Ras signaling

No Pathway Network information available for Ras signaling

Pathways in the Ras signaling SuperPath

#	Name	Source	Genes
1	Ras signaling	WikiPathways	ABL1 ABL2 AFDN AKT1 AKT2 AKT3 ARF6 BAD BCL2L1 BRAP BUB1B-PAK6 CALM1 CALM2 CALM3 CALML3 CALML4 CALML5 CALML6 CDC42 CHUK CSF1R EGFR ELK1 EPHA2 ETS1 ETS2 EXOC2 FASLG FGFR1 FGFR2 FGFR3 FGFR4 FLT1 FLT3 FLT4 FOXO4 GAB1 GAB2 GNB1 GNB2 GNB3 GNB4 GNB5 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 GNGT2 GRB2 GRIN1 GRIN2A GRIN2B HRAS HTR7 IGF1R IKBKB IKBKG INSR JMJD7-PLA2G4B KDR KIT KRAS KSR1 KSR2 LAT MAP2K1 MAP2K2 MAPK1 MAPK10 MAPK3 MAPK8 MAPK9 MET MRAS NF1 NFKB1 NGFR NRAS NTRK1 NTRK2 PAK1 PAK2 PAK3 PAK4 PAK5 PDGFRA PDGFRB PIK3CA PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PLA1A PLA2G10 PLA2G12A PLA2G12B PLA2G1B PLA2G2A PLA2G2C PLA2G2D PLA2G2E PLA2G2F PLA2G3 PLA2G4A PLA2G4B PLA2G4C PLA2G4D PLA2G4E PLA2G4F PLA2G5 PLA2G6 PLAAT3 PLCE1 PLCG1 PLCG2 PLD1 PLD2 PRKACA PRKACB PRKACG PRKCA PRKCB PRKCG PTPN11 RAB5A RAB5B RAB5C RAC1 RAC2 RAC3 RAF1 RALA RALB RALBP1 RALGDS RAP1A RAP1B RAPGEF5 RASA1 RASA2 RASA3 RASA4 RASA4B RASAL1 RASAL2 RASAL3 RASGRF1 RASGRF2 RASGRP1 RASGRP2 RASGRP3 RASGRP4 RASSF1 RASSF5 REL RELA RGL1 RGL2 RHOA RIN1 RRAS RRAS2 SHC1 SHC2 SHC3 SHC4 SHOC2 SOS1 SOS2 STK4 SYNGAP1 TEK TIAM1 TTBK1 ZAP70 (see all 183) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	JMJD7-PLA2G4B	JMJD7-PLA2G4B Readthrough	Protein Coding	1
2	PLA2G4C	Phospholipase A2 Group IVC	Protein Coding	1
3	PLA2G12B	Phospholipase A2 Group XIIB	Protein Coding	1
4	PLA2G10	Phospholipase A2 Group X	Protein Coding	1
5	PLA2G2F	Phospholipase A2 Group IIF	Protein Coding	1
6	RAP1B	RAP1B, Member Of RAS Oncogene Family	Protein Coding	1
7	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
8	RALB	RAS Like Proto-Oncogene B	Protein Coding	1
9	RALA	RAS Like Proto-Oncogene A	Protein Coding	1
10	RAB5C	RAB5C, Member RAS Oncogene Family	Protein Coding	1
11	RAB5B	RAB5B, Member RAS Oncogene Family	Protein Coding	1
12	PLA2G1B	Phospholipase A2 Group IB	Protein Coding	1
13	PLA1A	Phospholipase A1 Member A	Protein Coding	1
14	PLA2G3	Phospholipase A2 Group III	Protein Coding	1
15	PLA2G2C	Phospholipase A2 Group IIC	Protein Coding	1
16	ARF6	ARF GTPase 6	Protein Coding	1
17	PLA2G2E	Phospholipase A2 Group IIE	Protein Coding	1
18	PLA2G4D	Phospholipase A2 Group IVD	Protein Coding	1
19	PLA2G2D	Phospholipase A2 Group IID	Protein Coding	1
20	PLA2G4F	Phospholipase A2 Group IVF	Protein Coding	1
21	PLA2G4E	Phospholipase A2 Group IVE	Protein Coding	1
22	PLAAT3	Phospholipase A And Acyltransferase 3	Protein Coding	1
23	PLA2G4B	Phospholipase A2 Group IVB	Protein Coding	1
24	CDC42	Cell Division Cycle 42	Protein Coding	1
25	GAB2	GRB2 Associated Binding Protein 2	Protein Coding	1
26	RAPGEF5	Rap Guanine Nucleotide Exchange Factor 5	Protein Coding	1
27	RIN1	Ras And Rab Interactor 1	Protein Coding	1
28	RASAL2	RAS Protein Activator Like 2	Protein Coding	1
29	GNG8	G Protein Subunit Gamma 8	Protein Coding	1
30	SYNGAP1	Synaptic Ras GTPase Activating Protein 1	Protein Coding	1
31	IKBKG	Inhibitor Of Nuclear Factor Kappa B Kinase Regulatory Subunit Gamma	Protein Coding	1
32	RASAL1	RAS Protein Activator Like 1	Protein Coding	1
33	PLA2G6	Phospholipase A2 Group VI	Protein Coding	1
34	RASSF5	Ras Association Domain Family Member 5	Protein Coding	1
35	BRAP	BRCA1 Associated Protein	Protein Coding	1
36	PLA2G12A	Phospholipase A2 Group XIIA	Protein Coding	1
37	CALML3	Calmodulin Like 3	Protein Coding	1
38	CALM2	Calmodulin 2	Protein Coding	1
39	SHOC2	SHOC2 Leucine Rich Repeat Scaffold Protein	Protein Coding	1
40	CALM1	Calmodulin 1	Protein Coding	1
41	ZAP70	Zeta Chain Of T Cell Receptor Associated Protein Kinase 70	Protein Coding	1
42	TIAM1	TIAM Rac1 Associated GEF 1	Protein Coding	1
43	TEK	TEK Receptor Tyrosine Kinase	Protein Coding	1
44	STK4	Serine/Threonine Kinase 4	Protein Coding	1
45	SOS2	SOS Ras/Rho Guanine Nucleotide Exchange Factor 2	Protein Coding	1
46	SOS1	SOS Ras/Rac Guanine Nucleotide Exchange Factor 1	Protein Coding	1
47	SHC1	SHC Adaptor Protein 1	Protein Coding	1
48	RRAS	RAS Related	Protein Coding	1
49	BCL2L1	BCL2 Like 1	Protein Coding	1
50	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	1
51	REL	REL Proto-Oncogene, NF-KB Subunit	Protein Coding	1
52	GNB4	G Protein Subunit Beta 4	Protein Coding	1
53	RASGRF2	Ras Protein Specific Guanine Nucleotide Releasing Factor 2	Protein Coding	1
54	RASGRF1	Ras Protein Specific Guanine Nucleotide Releasing Factor 1	Protein Coding	1
55	RASA2	RAS P21 Protein Activator 2	Protein Coding	1
56	RASA1	RAS P21 Protein Activator 1	Protein Coding	1
57	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	1
58	RAF1	Raf-1 Proto-Oncogene, Serine/Threonine Kinase	Protein Coding	1
59	RAC3	Rac Family Small GTPase 3	Protein Coding	1
60	RAC2	Rac Family Small GTPase 2	Protein Coding	1
61	RAC1	Rac Family Small GTPase 1	Protein Coding	1
62	RAB5A	RAB5A, Member RAS Oncogene Family	Protein Coding	1
63	PTPN11	Protein Tyrosine Phosphatase Non-Receptor Type 11	Protein Coding	1
64	BAD	BCL2 Associated Agonist Of Cell Death	Protein Coding	1
65	MAP2K2	Mitogen-Activated Protein Kinase Kinase 2	Protein Coding	1
66	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	1
67	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
68	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
69	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
70	MAPK3	Mitogen-Activated Protein Kinase 3	Protein Coding	1
71	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	1
72	PRKCG	Protein Kinase C Gamma	Protein Coding	1
73	PRKCB	Protein Kinase C Beta	Protein Coding	1
74	PRKCA	Protein Kinase C Alpha	Protein Coding	1
75	PRKACG	Protein Kinase CAMP-Activated Catalytic Subunit Gamma	Protein Coding	1
76	PRKACB	Protein Kinase CAMP-Activated Catalytic Subunit Beta	Protein Coding	1
