Rab regulation of trafficking

Pathway network for the Rab regulation of trafficking SuperPath

Sources:

Reactome

Pathways in the Rab regulation of trafficking SuperPath

#	Name	Source	Genes
1	Rab regulation of trafficking	Reactome	AKT1 AKT2 AKT3 ALS2 ALS2CL ANKRD27 ARF6 CCZ1 CCZ1B CHM CHML DENND1A DENND1B DENND1C DENND2A DENND2B DENND2C DENND2D DENND3 DENND4A DENND4B DENND4C DENND5A DENND5B DENND6A DENND6B GABARAP GABARAPL2 GAPVD1 GDI1 GDI2 GGA1 GGA2 GGA3 HPS1 HPS4 MADD MAP1LC3B MON1A MON1B OPTN RAB10 RAB11A RAB11B RAB12 RAB13 RAB14 RAB18 RAB1A RAB1B RAB21 RAB27A RAB27B RAB31 RAB32 RAB33A RAB33B RAB35 RAB38 RAB39A RAB39B RAB3A RAB3GAP1 RAB3GAP2 RAB3IL1 RAB3IP RAB4A RAB5A RAB5B RAB5C RAB6A RAB6B RAB7A RAB7B RAB8A RAB8B RAB9A RAB9B RABEP1 RABGAP1 RABGEF1 RGP1 RIC1 RIN1 RIN2 RIN3 RINL SBF1 SBF2 SYTL1 TBC1D10A TBC1D10B TBC1D10C TBC1D13 TBC1D14 TBC1D15 TBC1D16 TBC1D17 TBC1D2 TBC1D20 TBC1D24 TBC1D25 TBC1D3 TBC1D3C TBC1D7 TRAPPC1 TRAPPC10 TRAPPC11 TRAPPC12 TRAPPC13 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6A TRAPPC6B TRAPPC8 TRAPPC9 TSC1 TSC2 ULK1 YWHAE (see all 123) (see less)
2	RAB GEFs exchange GTP for GDP on RABs	Reactome	AKT1 AKT2 AKT3 ALS2 ALS2CL ANKRD27 CCZ1 CCZ1B CHM CHML DENND1A DENND1B DENND1C DENND2A DENND2B DENND2C DENND2D DENND3 DENND4A DENND4B DENND4C DENND5A DENND5B DENND6A DENND6B GAPVD1 GDI1 GDI2 HPS1 HPS4 MADD MON1A MON1B RAB10 RAB12 RAB13 RAB14 RAB18 RAB1A RAB1B RAB21 RAB27A RAB27B RAB31 RAB32 RAB35 RAB38 RAB39A RAB39B RAB3A RAB3GAP1 RAB3GAP2 RAB3IL1 RAB3IP RAB5A RAB5B RAB5C RAB6A RAB6B RAB7A RAB7B RAB8A RAB8B RAB9A RAB9B RABGEF1 RGP1 RIC1 RIN1 RIN2 RIN3 RINL SBF1 SBF2 TRAPPC1 TRAPPC10 TRAPPC11 TRAPPC12 TRAPPC13 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC4 TRAPPC5 TRAPPC6A TRAPPC6B TRAPPC8 TRAPPC9 ULK1 YWHAE (see all 90) (see less)
3	TBC/RABGAPs	Reactome	ARF6 GABARAP GABARAPL2 GGA1 GGA2 GGA3 MAP1LC3B OPTN RAB11A RAB11B RAB33A RAB33B RAB35 RAB4A RAB5A RAB5B RAB5C RAB6A RAB6B RAB7A RAB7B RAB8A RAB8B RABEP1 RABGAP1 RABGEF1 SYTL1 TBC1D10A TBC1D10B TBC1D10C TBC1D13 TBC1D14 TBC1D15 TBC1D16 TBC1D17 TBC1D2 TBC1D20 TBC1D24 TBC1D25 TBC1D3 TBC1D3C TBC1D7 TSC1 TSC2 ULK1 (see all 45) (see less)

