RAC2 GTPase cycle

Pathway network for the RAC2 GTPase cycle SuperPath

Sources:

Reactome

Pathways in the RAC2 GTPase cycle SuperPath

#	Name	Source	Genes
1	RAC2 GTPase cycle	Reactome	ABI1 ABI2 ABR ANKLE2 ARHGAP1 ARHGAP17 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP42 ARHGDIA ARMCX3 BAIAP2L1 BCR BRK1 CAV1 CDC42 CDC42EP1 CDC42EP4 CYBA CYBB CYFIP1 DEF6 DEPDC1B DIAPH3 DOCK1 DOCK10 DOCK2 DOCK3 DOCK4 EMD EPHA2 ERBIN ESYT1 GARRE1 GIT1 GIT2 IQGAP1 ITGB1 LAMTOR1 LBR LEMD3 LMAN1 MCAM MCF2 MPP7 MTX1 NCF1 NCF2 NCF4 NCKAP1 NCKAP1L NHS OPHN1 PAK1 PAK2 PAK4 PGRMC2 PIK3CA PIK3R1 PIK3R2 PIK3R3 PLD2 PREX1 RAB7A RAC2 RACGAP1 SAMM50 SLITRK5 STBD1 SWAP70 SYDE1 TAOK3 TFRC TIAM1 TMPO TRIO VAMP3 VANGL1 VAPB VAV1 VAV2 VAV3 VRK2 WASF2 (see all 87) (see less)
2	RAC3 GTPase cycle	Reactome	ABI1 ABI2 ABL2 ABR AMIGO2 ARAP2 ARAP3 ARHGAP1 ARHGAP15 ARHGAP17 ARHGAP21 ARHGAP26 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP42 ARHGAP5 ARHGAP6 ARHGDIB BAIAP2 BAIAP2L1 BCR BRK1 CAV1 CDC42 CDC42EP1 CYBA CYBB CYFIP1 DEPDC1B DIAPH3 DOCK10 EMD EPHA2 ERBIN ESYT1 FERMT2 GARRE1 GIT1 GIT2 IL32 ITGB1 JAG1 LAMTOR1 LBR LEMD3 LMAN1 MCAM MCF2 MPP7 NCF1 NCF2 NCF4 NCKAP1 NCKAP1L NHS NOX1 NOX3 NOXA1 NOXO1 OCRL OPHN1 PAK1 PAK2 PAK4 PGRMC2 PIK3R1 PIK3R2 PREX1 RAB7A RAC3 RACGAP1 RAPGEF1 SLC1A5 SLITRK3 SLITRK5 SNAP23 SRGAP2 STBD1 SWAP70 SYDE1 TAOK3 TFRC TIAM1 TMPO TRIO VAMP3 VANGL1 VAV2 VRK2 WASF1 WASF2 YKT6 (see all 93) (see less)
3	RHOG GTPase cycle	Reactome	ANKLE2 ARFGAP3 ARHGAP1 ARHGAP21 ARHGAP32 ARHGAP35 ARHGAP39 ARHGAP5 ARHGDIA ARHGDIB ARHGDIG ARHGEF16 ARHGEF26 ARHGEF5 CAV1 CDC42 CDC42EP1 CYFIP1 DEPDC1B DIAPH3 DOCK1 DOCK2 DOCK3 DOCK4 DOCK5 ELMO2 EMD EPHA2 ERBIN ESYT1 GARRE1 HSPE1 IQGAP2 ITGB1 ITSN1 KALRN KTN1 LAMTOR1 LBR LEMD3 LETM1 LMAN1 MAP3K11 MCAM MCF2 MCF2L MPP7 NDUFA5 NDUFS3 OPHN1 PAK2 PAK4 PGRMC2 PIK3R1 PLD1 PLEKHG3 PREX1 RAB7A RHOG SHMT2 STBD1 STX5 TFRC TMPO TRIO VAMP3 VANGL1 VAPB VAV1 VAV2 VAV3 VRK2 YKT6 (see all 73) (see less)

