purine nucleotides de novo biosynthesis

Pathway network for the purine nucleotides de novo biosynthesis SuperPath

Sources:

PubChem
Reactome

Pathways in the purine nucleotides de novo biosynthesis SuperPath

#	Name	Source	Genes
1	purine nucleotides de novo biosynthesis	PubChem	ADSL ADSS1 ADSS2 AK1 AK2 AK3 AK4 AK5 AK7 AK8 ATIC GART GMPS GUK1 IMPDH1 IMPDH2 NME1 NME2 NME3 NME4 NME5 NME6 NME7 PAICS PFAS PPAT RRM1 RRM2 RRM2B (see all 29) (see less)
2	Interconversion of nucleotide di- and triphosphates	Reactome	AK1 AK2 AK4 AK5 AK6 AK7 AK8 AK9 CMPK1 CTPS1 CTPS2 DCTD DCTPP1 DTYMK DUT GLRX GSR GUK1 NME1 NME2 NME3 NME4 NUDT13 RRM1 RRM2 RRM2B TXN TXNRD1 TYMS (see all 29) (see less)
3	superpathway of purine nucleotides de novo biosynthesis I	PubChem	ADSL AK5 ATIC GART GUK1 IMPDH1 IMPDH2 NME1 NME2 PAICS PFAS PPAT RRM1 RRM2 (see all 14) (see less)
4	guanosine nucleotides de novo biosynthesis	PubChem	GMPS GUK1 IMPDH1 IMPDH2 NME1 NME2 NME3 NME4 NME5 NME6 NME7 RRM1 RRM2 RRM2B (see all 14) (see less)

Gene overlap in member pathways for purine nucleotides de novo biosynthesis SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	NME1	NME/NM23 Nucleoside Diphosphate Kinase 1	Protein Coding	4
2	GUK1	Guanylate Kinase 1	Protein Coding	4
3	NME2	NME/NM23 Nucleoside Diphosphate Kinase 2	Protein Coding	4
4	RRM1	Ribonucleotide Reductase Catalytic Subunit M1	Protein Coding	4
5	RRM2	Ribonucleotide Reductase Regulatory Subunit M2	Protein Coding	4
6	AK5	Adenylate Kinase 5	Protein Coding	3
7	NME3	NME/NM23 Nucleoside Diphosphate Kinase 3	Protein Coding	3
8	RRM2B	Ribonucleotide Reductase Regulatory TP53 Inducible Subunit M2B	Protein Coding	3
9	NME4	NME/NM23 Nucleoside Diphosphate Kinase 4	Protein Coding	3
10	IMPDH1	Inosine Monophosphate Dehydrogenase 1	Protein Coding	3
11	IMPDH2	Inosine Monophosphate Dehydrogenase 2	Protein Coding	3
12	AK7	Adenylate Kinase 7	Protein Coding	2
13	AK8	Adenylate Kinase 8	Protein Coding	2
14	NME5	NME/NM23 Family Member 5	Protein Coding	2
15	AK1	Adenylate Kinase 1	Protein Coding	2
16	NME6	NME/NM23 Nucleoside Diphosphate Kinase 6	Protein Coding	2
17	NME7	NME/NM23 Family Member 7	Protein Coding	2
18	AK4	Adenylate Kinase 4	Protein Coding	2
19	AK2	Adenylate Kinase 2	Protein Coding	2
20	ADSL	Adenylosuccinate Lyase	Protein Coding	2
21	GMPS	Guanine Monophosphate Synthase	Protein Coding	2
22	PAICS	Phosphoribosylaminoimidazole Carboxylase And Phosphoribosylaminoimidazolesuccinocarboxamide Synthase	Protein Coding	2
23	PPAT	Phosphoribosyl Pyrophosphate Amidotransferase	Protein Coding	2
24	PFAS	Phosphoribosylformylglycinamidine Synthase	Protein Coding	2
25	GART	Phosphoribosylglycinamide Formyltransferase, Phosphoribosylglycinamide Synthetase, Phosphoribosylaminoimidazole Synthetase	Protein Coding	2
26	ATIC	5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase	Protein Coding	2
27	ADSS2	Adenylosuccinate Synthase 2	Protein Coding	1
28	ADSS1	Adenylosuccinate Synthase 1	Protein Coding	1
29	AK3	Adenylate Kinase 3	Protein Coding	1
30	AK6	Adenylate Kinase 6	Protein Coding	1
31	CTPS1	CTP Synthase 1	Protein Coding	1
32	DCTD	DCMP Deaminase	Protein Coding	1
33	DTYMK	Deoxythymidylate Kinase	Protein Coding	1
34	DUT	Deoxyuridine Triphosphatase	Protein Coding	1
35	AK9	Adenylate Kinase 9	Protein Coding	1
36	NUDT13	Nudix Hydrolase 13	Protein Coding	1
37	GLRX	Glutaredoxin	Protein Coding	1
38	GSR	Glutathione-Disulfide Reductase	Protein Coding	1
39	CMPK1	Cytidine/Uridine Monophosphate Kinase 1	Protein Coding	1
40	CTPS2	CTP Synthase 2	Protein Coding	1
41	TXN	Thioredoxin	Protein Coding	1
42	TXNRD1	Thioredoxin Reductase 1	Protein Coding	1
43	TYMS	Thymidylate Synthetase	Protein Coding	1
44	DCTPP1	DCTP Pyrophosphatase 1	Protein Coding	1