77	PRKACA	Protein Kinase CAMP-Activated Catalytic Subunit Alpha	Protein Coding	1
78	PLD2	Phospholipase D2	Protein Coding	1
79	PLD1	Phospholipase D1	Protein Coding	1
80	PLCG2	Phospholipase C Gamma 2	Protein Coding	1
81	PLCG1	Phospholipase C Gamma 1	Protein Coding	1
82	PLA2G5	Phospholipase A2 Group V	Protein Coding	1
83	PLA2G4A	Phospholipase A2 Group IVA	Protein Coding	1
84	PLA2G2A	Phospholipase A2 Group IIA	Protein Coding	1
85	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	Protein Coding	1
86	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
87	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	Protein Coding	1
88	PIK3CB	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Beta	Protein Coding	1
89	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
90	PDGFRB	Platelet Derived Growth Factor Receptor Beta	Protein Coding	1
91	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	1
92	PLCE1	Phospholipase C Epsilon 1	Protein Coding	1
93	PAK3	P21 (RAC1) Activated Kinase 3	Protein Coding	1
94	PAK2	P21 (RAC1) Activated Kinase 2	Protein Coding	1
95	PAK1	P21 (RAC1) Activated Kinase 1	Protein Coding	1
96	NTRK2	Neurotrophic Receptor Tyrosine Kinase 2	Protein Coding	1
97	NTRK1	Neurotrophic Receptor Tyrosine Kinase 1	Protein Coding	1
98	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	1
99	NGFR	Nerve Growth Factor Receptor	Protein Coding	1
100	NFKB1	Nuclear Factor Kappa B Subunit 1	Protein Coding	1
101	NF1	Neurofibromin 1	Protein Coding	1
102	AFDN	Afadin, Adherens Junction Formation Factor	Protein Coding	1
103	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
104	RHOA	Ras Homolog Family Member A	Protein Coding	1
105	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	1
106	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	1
107	KDR	Kinase Insert Domain Receptor	Protein Coding	1
108	INSR	Insulin Receptor	Protein Coding	1
109	FASLG	Fas Ligand	Protein Coding	1
110	IKBKB	Inhibitor Of Nuclear Factor Kappa B Kinase Subunit Beta	Protein Coding	1
111	IGF1R	Insulin Like Growth Factor 1 Receptor	Protein Coding	1
112	HTR7	5-Hydroxytryptamine Receptor 7	Protein Coding	1
113	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	1
114	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
115	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	1
116	GRIN1	Glutamate Ionotropic Receptor NMDA Type Subunit 1	Protein Coding	1
117	KSR2	Kinase Suppressor Of Ras 2	Protein Coding	1
118	GNGT2	G Protein Subunit Gamma Transducin 2	Protein Coding	1
119	GNGT1	G Protein Subunit Gamma Transducin 1	Protein Coding	1
120	GNG11	G Protein Subunit Gamma 11	Protein Coding	1
121	GNG7	G Protein Subunit Gamma 7	Protein Coding	1
122	GNG5	G Protein Subunit Gamma 5	Protein Coding	1
123	GNB3	G Protein Subunit Beta 3	Protein Coding	1
124	GNB1	G Protein Subunit Beta 1	Protein Coding	1
125	LAT	Linker For Activation Of T Cells	Protein Coding	1
126	RASGRP3	RAS Guanyl Releasing Protein 3	Protein Coding	1
127	GAB1	GRB2 Associated Binding Protein 1	Protein Coding	1
128	ABL1	ABL Proto-Oncogene 1, Non-Receptor Tyrosine Kinase	Protein Coding	1
129	FLT4	Fms Related Receptor Tyrosine Kinase 4	Protein Coding	1
130	FLT3	Fms Related Receptor Tyrosine Kinase 3	Protein Coding	1
131	FLT1	Fms Related Receptor Tyrosine Kinase 1	Protein Coding	1
132	MRAS	Muscle RAS Oncogene Homolog	Protein Coding	1
133	RRAS2	RAS Related 2	Protein Coding	1
134	FGFR4	Fibroblast Growth Factor Receptor 4	Protein Coding	1
135	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	1
136	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	1
137	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	1
138	ETS2	ETS Proto-Oncogene 2, Transcription Factor	Protein Coding	1
139	ETS1	ETS Proto-Oncogene 1, Transcription Factor	Protein Coding	1
140	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	1
141	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
142	EPHA2	EPH Receptor A2	Protein Coding	1
143	EGFR	Epidermal Growth Factor Receptor	Protein Coding	1
144	CSF1R	Colony Stimulating Factor 1 Receptor	Protein Coding	1
145	CHUK	Component Of Inhibitor Of Nuclear Factor Kappa B Kinase Complex	Protein Coding	1
146	RASSF1	Ras Association Domain Family Member 1	Protein Coding	1
147	RALBP1	RalA Binding Protein 1	Protein Coding	1
148	GNB5	G Protein Subunit Beta 5	Protein Coding	1
149	PAK4	P21 (RAC1) Activated Kinase 4	Protein Coding	1
150	RASGRP2	RAS Guanyl Releasing Protein 2	Protein Coding	1
151	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	1
152	AKT3	AKT Serine/Threonine Kinase 3	Protein Coding	1
153	CALML6	Calmodulin Like 6	Protein Coding	1
154	CALML4	Calmodulin Like 4	Protein Coding	1
155	KSR1	Kinase Suppressor Of Ras 1	Protein Coding	1
156	PIK3R3	Phosphoinositide-3-Kinase Regulatory Subunit 3	Protein Coding	1
157	TTBK1	Tau Tubulin Kinase 1	Protein Coding	1
158	RASGRP4	RAS Guanyl Releasing Protein 4	Protein Coding	1
159	BUB1B-PAK6	BUB1B-PAK6 Readthrough	Protein Coding	1
160	RASA4	RAS P21 Protein Activator 4	Protein Coding	1
161	CALM3	Calmodulin 3	Protein Coding	1
162	RASAL3	RAS Protein Activator Like 3	Protein Coding	1
163	RGL2	Ral Guanine Nucleotide Dissociation Stimulator Like 2	Protein Coding	1
164	PAK5	P21 (RAC1) Activated Kinase 5	Protein Coding	1
165	GNG12	G Protein Subunit Gamma 12	Protein Coding	1
166	EXOC2	Exocyst Complex Component 2	Protein Coding	1
167	GNG2	G Protein Subunit Gamma 2	Protein Coding	1
168	SHC3	SHC Adaptor Protein 3	Protein Coding	1
169	CALML5	Calmodulin Like 5	Protein Coding	1
170	GNG13	G Protein Subunit Gamma 13	Protein Coding	1
171	FOXO4	Forkhead Box O4	Protein Coding	1
172	SHC4	SHC Adaptor Protein 4	Protein Coding	1
173	GRB2	Growth Factor Receptor Bound Protein 2	Protein Coding	1
174	GNG10	G Protein Subunit Gamma 10	Protein Coding	1
175	GNG4	G Protein Subunit Gamma 4	Protein Coding	1
176	GNG3	G Protein Subunit Gamma 3	Protein Coding	1
