RAC1 GTPase cycle

No Pathway Network information available for RAC1 GTPase cycle

Pathways in the RAC1 GTPase cycle SuperPath

#	Name	Source	Genes
1	RAC1 GTPase cycle	Reactome	ABI1 ABI2 ABL2 ABR ALS2 AMIGO2 ARAP1 ARAP2 ARAP3 ARHGAP1 ARHGAP10 ARHGAP12 ARHGAP15 ARHGAP17 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP23 ARHGAP24 ARHGAP25 ARHGAP26 ARHGAP27 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP42 ARHGAP44 ARHGAP45 ARHGAP5 ARHGAP9 ARHGDIA ARHGDIB ARHGEF10 ARHGEF11 ARHGEF15 ARHGEF18 ARHGEF19 ARHGEF25 ARHGEF39 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 BAIAP2 BAIAP2L1 BCR BRK1 BUB1B-PAK6 CAV1 CDC42 CDC42BPA CDC42EP1 CDC42EP4 CHN1 CHN2 CIT CYBA CYBB CYFIP1 CYFIP2 DEF6 DEPDC1B DIAPH3 DLC1 DOCK1 DOCK10 DOCK11 DOCK2 DOCK3 DOCK4 DOCK5 DOCK6 DOCK7 DOCK8 DOCK9 ECT2 EMD EPHA2 ERBIN ESYT1 FAM13A FAM13B FARP1 FARP2 FERMT2 FGD5 FMNL1 GARRE1 GIT1 GIT2 GMIP GNA13 IQGAP1 IQGAP2 IQGAP3 ITGB1 JAG1 KALRN KTN1 LAMTOR1 LBR LEMD3 MCAM MCF2 MCF2L MPP7 MYO9B NCF1 NCF2 NCF4 NCKAP1 NCKAP1L NGEF NHS NISCH NOX1 NOX3 NOXA1 NOXO1 OPHN1 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PARD6A PIK3CA PIK3R1 PIK3R2 PIK3R3 PKN1 PKN2 PLD1 PLD2 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG6 PREX1 PREX2 RAB7A RAC1 RACGAP1 RALBP1 RASGRF2 SH3BP1 SLC1A5 SNAP23 SOS1 SOS2 SPATA13 SRGAP1 SRGAP2 SRGAP3 SWAP70 SYDE2 TAGAP TAOK3 TFRC TIAM1 TIAM2 TMPO TRIO VAMP3 VANGL1 VAV1 VAV2 VAV3 VRK2 WAS WASF1 WASF2 WASF3 WASL WIPF1 WIPF2 WIPF3 YKT6 (see all 185) (see less)
2	CDC42 GTPase cycle	Reactome	ABR ARAP1 ARAP2 ARAP3 ARFGAP2 ARFGAP3 ARHGAP1 ARHGAP10 ARHGAP11B ARHGAP17 ARHGAP20 ARHGAP21 ARHGAP22 ARHGAP24 ARHGAP26 ARHGAP27 ARHGAP29 ARHGAP30 ARHGAP31 ARHGAP32 ARHGAP33 ARHGAP35 ARHGAP39 ARHGAP4 ARHGAP40 ARHGAP42 ARHGAP44 ARHGAP45 ARHGAP5 ARHGAP9 ARHGDIA ARHGDIB ARHGDIG ARHGEF10 ARHGEF11 ARHGEF12 ARHGEF15 ARHGEF16 ARHGEF19 ARHGEF25 ARHGEF26 ARHGEF4 ARHGEF5 ARHGEF6 ARHGEF7 ARHGEF9 BAIAP2 BCR BUB1B-PAK6 CAV1 CDC42 CDC42BPA CDC42BPB CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 CDC42EP5 CDC42SE2 CHN1 CPNE8 DAAM1 DEF6 DEPDC1B DIAPH3 DLC1 DNMBP DOCK10 DOCK11 DOCK6 DOCK7 DOCK8 DOCK9 ECT2 FAM13B FARP1 FGD1 FGD2 FGD3 FGD4 FMNL1 FMNL2 FMNL3 FNBP1 FNBP1L GIT1 GIT2 GMIP GNA13 GOLGA8R IQGAP1 IQGAP2 IQGAP3 ITSN1 JUP KCTD3 KTN1 LAMTOR1 LBR MAP3K11 MCF2 MCF2L MYO9B NGEF OPHN1 PAK1 PAK2 PAK3 PAK4 PAK5 PAK6 PARD6A PIK3R1 PIK3R2 PLD1 PLEKHG1 PLEKHG2 PLEKHG3 PLEKHG4 PLEKHG4B PREX1 PREX2 RAB7A RACGAP1 RALBP1 RASGRF2 SCRIB SH3PXD2A SHKBP1 SNAP23 SPATA13 SRGAP1 SRGAP2 SRGAP3 STARD13 STARD8 STEAP3 STOM SYDE1 TAGAP TFRC TIAM1 TMPO TRIO VAMP3 VANGL1 VAV2 VAV3 WAS WASL WDR81 WDR91 WIPF1 WIPF2 WIPF3 YKT6 (see all 156) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	FARP1	FERM, ARH/RhoGEF And Pleckstrin Domain Protein 1	Protein Coding	2
2	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	2
3	DLC1	DLC1 Rho GTPase Activating Protein	Protein Coding	2
4	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	2
5	BAIAP2	BAR/IMD Domain Containing Adaptor Protein 2	Protein Coding	2
6	YKT6	YKT6 Vesicular SNARE Protein	Protein Coding	2
7	GNA13	G Protein Subunit Alpha 13	Protein Coding	2
8	BUB1B-PAK6	BUB1B-PAK6 Readthrough	Protein Coding	2
9	IQGAP2	IQ Motif Containing GTPase Activating Protein 2	Protein Coding	2
10	RALBP1	RalA Binding Protein 1	Protein Coding	2
11	CDC42EP1	CDC42 Effector Protein 1	Protein Coding	2
12	CHN1	Chimerin 1	Protein Coding	2
13	ARHGEF25	Rho Guanine Nucleotide Exchange Factor 25	Protein Coding	2
14	ARHGAP33	Rho GTPase Activating Protein 33	Protein Coding	2
15	ARAP2	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2	Protein Coding	2
16	ARAP1	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1	Protein Coding	2
17	TAGAP	T Cell Activation RhoGTPase Activating Protein	Protein Coding	2
18	IQGAP3	IQ Motif Containing GTPase Activating Protein 3	Protein Coding	2
19	ARHGEF19	Rho Guanine Nucleotide Exchange Factor 19	Protein Coding	2
20	DOCK11	Dedicator Of Cytokinesis 11	Protein Coding	2
21	ARHGAP42	Rho GTPase Activating Protein 42	Protein Coding	2
22	WIPF2	WAS/WASL Interacting Protein Family Member 2	Protein Coding	2
23	ECT2	Epithelial Cell Transforming 2	Protein Coding	2
24	ARHGAP27	Rho GTPase Activating Protein 27	Protein Coding	2