Gene overlap in member pathways for Rab regulation of trafficking SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RAB35	RAB35, Member RAS Oncogene Family	Protein Coding	3
2	RABGEF1	RAB Guanine Nucleotide Exchange Factor 1	Protein Coding	3
3	RAB7B	RAB7B, Member RAS Oncogene Family	Protein Coding	3
4	RAB8A	RAB8A, Member RAS Oncogene Family	Protein Coding	3
5	RAB6B	RAB6B, Member RAS Oncogene Family	Protein Coding	3
6	RAB8B	RAB8B, Member RAS Oncogene Family	Protein Coding	3
7	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	3
8	RAB5B	RAB5B, Member RAS Oncogene Family	Protein Coding	3
9	RAB6A	RAB6A, Member RAS Oncogene Family	Protein Coding	3
10	RAB5C	RAB5C, Member RAS Oncogene Family	Protein Coding	3
11	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	3
12	ULK1	Unc-51 Like Autophagy Activating Kinase 1	Protein Coding	3
13	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	2
14	OPTN	Optineurin	Protein Coding	2
15	DENND4A	DENN Domain Containing 4A	Protein Coding	2
16	RAB10	RAB10, Member RAS Oncogene Family	Protein Coding	2
17	RAB32	RAB32, Member RAS Oncogene Family	Protein Coding	2
18	RAB31	RAB31, Member RAS Oncogene Family	Protein Coding	2
19	CHM	CHM Rab Escort Protein	Protein Coding	2
20	CHML	CHM Like Rab Escort Protein	Protein Coding	2
21	GABARAP	GABA Type A Receptor-Associated Protein	Protein Coding	2
22	GABARAPL2	GABA Type A Receptor Associated Protein Like 2	Protein Coding	2
23	RAB39B	RAB39B, Member RAS Oncogene Family	Protein Coding	2
24	RAB3IP	RAB3A Interacting Protein	Protein Coding	2
25	TRAPPC6B	Trafficking Protein Particle Complex Subunit 6B	Protein Coding	2
26	TBC1D16	TBC1 Domain Family Member 16	Protein Coding	2
27	TRAPPC5	Trafficking Protein Particle Complex Subunit 5	Protein Coding	2
28	RINL	Ras And Rab Interactor Like	Protein Coding	2
29	TBC1D20	TBC1 Domain Family Member 20	Protein Coding	2
30	DENND5B	DENN Domain Containing 5B	Protein Coding	2
31	DENND2C	DENN Domain Containing 2C	Protein Coding	2
32	DENND1B	DENN Domain Containing 1B	Protein Coding	2
33	RAB12	RAB12, Member RAS Oncogene Family	Protein Coding	2
34	DENND6A	DENN Domain Containing 6A	Protein Coding	2
35	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	2
36	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	2
37	CCZ1B	CCZ1B Vacuolar Protein Trafficking And Biogenesis Associated	Protein Coding	2
38	TRAPPC8	Trafficking Protein Particle Complex Subunit 8	Protein Coding	2
39	MON1B	MON1 Vesicular Trafficking Associated B	Protein Coding	2
40	DENND3	DENN Domain Containing 3	Protein Coding	2
41	RAB3GAP1	RAB3 GTPase Activating Protein Catalytic Subunit 1	Protein Coding	2
