Purinergic signaling

Pathway network for the Purinergic signaling SuperPath

Sources:

WikiPathways
Reactome

Pathways in the Purinergic signaling SuperPath

#	Name	Source	Genes
1	Purinergic signaling	WikiPathways	ADORA1 ADORA2A ADORA2B ADORA3 GNAI1 GNAI2 GNAI3 GNAO1 GNAS GNAT1 GNAT2 GNAT3 GNAZ LPAR4 LPAR6 P2RX1 P2RX2 P2RX3 P2RX4 P2RX5 P2RX6 P2RX7 P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 P2RY8 PANX1 (see all 33) (see less)
2	Nucleotide-like (purinergic) receptors	Reactome	ADORA1 ADORA2A ADORA2B ADORA3 GPR17 LPAR4 LPAR6 P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 (see all 16) (see less)
3	P2Y receptors	Reactome	GPR17 LPAR4 LPAR6 P2RY1 P2RY10 P2RY11 P2RY12 P2RY13 P2RY14 P2RY2 P2RY4 P2RY6 (see all 12) (see less)
4	Nucleotide GPCRs	WikiPathways	ADORA1 ADORA2A ADORA2B ADORA3 LPAR4 LPAR6 LTB4R P2RY1 P2RY2 P2RY4 P2RY6 (see all 11) (see less)
5	Adenosine P1 receptors	Reactome	ADORA1 ADORA2A ADORA2B ADORA3

Gene overlap in member pathways for Purinergic signaling SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	P2RY2	Purinergic Receptor P2Y2	Protein Coding	4
2	P2RY1	Purinergic Receptor P2Y1	Protein Coding	4
3	ADORA3	Adenosine A3 Receptor	Protein Coding	4
4	ADORA2B	Adenosine A2b Receptor	Protein Coding	4
5	ADORA2A	Adenosine A2a Receptor	Protein Coding	4
6	ADORA1	Adenosine A1 Receptor	Protein Coding	4
7	LPAR6	Lysophosphatidic Acid Receptor 6	Protein Coding	4
8	P2RY6	Pyrimidinergic Receptor P2Y6	Protein Coding	4
9	P2RY4	Pyrimidinergic Receptor P2Y4	Protein Coding	4
10	LPAR4	Lysophosphatidic Acid Receptor 4	Protein Coding	4
11	P2RY12	Purinergic Receptor P2Y12	Protein Coding	3
12	P2RY11	Purinergic Receptor P2Y11	Protein Coding	3
13	P2RY14	Purinergic Receptor P2Y14	Protein Coding	3
14	P2RY13	Purinergic Receptor P2Y13	Protein Coding	3
15	P2RY10	P2Y Receptor Family Member 10	Protein Coding	3
16	GPR17	G Protein-Coupled Receptor 17	Protein Coding	2
17	P2RX7	Purinergic Receptor P2X 7	Protein Coding	1
18	P2RX4	Purinergic Receptor P2X 4	Protein Coding	1
19	P2RX3	Purinergic Receptor P2X 3	Protein Coding	1
20	P2RX1	Purinergic Receptor P2X 1	Protein Coding	1
21	GNAT3	G Protein Subunit Alpha Transducin 3	Protein Coding	1
22	P2RY8	P2Y Receptor Family Member 8	Protein Coding	1
23	GNAZ	G Protein Subunit Alpha Z	Protein Coding	1
24	GNAT2	G Protein Subunit Alpha Transducin 2	Protein Coding	1
25	GNAT1	G Protein Subunit Alpha Transducin 1	Protein Coding	1
26	GNAS	GNAS Complex Locus	Protein Coding	1
27	GNAO1	G Protein Subunit Alpha O1	Protein Coding	1
28	GNAI3	G Protein Subunit Alpha I3	Protein Coding	1
29	GNAI2	G Protein Subunit Alpha I2	Protein Coding	1
30	GNAI1	G Protein Subunit Alpha I1	Protein Coding	1
31	PANX1	Pannexin 1	Protein Coding	1
32	P2RX2	Purinergic Receptor P2X 2	Protein Coding	1
33	P2RX6	Purinergic Receptor P2X 6	Protein Coding	1
34	P2RX5	Purinergic Receptor P2X 5	Protein Coding	1
35	LTB4R	Leukotriene B4 Receptor	Protein Coding	1