25	SPATA13	Spermatogenesis Associated 13	Protein Coding	2
26	ARHGEF15	Rho Guanine Nucleotide Exchange Factor 15	Protein Coding	2
27	ARHGAP26	Rho GTPase Activating Protein 26	Protein Coding	2
28	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	2
29	DOCK9	Dedicator Of Cytokinesis 9	Protein Coding	2
30	SRGAP2	SLIT-ROBO Rho GTPase Activating Protein 2	Protein Coding	2
31	ARHGAP45	Rho GTPase Activating Protein 45	Protein Coding	2
32	CDC42EP4	CDC42 Effector Protein 4	Protein Coding	2
33	ARHGAP30	Rho GTPase Activating Protein 30	Protein Coding	2
34	NGEF	Neuronal Guanine Nucleotide Exchange Factor	Protein Coding	2
35	PLEKHG4	Pleckstrin Homology And RhoGEF Domain Containing G4	Protein Coding	2
36	PLEKHG3	Pleckstrin Homology And RhoGEF Domain Containing G3	Protein Coding	2
37	GIT1	GIT ArfGAP 1	Protein Coding	2
38	ABR	ABR Activator Of RhoGEF And GTPase	Protein Coding	2
39	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	2
40	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	2
41	KTN1	Kinectin 1	Protein Coding	2
42	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	2
43	ARHGAP4	Rho GTPase Activating Protein 4	Protein Coding	2
44	LBR	Lamin B Receptor	Protein Coding	2
45	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	2
46	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	2
47	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	2
48	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	2
49	MYO9B	Myosin IXB	Protein Coding	2
50	OPHN1	Oligophrenin 1	Protein Coding	2
51	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
52	DEF6	DEF6 Guanine Nucleotide Exchange Factor	Protein Coding	2
53	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	2
54	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	2
55	ARHGEF4	Rho Guanine Nucleotide Exchange Factor 4	Protein Coding	2
56	PARD6A	Par-6 Family Cell Polarity Regulator Alpha	Protein Coding	2
57	GMIP	GEM Interacting Protein	Protein Coding	2
58	FAM13B	Family With Sequence Similarity 13 Member B	Protein Coding	2
59	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	2
60	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
61	PLD1	Phospholipase D1	Protein Coding	2
62	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	2
63	ARHGAP17	Rho GTPase Activating Protein 17	Protein Coding	2
64	DOCK10	Dedicator Of Cytokinesis 10	Protein Coding	2
65	DEPDC1B	DEP Domain Containing 1B	Protein Coding	2
66	PAK6	P21 (RAC1) Activated Kinase 6	Protein Coding	2
67	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	2
68	PLEKHG1	Pleckstrin Homology And RhoGEF Domain Containing G1	Protein Coding	2
69	ARHGAP31	Rho GTPase Activating Protein 31	Protein Coding	2
70	SRGAP1	SLIT-ROBO Rho GTPase Activating Protein 1	Protein Coding	2
71	ARHGAP20	Rho GTPase Activating Protein 20	Protein Coding	2
72	DOCK6	Dedicator Of Cytokinesis 6	Protein Coding	2
73	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	2
74	ARHGAP21	Rho GTPase Activating Protein 21	Protein Coding	2
75	ARHGAP22	Rho GTPase Activating Protein 22	Protein Coding	2
76	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	2
77	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	2
78	ARHGAP9	Rho GTPase Activating Protein 9	Protein Coding	2
79	ARAP3	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3	Protein Coding	2
80	WIPF3	WAS/WASL Interacting Protein Family Member 3	Protein Coding	2
81	PLEKHG2	Pleckstrin Homology And RhoGEF Domain Containing G2	Protein Coding	2
82	TFRC	Transferrin Receptor	Protein Coding	2
83	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	2
84	TMPO	Thymopoietin	Protein Coding	2
85	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	2
86	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	2
87	WAS	WASP Actin Nucleation Promoting Factor	Protein Coding	2
88	WIPF1	WAS/WASL Interacting Protein Family Member 1	Protein Coding	2
89	FMNL1	Formin Like 1	Protein Coding	2
90	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	2
91	ARHGAP10	Rho GTPase Activating Protein 10	Protein Coding	2
92	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	2
93	PREX2	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 2	Protein Coding	2
94	ARHGAP39	Rho GTPase Activating Protein 39	Protein Coding	2
95	DIAPH3	Diaphanous Related Formin 3	Protein Coding	2