42	RAB18	RAB18, Member RAS Oncogene Family	Protein Coding	2
43	RAB21	RAB21, Member RAS Oncogene Family	Protein Coding	2
44	GGA2	Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 2	Protein Coding	2
45	GGA3	Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 3	Protein Coding	2
46	DENND5A	DENN Domain Containing 5A	Protein Coding	2
47	RABGAP1	RAB GTPase Activating Protein 1	Protein Coding	2
48	RAB38	RAB38, Member RAS Oncogene Family	Protein Coding	2
49	RAB3GAP2	RAB3 GTPase Activating Non-Catalytic Protein Subunit 2	Protein Coding	2
50	ALS2CL	ALS2 C-Terminal Like	Protein Coding	2
51	TBC1D10B	TBC1 Domain Family Member 10B	Protein Coding	2
52	GGA1	Golgi Associated, Gamma Adaptin Ear Containing, ARF Binding Protein 1	Protein Coding	2
53	GAPVD1	GTPase Activating Protein And VPS9 Domains 1	Protein Coding	2
54	GDI1	GDP Dissociation Inhibitor 1	Protein Coding	2
55	GDI2	GDP Dissociation Inhibitor 2	Protein Coding	2
56	TRAPPC3	Trafficking Protein Particle Complex Subunit 3	Protein Coding	2
57	DENND2A	DENN Domain Containing 2A	Protein Coding	2
58	HPS1	HPS1 Biogenesis Of Lysosomal Organelles Complex 3 Subunit 1	Protein Coding	2
59	TBC1D10C	TBC1 Domain Family Member 10C	Protein Coding	2
60	ARF6	ARF GTPase 6	Protein Coding	2
61	TBC1D3C	TBC1 Domain Family Member 3C	Protein Coding	2
62	DENND6B	DENN Domain Containing 6B	Protein Coding	2
63	TBC1D25	TBC1 Domain Family Member 25	Protein Coding	2
64	TRAPPC12	Trafficking Protein Particle Complex Subunit 12	Protein Coding	2
65	RAB9B	RAB9B, Member RAS Oncogene Family	Protein Coding	2
66	TBC1D7	TBC1 Domain Family Member 7	Protein Coding	2
67	TRAPPC4	Trafficking Protein Particle Complex Subunit 4	Protein Coding	2
68	RAB14	RAB14, Member RAS Oncogene Family	Protein Coding	2
69	CCZ1	CCZ1 Vacuolar Protein Trafficking And Biogenesis Associated	Protein Coding	2
70	TRAPPC2L	Trafficking Protein Particle Complex Subunit 2L	Protein Coding	2
71	RIN2	Ras And Rab Interactor 2	Protein Coding	2
72	TBC1D13	TBC1 Domain Family Member 13	Protein Coding	2
73	RAB39A	RAB39A, Member RAS Oncogene Family	Protein Coding	2
74	TBC1D2	TBC1 Domain Family Member 2	Protein Coding	2
75	DENND4C	DENN Domain Containing 4C	Protein Coding	2
76	TBC1D24	TBC1 Domain Family Member 24	Protein Coding	2
77	TBC1D14	TBC1 Domain Family Member 14	Protein Coding	2
78	RIC1	RIC1 Partner Of RAB6A GEF Complex	Protein Coding	2
79	ALS2	Alsin Rho Guanine Nucleotide Exchange Factor ALS2	Protein Coding	2
80	DENND1A	DENN Domain Containing 1A	Protein Coding	2
81	TRAPPC1	Trafficking Protein Particle Complex Subunit 1	Protein Coding	2
