RAF-independent MAPK1/3 activation

Pathway network for the RAF-independent MAPK1/3 activation SuperPath

Sources:

Reactome

Pathways in the RAF-independent MAPK1/3 activation SuperPath

#	Name	Source	Genes
1	RAF-independent MAPK1/3 activation	Reactome	CDK1 DUSP1 DUSP10 DUSP16 DUSP2 DUSP4 DUSP5 DUSP6 DUSP7 DUSP8 DUSP9 IL6 IL6R IL6ST JAK1 JAK2 MAP2K1 MAP2K2 MAPK1 MAPK3 PEA15 PTPN11 TYK2 (see all 23) (see less)
2	MAPK3 (ERK1) activation	Reactome	CDK1 IL6 IL6R IL6ST JAK1 JAK2 MAP2K1 MAPK3 PTPN11 TYK2 (see all 10) (see less)
3	MAPK1 (ERK2) activation	Reactome	IL6 IL6R IL6ST JAK1 JAK2 MAP2K2 MAPK1 PTPN11 TYK2 (see all 9) (see less)
4	Signaling by MAPK mutants	Reactome	DUSP10 DUSP16 DUSP6 DUSP7 DUSP8 DUSP9 MAPK1 (see all 7) (see less)

Gene overlap in member pathways for RAF-independent MAPK1/3 activation SuperPath

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	IL6	Interleukin 6	Protein Coding	3
2	IL6R	Interleukin 6 Receptor	Protein Coding	3
3	IL6ST	Interleukin 6 Cytokine Family Signal Transducer	Protein Coding	3
4	JAK1	Janus Kinase 1	Protein Coding	3
5	JAK2	Janus Kinase 2	Protein Coding	3
6	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	3
7	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	3
8	TYK2	Tyrosine Kinase 2	Protein Coding	3
9	DUSP10	Dual Specificity Phosphatase 10	Protein Coding	2
10	DUSP6	Dual Specificity Phosphatase 6	Protein Coding	2
11	DUSP7	Dual Specificity Phosphatase 7	Protein Coding	2
12	DUSP8	Dual Specificity Phosphatase 8	Protein Coding	2
13	DUSP9	Dual Specificity Phosphatase 9	Protein Coding	2
14	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	2
15	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	2
16	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	2
17	DUSP16	Dual Specificity Phosphatase 16	Protein Coding	2
18	CDK1	Cyclin Dependent Kinase 1	Protein Coding	2
19	DUSP1	Dual Specificity Phosphatase 1	Protein Coding	1
20	DUSP2	Dual Specificity Phosphatase 2	Protein Coding	1
21	DUSP4	Dual Specificity Phosphatase 4	Protein Coding	1
22	DUSP5	Dual Specificity Phosphatase 5	Protein Coding	1
23	PEA15	Proliferation And Apoptosis Adaptor Protein 15	Protein Coding	1