96	DOCK8	Dedicator Of Cytokinesis 8	Protein Coding	2
97	VANGL1	VANGL Planar Cell Polarity Protein 1	Protein Coding	2
98	ARHGAP24	Rho GTPase Activating Protein 24	Protein Coding	2
99	CDC42BPA	CDC42 Binding Protein Kinase Alpha	Protein Coding	2
100	DOCK7	Dedicator Of Cytokinesis 7	Protein Coding	2
101	CAV1	Caveolin 1	Protein Coding	2
102	SNAP23	Synaptosome Associated Protein 23	Protein Coding	2
103	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	2
104	ARHGEF7	Rho Guanine Nucleotide Exchange Factor 7	Protein Coding	2
105	WASL	WASP Like Actin Nucleation Promoting Factor	Protein Coding	2
106	VAMP3	Vesicle Associated Membrane Protein 3	Protein Coding	2
107	ARHGAP29	Rho GTPase Activating Protein 29	Protein Coding	2
108	ARHGEF6	Rac/Cdc42 Guanine Nucleotide Exchange Factor 6	Protein Coding	2
109	ARHGEF10	Rho Guanine Nucleotide Exchange Factor 10	Protein Coding	2
110	ARHGAP32	Rho GTPase Activating Protein 32	Protein Coding	2
111	GIT2	GIT ArfGAP 2	Protein Coding	2
112	ARHGEF11	Rho Guanine Nucleotide Exchange Factor 11	Protein Coding	2
113	SRGAP3	SLIT-ROBO Rho GTPase Activating Protein 3	Protein Coding	2
114	ARHGAP44	Rho GTPase Activating Protein 44	Protein Coding	2
115	CDC42	Cell Division Cycle 42	Protein Coding	2
116	ABI1	Abl Interactor 1	Protein Coding	1
117	FAM13A	Family With Sequence Similarity 13 Member A	Protein Coding	1
118	ABI2	Abl Interactor 2	Protein Coding	1
119	WASF2	WASP Family Member 2	Protein Coding	1
120	NCKAP1	NCK Associated Protein 1	Protein Coding	1
121	WASF3	WASP Family Member 3	Protein Coding	1
122	NOXA1	NADPH Oxidase Activator 1	Protein Coding	1
123	FERMT2	FERM Domain Containing Kindlin 2	Protein Coding	1
124	CIT	Citron Rho-Interacting Serine/Threonine Kinase	Protein Coding	1
125	NISCH	Nischarin	Protein Coding	1
126	CHN2	Chimerin 2	Protein Coding	1
127	NOXO1	NADPH Oxidase Organizer 1	Protein Coding	1
128	MPP7	MAGUK P55 Scaffold Protein 7	Protein Coding	1
129	FGD5	FYVE, RhoGEF And PH Domain Containing 5	Protein Coding	1
130	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	1
131	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	1
132	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	1
133	DOCK2	Dedicator Of Cytokinesis 2	Protein Coding	1
134	DOCK3	Dedicator Of Cytokinesis 3	Protein Coding	1
135	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
136	EPHA2	EPH Receptor A2	Protein Coding	1
137	EMD	Emerin	Protein Coding	1
138	SWAP70	Switching B Cell Complex Subunit SWAP70	Protein Coding	1
139	CYFIP1	Cytoplasmic FMR1 Interacting Protein 1	Protein Coding	1
140	ESYT1	Extended Synaptotagmin 1	Protein Coding	1
141	ARHGEF18	Rho/Rac Guanine Nucleotide Exchange Factor 18	Protein Coding	1
142	LEMD3	LEM Domain Containing 3	Protein Coding	1
143	SH3BP1	SH3 Domain Binding Protein 1	Protein Coding	1
144	TIAM2	TIAM Rac1 Associated GEF 2	Protein Coding	1
145	CYFIP2	Cytoplasmic FMR1 Interacting Protein 2	Protein Coding	1
146	ABL2	ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase	Protein Coding	1
147	NOX1	NADPH Oxidase 1	Protein Coding	1
148	NCKAP1L	NCK Associated Protein 1 Like	Protein Coding	1
149	AMIGO2	Adhesion Molecule With Ig Like Domain 2	Protein Coding	1
150	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
151	MCAM	Melanoma Cell Adhesion Molecule	Protein Coding	1
152	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	1
153	NCF4	Neutrophil Cytosolic Factor 4	Protein Coding	1
154	NHS	NHS Actin Remodeling Regulator	Protein Coding	1
155	NOX3	NADPH Oxidase 3	Protein Coding	1
156	TAOK3	TAO Kinase 3	Protein Coding	1
157	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
158	PLD2	Phospholipase D2	Protein Coding	1
159	PLEKHG6	Pleckstrin Homology And RhoGEF Domain Containing G6	Protein Coding	1
160	ARHGAP15	Rho GTPase Activating Protein 15	Protein Coding	1
161	BRK1	BRICK1 Subunit Of SCAR/WAVE Actin Nucleating Complex	Protein Coding	1
162	PKN1	Protein Kinase N1	Protein Coding	1
163	PKN2	Protein Kinase N2	Protein Coding	1
164	ERBIN	Erbb2 Interacting Protein	Protein Coding	1
165	BAIAP2L1	BAR/IMD Domain Containing Adaptor Protein 2 Like 1	Protein Coding	1
166	ARHGAP23	Rho GTPase Activating Protein 23	Protein Coding	1
167	ALS2	Alsin Rho Guanine Nucleotide Exchange Factor ALS2	Protein Coding	1
168	RAC1	Rac Family Small GTPase 1	Protein Coding	1