Gene overlap in member pathways for RAC2 GTPase cycle SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	3
2	PGRMC2	Progesterone Receptor Membrane Component 2	Protein Coding	3
3	CDC42EP1	CDC42 Effector Protein 1	Protein Coding	3
4	MPP7	MAGUK P55 Scaffold Protein 7	Protein Coding	3
5	EPHA2	EPH Receptor A2	Protein Coding	3
6	EMD	Emerin	Protein Coding	3
7	CYFIP1	Cytoplasmic FMR1 Interacting Protein 1	Protein Coding	3
8	ESYT1	Extended Synaptotagmin 1	Protein Coding	3
9	LEMD3	LEM Domain Containing 3	Protein Coding	3
10	ARHGAP35	Rho GTPase Activating Protein 35	Protein Coding	3
11	ITGB1	Integrin Subunit Beta 1	Protein Coding	3
12	ARHGAP1	Rho GTPase Activating Protein 1	Protein Coding	3
13	LBR	Lamin B Receptor	Protein Coding	3
14	LMAN1	Lectin, Mannose Binding 1	Protein Coding	3
15	MCAM	Melanoma Cell Adhesion Molecule	Protein Coding	3
16	MCF2	MCF.2 Cell Line Derived Transforming Sequence	Protein Coding	3
17	OPHN1	Oligophrenin 1	Protein Coding	3
18	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	3
19	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	3
20	LAMTOR1	Late Endosomal/Lysosomal Adaptor, MAPK And MTOR Activator 1	Protein Coding	3
21	DEPDC1B	DEP Domain Containing 1B	Protein Coding	3
22	ERBIN	Erbb2 Interacting Protein	Protein Coding	3
23	PREX1	Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1	Protein Coding	3
24	ARHGAP21	Rho GTPase Activating Protein 21	Protein Coding	3
25	TFRC	Transferrin Receptor	Protein Coding	3
26	TMPO	Thymopoietin	Protein Coding	3
27	TRIO	Trio Rho Guanine Nucleotide Exchange Factor	Protein Coding	3
28	VAV2	Vav Guanine Nucleotide Exchange Factor 2	Protein Coding	3
29	VRK2	VRK Serine/Threonine Kinase 2	Protein Coding	3
30	RAB7A	RAB7A, Member RAS Oncogene Family	Protein Coding	3
31	ARHGAP39	Rho GTPase Activating Protein 39	Protein Coding	3
32	DIAPH3	Diaphanous Related Formin 3	Protein Coding	3
33	VANGL1	VANGL Planar Cell Polarity Protein 1	Protein Coding	3
34	CAV1	Caveolin 1	Protein Coding	3
35	STBD1	Starch Binding Domain 1	Protein Coding	3
36	VAMP3	Vesicle Associated Membrane Protein 3	Protein Coding	3
37	GARRE1	Granule Associated Rac And RHOG Effector 1	Protein Coding	3
38	ARHGAP32	Rho GTPase Activating Protein 32	Protein Coding	3
39	CDC42	Cell Division Cycle 42	Protein Coding	3
40	ABI1	Abl Interactor 1	Protein Coding	2
41	ABI2	Abl Interactor 2	Protein Coding	2
42	WASF2	WASP Family Member 2	Protein Coding	2
43	VAV3	Vav Guanine Nucleotide Exchange Factor 3	Protein Coding	2
44	NCKAP1	NCK Associated Protein 1	Protein Coding	2
45	ARHGAP42	Rho GTPase Activating Protein 42	Protein Coding	2
46	CYBA	Cytochrome B-245 Alpha Chain	Protein Coding	2
47	CYBB	Cytochrome B-245 Beta Chain	Protein Coding	2
48	DOCK1	Dedicator Of Cytokinesis 1	Protein Coding	2
49	DOCK2	Dedicator Of Cytokinesis 2	Protein Coding	2
50	DOCK3	Dedicator Of Cytokinesis 3	Protein Coding	2
51	SWAP70	Switching B Cell Complex Subunit SWAP70	Protein Coding	2
52	ARHGAP26	Rho GTPase Activating Protein 26	Protein Coding	2
53	ANKLE2	Ankyrin Repeat And LEM Domain Containing 2	Protein Coding	2
54	SLITRK5	SLIT And NTRK Like Family Member 5	Protein Coding	2
55	GIT1	GIT ArfGAP 1	Protein Coding	2
56	ABR	ABR Activator Of RhoGEF And GTPase	Protein Coding	2
57	RACGAP1	Rac GTPase Activating Protein 1	Protein Coding	2
58	NCKAP1L	NCK Associated Protein 1 Like	Protein Coding	2
59	ARHGDIA	Rho GDP Dissociation Inhibitor Alpha	Protein Coding	2
60	NCF2	Neutrophil Cytosolic Factor 2	Protein Coding	2
61	NCF4	Neutrophil Cytosolic Factor 4	Protein Coding	2
62	NHS	NHS Actin Remodeling Regulator	Protein Coding	2
63	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	2
64	TAOK3	TAO Kinase 3	Protein Coding	2
65	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	2
66	ARHGAP17	Rho GTPase Activating Protein 17	Protein Coding	2
67	DOCK10	Dedicator Of Cytokinesis 10	Protein Coding	2
68	BRK1	BRICK1 Subunit Of SCAR/WAVE Actin Nucleating Complex	Protein Coding	2
69	BAIAP2L1	BAR/IMD Domain Containing Adaptor Protein 2 Like 1	Protein Coding	2
