PTEN Regulation

Pathway network for the PTEN Regulation SuperPath

Sources:

Reactome

Pathways in the PTEN Regulation SuperPath

#	Name	Source	Genes
1	PTEN Regulation	Reactome	ADRM1 AGO1 AGO2 AGO3 AGO4 AKT1 AKT2 AKT3 ATF2 ATN1 BMI1 CBX2 CBX4 CBX6 CBX8 CHD3 CHD4 COMMD3-BMI1 CSNK2A1 CSNK2A2 CSNK2B EED EGR1 EZH2 FRK GATAD2A GATAD2B HDAC1 HDAC2 HDAC3 HDAC5 HDAC7 JUN KDM1A LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 MAF1 MAPK1 MAPK3 MBD3 MECOM MKRN1 MLST8 MOV10 MTA1 MTA2 MTA3 MTOR NEDD4 NR2E1 OTUD3 PHC1 PHC2 PHC3 PML PPARG PREX2 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD1 PSMD11 PSMD12 PSMD13 PSMD14 PSMD2 PSMD3 PSMD6 PSMD7 PSMD8 PTEN RBBP4 RBBP7 RCOR1 REST RHEB RING1 RNF146 RNF2 RPS27A RPTOR RRAGA RRAGB RRAGC RRAGD SALL4 SCMH1 SEM1 SLC38A9 SNAI1 SNAI2 STUB1 SUZ12 TNKS TNKS2 TNRC6A TNRC6B TNRC6C TP53 TRIM27 UBA52 UBB UBC USP13 USP7 WWP2 (see all 126) (see less)
2	Regulation of PTEN gene transcription	Reactome	ATF2 ATN1 BMI1 CBX2 CBX4 CBX6 CBX8 CHD3 CHD4 COMMD3-BMI1 EED EGR1 EZH2 GATAD2A GATAD2B HDAC1 HDAC2 HDAC3 HDAC5 HDAC7 JUN KDM1A LAMTOR1 LAMTOR2 LAMTOR3 LAMTOR4 LAMTOR5 MAF1 MAPK1 MAPK3 MBD3 MECOM MLST8 MTA1 MTA2 MTA3 MTOR NR2E1 PHC1 PHC2 PHC3 PPARG RBBP4 RBBP7 RCOR1 REST RHEB RING1 RNF2 RPTOR RRAGA RRAGB RRAGC RRAGD SALL4 SCMH1 SLC38A9 SNAI1 SNAI2 SUZ12 TP53 (see all 61) (see less)
3	Regulation of PTEN localization	Reactome	NEDD4 PML PTEN RPS27A UBA52 UBB UBC USP7 (see all 8) (see less)
4	PTEN Loss of Function in Cancer	Reactome	PTEN

