RAS processing

No Pathway Network information available for RAS processing

Pathways in the RAS processing SuperPath

#	Name	Source	Genes
1	RAS processing	Reactome	ABHD17A ABHD17B ABHD17C ARL2 BCL2L1 CALM1 CALM2 CALM3 CHURC1-FNTB FNTA FNTB GOLGA7 HRAS ICMT KRAS LYPLA1 NRAS PDE6D PRKG2 RCE1 RPS27A UBA52 UBB UBC USP17L2 ZDHHC9 (see all 26) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	CHURC1-FNTB	CHURC1-FNTB Readthrough	Protein Coding	1
2	LYPLA1	Lysophospholipase 1	Protein Coding	1
3	FNTA	Farnesyltransferase, CAAX Box, Subunit Alpha	Protein Coding	1
4	FNTB	Farnesyltransferase, CAAX Box, Subunit Beta	Protein Coding	1
5	ICMT	Isoprenylcysteine Carboxyl Methyltransferase	Protein Coding	1
6	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
7	USP17L2	Ubiquitin Specific Peptidase 17 Like Family Member 2	Protein Coding	1
8	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
9	ARL2	ARF Like GTPase 2	Protein Coding	1
10	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
11	ABHD17B	Abhydrolase Domain Containing 17B, Depalmitoylase	Protein Coding	1
12	ZDHHC9	ZDHHC Palmitoyltransferase 9	Protein Coding	1
13	GOLGA7	Golgin A7	Protein Coding	1
14	PDE6D	Phosphodiesterase 6D	Protein Coding	1
15	PRKG2	Protein Kinase CGMP-Dependent 2	Protein Coding	1
16	ABHD17C	Abhydrolase Domain Containing 17C, Depalmitoylase	Protein Coding	1
17	BCL2L1	BCL2 Like 1	Protein Coding	1
18	RPS27A	Ribosomal Protein S27a	Protein Coding	1
19	UBA52	Ubiquitin A-52 Residue Ribosomal Protein Fusion Product 1	Protein Coding	1
20	UBB	Ubiquitin B	Protein Coding	1
21	UBC	Ubiquitin C	Protein Coding	1
22	CALM1	Calmodulin 1	Protein Coding	1
23	CALM2	Calmodulin 2	Protein Coding	1
24	CALM3	Calmodulin 3	Protein Coding	1
25	ABHD17A	Abhydrolase Domain Containing 17A, Depalmitoylase	Protein Coding	1
26	RCE1	Ras Converting CAAX Endopeptidase 1	Protein Coding	1