70	BCR	BCR Activator Of RhoGEF And GTPase	Protein Coding	2
71	NCF1	Neutrophil Cytosolic Factor 1	Protein Coding	2
72	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	2
73	VAV1	Vav Guanine Nucleotide Exchange Factor 1	Protein Coding	2
74	SYDE1	Synapse Defective Rho GTPase Activating Protein 1	Protein Coding	2
75	VAPB	VAMP Associated Protein B And C	Protein Coding	2
76	DOCK4	Dedicator Of Cytokinesis 4	Protein Coding	2
77	GIT2	GIT ArfGAP 2	Protein Coding	2
78	YKT6	YKT6 Vesicular SNARE Protein	Protein Coding	2
79	ARHGAP5	Rho GTPase Activating Protein 5	Protein Coding	2
80	ARHGDIB	Rho GDP Dissociation Inhibitor Beta	Protein Coding	2
81	CDC42EP4	CDC42 Effector Protein 4	Protein Coding	1
82	SAMM50	SAMM50 Sorting And Assembly Machinery Component	Protein Coding	1
83	MTX1	Metaxin 1	Protein Coding	1
84	DEF6	DEF6 Guanine Nucleotide Exchange Factor	Protein Coding	1
85	ARMCX3	Armadillo Repeat Containing X-Linked 3	Protein Coding	1
86	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
87	PLD2	Phospholipase D2	Protein Coding	1
88	RAC2	Rac Family Small GTPase 2	Protein Coding	1
89	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
90	IQGAP1	IQ Motif Containing GTPase Activating Protein 1	Protein Coding	1
91	BAIAP2	BAR/IMD Domain Containing Adaptor Protein 2	Protein Coding	1
92	NOXA1	NADPH Oxidase Activator 1	Protein Coding	1
93	FERMT2	FERM Domain Containing Kindlin 2	Protein Coding	1
94	ARAP2	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2	Protein Coding	1
95	NOXO1	NADPH Oxidase Organizer 1	Protein Coding	1
96	JAG1	Jagged Canonical Notch Ligand 1	Protein Coding	1
97	SLITRK3	SLIT And NTRK Like Family Member 3	Protein Coding	1
98	SRGAP2	SLIT-ROBO Rho GTPase Activating Protein 2	Protein Coding	1
99	ABL2	ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase	Protein Coding	1
100	NOX1	NADPH Oxidase 1	Protein Coding	1
101	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
102	AMIGO2	Adhesion Molecule With Ig Like Domain 2	Protein Coding	1
103	ARHGAP6	Rho GTPase Activating Protein 6	Protein Coding	1
104	OCRL	OCRL Inositol Polyphosphate-5-Phosphatase	Protein Coding	1
105	NOX3	NADPH Oxidase 3	Protein Coding	1
106	ARHGAP15	Rho GTPase Activating Protein 15	Protein Coding	1
107	RAC3	Rac Family Small GTPase 3	Protein Coding	1
108	ARAP3	ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 3	Protein Coding	1
109	SLC1A5	Solute Carrier Family 1 Member 5	Protein Coding	1
110	SNAP23	Synaptosome Associated Protein 23	Protein Coding	1
111	WASF1	WASP Family Member 1	Protein Coding	1
112	IL32	Interleukin 32	Protein Coding	1
113	IQGAP2	IQ Motif Containing GTPase Activating Protein 2	Protein Coding	1
114	MCF2L	MCF.2 Cell Line Derived Transforming Sequence Like	Protein Coding	1
115	PLEKHG3	Pleckstrin Homology And RhoGEF Domain Containing G3	Protein Coding	1
116	ARHGEF26	Rho Guanine Nucleotide Exchange Factor 26	Protein Coding	1
117	ARFGAP3	ARF GTPase Activating Protein 3	Protein Coding	1
118	ARHGEF16	Rho Guanine Nucleotide Exchange Factor 16	Protein Coding	1
119	HSPE1	Heat Shock Protein Family E (Hsp10) Member 1	Protein Coding	1
120	KTN1	Kinectin 1	Protein Coding	1
121	RHOG	Ras Homolog Family Member G	Protein Coding	1
122	LETM1	Leucine Zipper And EF-Hand Containing Transmembrane Protein 1	Protein Coding	1
123	ARHGDIG	Rho GDP Dissociation Inhibitor Gamma	Protein Coding	1
124	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
125	NDUFA5	NADH:Ubiquinone Oxidoreductase Subunit A5	Protein Coding	1
126	NDUFS3	NADH:Ubiquinone Oxidoreductase Core Subunit S3	Protein Coding	1
127	PLD1	Phospholipase D1	Protein Coding	1
128	ELMO2	Engulfment And Cell Motility 2	Protein Coding	1
129	ITSN1	Intersectin 1	Protein Coding	1
130	SHMT2	Serine Hydroxymethyltransferase 2	Protein Coding	1
131	STX5	Syntaxin 5	Protein Coding	1
132	ARHGEF5	Rho Guanine Nucleotide Exchange Factor 5	Protein Coding	1
133	DOCK5	Dedicator Of Cytokinesis 5	Protein Coding	1
134	KALRN	Kalirin RhoGEF Kinase	Protein Coding	1