82	RAB1A	RAB1A, Member RAS Oncogene Family	Protein Coding	2
83	RAB3A	RAB3A, Member RAS Oncogene Family	Protein Coding	2
84	RAB3IL1	RAB3A Interacting Protein Like 1	Protein Coding	2
85	RAB4A	RAB4A, Member RAS Oncogene Family	Protein Coding	2
86	RAB13	RAB13, Member RAS Oncogene Family	Protein Coding	2
87	RAB27A	RAB27A, Member RAS Oncogene Family	Protein Coding	2
88	RAB27B	RAB27B, Member RAS Oncogene Family	Protein Coding	2
89	TRAPPC11	Trafficking Protein Particle Complex Subunit 11	Protein Coding	2
90	SBF1	SET Binding Factor 1	Protein Coding	2
91	TRAPPC2	Trafficking Protein Particle Complex Subunit 2	Protein Coding	2
92	TBC1D15	TBC1 Domain Family Member 15	Protein Coding	2
93	DENND2B	DENN Domain Containing 2B	Protein Coding	2
94	TRAPPC10	Trafficking Protein Particle Complex Subunit 10	Protein Coding	2
95	TSC1	TSC Complex Subunit 1	Protein Coding	2
96	TSC2	TSC Complex Subunit 2	Protein Coding	2
97	TBC1D3	TBC1 Domain Family Member 3	Protein Coding	2
98	YWHAE	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Epsilon	Protein Coding	2
99	TRAPPC6A	Trafficking Protein Particle Complex Subunit 6A	Protein Coding	2
100	TBC1D17	TBC1 Domain Family Member 17	Protein Coding	2
101	RIN3	Ras And Rab Interactor 3	Protein Coding	2
102	DENND1C	DENN Domain Containing 1C	Protein Coding	2
103	DENND2D	DENN Domain Containing 2D	Protein Coding	2
104	TRAPPC13	Trafficking Protein Particle Complex Subunit 13	Protein Coding	2
105	MAP1LC3B	Microtubule Associated Protein 1 Light Chain 3 Beta	Protein Coding	2
106	SBF2	SET Binding Factor 2	Protein Coding	2
107	RAB1B	RAB1B, Member RAS Oncogene Family	Protein Coding	2
108	RAB33B	RAB33B, Member RAS Oncogene Family	Protein Coding	2
109	TRAPPC9	Trafficking Protein Particle Complex Subunit 9	Protein Coding	2
110	TBC1D10A	TBC1 Domain Family Member 10A	Protein Coding	2
111	ANKRD27	Ankyrin Repeat Domain 27	Protein Coding	2
112	MON1A	MON1 Vesicular Trafficking Associated A	Protein Coding	2
113	SYTL1	Synaptotagmin Like 1	Protein Coding	2
114	MADD	MAP Kinase Activating Death Domain	Protein Coding	2
115	RAB11A	RAB11A, Member RAS Oncogene Family	Protein Coding	2
116	HPS4	HPS4 Biogenesis Of Lysosomal Organelles Complex 3 Subunit 2	Protein Coding	2
117	RABEP1	Rabaptin, RAB GTPase Binding Effector Protein 1	Protein Coding	2
118	RAB11B	RAB11B, Member RAS Oncogene Family	Protein Coding	2
119	RAB33A	RAB33A, Member RAS Oncogene Family	Protein Coding	2
120	RAB9A	RAB9A, Member RAS Oncogene Family	Protein Coding	2
121	RIN1	Ras And Rab Interactor 1	Protein Coding	2
122	RGP1	RGP1 Partner Of RAB6A GEF Complex	Protein Coding	2
123	DENND4B	DENN Domain Containing 4B	Protein Coding	2