Disorders associated with RAS processing SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	7.60
2	Nevus, epidermal	Enrichment	HRAS, KRAS, NRAS	6.66
3	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	6.46
4	Lung non-small cell carcinoma	Enrichment	HRAS, KRAS, NRAS	5.99
5	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, NRAS	5.55
6	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	5.45
7	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	4.98
8	Noonan syndrome 1	Enrichment	HRAS, KRAS, NRAS	4.97
9	Rasopathy	Enrichment	HRAS, KRAS, NRAS	4.80
10	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	KRAS, NRAS	4.67
11	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS	4.66
12	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3	4.61
13	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	4.13
14	Leukemia, chronic myeloid	Enrichment	KRAS, NRAS	4.13
15	Noonan syndrome 3	Enrichment	HRAS, KRAS	4.13
16	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	4.13
17	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS	4.01
18	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NRAS	3.64
19	Bladder cancer	Enrichment	HRAS, KRAS	2.86
20	Long qt syndrome	Enrichment	CALM1, CALM2	2.80
21	Non-immune hydrops fetalis	Enrichment	HRAS, KRAS	2.80
22	Oculoectodermal syndrome	Enrichment	KRAS	2.72
23	Melanosis, neurocutaneous	Enrichment	NRAS	2.72
24	Noonan syndrome 6	Enrichment	NRAS	2.72
25	Joubert syndrome 22	Enrichment	PDE6D	2.72
26	Spondylometaphyseal dysplasia, pagnamenta type	Enrichment	PRKG2	2.72
27	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	2.72
28	Long qt syndrome 16	Enrichment	CALM3	2.72
29	Long qt syndrome 15	Enrichment	CALM2	2.72
30	Congenital pulmonary airway malformation	Enrichment	KRAS	2.72
31	Phakomatosis pigmentokeratotica	Enrichment	HRAS	2.72
32	Neurocutaneous melanocytosis	Enrichment	NRAS	2.72
33	Leukemia, acute myeloid	Enrichment	KRAS, NRAS	2.58
34	Costello syndrome	Enrichment	HRAS	2.42
35	Intellectual developmental disorder, x-linked, syndromic, raymond type	Enrichment	ZDHHC9	2.42
36	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	2.42
37	Encephalocraniocutaneous lipomatosis	Enrichment	KRAS	2.42
38	Long qt syndrome 14	Enrichment	CALM1	2.42
39	Acromesomelic dysplasia 4	Enrichment	PRKG2	2.42
40	Submucosal cleft palate	Enrichment	UBB	2.42
41	Cleft hard palate	Enrichment	UBB	2.42
42	Wooly hair nevus	Enrichment	HRAS	2.42
43	Intellectual developmental disorder, x-linked, syndromic, lujan-fryns type	Enrichment	ZDHHC9	2.24
44	Uvula, bifid	Enrichment	UBB	2.24
45	Langerhans cell histiocytosis	Enrichment	NRAS	2.24
46	Cleft soft palate	Enrichment	UBB	2.24
47	Microcornea, rod-cone dystrophy, cataract, and posterior staphyloma 1	Enrichment	ARL2	2.24
48	Spermatocytoma	Enrichment	HRAS	2.24
49	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS	2.12
50	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	2.12
51	Cardiofaciocutaneous syndrome	Enrichment	KRAS	2.12
52	Lung sarcomatoid carcinoma	Enrichment	KRAS	2.12
53	Pilocytic astrocytoma	Enrichment	KRAS	2.12
54	Epidermolytic nevus	Enrichment	HRAS	2.12
55	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.94
56	Breast adenocarcinoma	Enrichment	KRAS	1.94
57	Lung squamous cell carcinoma	Enrichment	KRAS	1.94
58	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS	1.87
59	Gallbladder cancer	Enrichment	KRAS	1.87
60	Pilomyxoid astrocytoma	Enrichment	KRAS	1.87
61	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	1.82
62	Arteriovenous malformation	Enrichment	HRAS	1.77
63	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS	1.72
64	Orofaciodigital syndrome vi	Enrichment	PDE6D	1.68
65	Lip and oral cavity carcinoma	Enrichment	HRAS	1.64
66	Protein-deficiency anemia	Enrichment	NRAS	1.61
67	Lung cancer susceptibility 3	Enrichment	KRAS	1.58
68	Lynch syndrome	Enrichment	KRAS	1.55
69	Rhabdomyosarcoma	Enrichment	HRAS	1.52
70	Sudden infant death syndrome	Enrichment	CALM2	1.49
71	Arteriovenous malformations of the brain	Enrichment	KRAS	1.45
72	Pancreatic cancer	Enrichment	KRAS	1.33
73	Hydrops fetalis, nonimmune	Enrichment	HRAS	1.31
74	Isolated joubert syndrome	Enrichment	PDE6D	1.25
75	Lung cancer	Enrichment	KRAS	1.22
76	Gastric cancer	Enrichment	KRAS	1.10
77	Hereditary breast carcinoma	Enrichment	KRAS	1.09
78	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS	1.00
79	Myeloma, multiple	Enrichment	KRAS	0.99
80	Breast cancer	Enrichment	KRAS	0.87
81	Colorectal cancer	Enrichment	NRAS	0.81
82	Ovarian cancer	Enrichment	KRAS	0.75

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Pathway Network for RAS processing

Member Pathways for RAS processing

Pathways in the RAS processing SuperPath

Associated Genes for RAS processing

Associated Disorders for RAS processing

Disorders associated with RAS processing SuperPath

STRING Interaction Network for RAS processing

Sources for RAS processing