Disorders associated with RAC2 GTPase cycle SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Chronic granulomatous disease	Enrichment	CYBA, CYBB, NCF1, NCF2, NCF4	8.92
2	Immunodeficiency 72 with autoinflammation and lymphoproliferation	Enrichment	NCKAP1, NCKAP1L	4.39
3	Immunodeficiency 72	Enrichment	NCKAP1, NCKAP1L	4.39
4	Granulomatous disease, chronic, autosomal recessive, 2	Enrichment	NCF1, NCF2	3.92
5	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.92
6	Granulomatous disease, chronic, x-linked	Enrichment	CYBB, NCF1	3.62
7	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA, PIK3R2	3.62
8	Martsolf syndrome 1	Enrichment	ARHGAP35, ARHGAP5	3.55
9	Neural tube defects	Enrichment	ITGB1, VANGL1	2.67
10	Cataract 44	Enrichment	EPHA2, NHS	2.28
11	Buschke-ollendorff syndrome	Enrichment	LEMD3	2.27
12	Ramon syndrome	Enrichment	ELMO2	2.27
13	Lipodystrophy, congenital generalized, type 3	Enrichment	CAV1	2.27
14	Cardiac valvular dysplasia 1	Enrichment	PLD1	2.27
15	Nephrotic syndrome, type 8	Enrichment	ARHGDIA	2.27
16	Greenberg dysplasia	Enrichment	LBR	2.27
17	Pulmonary hypertension, primary, 3	Enrichment	CAV1	2.27
18	Pelger-huet anomaly	Enrichment	LBR	2.27
19	Microcephaly 16, primary, autosomal recessive	Enrichment	ANKLE2	2.27
20	Spinal muscular atrophy, late-onset, finkel type	Enrichment	VAPB	2.27
21	Intellectual developmental disorder, x-linked, syndromic, billuart type	Enrichment	OPHN1	2.27
22	Rhizomelic skeletal dysplasia with or without pelger-huet anomaly	Enrichment	LBR	2.27
23	Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction	Enrichment	LETM1	2.27
24	Knobloch syndrome 2	Enrichment	PAK2	2.27
25	Charcot-marie-tooth disease, axonal, type 2b	Enrichment	RAB7A	2.27
26	Short syndrome	Enrichment	PIK3R1	2.27
27	Mitochondrial complex i deficiency, nuclear type 8	Enrichment	NDUFS3	2.27
28	Charcot-marie-tooth disease type 2b	Enrichment	RAB7A	2.27
29	Vascular malformation, primary intraosseous	Enrichment	ELMO2	2.27
30	Lipodystrophy, familial partial, type 7	Enrichment	CAV1	2.27
31	Amyotrophic lateral sclerosis 8	Enrichment	VAPB	2.27
32	Auditory neuropathy, autosomal dominant 1	Enrichment	DIAPH3	2.27
33	Immunodeficiency 40	Enrichment	DOCK2	2.27
34	Congenital disorder of glycosylation, type iiaa	Enrichment	STX5	2.27
35	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.27
36	Immunodeficiency 46	Enrichment	TFRC	2.27
37	Neurodevelopmental disorder with cardiomyopathy, spasticity, and brain abnormalities	Enrichment	SHMT2	2.27
38	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.27
39	Reynolds syndrome	Enrichment	LBR	2.27
40	Takenouchi-kosaki syndrome	Enrichment	CDC42	2.27
41	Intellectual developmental disorder, autosomal dominant 63, with macrocephaly	Enrichment	TRIO	2.27
42	Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia	Enrichment	DOCK3	2.27
43	Melorheostosis with osteopoikilosis	Enrichment	LEMD3	2.27
44	Primary intraosseous venous malformation	Enrichment	ELMO2	2.27
45	Autosomal dominant adult-onset proximal spinal muscular atrophy	Enrichment	VAPB	2.27
46	Nocarh syndrome	Enrichment	CDC42	2.27
47	Isolated osteopoikilosis	Enrichment	LEMD3	2.27
48	Autosomal dominant combined immunodeficiency due to erbin deficiency	Enrichment	ERBIN	2.27
49	Temporomandibular joint anomaly	Enrichment	DOCK1	2.27