Gene overlap in member pathways for PTEN Regulation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PTEN	Phosphatase And Tensin Homolog	Protein Coding	3
2	HDAC5	Histone Deacetylase 5	Protein Coding	2
3	COMMD3-BMI1	COMMD3-BMI1 Readthrough	Protein Coding	2
4	RRAGB	Ras Related GTP Binding B	Protein Coding	2
5	LAMTOR5	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 5	Protein Coding	2
6	RRAGA	Ras Related GTP Binding A	Protein Coding	2
7	CHD3	Chromodomain Helicase DNA Binding Protein 3	Protein Coding	2
8	CHD4	Chromodomain Helicase DNA Binding Protein 4	Protein Coding	2
9	ATF2	Activating Transcription Factor 2	Protein Coding	2
10	SLC38A9	Solute Carrier Family 38 Member 9	Protein Coding	2
11	ATN1	Atrophin 1	Protein Coding	2
12	PHC1	Polyhomeotic Homolog 1	Protein Coding	2
13	PHC2	Polyhomeotic Homolog 2	Protein Coding	2
14	EGR1	Early Growth Response 1	Protein Coding	2
15	MECOM	MDS1 And EVI1 Complex Locus	Protein Coding	2
16	EZH2	Enhancer Of Zeste 2 Polycomb Repressive Complex 2 Subunit	Protein Coding	2
17	SCMH1	Scm Polycomb Group Protein Homolog 1	Protein Coding	2
18	KDM1A	Lysine Demethylase 1A	Protein Coding	2
19	RCOR1	REST Corepressor 1	Protein Coding	2
20	CBX6	Chromobox 6	Protein Coding	2
21	SUZ12	SUZ12 Polycomb Repressive Complex 2 Subunit	Protein Coding	2
22	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	2
23	LAMTOR2	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 2	Protein Coding	2
24	HDAC1	Histone Deacetylase 1	Protein Coding	2
25	HDAC2	Histone Deacetylase 2	Protein Coding	2
26	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	2
27	LAMTOR4	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 4	Protein Coding	2
28	NEDD4	NEDD4 E3 Ubiquitin Protein Ligase	Protein Coding	2
29	HDAC7	Histone Deacetylase 7	Protein Coding	2
30	MBD3	Methyl-CpG Binding Domain Protein 3	Protein Coding	2
31	PML	PML Nuclear Body Scaffold	Protein Coding	2
32	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	2
33	GATAD2A	GATA Zinc Finger Domain Containing 2A	Protein Coding	2
34	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	2
35	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	2
36	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
37	SALL4	Spalt Like Transcription Factor 4	Protein Coding	2
38	CBX8	Chromobox 8	Protein Coding	2
39	GATAD2B	GATA Zinc Finger Domain Containing 2B	Protein Coding	2
40	MTA3	Metastasis Associated 1 Family Member 3	Protein Coding	2
41	RPTOR	Regulatory Associated Protein Of MTOR Complex 1	Protein Coding	2
42	RRAGD	Ras Related GTP Binding D	Protein Coding	2
43	RBBP4	RB Binding Protein 4, Chromatin Remodeling Factor	Protein Coding	2
44	RBBP7	RB Binding Protein 7, Chromatin Remodeling Factor	Protein Coding	2
45	REST	RE1 Silencing Transcription Factor	Protein Coding	2
46	RHEB	Ras Homolog, MTORC1 Binding	Protein Coding	2
47	RING1	Ring Finger Protein 1	Protein Coding	2
48	RNF2	Ring Finger Protein 2	Protein Coding	2
49	RPS27A	Ribosomal Protein S27a	Protein Coding	2
50	RRAGC	Ras Related GTP Binding C	Protein Coding	2
51	MLST8	MTOR Associated Protein MLST8	Protein Coding	2
52	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	2
53	SNAI2	Snail Family Transcriptional Repressor 2	Protein Coding	2
54	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	2
55	NR2E1	Nuclear Receptor Subfamily 2 Group E Member 1	Protein Coding	2
56	TP53	Tumor Protein P53	Protein Coding	2
57	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	2
58	UBB	Ubiquitin B	Protein Coding	2
59	UBC	Ubiquitin C	Protein Coding	2
60	USP7	Ubiquitin Specific Peptidase 7	Protein Coding	2
61	PHC3	Polyhomeotic Homolog 3	Protein Coding	2
62	MAF1	MAF1 Negative Regulator Of RNA Polymerase III	Protein Coding	2
63	CBX2	Chromobox 2	Protein Coding	2