177	GNB2	G Protein Subunit Beta 2	Protein Coding	1
178	ABL2	ABL Proto-Oncogene 2, Non-Receptor Tyrosine Kinase	Protein Coding	1
179	SHC2	SHC Adaptor Protein 2	Protein Coding	1
180	RGL1	Ral Guanine Nucleotide Dissociation Stimulator Like 1	Protein Coding	1
181	RASA3	RAS P21 Protein Activator 3	Protein Coding	1
182	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
183	RASA4B	RAS P21 Protein Activator 4B	Protein Coding	1

Disorders associated with Ras signaling SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Noonan syndrome 1	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NRAS, PTPN11, RAF1, RASA2, RRAS, RRAS2, SHOC2, SOS1, SOS2	16.00
2	Rasopathy	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, MRAS, NF1, NRAS, PTPN11, RAF1, RRAS2, SHOC2, SOS1, SOS2	16.00
3	Noonan syndrome and noonan-related syndrome	Enrichment	HRAS, KRAS, MAP2K1, MAP2K2, NRAS, PTPN11, RAF1, SHOC2, SOS1	10.99
4	Lung non-small cell carcinoma	Enrichment	EGFR, HRAS, KRAS, MAP2K1, NRAS, PIK3CA	8.62
5	Nevus, epidermal	Enrichment	FGFR3, HRAS, KRAS, NRAS, PIK3CA	8.06
6	Noonan syndrome 3	Enrichment	HRAS, KRAS, PTPN11, RAF1, SOS1	8.06
7	Arteriovenous malformation	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1, TEK	7.29
8	Myopathy, x-linked, with excessive autophagy	Enrichment	HRAS, MAP2K1, PIK3CA, RASA1, TEK	7.00
9	Juvenile myelomonocytic leukemia	Enrichment	KRAS, NF1, NRAS, PTPN11, RRAS	6.51
10	Lip and oral cavity carcinoma	Enrichment	ABL1, EGFR, HRAS, KIT, PIK3CA	6.51
11	Lung squamous cell carcinoma	Enrichment	EGFR, FGFR3, KRAS, PIK3CA	6.33
12	Capillary malformation-arteriovenous malformation 1	Enrichment	KRAS, MAP2K1, PIK3CA, RASA1	5.96
13	Pilomyxoid astrocytoma	Enrichment	FGFR1, KRAS, NTRK2, RAF1	5.96
14	Bladder cancer	Enrichment	EGFR, FGFR3, HRAS, KRAS, NF1, PIK3CA	5.69
15	Ovarian cancer	Enrichment	AKT1, EGFR, KIT, KRAS, MET, NTRK1, PDGFRA, PIK3CA, RRAS2	5.06
16	Schimmelpenning-feuerstein-mims syndrome	Enrichment	HRAS, KRAS, NRAS	5.02
17	Cardiofaciocutaneous syndrome 1	Enrichment	KRAS, MAP2K1, MAP2K2	5.02
18	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	AKT3, PIK3CA, PIK3R2	5.02
19	Cardiofaciocutaneous syndrome	Enrichment	KRAS, MAP2K1, MAP2K2	5.02
20	Chronic myelogenous leukemia, bcr-abl1 positive	Enrichment	ABL1, KRAS, NRAS	5.02
21	Colorectal cancer	Enrichment	AKT1, FGFR2, FGFR3, MET, NRAS, PIK3CA, PIK3R1, PLA2G2A	4.65
22	Primary hypereosinophilic syndrome	Enrichment	FGFR1, PDGFRA, PDGFRB	4.63
23	Microcephaly	Enrichment	ABL1, GNB1, GRIN2B, IGF1R, MAPK1, PAK3, PLA2G6, PTPN11, SYNGAP1	4.37
24	Hemangioma, capillary infantile	Enrichment	FLT4, KDR, RASA1	4.33
25	Breast adenocarcinoma	Enrichment	AKT1, KRAS, PIK3CA	4.33
26	Lung cancer	Enrichment	EGFR, FASLG, KRAS, MET, PIK3CA	4.20
27	Leukemia, chronic myeloid	Enrichment	ABL1, KRAS, NRAS	4.09
28	Melanocytic nevus syndrome, congenital	Enrichment	HRAS, NRAS, RAF1	3.89
29	Catecholaminergic polymorphic ventricular tachycardia	Enrichment	CALM1, CALM2, CALM3	3.89
30	Keratosis, seborrheic	Enrichment	FGFR3, PIK3CA	3.74
31	Pfeiffer syndrome	Enrichment	FGFR1, FGFR2	3.74
32	Jackson-weiss syndrome	Enrichment	FGFR1, FGFR2	3.74
33	Encephalocraniocutaneous lipomatosis	Enrichment	FGFR1, KRAS	3.74
34	Ras-associated autoimmune leukoproliferative disorder	Enrichment	KRAS, NRAS	3.74
35	Rosette-forming glioneuronal tumor	Enrichment	FGFR1, PIK3CA	3.74
36	Immune system disease	Enrichment	CDC42, PIK3CD	3.74
37	Crouzon syndrome	Enrichment	FGFR2, FGFR3	3.27
38	Lacrimoauriculodentodigital syndrome 1	Enrichment	FGFR2, FGFR3	3.27
39	Langerhans cell histiocytosis	Enrichment	MAP2K1, NRAS	3.27
40	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	3.27
41	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3CD, PIK3R1	3.27
42	Large congenital melanocytic nevus	Enrichment	HRAS, NRAS	3.27
43	Testicular germ cell cancer	Enrichment	FGFR3, KIT	3.27
44	Immunodeficiency 14	Enrichment	PIK3CD, PIK3R1	3.27
45	Spermatocytoma	Enrichment	FGFR3, HRAS	3.27
46	Differentiated thyroid carcinoma	Enrichment	HRAS, KRAS, NRAS, NTRK1	3.23
47	Long qt syndrome 1	Enrichment	CALM1, CALM2, CALM3, PTPN11	3.18
48	Non-immune hydrops fetalis	Enrichment	FLT4, HRAS, KRAS, PTPN11	3.12
49	Myeloma, multiple	Enrichment	FGFR3, FLT3, KRAS, NF1, PIK3R2	3.03
50	Neurofibromatosis-noonan syndrome	Enrichment	MAP2K2, NF1	2.97
51	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1	Enrichment	AKT3, PIK3R2	2.97
52	Saethre-chotzen syndrome	Enrichment	FGFR2, FGFR3	2.97
53	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CDC42, PTPN11	2.97
54	Noonan syndrome with multiple lentigines	Enrichment	PTPN11, RAF1	2.97
55	Pilocytic astrocytoma	Enrichment	KRAS, NF1	2.97
56	Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22)	Enrichment	FLT3, KIT	2.97
57	Gliosarcoma	Enrichment	EGFR, FGFR1, FGFR3	2.93
58	Giant cell glioblastoma	Enrichment	EGFR, FGFR1, FGFR3	2.85
59	Complex neurodevelopmental disorder	Enrichment	GNB2, GRIN2B, PAK3, RAC3, RALA, SYNGAP1, TIAM1	2.84
60	Hemifacial hyperplasia	Enrichment	FGFR2, FGFR3	2.75
61	Capillary malformations, congenital	Enrichment	PIK3CA, RASA1	2.75
62	Acute myeloid leukemia with maturation	Enrichment	FLT3, KIT	2.75
63	Hemimegalencephaly	Enrichment	AKT3, PIK3CA	2.75
64	Acute myeloid leukemia with t(8;21)(q22;q22) translocation	Enrichment	FLT3, KIT	2.75
65	Leukemia, acute myeloid	Enrichment	FLT3, KIT, KRAS, NRAS	2.70
66	Craniosynostosis	Enrichment	FGFR2, FGFR3, GRIN2B	2.63
67	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA, RASA1	2.58
68	Cowden syndrome 1	Enrichment	EGFR, PIK3CA	2.58
69	Hemihyperplasia, isolated	Enrichment	PIK3CA, RHOA	2.58
70	Testicular germ cell tumor	Enrichment	FGFR3, KIT	2.58
71	46,xy disorder of sex development	Enrichment	FGFR3, INSR	2.58
72	Gastric cancer	Enrichment	FGFR2, KRAS, NF1, PIK3CA	2.58