50	Early-onset nuclear cataract	Enrichment	EPHA2, NHS	2.24
51	Macrodactyly	Enrichment	PIK3CA	2.19
52	Granulomatous disease, chronic, autosomal recessive, 4	Enrichment	CYBA	2.19
53	Nance-horan syndrome	Enrichment	NHS	2.19
54	Immunodeficiency 34	Enrichment	CYBB	2.19
55	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	2.19
56	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.19
57	Cowden syndrome 5	Enrichment	PIK3CA	2.19
58	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.19
59	Immunodeficiency 87 and autoimmunity	Enrichment	DEF6	2.19
60	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	2.19
61	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	2.19
62	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.19
63	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.19
64	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	2.19
65	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	2.19
66	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.19
67	Hypospadias	Enrichment	PIK3CA	2.19
68	Congenital dyserythropoietic anemia type iiib	Enrichment	RACGAP1	2.19
69	Rare venous malformation	Enrichment	PIK3CA	2.19
70	Diaphragmatic eventration	Enrichment	PIK3CA	2.19
71	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	2.19
72	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	2.19
73	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.19
74	Rare combined vascular malformation	Enrichment	PIK3CA	2.19
75	Anemia, congenital dyserythropoietic, type iiib, autosomal recessive	Enrichment	RACGAP1	2.19
76	Cavernous lymphangioma	Enrichment	PIK3CA	2.19
77	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.19
78	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.19
79	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.19
80	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	2.19
81	Macrodactyly of toe	Enrichment	PIK3CA	2.19
82	Neurodevelopmental disorder with absent language and variable seizures	Enrichment	WASF1	2.16
83	Charcot-marie-tooth disease, axonal, type 2hh	Enrichment	JAG1	2.16
84	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	2.16
85	Lowe oculocerebrorenal syndrome	Enrichment	OCRL	2.16
86	Deafness, congenital heart defects, and posterior embryotoxon	Enrichment	JAG1	2.16
87	Myopathy, x-linked, with postural muscle atrophy	Enrichment	EMD	1.97
88	Deafness, autosomal recessive 28	Enrichment	TRIO	1.97
89	Osteopoikilosis	Enrichment	LEMD3	1.97
90	Immune system disease	Enrichment	CDC42	1.97
91	Combined deficiency of factor v and factor viii	Enrichment	LMAN1	1.97
92	12q14 microdeletion syndrome	Enrichment	LEMD3	1.97
93	X-linked emery-dreifuss muscular dystrophy	Enrichment	EMD	1.97
94	Anemia, congenital dyserythropoietic, type iiia	Enrichment	RACGAP1	1.89
95	Granulomatous disease, chronic, autosomal recessive, 1	Enrichment	NCF1	1.89
96	Cataract 40	Enrichment	NHS	1.89
97	Keratosis, seborrheic	Enrichment	PIK3CA	1.89
98	Granulomatous disease, chronic, autosomal recessive, 3	Enrichment	NCF4	1.89
99	Noonan syndrome 8	Enrichment	PIK3CA	1.89
100	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	1.89
101	Syndromic x-linked intellectual disability	Enrichment	NHS	1.89
102	Dent disease 2	Enrichment	OCRL	1.86