64	CBX4	Chromobox 4	Protein Coding	2
65	LAMTOR3	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 3	Protein Coding	2
66	EED	Embryonic Ectoderm Development	Protein Coding	2
67	HDAC3	Histone Deacetylase 3	Protein Coding	2
68	MTA1	Metastasis Associated 1	Protein Coding	2
69	MTA2	Metastasis Associated 1 Family Member 2	Protein Coding	2
70	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
71	PSMD14	Proteasome 26S Subunit, Non-ATPase 14	Protein Coding	1
72	STUB1	STIP1 Homology And U-Box Containing Protein 1	Protein Coding	1
73	ADRM1	ADRM1 26S Proteasome Ubiquitin Receptor	Protein Coding	1
74	WWP2	WW Domain Containing E3 Ubiquitin Protein Ligase 2	Protein Coding	1
75	CSNK2A1	Casein Kinase 2 Alpha 1	Protein Coding	1
76	CSNK2A2	Casein Kinase 2 Alpha 2	Protein Coding	1
77	CSNK2B	Casein Kinase 2 Beta	Protein Coding	1
78	AGO3	Argonaute RISC Catalytic Component 3	Protein Coding	1
79	AGO4	Argonaute RISC Component 4	Protein Coding	1
80	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
81	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
82	TNRC6B	Trinucleotide Repeat Containing Adaptor 6B	Protein Coding	1
83	OTUD3	OTU Deubiquitinase 3	Protein Coding	1
84	MKRN1	Makorin Ring Finger Protein 1	Protein Coding	1
85	FRK	Fyn Related Src Family Tyrosine Kinase	Protein Coding	1
86	AGO1	Argonaute RISC Component 1	Protein Coding	1
87	AGO2	Argonaute RISC Catalytic Component 2	Protein Coding	1
88	TNRC6A	Trinucleotide Repeat Containing Adaptor 6A	Protein Coding	1
89	MOV10	Mov10 RNA Helicase	Protein Coding	1
90	PSMA1	Proteasome 20S Subunit Alpha 1	Protein Coding	1
91	PSMA2	Proteasome 20S Subunit Alpha 2	Protein Coding	1
92	PSMA3	Proteasome 20S Subunit Alpha 3	Protein Coding	1
93	PSMA4	Proteasome 20S Subunit Alpha 4	Protein Coding	1
94	PSMA5	Proteasome 20S Subunit Alpha 5	Protein Coding	1
95	PSMA6	Proteasome 20S Subunit Alpha 6	Protein Coding	1
96	PSMA7	Proteasome 20S Subunit Alpha 7	Protein Coding	1
97	PSMB1	Proteasome 20S Subunit Beta 1	Protein Coding	1
98	PSMB2	Proteasome 20S Subunit Beta 2	Protein Coding	1
99	PSMB3	Proteasome 20S Subunit Beta 3	Protein Coding	1
100	PSMB4	Proteasome 20S Subunit Beta 4	Protein Coding	1
101	PSMB5	Proteasome 20S Subunit Beta 5	Protein Coding	1
102	PSMB6	Proteasome 20S Subunit Beta 6	Protein Coding	1
103	PSMB7	Proteasome 20S Subunit Beta 7	Protein Coding	1
104	PSMC1	Proteasome 26S Subunit, ATPase 1	Protein Coding	1
105	PSMC2	Proteasome 26S Subunit, ATPase 2	Protein Coding	1
106	PSMC3	Proteasome 26S Subunit, ATPase 3	Protein Coding	1
107	PSMC4	Proteasome 26S Subunit, ATPase 4	Protein Coding	1
108	PSMC5	Proteasome 26S Subunit, ATPase 5	Protein Coding	1
109	PSMC6	Proteasome 26S Subunit, ATPase 6	Protein Coding	1
110	PSMD1	Proteasome 26S Subunit, Non-ATPase 1	Protein Coding	1
111	PSMD2	Proteasome 26S Subunit Ubiquitin Receptor, Non-ATPase 2	Protein Coding	1
112	PSMD3	Proteasome 26S Subunit, Non-ATPase 3	Protein Coding	1
113	PSMD7	Proteasome 26S Subunit, Non-ATPase 7	Protein Coding	1
114	PSMD8	Proteasome 26S Subunit, Non-ATPase 8	Protein Coding	1
115	PSMD11	Proteasome 26S Subunit, Non-ATPase 11	Protein Coding	1
116	PSMD12	Proteasome 26S Subunit, Non-ATPase 12	Protein Coding	1
117	PSMD13	Proteasome 26S Subunit, Non-ATPase 13	Protein Coding	1
118	TNRC6C	Trinucleotide Repeat Containing Adaptor 6C	Protein Coding	1
119	TRIM27	Tripartite Motif Containing 27	Protein Coding	1
120	SEM1	SEM1 26S Proteasome Subunit	Protein Coding	1
121	PREX2	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2	Protein Coding	1
122	TNKS2	Tankyrase 2	Protein Coding	1
123	RNF146	Ring Finger Protein 146	Protein Coding	1
124	TNKS	Tankyrase	Protein Coding	1
125	USP13	Ubiquitin Specific Peptidase 13	Protein Coding	1
126	PSMD6	Proteasome 26S Subunit, Non-ATPase 6	Protein Coding	1