73	Breast cancer	Enrichment	AKT1, GNG3, KRAS, PIK3CA, SHC1	2.47
74	Thyroid cancer, nonmedullary, 2	Enrichment	HRAS, NRAS	2.44
75	Gastrointestinal stromal tumor	Enrichment	KIT, PDGFRA	2.44
76	Gallbladder cancer	Enrichment	KRAS, PIK3CA	2.44
77	Follicular thyroid carcinoma	Enrichment	HRAS, NRAS	2.44
78	B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	Enrichment	ABL1, FLT3	2.44
79	Hydrops fetalis, nonimmune	Enrichment	FLT4, HRAS, PTPN11	2.30
80	Ellis-van creveld syndrome	Enrichment	PRKACA, PRKACB	2.21
81	Cowden syndrome	Enrichment	AKT1, PIK3CA	2.21
82	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3CD, PIK3R1	2.12
83	Inherited cancer-predisposing syndrome	Enrichment	EGFR, KIT, MET, NF1, PDGFRA, PTPN11	2.05
84	Pectus excavatum	Enrichment	PTPN11, SHOC2	2.04
85	Leukemia, acute lymphoblastic	Enrichment	FLT3, GNB1	2.04
86	Specific learning disability	Enrichment	MAPK1, PTPN11	2.04
87	Severe combined immunodeficiency	Enrichment	IKBKB, STK4, ZAP70	2.01
88	Meningioma	Enrichment	AKT1, PIK3CA	1.96
89	Nk-cell enteropathy	Enrichment	IGF1R, PIK3CB	1.89
90	Hypochondroplasia	Enrichment	FGFR3	1.87
91	Macrodactyly	Enrichment	PIK3CA	1.87
92	Proteus syndrome	Enrichment	AKT1	1.87
93	Beare-stevenson cutis gyrata syndrome	Enrichment	FGFR2	1.87
94	Osteoglophonic dysplasia	Enrichment	FGFR1	1.87
95	Metachondromatosis	Enrichment	PTPN11	1.87
96	Cystic angiomatosis of bone, diffuse	Enrichment	RASA1	1.87
97	Thanatophoric dysplasia, type i	Enrichment	FGFR3	1.87
98	Trigonocephaly 1	Enrichment	FGFR1	1.87
99	Hypoinsulinemic hypoglycemia with hemihypertrophy	Enrichment	AKT2	1.87
100	Donohue syndrome	Enrichment	INSR	1.87
101	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	1.87
102	Oculoectodermal syndrome	Enrichment	KRAS	1.87
103	Muenke syndrome	Enrichment	FGFR3	1.87
104	Intellectual developmental disorder, x-linked 30	Enrichment	PAK3	1.87
105	Premature aging syndrome, penttinen type	Enrichment	PDGFRB	1.87
106	Incontinentia pigmenti	Enrichment	IKBKG	1.87
107	Hyperinsulinemic hypoglycemia, familial, 5	Enrichment	INSR	1.87
108	Deafness, autosomal recessive 26	Enrichment	GAB1	1.87
109	Autoinflammatory disease, systemic, x-linked	Enrichment	IKBKG	1.87
110	Noonan syndrome 5	Enrichment	RAF1	1.87
111	Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	Enrichment	INSR	1.87
112	Osteopetrosis and infantile neuroaxonal dystrophy	Enrichment	PLA2G6	1.87
113	Diabetes mellitus, insulin-resistant, with acanthosis nigricans	Enrichment	INSR	1.87
114	Noonan syndrome 4	Enrichment	SOS1	1.87
115	Hypereosinophilic syndrome, idiopathic	Enrichment	PDGFRA	1.87
116	Immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis	Enrichment	RAC2	1.87
117	Mastocytosis, cutaneous	Enrichment	KIT	1.87
118	Scaphocephaly, maxillary retrusion, and impaired intellectual development	Enrichment	FGFR2	1.87
119	Melorheostosis, isolated	Enrichment	MAP2K1	1.87
120	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	1.87
121	Apert syndrome	Enrichment	FGFR2	1.87
122	Leopard syndrome 1	Enrichment	PTPN11	1.87
123	Cardiomyopathy, dilated, 1nn	Enrichment	RAF1	1.87
124	Cowden syndrome 5	Enrichment	PIK3CA	1.87
125	Cardiac valvular dysplasia 1	Enrichment	PLD1	1.87
126	Cardiofaciocutaneous syndrome 3	Enrichment	MAP2K1	1.87
127	Myofibromatosis, infantile, 1	Enrichment	PDGFRB	1.87
128	Melanosis, neurocutaneous	Enrichment	NRAS	1.87
129	Fleck retina, familial benign	Enrichment	PLA2G5	1.87
130	Thanatophoric dysplasia, type ii	Enrichment	FGFR3	1.87
131	Noonan syndrome 9	Enrichment	SOS2	1.87
132	Bleeding disorder, platelet-type, 18	Enrichment	RASGRP2	1.87
133	Noonan syndrome 6	Enrichment	NRAS	1.87
134	Fetal encasement syndrome	Enrichment	CHUK	1.87
135	Gist-plus syndrome	Enrichment	PDGFRA	1.87
136	Camptodactyly, tall stature, and hearing loss syndrome	Enrichment	FGFR3	1.87
137	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	1.87
138	Bent bone dysplasia syndrome 1	Enrichment	FGFR2	1.87
139	Hiatt-neu-cooper neurodevelopmental syndrome	Enrichment	RALA	1.87
140	Noonan syndrome 11	Enrichment	MRAS	1.87
141	Immunodeficiency 64 with lymphoproliferation	Enrichment	RASGRP1	1.87
142	Cerebral cavernous malformations 4	Enrichment	PIK3CA	1.87
143	Immunodeficiency 15b	Enrichment	IKBKB	1.87
144	Neurodevelopmental disorder with hypotonia and dysmorphic facies	Enrichment	GNB2	1.87
145	Noonan syndrome 13	Enrichment	MAPK1	1.87
146	Developmental and epileptic encephalopathy 58	Enrichment	NTRK2	1.87
147	Immunodeficiency 15a	Enrichment	IKBKB	1.87
148	Immunodeficiency 92	Enrichment	REL	1.87
149	Neurodegeneration with brain iron accumulation 2a	Enrichment	PLA2G6	1.87
150	Venous malformations, multiple cutaneous and mucosal	Enrichment	TEK	1.87
151	Knobloch syndrome 2	Enrichment	PAK2	1.87
152	Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies	Enrichment	RAC3	1.87
153	Immunodeficiency 48	Enrichment	ZAP70	1.87
154	Short syndrome	Enrichment	PIK3R1	1.87
155	Intellectual developmental disorder with macrocephaly, seizures, and speech delay	Enrichment	PAK1	1.87
156	Ectodermal dysplasia and immunodeficiency 1	Enrichment	IKBKG	1.87
157	Immune dysregulation, autoimmunity, and autoinflammation	Enrichment	PLCG1	1.87
158	Osteofibrous dysplasia	Enrichment	MET	1.87
159	Immunodeficiency 110 with lymphoproliferation	Enrichment	STK4	1.87
160	Myeloid and lymphoid neoplasms associated with pdgfra rearrangement	Enrichment	PDGFRA	1.87
161	Immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia	Enrichment	RAC2	1.87
162	Cardioacrofacial dysplasia 2	Enrichment	PRKACB	1.87
163	Cardiofaciocutaneous syndrome 2	Enrichment	KRAS	1.87
164	Deafness, autosomal recessive 97	Enrichment	MET	1.87
165	Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2	Enrichment	AKT3	1.87
166	Lodder-merla syndrome, type 2, with developmental delay and with or without cardiac arrhythmia	Enrichment	GNB5	1.87