103	Factor v and factor viii, combined deficiency of, 1	Enrichment	LMAN1	1.79
104	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	1.79
105	Intellectual developmental disorder, autosomal dominant 44, with microcephaly	Enrichment	TRIO	1.79
106	Immunodeficiency 14	Enrichment	PIK3R1	1.79
107	Autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia	Enrichment	CYBA	1.72
108	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.72
109	Chromosome 8p11 myeloproliferative syndrome	Enrichment	BCR	1.72
110	Autoimmune polyendocrine syndrome type 1	Enrichment	CYBA	1.72
111	Keratoacanthoma	Enrichment	PIK3CA	1.72
112	Alagille syndrome 1	Enrichment	JAG1	1.69
113	Dent disease	Enrichment	OCRL	1.69
114	Intellectual developmental disorder, autosomal dominant 1	Enrichment	ITSN1	1.67
115	Emery-dreifuss muscular dystrophy 1, x-linked	Enrichment	EMD	1.67
116	Sacral defect with anterior meningocele	Enrichment	VANGL1	1.67
117	Emery-dreifuss muscular dystrophy	Enrichment	EMD	1.67
118	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42	1.67
119	Oligohydramnios	Enrichment	OPHN1	1.67
120	Knobloch syndrome	Enrichment	PAK2	1.67
121	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	BCR	1.59
122	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	PIK3R2	1.59
123	Cerebrovascular disease	Enrichment	PIK3CA	1.59
124	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.59
125	Cataract 6, multiple types	Enrichment	EPHA2	1.57
126	Knobloch syndrome 1	Enrichment	PAK2	1.57
127	Aniridia	Enrichment	EPHA2	1.57
128	Diffuse cutaneous systemic sclerosis	Enrichment	CAV1	1.57
129	Middle aortic syndrome	Enrichment	JAG1	1.57
130	Capillary malformations, congenital	Enrichment	PIK3CA	1.50
131	Hemimegalencephaly	Enrichment	PIK3CA	1.50
132	Wolf-hirschhorn syndrome	Enrichment	LETM1	1.50
133	Anterior segment dysgenesis 5	Enrichment	ARHGAP35	1.50
134	Limited scleroderma	Enrichment	CAV1	1.50
135	Overgrowth syndrome	Enrichment	PIK3R1	1.43
136	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.42
137	Cowden syndrome 1	Enrichment	PIK3CA	1.42
138	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.42
139	Breast adenocarcinoma	Enrichment	PIK3CA	1.42
140	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.42
141	Early-onset posterior polar cataract	Enrichment	EPHA2	1.37
142	Nevus, epidermal	Enrichment	PIK3CA	1.36
143	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.36
144	Leukemia, chronic myeloid	Enrichment	BCR	1.36
145	Gallbladder cancer	Enrichment	PIK3CA	1.36
146	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	BCR	1.36
147	Coronary heart disease 5	Enrichment	KALRN	1.32
148	Leukoencephalopathy with vanishing white matter	Enrichment	ANKLE2	1.32
149	Peters-plus syndrome	Enrichment	ARHGAP35	1.28
150	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.28
151	Complex neurodevelopmental disorder	Enrichment	RAC3, TIAM1, WASF1	1.27
152	Cardiomyopathy, familial hypertrophic, 4	Enrichment	NCF1	1.25
153	Arteriovenous malformation	Enrichment	PIK3CA	1.25
154	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.25
155	Cowden syndrome	Enrichment	PIK3CA	1.25
156	Combined immunodeficiency	Enrichment	TFRC	1.24
157	Combined t cell and b cell immunodeficiency	Enrichment	TFRC	1.24
158	Heritable pulmonary arterial hypertension	Enrichment	CAV1	1.24