169	SLC1A5	Solute Carrier Family 1 Member 5	Protein Coding	1
170	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	1
171	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
172	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
173	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	1
174	VRK2	VRK Serine/Threonine Kinase 2	Protein Coding	1
175	DOCK5	Dedicator Of Cytokinesis 5	Protein Coding	1
176	SYDE2	Synapse Defective Rho GTPase Homolog 2	Protein Coding	1
177	ARHGEF39	Rho Guanine Nucleotide Exchange Factor 39	Protein Coding	1
178	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
179	WASF1	WASP Family Member 1	Protein Coding	1
180	KALRN	Kalirin RhoGEF Kinase	Protein Coding	1
181	ARHGAP12	Rho GTPase Activating Protein 12	Protein Coding	1
182	GARRE1	Granule Associated Rac And RHOG Effector 1	Protein Coding	1
183	DOCK4	Dedicator Of Cytokinesis 4	Protein Coding	1
184	FARP2	FERM, ARH/RhoGEF And Pleckstrin Domain Protein 2	Protein Coding	1
185	ARHGAP25	Rho GTPase Activating Protein 25	Protein Coding	1
186	GOLGA8R	Golgin A8 Family Member R	Protein Coding	1
187	CDC42EP2	CDC42 Effector Protein 2	Protein Coding	1
188	CDC42EP3	CDC42 Effector Protein 3	Protein Coding	1
189	FMNL2	Formin Like 2	Protein Coding	1
190	FGD4	FYVE, RhoGEF And PH Domain Containing 4	Protein Coding	1
191	WDR81	WD Repeat Domain 81	Protein Coding	1
192	CPNE8	Copine 8	Protein Coding	1
193	CDC42EP5	CDC42 Effector Protein 5	Protein Coding	1
194	PLEKHG4B	Pleckstrin Homology And RhoGEF Domain Containing G4B	Protein Coding	1
195	STOM	Stomatin	Protein Coding	1
196	FGD2	FYVE, RhoGEF And PH Domain Containing 2	Protein Coding	1
197	FGD1	FYVE, RhoGEF And PH Domain Containing 1	Protein Coding	1
198	DAAM1	Dishevelled Associated Activator Of Morphogenesis 1	Protein Coding	1
199	FNBP1	Formin Binding Protein 1	Protein Coding	1
200	ARHGEF9	Cdc42 Guanine Nucleotide Exchange Factor 9	Protein Coding	1
201	DNMBP	Dynamin Binding Protein	Protein Coding	1
202	ARHGEF12	Rho Guanine Nucleotide Exchange Factor 12	Protein Coding	1
203	SCRIB	Scribble Planar Cell Polarity Protein	Protein Coding	1
204	ARHGEF26	Rho Guanine Nucleotide Exchange Factor 26	Protein Coding	1
205	ARFGAP3	ARF GTPase Activating Protein 3	Protein Coding	1
206	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	1
207	WDR91	WD Repeat Domain 91	Protein Coding	1
208	ARHGAP40	Rho GTPase Activating Protein 40	Protein Coding	1
209	JUP	Junction Plakoglobin	Protein Coding	1
210	ARHGDIG	Rho GDP Dissociation Inhibitor Gamma	Protein Coding	1
211	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
212	KCTD3	Potassium Channel Tetramerization Domain Containing 3	Protein Coding	1
213	FNBP1L	Formin Binding Protein 1 Like	Protein Coding	1
214	STEAP3	STEAP3 Metalloreductase	Protein Coding	1
215	CDC42SE2	CDC42 Small Effector 2	Protein Coding	1
216	ITSN1	Intersectin 1	Protein Coding	1
217	ARFGAP2	ARF GTPase Activating Protein 2	Protein Coding	1
218	SYDE1	Synapse Defective Rho GTPase Activating Protein 1	Protein Coding	1
219	ARHGAP11B	Rho GTPase Activating Protein 11B	Protein Coding	1
220	FGD3	FYVE, RhoGEF And PH Domain Containing 3	Protein Coding	1
221	STARD13	StAR Related Lipid Transfer Domain Containing 13	Protein Coding	1
222	FMNL3	Formin Like 3	Protein Coding	1
223	SHKBP1	SH3KBP1 Binding Protein 1	Protein Coding	1
224	CDC42BPB	CDC42 Binding Protein Kinase Beta	Protein Coding	1
225	SH3PXD2A	SH3 And PX Domains 2A	Protein Coding	1
226	STARD8	StAR Related Lipid Transfer Domain Containing 8	Protein Coding	1

Disorders associated with RAC1 GTPase cycle SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic granulomatous disease	Enrichment	CYBA, CYBB, NCF1, NCF2, NCF4	7.27
2	Wiskott-aldrich syndrome	Enrichment	WAS, WIPF1	3.88
3	Immunodeficiency 72 with autoinflammation and lymphoproliferation	Enrichment	NCKAP1, NCKAP1L	3.73
4	Immunodeficiency 72	Enrichment	NCKAP1, NCKAP1L	3.73
5	Adams-oliver syndrome 1	Enrichment	ARHGAP31, DOCK6	3.41
6	Neural tube defects	Enrichment	DLC1, SCRIB, VANGL1	3.41
7	Alagille syndrome 1	Enrichment	FAM13A, JAG1	3.26
8	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1, NCF2	3.26
9	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.26
10	Granulomatous disease, chronic, x-linked	Enrichment	CYBB, NCF1	2.96