Disorders associated with Rab regulation of trafficking SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Warburg micro syndrome 1	Enrichment	RAB18, RAB3GAP1, RAB3GAP2, TBC1D20	8.19
2	Lymphangioleiomyomatosis	Enrichment	TSC1, TSC2	4.97
3	Tuberous sclerosis 1	Enrichment	TSC1, TSC2	4.49
4	Hamartoma	Enrichment	TSC1, TSC2	4.49
5	Hermansky-pudlak syndrome due to bloc-3 deficiency	Enrichment	HPS1, HPS4	4.36
6	Focal cortical dysplasia, type ii	Enrichment	TSC1, TSC2	4.19
7	Tuberous sclerosis	Enrichment	TSC1, TSC2	4.19
8	Isolated focal cortical dysplasia type ii	Enrichment	TSC1, TSC2	4.19
9	Adult hepatocellular carcinoma	Enrichment	TSC1, TSC2	3.42
10	Martsolf syndrome 1	Enrichment	RAB3GAP1, RAB3GAP2	3.37
11	Auditory neuropathy	Enrichment	RAB33A, RAB9B, TBC1D24	2.79
12	Deafness, autosomal recessive 86	Enrichment	TBC1D24	2.48
13	Charcot-marie-tooth disease, axonal, type 2b	Enrichment	RAB7A	2.48
14	Charcot-marie-tooth disease type 2b	Enrichment	RAB7A	2.48
15	Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter	Enrichment	RAB11B	2.48
16	Epilepsy, rolandic, with paroxysmal exercise-induced dystonia and writer's cramp	Enrichment	TBC1D24	2.48
17	Deafness, autosomal dominant 65	Enrichment	TBC1D24	2.48
18	Warburg micro syndrome 4	Enrichment	TBC1D20	2.48
19	Tbc1d24-related disorders	Enrichment	TBC1D24	2.48
20	Focal epilepsy-intellectual disability-cerebro-cerebellar malformation	Enrichment	TBC1D24	2.48
21	Progressive myoclonic epilepsy with dystonia	Enrichment	TBC1D24	2.48
22	Isolated megalencephaly	Enrichment	TBC1D7	2.48
23	Periodic paralysis	Enrichment	TBC1D24	2.48
24	Movement disease	Enrichment	RAB3GAP1, TBC1D24	2.37
25	Hermansky-pudlak syndrome	Enrichment	HPS1, HPS4	2.36
26	Hermansky-pudlak syndrome 1	Enrichment	HPS1, HPS4	2.31
27	Charcot-marie-tooth disease type 4	Enrichment	SBF1, SBF2	2.21
28	Spondyloepimetaphyseal dysplasia, x-linked, with hypomyelinating leukodystrophy	Enrichment	RAB33A	2.18
29	Charcot-marie-tooth disease, x-linked recessive, 4, with or without cerebellar ataxia	Enrichment	RAB33A	2.18
30	Combined oxidative phosphorylation deficiency 6	Enrichment	RAB33A	2.18
31	Myoclonic epilepsy, familial infantile	Enrichment	TBC1D24	2.18
32	Nephrotic syndrome, type 17	Enrichment	GGA3	2.18
33	Smith-mccort dysplasia	Enrichment	RAB33B	2.18
34	Developmental and epileptic encephalopathy 16	Enrichment	TBC1D24	2.18
35	Amyotrophic lateral sclerosis 12 with or without frontotemporal dementia	Enrichment	OPTN	2.18
36	Smith-mccort dysplasia 2	Enrichment	RAB33B	2.18
37	Amyotrophic lateral sclerosis type 12	Enrichment	OPTN	2.18
38	Charcot-marie-tooth disease x-linked recessive 4	Enrichment	RAB33A	2.18
39	Proteus syndrome	Enrichment	AKT1	2.18
40	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	2.18
41	Amyotrophic lateral sclerosis 2, juvenile	Enrichment	ALS2	2.18
42	Waisman syndrome	Enrichment	RAB39B	2.18
43	Griscelli syndrome, type 2	Enrichment	RAB27A	2.18
44	Spastic paralysis, infantile-onset ascending	Enrichment	ALS2	2.18
45	Warburg micro syndrome 2	Enrichment	RAB3GAP2	2.18
46	Intellectual developmental disorder, autosomal recessive 13	Enrichment	TRAPPC9	2.18