167	Crouzon syndrome with acanthosis nigricans	Enrichment	FGFR3	1.87
168	Hemifacial myohyperplasia	Enrichment	PIK3CA	1.87
169	Noonan syndrome-like disorder with loose anagen hair 1	Enrichment	SHOC2	1.87
170	Parkinson disease 14, autosomal recessive	Enrichment	PLA2G6	1.87
171	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal recessive	Enrichment	GRIN1	1.87
172	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	1.87
173	Spinocerebellar ataxia 14	Enrichment	PRKCG	1.87
174	Melorheostosis	Enrichment	MAP2K1	1.87
175	Autism 9	Enrichment	MET	1.87
176	Neurodegeneration with brain iron accumulation 2b	Enrichment	PLA2G6	1.87
177	Leopard syndrome 2	Enrichment	RAF1	1.87
178	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	1.87
179	Basal ganglia calcification, idiopathic, 4	Enrichment	PDGFRB	1.87
180	Cytosolic phospholipase-a2 alpha deficiency associated bleeding disorder	Enrichment	PLA2G4A	1.87
181	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	1.87
182	Cardiofaciocutaneous syndrome 4	Enrichment	MAP2K2	1.87
183	Autoinflammation, antibody deficiency, and immune dysregulation	Enrichment	PLCG2	1.87
184	Thrombocytopenia 11 with multiple congenital anomalies and dysmorphic facies	Enrichment	RAP1B	1.87
185	Long qt syndrome 16	Enrichment	CALM3	1.87
186	Cowden syndrome 6	Enrichment	AKT1	1.87
187	Pigmented nodular adrenocortical disease, primary, 4	Enrichment	PRKACA	1.87
188	Immunodeficiency 14b, autosomal recessive	Enrichment	PIK3CD	1.87
189	Myeloid and lymphoid neoplasms associated with pdgfrb rearrangement	Enrichment	PDGFRB	1.87
190	Charcot-marie-tooth disease, dominant intermediate f	Enrichment	GNB4	1.87
191	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	1.87
192	Acute myeloid leukemia with minimal differentiation	Enrichment	FLT3	1.87
193	Developmental and epileptic encephalopathy 101	Enrichment	GRIN1	1.87
194	Obesity, hyperphagia, and developmental delay	Enrichment	NTRK2	1.87
195	Neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant	Enrichment	GRIN1	1.87
196	Achondroplasia, severe, with developmental delay and acanthosis nigricans	Enrichment	FGFR3	1.87
197	Kosaki overgrowth syndrome	Enrichment	PDGFRB	1.87
198	Familial cold autoinflammatory syndrome 3	Enrichment	PLCG2	1.87
199	Autoimmune disease, multisystem, infantile-onset, 2	Enrichment	ZAP70	1.87
200	Hartsfield syndrome	Enrichment	FGFR1	1.87
201	Congenital heart defects, multiple types, 7	Enrichment	FLT4	1.87
202	Cardioacrofacial dysplasia 1	Enrichment	PRKACA	1.87
203	Gastrointestinal ulceration, recurrent, with dysfunctional platelets	Enrichment	PLA2G4A	1.87
204	Ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies	Enrichment	RHOA	1.87
205	Takenouchi-kosaki syndrome	Enrichment	CDC42	1.87
206	Intellectual developmental disorder, autosomal dominant 42	Enrichment	GNB1	1.87
207	Glaucoma 3, primary congenital, e	Enrichment	TEK	1.87
208	Bartsocas-papas syndrome 2	Enrichment	CHUK	1.87
209	Sick sinus syndrome 4	Enrichment	GNB2	1.87
210	Brain abnormalities, neurodegeneration, and dysosteosclerosis	Enrichment	CSF1R	1.87
211	Neurodevelopmental disorder with language delay and seizures	Enrichment	TIAM1	1.87
212	Ocular pterygium-digital keloid dysplasia syndrome	Enrichment	PDGFRB	1.87
213	Linear hypopigmentation and craniofacial asymmetry with acral, ocular and brain anomalies	Enrichment	RHOA	1.87
214	Immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia	Enrichment	RAC2	1.87
215	Chronic mast cell leukemia	Enrichment	KIT	1.87
216	Trigonitis	Enrichment	RAF1	1.87
217	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	1.87
218	Tufted angioma of skin	Enrichment	KDR	1.87
219	Plexiform neurofibroma	Enrichment	NF1	1.87
220	Arthrogryposis, distal, type 11	Enrichment	MET	1.87
221	Neurofibroma	Enrichment	NF1	1.87
222	Lacrimoauriculodentodigital syndrome 2	Enrichment	FGFR3	1.87
223	Long qt syndrome 15	Enrichment	CALM2	1.87
224	Csf1r-related disorder	Enrichment	CSF1R	1.87
225	Lipodystrophy, familial partial, type 9	Enrichment	PLAAT3	1.87
226	Hypospadias	Enrichment	PIK3CA	1.87
227	Bockenheimer syndrome	Enrichment	TEK	1.87
228	Capillary hemangioma	Enrichment	AKT3	1.87
229	Neurofibromatosis	Enrichment	NF1	1.87
230	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	1.87
231	Landau-kleffner syndrome	Enrichment	GRIN2A	1.87
232	Chromosome 17q11.2 deletion syndrome	Enrichment	NF1	1.87
233	Isolated bone marrow mastocytosis	Enrichment	KIT	1.87
234	Congenital pulmonary airway malformation	Enrichment	KRAS	1.87
235	Smoldering systemic mastocytosis	Enrichment	KIT	1.87
236	Optic nerve glioma	Enrichment	NF1	1.87
237	Rare venous malformation	Enrichment	PIK3CA	1.87
238	Immunodeficiency 64	Enrichment	RASGRP1	1.87
239	Gorham's disease	Enrichment	RASA1	1.87
240	Diaphragmatic eventration	Enrichment	PIK3CA	1.87
241	Infantile lad-like disease due to rac2 deficiency	Enrichment	RAC2	1.87
242	Fgfr3-related chondrodysplasia	Enrichment	FGFR3	1.87
243	Ebv-induced lymphoproliferative disease due to rasgrp1 deficiency	Enrichment	RASGRP1	1.87
244	Reticular dysgenesis-like severe combined immunodeficiency	Enrichment	RAC2	1.87
245	Nocarh syndrome	Enrichment	CDC42	1.87
246	Mastocytosis	Enrichment	KIT	1.87
247	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	1.87
248	Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to ikbka deficiency	Enrichment	CHUK	1.87
249	Camptodactyly-tall stature-scoliosis-hearing loss syndrome	Enrichment	FGFR3	1.87
250	Early-onset calcifying leukoencephalopathy-skeletal dysplasia	Enrichment	CSF1R	1.87
251	Rare combined vascular malformation	Enrichment	PIK3CA	1.87
252	Cavernous lymphangioma	Enrichment	PIK3CA	1.87
253	Intellectual disability, autosomal dominant 8	Enrichment	GRIN1	1.87
254	Cryptogenic multifocal ulcerous stenosing enteritis	Enrichment	PLA2G4A	1.87
255	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	1.87