159	Combined t and b cell immunodeficiency	Enrichment	TFRC	1.24
160	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.21
161	Amelogenesis imperfecta, type ie	Enrichment	ARHGAP6	1.18
162	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.17
163	Cataract	Enrichment	EPHA2	1.14
164	Juvenile myelomonocytic leukemia	Enrichment	ARHGAP26	1.13
165	Meningioma	Enrichment	PIK3CA	1.13
166	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.13
167	Amelogenesis imperfecta	Enrichment	ARHGAP6	1.07
168	Syndromic intellectual disability	Enrichment	TRIO	1.06
169	Lynch syndrome	Enrichment	PIK3CA	1.04
170	Neuromuscular disease	Enrichment	EMD	1.03
171	Arteriovenous malformations of the brain	Enrichment	LEMD3	1.01
172	Neuropathy, hereditary motor and sensory, okinawa type	Enrichment	EMD	1.01
173	Esophageal atresia/tracheoesophageal fistula	Enrichment	ITSN1	1.01
174	Colorectal cancer	Enrichment	PIK3CA, PIK3R1	0.97
175	Heart, malformation of	Enrichment	JAG1	0.93
176	Williams-beuren syndrome	Enrichment	NCF1	0.92
177	Jeune thoracic dystrophy	Enrichment	LBR	0.90
178	Endometrial cancer	Enrichment	PIK3CA	0.90
179	Hepatocellular carcinoma	Enrichment	PIK3CA	0.88
180	Hepatoblastoma	Enrichment	JAG1	0.87
181	Precursor t-cell acute lymphoblastic leukemia	Enrichment	BCR	0.86
182	Asphyxiating thoracic dystrophy	Enrichment	LBR	0.85
183	Microcephaly	Enrichment	ANKLE2, TRIO	0.85
184	Primary autosomal recessive microcephaly	Enrichment	ANKLE2	0.80
185	Short-rib thoracic dysplasia 1 with or without polydactyly	Enrichment	LBR	0.79
186	Tetralogy of fallot	Enrichment	JAG1	0.79
187	Genetic steroid-resistant nephrotic syndrome	Enrichment	ARHGDIA	0.78
188	Bladder cancer	Enrichment	PIK3CA	0.77
189	Prostate cancer	Enrichment	PIK3CA	0.77
190	Mitochondrial complex i deficiency, nuclear type 1	Enrichment	NDUFS3	0.73
191	Lung cancer	Enrichment	PIK3CA	0.73
192	Myopathy	Enrichment	EMD	0.71
193	Autosomal dominant non-syndromic intellectual disability	Enrichment	ITSN1	0.63
194	Gastric cancer	Enrichment	PIK3CA	0.62
195	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	DIAPH3	0.61
196	Hereditary breast carcinoma	Enrichment	PIK3CA	0.61
197	Familial isolated dilated cardiomyopathy	Enrichment	TMPO	0.60
198	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	VAPB	0.57
199	Hypertelorism	Enrichment	PIK3CA	0.55
200	Myeloma, multiple	Enrichment	PIK3R2	0.52
201	Autism	Enrichment	DOCK4	0.49
202	Dilated cardiomyopathy	Enrichment	EMD	0.45
203	Breast cancer	Enrichment	PIK3CA	0.42
204	Congenital nervous system abnormality	Enrichment	OPHN1	0.36
205	Nervous system disease	Enrichment	OPHN1	0.36
206	Ovarian cancer	Enrichment	PIK3CA	0.32
207	Hereditary retinal dystrophy	Enrichment	JAG1	0.06
208	Fundus dystrophy	Enrichment	JAG1	0.06

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RAC2 GTPase cycle

Pathway Network for RAC2 GTPase cycle

Pathway network for the RAC2 GTPase cycle SuperPath

Member Pathways for RAC2 GTPase cycle

Pathways in the RAC2 GTPase cycle SuperPath

Gene overlap in member pathways for RAC2 GTPase cycle SuperPath

Associated Genes for RAC2 GTPase cycle

Associated Disorders for RAC2 GTPase cycle

Disorders associated with RAC2 GTPase cycle SuperPath

STRING Interaction Network for RAC2 GTPase cycle

Sources for RAC2 GTPase cycle