11	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	2.96
12	Martsolf syndrome 1	Enrichment	ARHGAP35, ARHGAP5	2.89
13	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B-PAK6, PAK6	2.89
14	Adams-oliver syndrome	Enrichment	ARHGAP31, DOCK6	2.58
15	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1B-PAK6, PAK6	2.45
16	Thrombocytopenia 1	Enrichment	WAS	1.94
17	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	1.94
18	Developmental and epileptic encephalopathy 8	Enrichment	ARHGEF9	1.94
19	Autoinflammatory disease, multisystem, with immune dysregulation, x-linked	Enrichment	DOCK11	1.94
20	Arrhythmogenic right ventricular dysplasia, familial, 12	Enrichment	JUP	1.94
21	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	1.94
22	Type 1 diabetes mellitus 21	Enrichment	TAGAP	1.94
23	Cardiac valvular dysplasia 1	Enrichment	PLD1	1.94
24	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	1.94
25	Charcot-marie-tooth disease, demyelinating, type 4h	Enrichment	FGD4	1.94
26	Wiskott-aldrich syndrome 2	Enrichment	WIPF1	1.94
27	Greenberg dysplasia	Enrichment	LBR	1.94
28	Pulmonary hypertension, primary, 3	Enrichment	CAV1	1.94
29	Pelger-huet anomaly	Enrichment	LBR	1.94
30	Naxos disease	Enrichment	JUP	1.94
31	Immunodeficiency 87 and autoimmunity	Enrichment	DEF6	1.94
32	Intellectual developmental disorder, x-linked, syndromic, billuart type	Enrichment	OPHN1	1.94
33	Rhizomelic skeletal dysplasia with or without pelger-huet anomaly	Enrichment	LBR	1.94
34	Knobloch syndrome 2	Enrichment	PAK2	1.94
35	Charcot-marie-tooth disease, axonal, type 2b	Enrichment	RAB7A	1.94
36	Short syndrome	Enrichment	PIK3R1	1.94
37	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.94
38	Charcot-marie-tooth disease type 2b	Enrichment	RAB7A	1.94
39	Intellectual developmental disorder, x-linked 46	Enrichment	ARHGEF6	1.94
40	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	1.94
41	Charcot-marie-tooth disease type 4h	Enrichment	FGD4	1.94
42	Slowed nerve conduction velocity, autosomal dominant	Enrichment	ARHGEF10	1.94
43	Auditory neuropathy, autosomal dominant 1	Enrichment	DIAPH3	1.94
44	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 2	Enrichment	WDR81	1.94
45	Microlissencephaly	Enrichment	WDR81	1.94
46	Celiac disease 4	Enrichment	MYO9B	1.94
47	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.94
48	Immunodeficiency 46	Enrichment	TFRC	1.94
49	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.94
50	Reynolds syndrome	Enrichment	LBR	1.94
51	Brain small vessel disease 5 with osteoporosis	Enrichment	ARHGEF15	1.94
52	Was-related disorders	Enrichment	WAS	1.94
53	Takenouchi-kosaki syndrome	Enrichment	CDC42	1.94
54	Chilton-okur-chung neurodevelopmental syndrome	Enrichment	CDC42BPB	1.94
55	Hydrocephalus, congenital, 3, with brain anomalies	Enrichment	WDR81	1.94
56	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	1.94
57	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	1.94
58	Congenital dyserythropoietic anemia type iiib	Enrichment	RACGAP1	1.94
59	Nocarh syndrome	Enrichment	CDC42	1.94
60	Anemia, congenital dyserythropoietic, type iiib, autosomal recessive	Enrichment	RACGAP1	1.94
61	Macrodactyly	Enrichment	PIK3CA	1.87
62	Buschke-ollendorff syndrome	Enrichment	LEMD3	1.87
63	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	1.87
64	Amyotrophic lateral sclerosis 2, juvenile	Enrichment	ALS2	1.87
65	Nance-horan syndrome	Enrichment	NHS	1.87
66	Immunodeficiency 34	Enrichment	CYBB	1.87
67	Noonan syndrome 4	Enrichment	SOS1	1.87
68	Spastic paralysis, infantile-onset ascending	Enrichment	ALS2	1.87
69	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	1.87
70	Cowden syndrome 5	Enrichment	PIK3CA	1.87
71	Noonan syndrome 9	Enrichment	SOS2	1.87
72	Cerebral cavernous malformations 4	Enrichment	PIK3CA	1.87
73	Neurodevelopmental disorder with absent language and variable seizures	Enrichment	WASF1	1.87
74	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	1.87
75	Retinitis pigmentosa 78	Enrichment	ARHGEF18	1.87
76	Hemifacial myohyperplasia	Enrichment	PIK3CA	1.87
77	Immunodeficiency 40	Enrichment	DOCK2	1.87
78	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	1.87
79	Als2-related disorder	Enrichment	ALS2	1.87
80	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	1.87