47	Parkinson disease 26, autosomal dominant	Enrichment	RAB32	2.18
48	Intellectual developmental disorder, x-linked 41	Enrichment	GDI1	2.18
49	Intellectual developmental disorder, x-linked 72	Enrichment	RAB39B	2.18
50	Deeah syndrome	Enrichment	MADD	2.18
51	Martsolf syndrome 2	Enrichment	RAB3GAP1	2.18
52	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	2.18
53	Developmental and epileptic encephalopathy 49	Enrichment	DENND5A	2.18
54	Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy	Enrichment	TRAPPC6B	2.18
55	Cowden syndrome 6	Enrichment	AKT1	2.18
56	Warburg micro syndrome 3	Enrichment	RAB18	2.18
57	Hermansky-pudlak syndrome 4	Enrichment	HPS4	2.18
58	Als2-related disorder	Enrichment	ALS2	2.18
59	Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy	Enrichment	TRAPPC4	2.18
60	Intellectual disability-hyperkinetic movement-truncal ataxia syndrome	Enrichment	TRAPPC11	2.18
61	Neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia	Enrichment	MADD	2.18
62	Griscelli syndrome	Enrichment	RAB27A	2.18
63	Neurodevelopmental disorder with microcephaly, short stature, and speech delay	Enrichment	TRAPPC10	2.18
64	Capillary hemangioma	Enrichment	AKT3	2.18
65	Autosomal recessive spastic paraplegia type 69	Enrichment	RAB3GAP2	2.18
66	Distal 17p13.3 microdeletion syndrome	Enrichment	YWHAE	2.18
67	Infantile-onset ascending hereditary spastic paralysis	Enrichment	ALS2	2.18
68	Intellectual disability-obesity-brain malformations-facial dysmorphism syndrome	Enrichment	TRAPPC9	2.18
69	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	2.18
70	West syndrome	Enrichment	TBC1D24, TSC2	2.03
71	Polycystic kidney disease, infantile severe, with tuberous sclerosis	Enrichment	TSC2	2.00
72	Glaucoma, normal tension	Enrichment	OPTN	2.00
73	Tuberous sclerosis 2	Enrichment	TSC2	2.00
74	Deafness, onychodystrophy, osteodystrophy, impaired intellectual development, and seizures syndrome	Enrichment	TBC1D24	2.00
75	Macrocephaly/megalencephaly syndrome, autosomal recessive	Enrichment	TBC1D7	2.00
76	Epilepsy, progressive myoclonic, 1b	Enrichment	TBC1D24	2.00
77	Deafness, x-linked 5, with peripheral neuropathy	Enrichment	RAB33A	2.00
78	X-linked deafness 5	Enrichment	RAB33A	2.00
79	Xanthinuria, type ii	Enrichment	TSC2	2.00
80	Combined oxidative phosphorylation deficiency	Enrichment	RAB33A	2.00
81	Spondyloepiphyseal dysplasia tarda, x-linked	Enrichment	TRAPPC2	1.88
82	Primary lateral sclerosis, juvenile	Enrichment	ALS2	1.88
83	Catifa syndrome	Enrichment	RIC1	1.88
84	Encephalopathy, progressive, early-onset, with episodic rhabdomyolysis	Enrichment	TRAPPC2L	1.88
85	Senior-loken syndrome 7	Enrichment	AKT3	1.88
86	Spondyloepiphyseal dysplasia tarda	Enrichment	TRAPPC2	1.88
87	Muscular dystrophy, limb-girdle, autosomal recessive 18	Enrichment	TRAPPC11	1.88
88	Bardet-biedl syndrome 16	Enrichment	AKT3	1.88
89	Encephalopathy, progressive, early-onset, with brain atrophy and spasticity	Enrichment	TRAPPC12	1.88
90	Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies	Enrichment	TRAPPC4	1.88
91	Early-onset progressive encephalopathy-hearing loss-pons hypoplasia-brain atrophy syndrome	Enrichment	TRAPPC12	1.88