Disorders associated with RAF-independent MAPK1/3 activation SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Breast implant-associated anaplastic large cell lymphoma	Enrichment	JAK1, JAK2	5.93
2	Noonan syndrome and noonan-related syndrome	Enrichment	MAP2K1, MAP2K2, PTPN11	5.72
3	Noonan syndrome 1	Enrichment	MAP2K1, MAP2K2, PTPN11	5.13
4	Rasopathy	Enrichment	MAP2K1, MAP2K2, PTPN11	4.97
5	Cardiofaciocutaneous syndrome 1	Enrichment	MAP2K1, MAP2K2	4.78
6	Cardiofaciocutaneous syndrome	Enrichment	MAP2K1, MAP2K2	4.78
7	Specific learning disability	Enrichment	MAPK1, PTPN11	4.67
8	Noonan syndrome 13	Enrichment	MAPK1	3.29
9	Hypogonadotropic hypogonadism 19 with or without anosmia	Enrichment	DUSP6	3.29
10	Metachondromatosis	Enrichment	PTPN11	3.18
11	Immunodeficiency 35	Enrichment	TYK2	3.18
12	Leopard syndrome 1	Enrichment	PTPN11	3.18
13	Stuve-wiedemann syndrome 2	Enrichment	IL6ST	3.18
14	Hyper-ige syndrome 4a, autosomal dominant, with recurrent infections	Enrichment	IL6ST	3.18
15	Interleukin 6, serum level of, quantitative trait locus	Enrichment	IL6R	3.18
16	Soluble interleukin-6 receptor, serum level of, quantitative trait locus	Enrichment	IL6R	3.18
17	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	3.18
18	Hyper-ige syndrome 5, autosomal recessive, with recurrent infections	Enrichment	IL6R	3.18
19	Hyper-ige syndrome 4b, autosomal recessive, with recurrent infections	Enrichment	IL6ST	3.18
20	Immunodeficiency 94 with autoinflammation and dysmorphic facies	Enrichment	IL6ST	3.18
21	Mendelian susceptibility to mycobacterial diseases due to partial jak1 deficiency	Enrichment	JAK1	3.18
22	Malignant astrocytoma	Enrichment	PTPN11	3.18
23	Melorheostosis, isolated	Enrichment	MAP2K1	3.13
24	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	3.13
25	Melorheostosis	Enrichment	MAP2K1	3.13
26	Thrombocythemia 3	Enrichment	JAK2	2.88
27	Werner syndrome	Enrichment	PTPN11	2.88
28	Autoinflammation, immune dysregulation, and eosinophilia	Enrichment	JAK1	2.88
29	Polycythemia	Enrichment	JAK2	2.88
30	Lymphomatoid papulosis	Enrichment	TYK2	2.88
31	Hypereosinophilic syndrome	Enrichment	JAK2	2.88
32	Tafro syndrome	Enrichment	MAP2K2	2.88
33	Primary cutaneous anaplastic large cell lymphoma	Enrichment	TYK2	2.88
34	Polycythemia vera	Enrichment	JAK2	2.70
35	Stuve-wiedemann syndrome 1	Enrichment	IL6ST	2.70
36	Tricuspid valve insufficiency	Enrichment	PTPN11	2.70
37	Stüve-wiedemann syndrome	Enrichment	IL6ST	2.70
38	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	2.69
39	Langerhans cell histiocytosis	Enrichment	MAP2K1	2.66
40	Kaposi sarcoma	Enrichment	IL6	2.58
41	Erythrocytosis, familial, 1	Enrichment	JAK2	2.58
42	Budd-chiari syndrome	Enrichment	JAK2	2.58
43	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2	2.58
44	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.58
45	Noonan syndrome with multiple lentigines	Enrichment	PTPN11	2.58
46	Systemic-onset juvenile idiopathic arthritis	Enrichment	IL6	2.58
47	Autism spectrum disorder	Enrichment	MAP2K1, PTPN11	2.56
48	Microcephaly	Enrichment	MAPK1, PTPN11	2.55
49	Rheumatoid arthritis, systemic juvenile	Enrichment	IL6	2.48
50	Lymphoma	Enrichment	PTPN11	2.48
51	Myeloproliferative neoplasm	Enrichment	JAK2	2.48
52	Type 1 diabetes mellitus	Enrichment	IL6	2.40
53	Patent ductus arteriosus	Enrichment	PTPN11	2.40
54	Myelofibrosis	Enrichment	JAK2	2.33
55	Noonan syndrome 3	Enrichment	PTPN11	2.33
56	Essential thrombocythemia	Enrichment	JAK2	2.33
57	Capillary malformation-arteriovenous malformation 1	Enrichment	MAP2K1	2.29
58	Inflammatory bowel disease 1	Enrichment	IL6	2.22
59	Leukemia, acute lymphoblastic 3	Enrichment	JAK2	2.22
60	Arteriovenous malformation	Enrichment	MAP2K1	2.18
61	Pectus excavatum	Enrichment	PTPN11	2.14
62	Myopathy, x-linked, with excessive autophagy	Enrichment	MAP2K1	2.13
63	Epicanthus	Enrichment	PTPN11	2.10
64	Juvenile myelomonocytic leukemia	Enrichment	PTPN11	2.10
65	Congenital long qt syndrome	Enrichment	PTPN11	2.10
66	Lung non-small cell carcinoma	Enrichment	MAP2K1	2.09
67	Heart, malformation of	Enrichment	MAPK1	2.03
68	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	DUSP6	2.03
69	Kallmann syndrome	Enrichment	DUSP6	1.93
70	Patent foramen ovale	Enrichment	PTPN11	1.93
71	Arteriovenous malformations of the brain	Enrichment	IL6	1.90
72	Scoliosis	Enrichment	PTPN11	1.80
73	Hydrops fetalis, nonimmune	Enrichment	PTPN11	1.77
74	Strabismus	Enrichment	PTPN11	1.75
75	Long qt syndrome 1	Enrichment	PTPN11	1.70
76	Non-immune hydrops fetalis	Enrichment	PTPN11	1.69
77	Leukemia, acute myeloid	Enrichment	JAK2	1.58
78	Type 2 diabetes mellitus	Enrichment	IL6	1.56
79	Hypertrophic cardiomyopathy	Enrichment	PTPN11	1.55
80	Thrombocytopenia	Enrichment	PTPN11	1.50
81	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	1.44
82	Primary ovarian insufficiency	Enrichment	JAK2	1.41
83	Inherited cancer-predisposing syndrome	Enrichment	PTPN11	1.07

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

RAF-independent MAPK1/3 activation

Pathway Network for RAF-independent MAPK1/3 activation

Pathway network for the RAF-independent MAPK1/3 activation SuperPath

Member Pathways for RAF-independent MAPK1/3 activation

Pathways in the RAF-independent MAPK1/3 activation SuperPath

Gene overlap in member pathways for RAF-independent MAPK1/3 activation SuperPath

Associated Genes for RAF-independent MAPK1/3 activation

Associated Disorders for RAF-independent MAPK1/3 activation

Disorders associated with RAF-independent MAPK1/3 activation SuperPath

STRING Interaction Network for RAF-independent MAPK1/3 activation

Sources for RAF-independent MAPK1/3 activation