81	Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia	Enrichment	DOCK3	1.87
82	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	1.87
83	Melorheostosis with osteopoikilosis	Enrichment	LEMD3	1.87
84	Hypospadias	Enrichment	PIK3CA	1.87
85	Rare venous malformation	Enrichment	PIK3CA	1.87
86	Diaphragmatic eventration	Enrichment	PIK3CA	1.87
87	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	1.87
88	Rare combined vascular malformation	Enrichment	PIK3CA	1.87
89	Cavernous lymphangioma	Enrichment	PIK3CA	1.87
90	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	1.87
91	Isolated osteopoikilosis	Enrichment	LEMD3	1.87
92	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	1.87
93	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	1.87
94	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	1.87
95	Autosomal dominant combined immunodeficiency due to erbin deficiency	Enrichment	ERBIN	1.87
96	Macrodactyly of toe	Enrichment	PIK3CA	1.87
97	Infantile-onset ascending hereditary spastic paralysis	Enrichment	ALS2	1.87
98	Temporomandibular joint anomaly	Enrichment	DOCK1	1.87
99	Cataract 44	Enrichment	EPHA2, NHS	1.66
100	Anemia, congenital dyserythropoietic, type iiia	Enrichment	RACGAP1	1.64
101	Neutropenia, severe congenital, x-linked	Enrichment	WAS	1.64
102	Deafness, autosomal recessive 28	Enrichment	TRIO	1.64
103	Anemia, hypochromic microcytic, with iron overload 2	Enrichment	STEAP3	1.64
104	Duane retraction syndrome 2	Enrichment	CHN1	1.64
105	Adams-oliver syndrome 2	Enrichment	DOCK6	1.64
106	Spastic paraplegia 70, autosomal recessive	Enrichment	ARHGAP9	1.64
107	Hypobetalipoproteinemia, familial, 2	Enrichment	DOCK7	1.64
108	Developmental and epileptic encephalopathy 23	Enrichment	DOCK7	1.64
109	Immune system disease	Enrichment	CDC42	1.64
110	Paget's disease of bone	Enrichment	DOCK6	1.64
111	Aarskog syndrome	Enrichment	FGD1	1.64
112	Cataract 48	Enrichment	DNMBP	1.64
113	Crohn's disease	Enrichment	FMNL2	1.64
114	Malignant peripheral nerve sheath tumor with perineurial differentiation	Enrichment	SH3PXD2A	1.64
115	Malignant triton tumor	Enrichment	SH3PXD2A	1.64
116	Early-onset nuclear cataract	Enrichment	EPHA2, NHS	1.61
117	Fibromatosis, gingival, 1	Enrichment	SOS1	1.57
118	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	1.57
119	Cataract 40	Enrichment	NHS	1.57
120	Myopathy, x-linked, with postural muscle atrophy	Enrichment	EMD	1.57
121	Pulmonic stenosis	Enrichment	SOS1	1.57
122	Keratosis, seborrheic	Enrichment	PIK3CA	1.57
123	Granulomatous disease, chronic, autosomal recessive, 3	Enrichment	NCF4	1.57
124	Primary lateral sclerosis, juvenile	Enrichment	ALS2	1.57
125	Noonan syndrome 8	Enrichment	PIK3CA	1.57
126	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.57
127	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.57
128	Syndromic x-linked intellectual disability	Enrichment	NHS	1.57
129	Osteopoikilosis	Enrichment	LEMD3	1.57
130	12q14 microdeletion syndrome	Enrichment	LEMD3	1.57
131	X-linked emery-dreifuss muscular dystrophy	Enrichment	EMD	1.57
132	Arteriovenous malformations of the brain	Enrichment	LEMD3, PREX2	1.57
133	Hyper-ige syndrome 2, autosomal recessive, with recurrent infections	Enrichment	DOCK8	1.47
134	Aarskog-scott syndrome	Enrichment	FGD1	1.47
135	Intellectual developmental disorder, x-linked, syndromic, claes-jensen type	Enrichment	FGD1	1.47
136	Spinocerebellar ataxia 4	Enrichment	PLEKHG4	1.47
137	Hypercholanemia, familial 1	Enrichment	DOCK6	1.47
138	Epidermolysis bullosa, lethal acantholytic	Enrichment	JUP	1.47
139	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	1.47
140	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.47
141	Hyper-ige syndrome 3, autosomal recessive, with recurrent infections	Enrichment	DOCK8	1.47
142	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	1.47
143	Leukodystrophy and acquired microcephaly with or without dystonia	Enrichment	PLEKHG2	1.47
144	Immunodeficiency 14	Enrichment	PIK3R1	1.47
145	Duane retraction syndrome	Enrichment	CHN1	1.47
146	Syndromic x-linked intellectual disability claes-jensen type	Enrichment	FGD1	1.47
147	Noonan syndrome 1	Enrichment	SOS1, SOS2	1.41
148	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	1.39
149	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.39