92	Amyotrophic lateral sclerosis 10 with or without frontotemporal dementia	Enrichment	OPTN	1.78
93	Glaucoma, primary open angle	Enrichment	OPTN	1.70
94	Keratoconus	Enrichment	TSC1	1.70
95	Pelizaeus-merzbacher disease	Enrichment	RAB9B	1.70
96	Spastic paraplegia 2, x-linked	Enrichment	RAB9B	1.70
97	Charcot-marie-tooth disease, demyelinating, type 4b3	Enrichment	SBF1	1.70
98	Miller-dieker lissencephaly syndrome	Enrichment	YWHAE	1.70
99	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	YWHAE	1.70
100	Charcot-marie-tooth disease type 4b3	Enrichment	SBF1	1.70
101	Congenital diarrhea	Enrichment	MON1A	1.70
102	Pelizeaus-merzbacher spectrum disorder	Enrichment	RAB9B	1.70
103	Tyrosinemia	Enrichment	ALS2	1.70
104	Polycystic kidney disease 1 with or without polycystic liver disease	Enrichment	TSC2	1.64
105	Polycystic kidney disease 1	Enrichment	TSC2	1.64
106	Parkinsonism	Enrichment	TBC1D24	1.64
107	Motor neuron disease	Enrichment	OPTN	1.64
108	Non-syndromic x-linked intellectual disability	Enrichment	GDI1, RAB39B	1.63
109	Achalasia-addisonianism-alacrima syndrome	Enrichment	TRAPPC11	1.58
110	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3	1.58
111	Choroideremia	Enrichment	CHM	1.58
112	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3	1.58
113	Charcot-marie-tooth disease, demyelinating, type 4b2	Enrichment	SBF2	1.58
114	Charcot-marie-tooth disease type 4b2	Enrichment	SBF2	1.58
115	Mucopolysaccharidosis iv	Enrichment	TRAPPC2L	1.58
116	Developmental and epileptic encephalopathy 14	Enrichment	TBC1D24	1.53
117	Charcot-marie-tooth disease	Enrichment	SBF1, SBF2	1.52
118	Kbg syndrome	Enrichment	TRAPPC2L	1.48
119	Mucopolysaccharidosis, type iva	Enrichment	TRAPPC2L	1.48
120	Muscular dystrophy, limb-girdle, autosomal recessive 23	Enrichment	TRAPPC11	1.48
121	Congenital ptosis	Enrichment	RAB3GAP1	1.48
122	Night blindness	Enrichment	CHM	1.48
123	Hemimegalencephaly	Enrichment	AKT3	1.48
124	Multiple acyl-coa dehydrogenase deficiency, severe neonatal type	Enrichment	MADD	1.48
125	Endometrial stromal sarcoma	Enrichment	YWHAE	1.48
126	Specific learning disability	Enrichment	TBC1D24	1.44
127	Autosomal recessive intellectual developmental disorder	Enrichment	TRAPPC9	1.41
128	Breast adenocarcinoma	Enrichment	AKT1	1.41
129	Hypertrichosis	Enrichment	RAB3GAP1	1.41
130	Kidney clear cell sarcoma	Enrichment	YWHAE	1.41
131	Oligospermia	Enrichment	TBC1D25	1.37
132	Myoclonic epilepsy of unverricht and lundborg	Enrichment	TBC1D24	1.34
133	Megacolon	Enrichment	AKT3	1.34
134	Congenital nervous system abnormality	Enrichment	TBC1D24, TSC2	1.32
135	Nervous system disease	Enrichment	TBC1D24, TSC2	1.32
136	Autosomal dominant polycystic kidney disease	Enrichment	TSC2	1.31
137	Kidney disease	Enrichment	TSC1	1.31
138	Isolated congenital microcephaly	Enrichment	RAB11A	1.29
139	Spastic paraplegia 4, autosomal dominant	Enrichment	TRAPPC2	1.29
140	Cryptorchidism	Enrichment	RAB3GAP1	1.29
141	Cryptorchidism, unilateral or bilateral	Enrichment	RAB3GAP1	1.24
142	Limb-girdle muscular dystrophy	Enrichment	TRAPPC11	1.24
