Rap1 signalling

No Pathway Network information available for Rap1 signalling

Pathways in the Rap1 signalling SuperPath

#	Name	Source	Genes
1	Rap1 signalling	Reactome	PRKACA PRKACB PRKACG PRKG1 RAF1 RAP1A RAP1B RAP1GAP RAP1GAP2 RAPGEF3 RAPGEF4 RASGRP1 RASGRP2 SIPA1 YWHAB YWHAZ (see all 16) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	1
2	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
3	RAPGEF3	Rap Guanine Nucleotide Exchange Factor 3	Protein Coding	1
4	RAPGEF4	Rap Guanine Nucleotide Exchange Factor 4	Protein Coding	1
5	RAP1GAP2	RAP1 GTPase Activating Protein 2	Protein Coding	1
6	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
7	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
8	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
9	PRKG1	Protein Kinase CGMP-Dependent 1	Protein Coding	1
10	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
11	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
12	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
13	RAP1GAP	RAP1 GTPase Activating Protein	Protein Coding	1
14	SIPA1	Signal-Induced Proliferation-Associated 1	Protein Coding	1
15	YWHAB	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Beta	Protein Coding	1
16	YWHAZ	Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta	Protein Coding	1

Disorders associated with Rap1 signalling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	4.33
2	Noonan syndrome 5	Enrichment	RAF1	2.93
3	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	2.93
4	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	2.93
5	Aortic aneurysm, familial thoracic 8	Enrichment	PRKG1	2.93
6	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	2.93
7	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	2.93
8	Leopard syndrome 2	Enrichment	RAF1	2.93
9	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	2.93
10	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	2.93
11	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	2.93
12	Trigonitis	Enrichment	RAF1	2.93
13	Immunodeficiency 64	Enrichment	RASGRP1	2.93
14	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	2.93
15	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	2.63
16	Autoinflammatory disease, familial, behcet-like 3	Enrichment	SIPA1	2.63
17	Fibrolamellar carcinoma	Enrichment	PRKACA	2.63
18	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	YWHAZ	2.33
19	Noonan syndrome with multiple lentigines	Enrichment	RAF1	2.33
20	Noonan syndrome 3	Enrichment	RAF1	2.08
21	Pilomyxoid astrocytoma	Enrichment	RAF1	2.08
22	Melanocytic nevus syndrome, congenital	Enrichment	RAF1	2.03
23	Noonan syndrome and noonan-related syndrome	Enrichment	RAF1	1.76
24	Noonan syndrome 1	Enrichment	RAF1	1.57
25	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	1.55
26	Rasopathy	Enrichment	RAF1	1.52
27	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	1.42
28	Left ventricular noncompaction	Enrichment	RAF1	1.39
29	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	PRKG1	1.30
30	Autosomal dominant non-syndromic intellectual disability	Enrichment	YWHAZ	1.24
31	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	1.22
32	Dilated cardiomyopathy	Enrichment	RAF1	1.04

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for Rap1 signalling

Member Pathways for Rap1 signalling

Pathways in the Rap1 signalling SuperPath

Associated Genes for Rap1 signalling

Associated Disorders for Rap1 signalling

Disorders associated with Rap1 signalling SuperPath

STRING Interaction Network for Rap1 signalling

Sources for Rap1 signalling