150	Nuchal bleb, familial	Enrichment	SOS1	1.39
151	Polycystic kidney disease 2 with or without polycystic liver disease	Enrichment	FAM13A	1.39
152	Developmental and epileptic encephalopathy 65	Enrichment	CYFIP2	1.39
153	Polycystic kidney disease 2	Enrichment	FAM13A	1.39
154	Squamous cell carcinoma	Enrichment	FAM13A	1.39
155	Microcephaly 17, primary, autosomal recessive	Enrichment	CIT	1.39
156	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	1.39
157	Keratoacanthoma	Enrichment	PIK3CA	1.39
158	Tyrosinemia	Enrichment	ALS2	1.39
159	Intellectual developmental disorder, autosomal dominant 1	Enrichment	ITSN1	1.34
160	Sacral defect with anterior meningocele	Enrichment	VANGL1	1.34
161	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	1.34
162	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.34
163	Imerslund-grasbeck syndrome 2	Enrichment	CDC42BPB	1.34
164	Fetal akinesia deformation sequence 3	Enrichment	DOCK7	1.34
165	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.34
166	Oligohydramnios	Enrichment	OPHN1	1.34
167	Knobloch syndrome	Enrichment	PAK2	1.34
168	Rasopathy	Enrichment	SOS1, SOS2	1.31
169	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	EMD	1.27
170	Emery-dreifuss muscular dystrophy	Enrichment	EMD	1.27
171	Cerebrovascular disease	Enrichment	PIK3CA	1.27
172	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.27
173	Middle aortic syndrome	Enrichment	JAG1	1.27
174	Gingival fibromatosis	Enrichment	SOS1	1.27
175	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.27
176	Moebius syndrome	Enrichment	CHN1	1.25
177	Knobloch syndrome 1	Enrichment	PAK2	1.25
178	Robinow syndrome, autosomal dominant 2	Enrichment	CHN1	1.25
179	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.25
180	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGAP24, ARHGDIA	1.24
181	Cataract 6, multiple types	Enrichment	EPHA2	1.18
182	Capillary malformations, congenital	Enrichment	PIK3CA	1.18
183	Hemimegalencephaly	Enrichment	PIK3CA	1.18
184	Aniridia	Enrichment	EPHA2	1.18
185	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	WDR81	1.17
186	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	1.17
187	Megaloblastic anemia	Enrichment	CDC42BPB	1.17
188	Limited scleroderma	Enrichment	CAV1	1.17
189	Thyroid cancer, nonmedullary, 2	Enrichment	SRGAP1	1.11
190	Imerslund-grasbeck syndrome 1	Enrichment	CDC42BPB	1.11
191	Leukemia, chronic myeloid	Enrichment	BCR	1.11
192	Pilomyxoid astrocytoma	Enrichment	SRGAP3	1.11
193	Follicular thyroid carcinoma	Enrichment	SRGAP1	1.11
194	Overgrowth syndrome	Enrichment	PIK3R1	1.11
195	Moyamoya angiopathy	Enrichment	ARHGEF25	1.11
196	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	BCR	1.11
197	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.10
198	Cowden syndrome 1	Enrichment	PIK3CA	1.10
199	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.10
200	Breast adenocarcinoma	Enrichment	PIK3CA	1.10
201	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.10
202	Spondylocostal dysostosis 1, autosomal recessive	Enrichment	PLEKHG2	1.05
203	Complex neurodevelopmental disorder	Enrichment	DOCK3, PAK3, TIAM1, WASF1	1.05
204	Nevus, epidermal	Enrichment	PIK3CA	1.04
205	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.04
206	Noonan syndrome 3	Enrichment	SOS1	1.04
207	Gallbladder cancer	Enrichment	PIK3CA	1.04
208	Inflammatory bowel disease 1	Enrichment	FMNL2	1.00
209	Early-onset posterior polar cataract	Enrichment	EPHA2	0.98
210	Peters-plus syndrome	Enrichment	ARHGAP35	0.96
211	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	0.96
212	Autosomal dominant non-syndromic intellectual disability	Enrichment	DOCK8, ITSN1	0.95
213	Colorectal cancer	Enrichment	DLC1, PIK3CA, PIK3R1	0.94
214	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	0.93
215	Coronary heart disease 5	Enrichment	KALRN	0.93
216	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	0.93
217	Arteriovenous malformation	Enrichment	PIK3CA	0.93
218	Adult hepatocellular carcinoma	Enrichment	PIK3CA	0.93
219	Cowden syndrome	Enrichment	PIK3CA	0.93
220	Juvenile amyotrophic lateral sclerosis	Enrichment	ALS2	0.93
221	Combined immunodeficiency	Enrichment	TFRC	0.92
222	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	0.92
223	Heritable pulmonary arterial hypertension	Enrichment	CAV1	0.92
