics SuperPath

Associated Genes for Proton Pump Inhibitor Pathway, Pharmacodynamics

Associated Disorders for Proton Pump Inhibitor Pathway, Pharmacodynamics

Disorders associated with Proton Pump Inhibitor Pathway, Pharmacodynamics SuperPath

STRING Interaction Network for Proton Pump Inhibitor Pathway, Pharmacodynamics

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