Disorders associated with PTEN Regulation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Hemimegalencephaly	Enrichment	AKT3, MTOR, PTEN, RHEB	7.45
2	Weaver syndrome	Enrichment	EZH2, SUZ12	4.23
3	Vacterl association with hydrocephalus	Enrichment	PTEN	4.13
4	Papillary tumor of the pineal region	Enrichment	PTEN	4.13
5	Glioma susceptibility 2	Enrichment	PTEN	4.13
6	Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome	Enrichment	PTEN	4.13
7	Focal cortical dysplasia, type ii	Enrichment	MTOR, RHEB	3.93
8	Isolated focal cortical dysplasia type ii	Enrichment	MTOR, RHEB	3.93
9	Vacterl with hydrocephalus	Enrichment	PTEN	3.83
10	Juvenile polyposis of infancy	Enrichment	PTEN	3.83
11	Laryngeal squamous cell carcinoma	Enrichment	PTEN	3.66
12	Glioma	Enrichment	PTEN	3.53
13	Macrocephaly/autism syndrome	Enrichment	PTEN	3.43
14	Hemangioma	Enrichment	PTEN	3.43
15	Acute megakaryocytic leukemia	Enrichment	PTEN	3.43
16	Cowden syndrome 1	Enrichment	PTEN	3.35
17	Thyroid cancer, nonmedullary, 2	Enrichment	PTEN	3.29
18	Squamous cell carcinoma, head and neck	Enrichment	PTEN	3.29
19	Follicular thyroid carcinoma	Enrichment	PTEN	3.29
20	Cowden syndrome	Enrichment	PTEN	3.18
21	Melanoma	Enrichment	PTEN	3.13
22	Meningioma, familial	Enrichment	PTEN	3.09
23	Uterine corpus cancer	Enrichment	PTEN	3.09
24	Meningioma	Enrichment	PTEN	3.05
25	Complex neurodevelopmental disorder	Enrichment	AGO1, AGO2, CSNK2A1, PSMD12, RNF2, TNRC6B	2.98
26	Hao-fountain syndrome	Enrichment	USP7	2.93
27	Submucosal cleft palate	Enrichment	UBB	2.93
28	Cleft hard palate	Enrichment	UBB	2.93
29	Rhabdomyosarcoma	Enrichment	PTEN	2.93
30	Breast adenocarcinoma	Enrichment	AKT1, TP53	2.90
31	Diffuse large b-cell lymphoma	Enrichment	PTEN	2.85
32	Endometrial cancer	Enrichment	PTEN	2.81
33	Uvula, bifid	Enrichment	UBB	2.75
34	Cleft soft palate	Enrichment	UBB	2.75
35	Bladder cancer	Enrichment	PTEN	2.67
36	Prostate cancer	Enrichment	PTEN	2.67
37	Gliosarcoma	Enrichment	PPARG, TP53	2.64
38	Giant cell glioblastoma	Enrichment	PPARG, TP53	2.59
39	Gastric cancer	Enrichment	PTEN	2.50
40	Hereditary breast carcinoma	Enrichment	PTEN	2.49
41	Autism spectrum disorder	Enrichment	CSNK2A1, CSNK2B, EED, PTEN, TNRC6B	2.46
42	Polymicrogyria	Enrichment	AKT3, PSMC3	2.44
43	Hereditary breast ovarian cancer syndrome	Enrichment	PTEN	2.39
44	Spermatogenic failure, x-linked, 9	Enrichment	RBBP7	2.35
45	Immunodeficiency due to defect in mapbp-interacting protein	Enrichment	LAMTOR2	2.35
46	46,xy sex reversal 5	Enrichment	CBX2	2.35
47	Ivic syndrome	Enrichment	SALL4	2.35
48	Gand syndrome	Enrichment	GATAD2B	2.35
49	Microcephaly 11, primary, autosomal recessive	Enrichment	PHC1	2.35
50	Wilms tumor 6	Enrichment	REST	2.35
51	Congenital hypotonia, epilepsy, developmental delay, and digital anomalies	Enrichment	ATN1	2.35
52	Luo-schoch-yamamoto syndrome	Enrichment	RNF2	2.35
53	Noonan syndrome 13	Enrichment	MAPK1	2.35
54	Bone marrow failure syndrome 5	Enrichment	TP53	2.35
55	Papilloma of choroid plexus	Enrichment	TP53	2.35
56	Basal cell carcinoma 7	Enrichment	TP53	2.35
57	Imagawa-matsumoto syndrome	Enrichment	SUZ12	2.35
58	Anaplastic thyroid carcinoma	Enrichment	TP53	2.35
59	Radioulnar synostosis with amegakaryocytic thrombocytopenia 2	Enrichment	MECOM	2.35