256	Cutaneous mastocytoma	Enrichment	KIT	1.87
257	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	1.87
258	Grin2a-related disorders	Enrichment	GRIN2A	1.87
259	Typical urticaria pigmentosa	Enrichment	KIT	1.87
260	Phakomatosis pigmentokeratotica	Enrichment	HRAS	1.87
261	Microcephaly-corpus callosum and cerebellar vermis hypoplasia-facial dysmorphism-intellectual disability syndrom	Enrichment	RAC1	1.87
262	Nodular urticaria pigmentosa	Enrichment	KIT	1.87
263	Hartsfield-bixler-demyer syndrome	Enrichment	FGFR1	1.87
264	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	1.87
265	Pseudoxanthomatous diffuse cutaneous mastocytosis	Enrichment	KIT	1.87
266	Telangiectasia macularis eruptiva perstans	Enrichment	KIT	1.87
267	Acute mast cell leukemia	Enrichment	KIT	1.87
268	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	1.87
269	Rac2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome	Enrichment	RAC2	1.87
270	Non-syndromic unicoronal craniosynostosis	Enrichment	FGFR2	1.87
271	Familial benign flecked retina	Enrichment	PLA2G5	1.87
272	Plaque-form urticaria pigmentosa	Enrichment	KIT	1.87
273	Macrodactyly of toe	Enrichment	PIK3CA	1.87
274	Neurocutaneous melanocytosis	Enrichment	NRAS	1.87
275	Bullous diffuse cutaneous mastocytosis	Enrichment	KIT	1.87
276	Zap70-related severe combined immunodeficiency	Enrichment	ZAP70	1.87
277	Akt2-related familial partial lipodystrophy	Enrichment	AKT2	1.87
278	Malignant astrocytoma	Enrichment	PTPN11	1.87
279	Testis seminoma	Enrichment	KIT	1.87
280	Lung cancer susceptibility 3	Enrichment	EGFR, KRAS	1.83
281	Cerebral palsy	Enrichment	GNB1, GRIN2B, PDGFRB	1.81
282	Autism spectrum disorder	Enrichment	GNB1, GRIN2B, MAP2K1, NF1, PTPN11	1.80
283	Hydrocephalus	Enrichment	FGFR2, PDGFRB	1.77
284	Lynch syndrome	Enrichment	KRAS, PIK3CA	1.77
285	Rhabdomyosarcoma	Enrichment	HRAS, NF1	1.72
286	West syndrome	Enrichment	GRIN1, GRIN2B, NTRK2	1.67
287	Hereditary breast carcinoma	Enrichment	AKT1, KRAS, PIK3CA	1.67
288	Arteriovenous malformations of the brain	Enrichment	EGFR, KRAS	1.57
289	Lymphatic malformation 1	Enrichment	FLT4	1.57
290	Cafe-au-lait spots, multiple	Enrichment	NF1	1.57
291	Blue rubber bleb nevus	Enrichment	TEK	1.57
292	Myeloproliferative disorder, chronic, with eosinophilia	Enrichment	PDGFRB	1.57
293	Fibromatosis, gingival, 1	Enrichment	SOS1	1.57
294	Costello syndrome	Enrichment	HRAS	1.57
295	Insensitivity to pain, congenital, with anhidrosis	Enrichment	NTRK1	1.57
296	Intracranial hypertension, idiopathic	Enrichment	FLT4	1.57
297	Cervical cancer	Enrichment	FGFR3	1.57
298	Immunodeficiency 33	Enrichment	IKBKG	1.57
299	Pulmonic stenosis	Enrichment	SOS1	1.57
300	Piebald trait	Enrichment	KIT	1.57
301	Hyperinsulinemic hypoglycemia, familial, 4	Enrichment	INSR	1.57
302	Aural atresia, congenital	Enrichment	FGFR2	1.57
303	Intellectual developmental disorder, autosomal recessive 5	Enrichment	SYNGAP1	1.57
304	Ventricular tachycardia, catecholaminergic polymorphic, 4	Enrichment	CALM1	1.57
305	Roifman-chitayat syndrome	Enrichment	PIK3CD	1.57
306	Bleeding disorder, platelet-type, 19	Enrichment	PRKACG	1.57
307	Angioma, tufted	Enrichment	KDR	1.57
308	Night blindness, congenital stationary, type 1h	Enrichment	GNB3	1.57
309	Noonan syndrome 8	Enrichment	PIK3CA	1.57
310	Immunodeficiency, common variable, 12, with autoimmunity	Enrichment	NFKB1	1.57
311	Long qt syndrome 14	Enrichment	CALM1	1.57
312	Pain sensitivity quantitative trait locus 1	Enrichment	NTRK1	1.57
313	Antley-bixler syndrome without genital anomalies or disordered steroidogenesis	Enrichment	FGFR2	1.57
314	Intellectual developmental disorder, autosomal dominant 48	Enrichment	RAC1	1.57
315	Congenital heart defects and skeletal malformations syndrome	Enrichment	ABL1	1.57
316	Werner syndrome	Enrichment	PTPN11	1.57
317	Noonan syndrome 12	Enrichment	RRAS2	1.57
318	Autoinflammatory disease, familial, behcet-like 3	Enrichment	RELA	1.57
319	Chromosome 17q11.2 duplication syndrome, 1.4-mb	Enrichment	NF1	1.57
320	Infantile myofibromatosis	Enrichment	PDGFRB	1.57
321	Childhood hepatocellular carcinoma	Enrichment	MET	1.57
322	Noonan syndrome-like disorder with loose anagen hair	Enrichment	SHOC2	1.57
323	Rela fusion-positive ependymoma	Enrichment	RELA	1.57
324	Bilateral generalized polymicrogyria	Enrichment	GRIN1	1.57
325	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	1.57
326	Senior-loken syndrome 7	Enrichment	AKT3	1.57
327	Split hand-foot malformation	Enrichment	FGFR2	1.57
328	Papillary renal cell carcinoma	Enrichment	MET	1.57
329	Fibrolamellar carcinoma	Enrichment	PRKACA	1.57
330	Ectodermal dysplasia and immune deficiency	Enrichment	IKBKG	1.57
331	Bardet-biedl syndrome 9	Enrichment	NF1	1.57
332	Cervix carcinoma	Enrichment	FGFR3	1.57
333	Bardet-biedl syndrome 16	Enrichment	AKT3	1.57
334	Lodder-merla syndrome, type 1, with impaired intellectual development and cardiac arrhythmia	Enrichment	GNB5	1.57
335	Hereditary lymphedema i	Enrichment	FLT4	1.57
336	Glucosephosphate dehydrogenase deficiency	Enrichment	IKBKG	1.57
337	Immunodeficiency 52	Enrichment	LAT	1.57
338	Acute myeloid leukemia without maturation	Enrichment	FLT3	1.57
339	Interfrontal craniofaciosynostosis	Enrichment	FGFR1	1.57
340	Neurodevelopmental disorder with dysmorphic facies and cerebellar hypoplasia	Enrichment	EXOC2	1.57
341	Autosomal dominant nonsyndromic deafness	Enrichment	FGFR2	1.57
342	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	1.57
343	Chronic eosinophilic leukemia	Enrichment	PDGFRA	1.57
344	B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormality	Enrichment	PDGFRA	1.57
345	Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2)	Enrichment	FLT3	1.57
346	B-lymphoblastic leukemia/lymphoma with t	Enrichment	KIT	1.57
347	Common variable immunodeficiency 12	Enrichment	NFKB1	1.57
348	Pleomorphic rhabdomyosarcoma	Enrichment	NF1	1.57