224	Combined t and b cell immunodeficiency	Enrichment	TFRC	0.92
225	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	0.89
226	Juvenile myelomonocytic leukemia	Enrichment	ARHGAP26	0.89
227	Inherited isolated arrhythmogenic ventricular dysplasia, biventricular variant	Enrichment	JUP	0.89
228	Inherited isolated arrhythmogenic cardiomyopathy, dominant-left variant	Enrichment	JUP	0.89
229	Hypercholesterolemia, familial, 1	Enrichment	DOCK6	0.85
230	Lung non-small cell carcinoma	Enrichment	PIK3CA	0.85
231	Cleft lip/palate	Enrichment	ARHGAP29	0.83
232	Inherited isolated arrhythmogenic cardiomyopathy, dominant-right variant	Enrichment	JUP	0.83
233	Meningioma	Enrichment	PIK3CA	0.82
234	Lip and oral cavity carcinoma	Enrichment	PIK3CA	0.82
235	Familial hypercholesterolemia	Enrichment	DOCK6	0.80
236	Aortic valve disease 1	Enrichment	SOS1	0.79
237	Microcephaly	Enrichment	PAK3, TRIO, WDR81	0.77
238	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	KCTD3	0.77
239	Wolff-parkinson-white syndrome	Enrichment	JUP	0.77
240	Arrhythmogenic right ventricular cardiomyopathy	Enrichment	JUP	0.77
241	Cataract	Enrichment	EPHA2	0.76
242	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.76
243	Syndromic intellectual disability	Enrichment	TRIO	0.75
244	Lynch syndrome	Enrichment	PIK3CA	0.73
245	Noonan syndrome and noonan-related syndrome	Enrichment	SOS1	0.73
246	Charcot-marie-tooth disease type 4	Enrichment	FGD4	0.73
247	Esophageal atresia/tracheoesophageal fistula	Enrichment	ITSN1	0.70
248	Interstitial lung disease 2	Enrichment	FAM13A	0.68
249	Heart, malformation of	Enrichment	JAG1	0.66
250	Neuromuscular disease	Enrichment	EMD	0.66
251	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	EMD	0.64
252	Precursor t-cell acute lymphoblastic leukemia	Enrichment	BCR	0.63
253	Williams-beuren syndrome	Enrichment	NCF1	0.62
254	Endometrial cancer	Enrichment	PIK3CA	0.60
255	Hepatoblastoma	Enrichment	JAG1	0.60
256	Jeune thoracic dystrophy	Enrichment	LBR	0.60
257	Hepatocellular carcinoma	Enrichment	PIK3CA	0.58
258	Asphyxiating thoracic dystrophy	Enrichment	LBR	0.56
259	Severe covid-19	Enrichment	DOCK8	0.54
260	Tetralogy of fallot	Enrichment	JAG1	0.52
261	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	LBR	0.50
262	Severe combined immunodeficiency	Enrichment	DOCK8	0.50
263	Cakut	Enrichment	SRGAP1	0.49
264	Bladder cancer	Enrichment	PIK3CA	0.48
265	Prostate cancer	Enrichment	PIK3CA	0.48
266	Non-syndromic x-linked intellectual disability	Enrichment	ARHGEF6	0.47
267	Developmental and epileptic encephalopathy	Enrichment	ARHGEF15	0.47
268	Lung cancer	Enrichment	PIK3CA	0.45
269	Primary autosomal recessive microcephaly	Enrichment	CIT	0.45
270	Cerebral palsy	Enrichment	ARHGAP31	0.44
271	Charcot-marie-tooth disease	Enrichment	ARHGEF10	0.42
272	Myopathy	Enrichment	EMD	0.37
273	Thrombocytopenia	Enrichment	WAS	0.37
274	Gastric cancer	Enrichment	PIK3CA	0.35
275	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	DIAPH3	0.34
276	Hereditary breast carcinoma	Enrichment	PIK3CA	0.34
277	Familial isolated dilated cardiomyopathy	Enrichment	TMPO	0.34
278	Myeloma, multiple	Enrichment	PIK3R2	0.32
279	Hypertelorism	Enrichment	PIK3CA	0.29
280	Undetermined early-onset epileptic encephalopathy	Enrichment	CYFIP2	0.27
281	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	ALS2	0.26
282	Dilated cardiomyopathy	Enrichment	JUP	0.22
283	Autism	Enrichment	DOCK4	0.20
284	Breast cancer	Enrichment	PIK3CA	0.19
285	Congenital nervous system abnormality	Enrichment	OPHN1	0.15
286	Nervous system disease	Enrichment	OPHN1	0.15
287	Autism spectrum disorder	Enrichment	CDC42BPB	0.14
288	Ovarian cancer	Enrichment	PIK3CA	0.12
289	Hereditary retinal dystrophy	Enrichment	ARHGEF18, JAG1	0.04
290	Fundus dystrophy	Enrichment	ARHGEF18, JAG1	0.04
291	Retinitis pigmentosa	Enrichment	ARHGEF18	0.02

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RAC1 GTPase cycle

Pathway Network for RAC1 GTPase cycle

Member Pathways for RAC1 GTPase cycle

Pathways in the RAC1 GTPase cycle SuperPath

Associated Genes for RAC1 GTPase cycle

Associated Disorders for RAC1 GTPase cycle

Disorders associated with RAC1 GTPase cycle SuperPath

STRING Interaction Network for RAC1 GTPase cycle

Sources for RAC1 GTPase cycle