Disorders associated with purine nucleotides de novo biosynthesis SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Aica-ribosiduria due to atic deficiency	Enrichment	ATIC	2.99
2	Adenylosuccinase deficiency	Enrichment	ADSL	2.99
3	Retinitis pigmentosa 10	Enrichment	IMPDH1	2.99
4	Impdh2 enzyme activity, variation in	Enrichment	IMPDH2	2.99
5	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6	Enrichment	RRM1	2.99
6	Leber congenital amaurosis 11	Enrichment	IMPDH1	2.99
7	Mitochondrial dna depletion syndrome 8b	Enrichment	RRM2B	2.99
8	Ciliary dyskinesia, primary, 48, without situs inversus	Enrichment	NME5	2.99
9	Rrm2b mitochondrial dna maintenance defects	Enrichment	RRM2B	2.99
10	Phosphoribosylaminoimidazole carboxylase deficiency	Enrichment	PAICS	2.69
11	Mitochondrial dna depletion syndrome 21	Enrichment	GUK1	2.69
12	Fanconi renotubular syndrome 1	Enrichment	RRM2B	2.69
13	Rod-cone dystrophy, sensorineural deafness, and fanconi-type renal dysfunction	Enrichment	RRM2B	2.69
14	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 5	Enrichment	RRM2B	2.69
15	Mitochondrial dna depletion syndrome 8a	Enrichment	RRM2B	2.69
16	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 2	Enrichment	RRM2B	2.69
17	Spermatogenic failure 27	Enrichment	AK7	2.67
18	Myopathy, distal, 5	Enrichment	ADSS1	2.67
19	Immunodeficiency 24	Enrichment	CTPS1	2.67
20	Anemia, congenital, nonspherocytic hemolytic, 10	Enrichment	GSR	2.67
21	Bone marrow failure and diabetes mellitus syndrome	Enrichment	DUT	2.67
22	Neurodegeneration, childhood-onset, with progressive microcephaly	Enrichment	DTYMK	2.67
23	Glomerulopathy with fibronectin deposits 2	Enrichment	ATIC	2.51
24	Cerebroretinal microangiopathy with calcifications and cysts 1	Enrichment	PFAS	2.51
25	Gtp cyclohydrolase 1-deficient dopa-responsive dystonia	Enrichment	IMPDH2	2.51
26	Idiopathic camptocormia	Enrichment	RRM2B	2.51
27	Immunoerythromyeloid hypoplasia	Enrichment	AK2	2.37
28	Reticular dysgenesis	Enrichment	AK2	2.37
29	Anemia, congenital, nonspherocytic hemolytic, 3	Enrichment	AK1	2.37
30	Spermatogenic failure 89	Enrichment	AK9	2.37
31	Dyskeratosis congenita, digenic	Enrichment	TYMS	2.37
32	Kearns-sayre syndrome	Enrichment	RRM2B	2.29
33	Early myoclonic encephalopathy	Enrichment	ADSL	2.21
34	Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal dominant 1	Enrichment	RRM2B	2.21
35	Mitochondrial neurogastrointestinal encephalomyopathy	Enrichment	RRM2B	2.03
36	Isolated tracheo-esophageal fistula	Enrichment	GART	1.99
37	Esophageal atresia/tracheoesophageal fistula	Enrichment	GART	1.71
38	Dyskeratosis congenita	Enrichment	PFAS	1.71
39	Retinitis pigmentosa	Enrichment	IMPDH1, RRM2B	1.71
40	Postsynaptic congenital myasthenic syndromes	Enrichment	AK9	1.60
41	Visceral heterotaxy 5	Enrichment	NME7	1.50
42	Dystonia	Enrichment	IMPDH2	1.45
43	Nephrotic syndrome	Enrichment	ATIC	1.36
44	Non-syndromic male infertility due to sperm motility disorder	Enrichment	AK7	1.32
45	Sensorineural hearing loss	Enrichment	RRM2B	1.31
46	Severe combined immunodeficiency	Enrichment	AK2	1.17
47	Primary ciliary dyskinesia	Enrichment	NME5	1.12
48	Fetal akinesia deformation sequence 1	Enrichment	ADSS1	1.12
49	Distal arthrogryposis	Enrichment	ADSS1	1.07
50	Mitochondrial disease	Enrichment	RRM2B	1.06
51	Leber plus disease	Enrichment	IMPDH1	1.03
52	Hereditary retinal dystrophy	Enrichment	IMPDH1	0.58
53	Fundus dystrophy	Enrichment	IMPDH1	0.58

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

purine nucleotides de novo biosynthesis

Pathway Network for purine nucleotides de novo biosynthesis

Pathway network for the purine nucleotides de novo biosynthesis SuperPath

Member Pathways for purine nucleotides de novo biosynthesis

Pathways in the purine nucleotides de novo biosynthesis SuperPath

Gene overlap in member pathways for purine nucleotides de novo biosynthesis SuperPath

Associated Genes for purine nucleotides de novo biosynthesis

Associated Disorders for purine nucleotides de novo biosynthesis

Disorders associated with purine nucleotides de novo biosynthesis SuperPath

STRING Interaction Network for purine nucleotides de novo biosynthesis

Sources for purine nucleotides de novo biosynthesis