349	Tafro syndrome	Enrichment	MAP2K2	1.57
350	Infantile osteopetrosis with neuroaxonal dysplasia	Enrichment	PLA2G6	1.57
351	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	1.57
352	Cerebral visual impairment	Enrichment	GNB1	1.57
353	Wooly hair nevus	Enrichment	HRAS	1.57
354	Autosomal dominant non-syndromic intellectual disability	Enrichment	GNB1, GRIN1, GRIN2B	1.53
355	Endometrial cancer	Enrichment	FGFR2, PIK3CA	1.49
356	Hepatocellular carcinoma	Enrichment	MET, PIK3CA	1.46
357	Precursor t-cell acute lymphoblastic leukemia	Enrichment	ABL1, FLT3	1.42
358	Achondroplasia	Enrichment	FGFR3	1.40
359	Jacobsen syndrome	Enrichment	ETS1	1.40
360	Hypogonadotropic hypogonadism 2 with or without anosmia	Enrichment	FGFR1	1.40
361	Larsen syndrome	Enrichment	FGFR3	1.40
362	Thyroid carcinoma, familial medullary	Enrichment	NTRK1	1.40
363	Pompe disease, infantile-onset	Enrichment	PIK3CA	1.40
364	Watson syndrome	Enrichment	NF1	1.40
365	Immunodeficiency 98 with autoinflammation, x-linked	Enrichment	FASLG	1.40
366	Leukoencephalopathy, hereditary diffuse, with spheroids 1	Enrichment	CSF1R	1.40
367	Nuchal bleb, familial	Enrichment	SOS1	1.40
368	Late-onset retinal degeneration	Enrichment	PLA2G5	1.40
369	Intellectual developmental disorder, autosomal dominant 5	Enrichment	SYNGAP1	1.40
370	Nephrotic syndrome, type 3	Enrichment	PLCE1	1.40
371	Neurofibromatosis, familial spinal	Enrichment	NF1	1.40
372	Chromosome 8p11 myeloproliferative syndrome	Enrichment	FGFR1	1.40
373	Chromosome 17q11.2 deletion syndrome, 1.4-mb	Enrichment	NF1	1.40
374	Neonatal nephrocutaneous inflammatory syndrome	Enrichment	EGFR	1.40
375	Wieacker-wolff syndrome	Enrichment	RASA1	1.40
376	Polycystic kidney disease 4	Enrichment	SHOC2	1.40
377	Hamartoma	Enrichment	FGFR3	1.40
378	T-cell acute lymphoblastic leukemia	Enrichment	ABL1	1.40
379	Brain cancer	Enrichment	NF1	1.40
380	Growth delay due to insulin-like growth factor i resistance	Enrichment	IGF1R	1.40
381	Neonatal inflammatory skin and bowel disease	Enrichment	EGFR	1.40
382	Tricuspid valve insufficiency	Enrichment	PTPN11	1.40
383	Mixed phenotype acute leukemia with t	Enrichment	FLT3	1.40
384	Renal cell carcinoma	Enrichment	MET	1.40
385	Testicular cancer	Enrichment	FGFR3	1.40
386	Keratoacanthoma	Enrichment	PIK3CA	1.40
387	Scoliosis	Enrichment	GRIN2B, PTPN11	1.39
388	Tetralogy of fallot	Enrichment	FLT4, KDR	1.32
389	Strabismus	Enrichment	GNB1, PTPN11	1.29
390	Diffuse gastric and lobular breast cancer syndrome	Enrichment	KRAS	1.28
391	Spastic paraplegia 17, autosomal dominant	Enrichment	GNG3	1.28
392	Astigmatism	Enrichment	GRIN2B	1.28
393	Autoimmune lymphoproliferative syndrome	Enrichment	FASLG	1.28
394	Lipodystrophy, congenital generalized, type 2	Enrichment	GNG3	1.28
395	Glaucoma 3, primary infantile, b	Enrichment	TEK	1.28
396	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	MAPK1	1.28
397	Lung sarcomatoid carcinoma	Enrichment	KRAS	1.28
398	Chronic myelomonocytic leukemia	Enrichment	FLT3	1.28
399	Hereditary ataxia	Enrichment	PRKCG	1.28
400	Ciliary dyskinesia, primary, 22	Enrichment	RASSF1	1.28
401	Cerebrovascular disease	Enrichment	PIK3CA	1.28
402	Embryonal rhabdomyosarcoma	Enrichment	NF1	1.28
403	Epidermolytic nevus	Enrichment	HRAS	1.28
404	Familial cerebral cavernous malformations	Enrichment	PIK3CA	1.28
405	Knobloch syndrome	Enrichment	PAK2	1.28
406	Non-syndromic bicoronal craniosynostosis	Enrichment	FGFR3	1.28
407	Systemic mastocytosis with associated hematologic neoplasm	Enrichment	KIT	1.28
408	Glioma	Enrichment	FGFR2	1.28
409	Middle aortic syndrome	Enrichment	NF1	1.28
410	Gingival fibromatosis	Enrichment	SOS1	1.28
411	Male infertility due to gonadal dysgenesis or sperm disorder	Enrichment	SOS2	1.28
412	Familial sick sinus syndrome	Enrichment	GNB2	1.28
413	Long qt syndrome	Enrichment	CALM1, CALM2	1.19
414	Cataract 6, multiple types	Enrichment	EPHA2	1.18
415	Anemia, congenital, nonspherocytic hemolytic, 1	Enrichment	IKBKG	1.18
416	Polycystic kidney disease 3 with or without polycystic liver disease	Enrichment	SHOC2	1.18
417	Rhabdomyosarcoma 2	Enrichment	NF1	1.18
418	Insulin-like growth factor i	Enrichment	IGF1R	1.18
419	Knobloch syndrome 1	Enrichment	PAK2	1.18
420	Mosaic variegated aneuploidy syndrome 1	Enrichment	BUB1B-PAK6	1.18
421	Pre-eclampsia	Enrichment	FLT1	1.18
422	Lymphoma	Enrichment	PTPN11	1.18
423	Holoprosencephaly	Enrichment	FGFR1	1.18
424	Aniridia	Enrichment	EPHA2	1.18
425	Sleep disorder	Enrichment	GRIN2B	1.18
426	Telangiectasia, hereditary hemorrhagic, type 1	Enrichment	RASA1	1.11
427	Split-hand/foot malformation 1	Enrichment	FGFR2	1.11
428	Holoprosencephaly 1	Enrichment	FGFR1	1.11
429	Ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy	Enrichment	CALM1	1.11
430	Basal cell carcinoma 1	Enrichment	RASA1	1.11
431	Patent ductus arteriosus	Enrichment	PTPN11	1.11
432	Glaucoma 3, primary congenital, a	Enrichment	TEK	1.04
433	Squamous cell carcinoma, head and neck	Enrichment	EGFR	1.04
434	Renal cell carcinoma, papillary, 1	Enrichment	MET	1.04
435	Neuropathy, hereditary sensory and autonomic, type v	Enrichment	NTRK1	1.04
436	Hereditary hemorrhagic telangiectasia	Enrichment	RASA1	1.04
437	Megacolon	Enrichment	AKT3	1.04
438	Common variable immunodeficiency	Enrichment	NFKB1	1.04
439	Overgrowth syndrome	Enrichment	PIK3R1	1.04
440	Moyamoya angiopathy	Enrichment	ABL1	1.04
441	Epilepsy	Enrichment	GRIN2A, GRIN2B	0.99
442	Arthrogryposis, distal, type 1a	Enrichment	MET	0.99
443	Basal ganglia calcification, idiopathic, 1	Enrichment	PDGFRB	0.99
444	Polycystic kidney disease 4 with or without polycystic liver disease	Enrichment	SHOC2	0.99
445	Ewing sarcoma	Enrichment	NF1	0.99
446	Lennox-gastaut syndrome	Enrichment	MAPK10	0.99
447	Catecholaminergic polymorphic ventricular tachycardia 1	Enrichment	CALM1	0.99
448	Mosaic variegated aneuploidy syndrome	Enrichment	BUB1B-PAK6	0.99
