PTF1A related regulatory pathway

No Pathway Network information available for PTF1A related regulatory pathway

Pathways in the PTF1A related regulatory pathway SuperPath

#	Name	Source	Genes
1	PTF1A related regulatory pathway	WikiPathways	CTNNB1 FGF10 HES1 KAT2B NKX6-1 NOTCH1 PDX1 PROX1 PTF1A RBPJ RBPJL (see all 11) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PROX1	Prospero Homeobox 1	Protein Coding	1
2	NOTCH1	Notch Receptor 1	Protein Coding	1
3	NKX6-1	NK6 Homeobox 1	Protein Coding	1
4	PDX1	Pancreatic And Duodenal Homeobox 1	Protein Coding	1
5	RBPJ	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region	Protein Coding	1
6	HES1	Hes Family BHLH Transcription Factor 1	Protein Coding	1
7	PTF1A	Pancreas Associated Transcription Factor 1a	Protein Coding	1
8	FGF10	Fibroblast Growth Factor 10	Protein Coding	1
9	CTNNB1	Catenin Beta 1	Protein Coding	1
10	KAT2B	Lysine Acetyltransferase 2B	Protein Coding	1
11	RBPJL	Recombination Signal Binding Protein For Immunoglobulin Kappa J Region Like	Protein Coding	1

Disorders associated with PTF1A related regulatory pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Pancreas, dorsal, agenesis of	Enrichment	PDX1, PTF1A	6.22
2	Type 2 diabetes mellitus	Enrichment	PDX1, RBPJ, RBPJL	5.35
3	Adams-oliver syndrome	Enrichment	NOTCH1, RBPJ	4.90
4	Maturity-onset diabetes of the young	Enrichment	PDX1, PTF1A	3.95
5	Pancreatic agenesis 1	Enrichment	PDX1	3.09
6	Maturity-onset diabetes of the young, type 4	Enrichment	PDX1	3.09
7	Pancreatic and cerebellar agenesis	Enrichment	PTF1A	3.09
8	Aplasia of lacrimal and salivary glands	Enrichment	FGF10	3.09
9	Lacrimoauriculodentodigital syndrome 3	Enrichment	FGF10	3.09
10	Adenoid ameloblastoma	Enrichment	CTNNB1	3.09
11	Interstitial lung disease specific to childhood	Enrichment	FGF10	3.09
12	Microcystic stromal tumor	Enrichment	CTNNB1	3.09
13	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	2.79
14	Pulmonary hypoplasia, primary	Enrichment	FGF10	2.79
15	Kallikrein, decreased urinary activity of	Enrichment	PTF1A	2.79
16	Adams-oliver syndrome 5	Enrichment	NOTCH1	2.79
17	Adams-oliver syndrome 3	Enrichment	RBPJ	2.79
18	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	2.79
19	Pancreatic agenesis 2	Enrichment	PTF1A	2.79
20	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	2.79
21	Teratoma	Enrichment	CTNNB1	2.79
22	Desmoid disease, hereditary	Enrichment	CTNNB1	2.61
23	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGF10	2.61
24	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	2.61
25	Anus, imperforate	Enrichment	CTNNB1	2.61
26	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	2.61
27	Desmoid tumor	Enrichment	CTNNB1	2.61
28	Keratoacanthoma	Enrichment	NOTCH1	2.61
29	Pilomatrixoma	Enrichment	CTNNB1	2.49
30	Alazami syndrome	Enrichment	CTNNB1	2.49
31	Craniopharyngioma	Enrichment	CTNNB1	2.49
32	Exudative vitreoretinopathy 1	Enrichment	CTNNB1	2.39
33	Weyers acrofacial dysostosis	Enrichment	CTNNB1	2.31
34	Adrenocortical carcinoma	Enrichment	CTNNB1	2.31
35	Gallbladder cancer	Enrichment	CTNNB1	2.25
36	Exudative vitreoretinopathy	Enrichment	CTNNB1	2.19
37	Permanent neonatal diabetes mellitus	Enrichment	PDX1	2.19
38	Hypoplastic left heart syndrome	Enrichment	NOTCH1	2.19
39	Orofacial cleft 1	Enrichment	FGF10	2.14
40	Adult hepatocellular carcinoma	Enrichment	CTNNB1	2.14
41	Aortic valve disease 1	Enrichment	NOTCH1	1.98
42	Medulloblastoma	Enrichment	CTNNB1	1.95
43	Aortic aneurysm, familial thoracic 1	Enrichment	NOTCH1	1.95
44	Lung cancer susceptibility 3	Enrichment	FGF10	1.95
45	Polycystic liver disease	Enrichment	CTNNB1	1.86
46	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1	1.86
47	Hepatoblastoma	Enrichment	CTNNB1	1.77
48	Hepatocellular carcinoma	Enrichment	CTNNB1	1.75
49	Tetralogy of fallot	Enrichment	NOTCH1	1.68
50	Bladder cancer	Enrichment	CTNNB1	1.63
51	Connective tissue disease	Enrichment	NOTCH1	1.59
52	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	NOTCH1	1.45
53	Colorectal cancer	Enrichment	CTNNB1	1.17
54	Ovarian cancer	Enrichment	CTNNB1	1.10
55	Congenital nervous system abnormality	Enrichment	CTNNB1	1.08
56	Nervous system disease	Enrichment	CTNNB1	1.08
57	Microcephaly	Enrichment	CTNNB1	1.02

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

PTF1A related regulatory pathway

Pathway Network for PTF1A related regulatory pathway

Member Pathways for PTF1A related regulatory pathway

Pathways in the PTF1A related regulatory pathway SuperPath

Associated Genes for PTF1A related regulatory pathway

Associated Disorders for PTF1A related regulatory pathway

Disorders associated with PTF1A related regulatory pathway SuperPath

STRING Interaction Network for PTF1A related regulatory pathway

Sources for PTF1A related regulatory pathway