Disorders associated with Purinergic signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Achromatopsia 4	Enrichment	GNAI3, GNAT2	4.46
2	Acute encephalopathy with biphasic seizures and late reduced diffusion	Enrichment	ADORA2A	3.53
3	Bleeding disorder, platelet-type, 8	Enrichment	P2RY12	2.75
4	Woolly hair, autosomal recessive 3	Enrichment	LPAR6	2.61
5	Hypotrichosis 8	Enrichment	LPAR6	2.61
6	Deafness, autosomal dominant 41	Enrichment	P2RX2	2.61
7	Pseudohypoparathyroidism, type ic	Enrichment	GNAS	2.61
8	Osseous heteroplasia, progressive	Enrichment	GNAS	2.61
9	Neurodevelopmental disorder with involuntary movements	Enrichment	GNAO1	2.61
10	Ventricular tachycardia, familial	Enrichment	GNAI2	2.61
11	Acth-independent macronodular adrenal hyperplasia 1	Enrichment	GNAS	2.61
12	Pituitary adenoma 3, multiple types	Enrichment	GNAS	2.61
13	Neurodevelopmental disorder with hypotonia, impaired speech, and behavioral abnormalities	Enrichment	GNAI1	2.61
14	Developmental and epileptic encephalopathy 17	Enrichment	GNAO1	2.61
15	Night blindness, congenital stationary, autosomal dominant 3	Enrichment	GNAT1	2.61
16	Night blindness, congenital stationary, type 1g	Enrichment	GNAT1	2.61
17	Disorders of gnas inactivation	Enrichment	GNAS	2.61
18	Monostotic fibrous dysplasia	Enrichment	GNAS	2.61
19	Gnao1-related disorder	Enrichment	GNAO1	2.61
20	Mazabraud syndrome	Enrichment	GNAS	2.61
21	Nizon-isidor syndrome	Enrichment	P2RY12	2.58
22	Familial woolly hair syndrome	Enrichment	LPAR6	2.39
23	Pseudohypoparathyroidism, type ia	Enrichment	GNAS	2.31
24	Pituitary adenoma 4, acth-secreting	Enrichment	GNAI2	2.31
25	Pigmented nodular adrenocortical disease, primary, 1	Enrichment	GNAS	2.31
26	Pseudopseudohypoparathyroidism	Enrichment	GNAS	2.31
27	Oocyte/zygote/embryo maturation arrest 7	Enrichment	PANX1	2.31
28	Pseudohypoparathyroidism	Enrichment	GNAS	2.31
29	Hypopituitarism	Enrichment	GNAI2	2.31
30	Acth-independent macronodular adrenal hyperplasia	Enrichment	GNAS	2.31
31	Narcolepsy 1	Enrichment	P2RY11	2.15
32	Hypotrichosis simplex	Enrichment	LPAR6	2.14
33	Mccune-albright syndrome	Enrichment	GNAS	2.14
34	Cushing syndrome due to bilateral macronodular adrenocortical disease	Enrichment	GNAS	2.14
35	Pseudohypoparathyroidism, type ib	Enrichment	GNAS	2.01
36	Auriculocondylar syndrome 1	Enrichment	GNAI3	2.01
37	Night blindness, congenital stationary, type 1c	Enrichment	GNAT1	1.92
38	Female infertility due to oocyte meiotic arrest	Enrichment	PANX1	1.92
39	Brachydactyly	Enrichment	GNAS	1.77
40	Spastic paraplegia 4, autosomal dominant	Enrichment	GNAS	1.71
41	Choreatic disease	Enrichment	GNAO1	1.71
42	Primary hyperaldosteronism	Enrichment	GNAS	1.66
43	Differentiated thyroid carcinoma	Enrichment	LPAR4	1.63
44	Leukemia, chronic lymphocytic	Enrichment	P2RX7	1.62
45	Achromatopsia	Enrichment	GNAT2	1.62
46	Movement disease	Enrichment	GNAO1	1.58
47	Cone-rod dystrophy 6	Enrichment	GNAT2	1.47
48	Rare genetic intellectual disability	Enrichment	GNAO1	1.44
49	Thrombocytopenia	Enrichment	P2RY12	1.38
50	Early infantile developmental and epileptic encephalopathy	Enrichment	GNAO1	1.37
51	Congenital stationary night blindness	Enrichment	GNAT1	1.26
52	Cone dystrophy	Enrichment	GNAT2	1.25
53	Developmental and epileptic encephalopathy 1	Enrichment	GNAO1	1.23
54	Eye disease	Enrichment	GNAT2	1.09
55	Developmental and epileptic encephalopathy	Enrichment	GNAO1	1.08
56	West syndrome	Enrichment	GNAO1	0.99
57	Body mass index quantitative trait locus 11	Enrichment	GNAS	0.94
58	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	P2RX2	0.92
59	Myeloma, multiple	Enrichment	P2RY8	0.89
60	Hereditary retinal dystrophy	Enrichment	GNAT1, GNAT2	0.81
61	Fundus dystrophy	Enrichment	GNAT1, GNAT2	0.81
62	Congenital nervous system abnormality	Enrichment	GNAO1	0.64
63	Nervous system disease	Enrichment	GNAO1	0.64
64	Microcephaly	Enrichment	GNAO1	0.59
65	Retinitis pigmentosa	Enrichment	GNAT1	0.39

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Purinergic signaling

Pathway Network for Purinergic signaling

Pathway network for the Purinergic signaling SuperPath

Member Pathways for Purinergic signaling

Pathways in the Purinergic signaling SuperPath

Gene overlap in member pathways for Purinergic signaling SuperPath

Associated Genes for Purinergic signaling

Associated Disorders for Purinergic signaling

Disorders associated with Purinergic signaling SuperPath

STRING Interaction Network for Purinergic signaling

Sources for Purinergic signaling