60	Deafness, autosomal dominant 27	Enrichment	REST	2.35
61	Cleft palate, psychomotor retardation, and distinctive facial features	Enrichment	KDM1A	2.35
62	Ductal carcinoma in situ	Enrichment	TP53	2.35
63	Fibromatosis, gingival, 5	Enrichment	REST	2.35
64	Cohen-gibson syndrome	Enrichment	EED	2.35
65	Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome	Enrichment	GATAD2B	2.35
66	Thyroid gland undifferentiated carcinoma	Enrichment	TP53	2.35
67	Small-cell carcinoma of the ovary of hypercalcemic type	Enrichment	TP53	2.35
68	Pparg-associated congenital generalized lipodystrophy	Enrichment	PPARG	2.35
69	Palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndrome	Enrichment	KDM1A	2.35
70	Diffuse pediatric-type high-grade glioma, h3-wildtype and idh-wildtype	Enrichment	TP53	2.35
71	Acth-independent macronodular adrenal hyperplasia 3	Enrichment	KDM1A	2.35
72	Choroid plexus cancer	Enrichment	TP53	2.35
73	Pleomorphic xanthoastrocytoma	Enrichment	TP53	2.35
74	Sall4-related disorders	Enrichment	SALL4	2.35
75	Primary immunodeficiency syndrome due to p14 deficiency	Enrichment	LAMTOR2	2.35
76	Tubular renal disease-cardiomyopathy syndrome	Enrichment	RRAGD	2.35
77	Breast cancer	Enrichment	AKT1, JUN, PTEN, TP53	2.28
78	Ovarian cancer	Enrichment	PTEN	2.13
79	Acute promyelocytic leukemia	Enrichment	PML	2.12
80	Congenital nervous system abnormality	Enrichment	PTEN	2.11
81	Nervous system disease	Enrichment	PTEN	2.11
82	Fibromatosis, gingival, 1	Enrichment	REST	2.05
83	Dentatorubral-pallidoluysian atrophy	Enrichment	ATN1	2.05
84	Adrenocortical carcinoma, hereditary	Enrichment	TP53	2.05
85	Carotid intimal medial thickness 1	Enrichment	PPARG	2.05
86	Cervical cancer	Enrichment	TP53	2.05
87	Piebald trait	Enrichment	SNAI2	2.05
88	Duane-radial ray syndrome	Enrichment	SALL4	2.05
89	Sifrim-hitz-weiss syndrome	Enrichment	CHD4	2.05
90	Lymphoma, hodgkin, classic	Enrichment	TP53	2.05
91	Hypomagnesemia 7, renal, with or without dilated cardiomyopathy	Enrichment	RRAGD	2.05
92	Snijders blok-campeau syndrome	Enrichment	CHD3	2.05
93	Cebalid syndrome	Enrichment	MTOR	2.05
94	Congenital fibrosarcoma	Enrichment	TP53	2.05
95	Li-fraumeni syndrome 1	Enrichment	TP53	2.05
96	Sarcoma	Enrichment	TP53	2.05
97	Cervix carcinoma	Enrichment	TP53	2.05
98	Hodgkin's lymphoma	Enrichment	TP53	2.05
99	Smith-kingsmore syndrome	Enrichment	MTOR	2.05
100	Radioulnar synostosis	Enrichment	MECOM	2.05
101	Long-olsen-distelmaier syndrome	Enrichment	RRAGC	2.05
102	Familial partial lipodystrophy	Enrichment	PPARG	2.05
103	Acute myeloid leukemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2)	Enrichment	MECOM	2.05
104	Pleomorphic rhabdomyosarcoma	Enrichment	TP53	2.05
105	Radio-ulnar synostosis-amegakaryocytic thrombocytopenia syndrome	Enrichment	MECOM	2.05
106	Proteus syndrome	Enrichment	AKT1	2.03
107	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.03
108	Global developmental delay with speech and behavioral abnormalities	Enrichment	TNRC6B	2.03
109	Neurodevelopmental disorder with microcephaly, hypotonia, and absent language	Enrichment	PSMB1	2.03
110	Stankiewicz-isidor syndrome	Enrichment	PSMD12	2.03