143	Cowden syndrome	Enrichment	AKT1	1.24
144	Juvenile amyotrophic lateral sclerosis	Enrichment	ALS2	1.24
145	Leukodystrophy	Enrichment	RAB33A	1.19
146	Polymicrogyria	Enrichment	AKT3	1.19
147	Inherited cancer-predisposing syndrome	Enrichment	TSC1, TSC2	1.15
148	Autism spectrum disorder	Enrichment	SBF1, TRAPPC9, TSC2	1.12
149	Muscular dystrophy, limb-girdle, autosomal recessive 2	Enrichment	TRAPPC11	1.11
150	Meningioma	Enrichment	AKT1	1.11
151	Developmental and epileptic encephalopathy 1	Enrichment	TBC1D24	1.10
152	Cleft lip/palate	Enrichment	RIC1	1.05
153	Bladder cancer	Enrichment	TSC1	1.04
154	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ALS2, OPTN	1.01
155	Cleft palate, isolated	Enrichment	RAB3GAP1	0.97
156	Esophageal atresia/tracheoesophageal fistula	Enrichment	RAB3GAP2	0.92
157	Autosomal recessive limb-girdle muscular dystrophy	Enrichment	TRAPPC11	0.92
158	Macs syndrome	Enrichment	RIN2	0.90
159	Benign epilepsy with centrotemporal spikes	Enrichment	TBC1D24	0.89
160	Centralopathic epilepsy	Enrichment	TBC1D24	0.88
161	Multisystem inflammatory syndrome in children	Enrichment	RAB27A	0.87
162	Sensorineural hearing loss	Enrichment	RAB33A	0.83
163	Autoinflammatory disease	Enrichment	RAB27A	0.83
164	Muscular dystrophy	Enrichment	TRAPPC11	0.83
165	Autosomal dominant non-syndromic intellectual disability	Enrichment	RAB11A	0.81
166	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	TBC1D24	0.80
167	Hirschsprung disease 1	Enrichment	DENND3	0.76
168	Primary autosomal recessive microcephaly	Enrichment	TRAPPC10	0.72
169	Connective tissue disease	Enrichment	TRAPPC2	0.72
170	Complex neurodevelopmental disorder	Enrichment	MADD, TRAPPC4	0.70
171	Genetic steroid-resistant nephrotic syndrome	Enrichment	GAPVD1	0.69
172	Eye disease	Enrichment	CHM	0.68
173	Ovarian cancer	Enrichment	AKT1, TSC2	0.63
174	Type 2 diabetes mellitus	Enrichment	AKT2	0.61
175	Bardet-biedl syndrome	Enrichment	TRAPPC3	0.61
176	Hereditary spastic paraplegia	Enrichment	RAB9B	0.61
177	Hereditary breast carcinoma	Enrichment	AKT1	0.59
178	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	TBC1D24	0.59
179	Autosomal recessive non-syndromic intellectual disability	Enrichment	TRAPPC9	0.49
180	Schizophrenia	Enrichment	TRAPPC9	0.49
181	Breast cancer	Enrichment	AKT1	0.40
182	Colorectal cancer	Enrichment	AKT1	0.36
183	Retinitis pigmentosa	Enrichment	CHM	0.12
184	Hereditary retinal dystrophy	Enrichment	CHM	0.07
185	Fundus dystrophy	Enrichment	CHM	0.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Rab regulation of trafficking

Pathway Network for Rab regulation of trafficking

Pathway network for the Rab regulation of trafficking SuperPath

Member Pathways for Rab regulation of trafficking

Pathways in the Rab regulation of trafficking SuperPath

Gene overlap in member pathways for Rab regulation of trafficking SuperPath

Associated Genes for Rab regulation of trafficking

Associated Disorders for Rab regulation of trafficking

Disorders associated with Rab regulation of trafficking SuperPath

STRING Interaction Network for Rab regulation of trafficking

Sources for Rab regulation of trafficking