449	Hypothyroidism	Enrichment	GNB1	0.99
450	Childhood-onset schizophrenia	Enrichment	TTBK1	0.99
451	Early-onset posterior polar cataract	Enrichment	EPHA2	0.99
452	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN1, GRIN2A	0.98
453	Type 2 diabetes mellitus	Enrichment	AKT2, INSR	0.96
454	Centralopathic epilepsy	Enrichment	GRIN1, GRIN2A	0.94
455	Neurofibromatosis, type i	Enrichment	NF1	0.94
456	Nephrotic syndrome, type 1	Enrichment	PLCE1	0.94
457	Coronary heart disease 5	Enrichment	IKBKG	0.94
458	Leukemia, acute lymphoblastic 3	Enrichment	NF1	0.94
459	Myoclonic-atonic epilepsy	Enrichment	SYNGAP1	0.94
460	Neurodevelopmental disorder with dysmorphic facies and distal limb anomalies	Enrichment	RAC1	0.94
461	Atypical chronic myeloid leukemia, bcr-abl1 negative	Enrichment	FLT3	0.94
462	Adult hepatocellular carcinoma	Enrichment	PIK3CA	0.94
463	Hypogonadotropic hypogonadism	Enrichment	FGFR1	0.94
464	Ventricular septal defect	Enrichment	TEK	0.94
465	Meier-gorlin syndrome 1	Enrichment	FGFR2	0.90
466	Ciliary dyskinesia, primary, 3	Enrichment	NFKB1	0.90
467	Neurodegeneration with brain iron accumulation	Enrichment	PLA2G6	0.90
468	Polymicrogyria	Enrichment	AKT3	0.90
469	Familial colorectal cancer	Enrichment	PLA2G2A	0.90
470	Primary bone dysplasia	Enrichment	FGFR3	0.90
471	Frontotemporal dementia 1	Enrichment	CSF1R	0.86
472	Myelodysplastic syndrome	Enrichment	GNB1	0.86
473	Combined immunodeficiency	Enrichment	ZAP70	0.86
474	Osteochondrodysplasia	Enrichment	FGFR3	0.86
475	Combined t cell and b cell immunodeficiency	Enrichment	ZAP70	0.86
476	Combined t and b cell immunodeficiency	Enrichment	ZAP70	0.86
477	Epicanthus	Enrichment	PTPN11	0.82
478	Septooptic dysplasia	Enrichment	FGFR1	0.82
479	Renal hypodysplasia/aplasia 3	Enrichment	FGFR3	0.82
480	Congenital long qt syndrome	Enrichment	PTPN11	0.82
481	Hypertelorism	Enrichment	FGFR2, PIK3CA	0.81
482	Aortic valve disease 1	Enrichment	SOS1	0.79
483	Alzheimer's disease	Enrichment	CSF1R	0.79
484	Stereotypic movement disorder	Enrichment	SYNGAP1	0.79
485	Protein-deficiency anemia	Enrichment	NRAS	0.79
486	Hereditary breast ovarian cancer syndrome	Enrichment	KRAS, NF1	0.77
487	Congenital nervous system abnormality	Enrichment	FGFR3, GNB5, PLA2G6	0.76
488	Nervous system disease	Enrichment	FGFR3, GNB5, PLA2G6	0.76
489	Hypogonadotropic hypogonadism 7 with or without anosmia	Enrichment	FGFR1	0.76
490	Pheochromocytoma	Enrichment	NF1	0.76
491	Heart disease	Enrichment	ABL1	0.76
492	Cataract	Enrichment	EPHA2	0.76
493	Cleft lip/palate	Enrichment	PDGFRA	0.76
494	46,xy partial gonadal dysgenesis	Enrichment	SOS1	0.76
495	Renal cell carcinoma, nonpapillary	Enrichment	MET	0.73
496	Primary ovarian insufficiency	Enrichment	KDR, NTRK1	0.72
497	Cerebellar hypoplasia/atrophy, epilepsy, and global developmental delay	Enrichment	PLA2G6	0.71
498	Microform holoprosencephaly	Enrichment	FGFR1	0.71
499	Lobar holoprosencephaly	Enrichment	FGFR1	0.71
500	Alzheimer disease, familial, 1	Enrichment	CSF1R	0.69
501	Hypertension, essential	Enrichment	GNB3	0.69
502	Cleft palate, isolated	Enrichment	GNB1	0.69
503	Dandy-walker syndrome	Enrichment	PDGFRB	0.69
504	Sudden infant death syndrome	Enrichment	CALM2	0.69
505	Cataract 44	Enrichment	EPHA2	0.69
506	Heart, malformation of	Enrichment	MAPK1	0.66
507	Patent foramen ovale	Enrichment	PTPN11	0.66
508	Early infantile developmental and epileptic encephalopathy	Enrichment	GRIN1	0.66
509	Semilobar holoprosencephaly	Enrichment	FGFR1	0.66
510	Normosmic congenital hypogonadotropic hypogonadism	Enrichment	FGFR1	0.66
511	Early-onset nuclear cataract	Enrichment	EPHA2	0.66
512	Focal segmental glomerulosclerosis	Enrichment	PLCE1	0.62
513	Cardiomyopathy, dilated, 1a	Enrichment	RAPGEF5	0.60
514	Hepatoblastoma	Enrichment	FGFR3	0.60
515	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	NF1	0.60
516	Attention deficit-hyperactivity disorder	Enrichment	GNB5	0.59
517	Tooth agenesis	Enrichment	FGFR1	0.59
518	Skin disease	Enrichment	NF1	0.59
519	Malaria	Enrichment	IKBKG	0.57
520	Congenital stationary night blindness	Enrichment	GNB3	0.57
521	Kallmann syndrome	Enrichment	FGFR1	0.57
522	Cardiomyopathy, familial hypertrophic, 1	Enrichment	RAF1	0.56
523	Pancreatic cancer	Enrichment	KRAS	0.54
524	Developmental and epileptic encephalopathy 1	Enrichment	GRIN1	0.54
525	Prostate cancer	Enrichment	PIK3CA	0.49
526	Connective tissue disease	Enrichment	FGFR3	0.45
527	Familial hypertrophic cardiomyopathy	Enrichment	RAF1	0.44
528	Genetic steroid-resistant nephrotic syndrome	Enrichment	PLCE1	0.43
529	Left ventricular noncompaction	Enrichment	RAF1	0.42
530	Dystonia	Enrichment	GNB1	0.42
531	Systemic lupus erythematosus	Enrichment	ETS1	0.39
532	Nephrotic syndrome	Enrichment	PLCE1	0.35
533	Hypertrophic cardiomyopathy	Enrichment	PTPN11	0.35
534	Thrombocytopenia	Enrichment	PTPN11	0.32
535	Spastic ataxia	Enrichment	PLA2G6	0.29
536	Familial isolated dilated cardiomyopathy	Enrichment	RAF1	0.29
537	Male infertility with azoospermia or oligozoospermia due to single gene mutation	Enrichment	PTPN11	0.27
538	Undetermined early-onset epileptic encephalopathy	Enrichment	NTRK2	0.27
539	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	CSF1R	0.26
540	Autosomal recessive non-syndromic intellectual disability	Enrichment	GRIN1	0.26
541	Dilated cardiomyopathy	Enrichment	RAF1	0.18
542	Rare autosomal recessive non-syndromic sensorineural deafness type dfnb	Enrichment	MET	0.15

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Ras signaling

Pathway Network for Ras signaling

Member Pathways for Ras signaling

Pathways in the Ras signaling SuperPath

Associated Genes for Ras signaling

Associated Disorders for Ras signaling

Disorders associated with Ras signaling SuperPath

STRING Interaction Network for Ras signaling

Sources for Ras signaling