111	Deafness, cataract, impaired intellectual development, and polyneuropathy	Enrichment	PSMC3	2.03
112	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.03
113	Cowden syndrome 6	Enrichment	AKT1	2.03
114	Epilepsy, familial adult myoclonic, 6	Enrichment	TNRC6A	2.03
115	Okur-chung neurodevelopmental syndrome	Enrichment	CSNK2A1	2.03
116	Craniodigital syndrome and intellectual disability syndrome	Enrichment	CSNK2B	2.03
117	Capillary hemangioma	Enrichment	AKT3	2.03
118	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.03
119	Inherited cancer-predisposing syndrome	Enrichment	PTEN	2.01
120	Osteogenic sarcoma	Enrichment	TP53	1.87
121	Nasopharyngeal carcinoma	Enrichment	TP53	1.87
122	Atypical teratoid rhabdoid tumor	Enrichment	TP53	1.87
123	Anaplastic astrocytoma	Enrichment	TP53	1.87
124	Squamous cell carcinoma	Enrichment	TP53	1.87
125	Adenocarcinoma	Enrichment	TP53	1.87
126	Duane retraction syndrome	Enrichment	SALL4	1.87
127	Bone osteosarcoma	Enrichment	TP53	1.87
128	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	KDM1A	1.87
129	Small cell cancer of the lung	Enrichment	TP53	1.75
130	Thyroid cancer, nonmedullary, 1	Enrichment	TP53	1.75
131	Lipodystrophy, familial partial, type 3	Enrichment	PPARG	1.75
132	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.75
133	Leptin deficiency or dysfunction	Enrichment	PPARG	1.75
134	Congenital generalized lipodystrophy	Enrichment	PPARG	1.75
135	Lung sarcomatoid carcinoma	Enrichment	TP53	1.75
136	Embryonal rhabdomyosarcoma	Enrichment	TP53	1.75
137	Gingival fibromatosis	Enrichment	REST	1.75
138	Premature ovarian failure 3	Enrichment	AGO2	1.73
139	Birk-aharoni syndrome	Enrichment	PSMC1	1.73
140	Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures	Enrichment	AGO1	1.73
141	Spondyloepiphyseal dysplasia, nishimura type	Enrichment	WWP2	1.73
142	Spinocerebellar ataxia 48	Enrichment	STUB1	1.73
143	Poirier-bienvenu neurodevelopmental syndrome	Enrichment	CSNK2B	1.73
144	Proteasome-associated autoinflammatory syndrome 3	Enrichment	PSMB4	1.73
145	Senior-loken syndrome 7	Enrichment	AKT3	1.73
146	Bardet-biedl syndrome 16	Enrichment	AKT3	1.73
147	17q24.2 microdeletion syndrome	Enrichment	PSMD12	1.73
148	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	SALL4	1.65
149	Rhabdomyosarcoma 2	Enrichment	TP53	1.65
150	Lymphoma	Enrichment	TP53	1.65
151	Endometrial stromal sarcoma	Enrichment	SUZ12	1.65
152	Dyskeratosis congenita, autosomal dominant 1	Enrichment	MECOM	1.57
153	Li-fraumeni syndrome	Enrichment	TP53	1.57
154	Adrenocortical carcinoma	Enrichment	TP53	1.57
155	Prognathism, mandibular	Enrichment	CSNK2B	1.56
156	Proteasome-associated autoinflammatory syndrome 1	Enrichment	PSMB4	1.56
157	Proteosome-associated autoinflammatory syndrome	Enrichment	PSMB4	1.56
158	Lessel-kreienkamp syndrome	Enrichment	AGO2	1.56
159	Thyroid hemiagenesis	Enrichment	PSMD3	1.56
160	Differentiated thyroid carcinoma	Enrichment	PPARG, TRIM27	1.53
161	Esophageal cancer	Enrichment	TP53	1.51
162	Waardenburg syndrome, type 2e	Enrichment	SNAI2	1.51
163	Renal cell carcinoma, papillary, 1	Enrichment	MTOR	1.51
164	Dyskeratosis congenita, autosomal dominant 2	Enrichment	MECOM	1.51
165	Essential thrombocythemia	Enrichment	TP53	1.51
