purine deoxyribonucleosides degradation

Sources:

#	Name	Source	Genes
1	purine deoxyribonucleosides degradation	PubChem	ADA PNP
2	purine ribonucleosides degradation	PubChem	ADA PGM2 PNP
3	purine ribonucleosides degradation to ribose-1-phosphate	PubChem	ADA PGM2 PNP
4	purine deoxyribonucleosides degradation II	PubChem	ADA PNP
5	Nucleotide catabolism defects	Reactome	PNP
6	Defective PNP disrupts phosphorolysis of (deoxy)guanosine and (deoxy)inosine	Reactome	PNP
7	Defective ADA disrupts (deoxy)adenosine deamination	Reactome	ADA

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PNP	Purine Nucleoside Phosphorylase	Protein Coding	6
2	ADA	Adenosine Deaminase	Protein Coding	5
3	PGM2	Phosphoglucomutase 2	Protein Coding	2

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Purine-pyrimidine metabolic disorder	Direct
2	Purine nucleoside phosphorylase deficiency	Direct
3	Adenosine deaminase deficiency	Direct
4	Severe combined immunodeficiency	Enrichment	ADA, PNP	5.24
5	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency	Enrichment	ADA	3.35
6	Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative	Enrichment	ADA	3.13
7	Omenn syndrome	Enrichment	ADA	2.83

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for purine deoxyribonucleosides degradation