166	Gallbladder cancer	Enrichment	TP53	1.51
167	Overgrowth syndrome	Enrichment	MTOR	1.51
168	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	TP53	1.51
169	Glioma susceptibility 1	Enrichment	TP53	1.45
170	Lymphoma, non-hodgkin, familial	Enrichment	TP53	1.45
171	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.44
172	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.44
173	Enophthalmos	Enrichment	CSNK2B	1.44
174	Syndactyly	Enrichment	CSNK2B	1.44
175	Adult hepatocellular carcinoma	Enrichment	TP53	1.40
176	Primary hyperaldosteronism	Enrichment	TP53	1.40
177	Leukemia, chronic lymphocytic	Enrichment	TP53	1.36
178	Familial colorectal cancer	Enrichment	TP53	1.36
179	Colorectal cancer	Enrichment	AKT1, PPARG, TP53	1.33
180	Myelodysplastic syndrome	Enrichment	TP53	1.32
181	46,xy complete gonadal dysgenesis	Enrichment	CBX2	1.32
182	Specific learning disability	Enrichment	MAPK1	1.32
183	Lip and oral cavity carcinoma	Enrichment	TP53	1.28
184	Developmental dysplasia of the hip 1	Enrichment	PSMC3	1.26
185	Spinocerebellar ataxia, autosomal recessive 16	Enrichment	STUB1	1.26
186	Patent ductus arteriosus	Enrichment	PSMC3	1.26
187	Type 2 diabetes mellitus	Enrichment	AKT2, PPARG	1.24
188	Lung cancer susceptibility 3	Enrichment	TP53	1.21
189	Megacolon	Enrichment	AKT3	1.20
190	Renal cell carcinoma, nonpapillary	Enrichment	MTOR	1.18
191	Wilms tumor 1	Enrichment	REST	1.18
192	Rare genetic intellectual disability	Enrichment	MTOR	1.18
193	Isolated congenital microcephaly	Enrichment	PHC1	1.16
194	Isolated split hand-split foot malformation	Enrichment	SEM1	1.14
195	Heart, malformation of	Enrichment	MAPK1	1.11
196	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	TNRC6B	1.09
197	Hepatoblastoma	Enrichment	TP53	1.04
198	Hepatocellular carcinoma	Enrichment	TP53	1.02
199	Diamond-blackfan anemia 1	Enrichment	TP53	1.01
200	Pancreatic cancer	Enrichment	TP53	0.97
201	Primary autosomal recessive microcephaly	Enrichment	PHC1	0.87
202	Diamond-blackfan anemia	Enrichment	TP53	0.82
203	Patent foramen ovale	Enrichment	PSMC3	0.81
204	Arteriovenous malformations of the brain	Enrichment	PREX2	0.79
205	Leukemia, acute myeloid	Enrichment	TP53	0.78
206	Myocardial infarction	Enrichment	PSMA6	0.73
207	Thrombocytopenia	Enrichment	MECOM	0.71
208	Joubert syndrome 1	Enrichment	RCOR1	0.69
209	Body mass index quantitative trait locus 11	Enrichment	PPARG	0.69
210	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	REST	0.68
211	Myeloma, multiple	Enrichment	TP53	0.65
212	Primary ovarian insufficiency	Enrichment	MECOM	0.63
213	Microcephaly	Enrichment	MAPK1, PSMC3	0.50
214	Autosomal dominant non-syndromic intellectual disability	Enrichment	CSNK2B	0.43

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PTEN Regulation

Pathway Network for PTEN Regulation

Pathway network for the PTEN Regulation SuperPath

Member Pathways for PTEN Regulation

Pathways in the PTEN Regulation SuperPath

Gene overlap in member pathways for PTEN Regulation SuperPath

Associated Genes for PTEN Regulation

Associated Disorders for PTEN Regulation

Disorders associated with PTEN Regulation SuperPath

STRING Interaction Network for PTEN Regulation

Sources for PTEN Regulation