Reelin Pathway (Cajal-Retzius cells)

No Pathway Network information available for Reelin Pathway (Cajal-Retzius cells)

Pathways in the Reelin Pathway (Cajal-Retzius cells) SuperPath

#	Name	Source	Genes
1	Reelin Pathway (Cajal-Retzius cells)	QIAGEN	ACTA1 ACTA2 ACTB ACTG1 ACTG2 APBB1 APC APOE APP AXIN1 CDK5 CDK5R1 CDK5R2 CNR1 CNR2 CTNNB1 DAB1 DKK1 DKK2 DKK4 DVL1 ELK1 FYN FZD1 FZD10 FZD2 FZD3 FZD4 FZD5 FZD6 FZD7 FZD8 FZD9 GSK3B ITGA1 ITGA10 ITGA11 ITGA2 ITGA2B ITGA3 ITGA4 ITGA5 ITGA6 ITGA7 ITGA8 ITGA9 ITGAD ITGAE ITGAL ITGAM ITGAV ITGAX ITGB1 ITGB2 ITGB3 ITGB4 ITGB5 ITGB6 ITGB7 ITGB8 JUN KIF13A KIF1B KIF1C KIF21A KIF2A KIF2C LRP5 LRP6 LRP8 MAP2K7 MAP3K11 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPK9 MAPT NDEL1 PCDHA4 PPP2CA PPP2CB PPP2R1A PPP2R1B PPP2R2A PPP2R2B PPP2R2C PPP2R3A PPP2R3B PPP2R5A PPP2R5B PPP2R5C PPP2R5E PTPA RELN SRC VLDLR WNT1 WNT2 WNT3 (see all 101) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	1
2	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	1
3	ACTB	Actin Beta	Protein Coding	1
4	ACTG1	Actin Gamma 1	Protein Coding	1
5	ACTG2	Actin Gamma 2, Smooth Muscle	Protein Coding	1
6	APBB1	Amyloid Beta Precursor Protein Binding Family B Member 1	Protein Coding	1
7	APC	APC Regulator Of Wnt Signaling Pathway	Protein Coding	1
8	APOE	Apolipoprotein E	Protein Coding	1
9	APP	Amyloid Beta Precursor Protein	Protein Coding	1
10	AXIN1	Axin 1	Protein Coding	1
11	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
12	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	1
13	CDK5R2	Cyclin Dependent Kinase 5 Regulatory Subunit 2	Protein Coding	1
14	CNR1	Cannabinoid Receptor 1	Protein Coding	1
15	CNR2	Cannabinoid Receptor 2	Protein Coding	1
16	CTNNB1	Catenin Beta 1	Protein Coding	1
17	DAB1	DAB Adaptor Protein 1	Protein Coding	1
18	DKK1	Dickkopf Wnt Signaling Pathway Inhibitor 1	Protein Coding	1
19	DKK2	Dickkopf Wnt Signaling Pathway Inhibitor 2	Protein Coding	1
20	DKK4	Dickkopf Wnt Signaling Pathway Inhibitor 4	Protein Coding	1
21	DVL1	Dishevelled Segment Polarity Protein 1	Protein Coding	1
22	ELK1	ETS Transcription Factor ELK1	Protein Coding	1
23	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
24	FZD1	Frizzled Class Receptor 1	Protein Coding	1
25	FZD10	Frizzled Class Receptor 10	Protein Coding	1
26	FZD2	Frizzled Class Receptor 2	Protein Coding	1
27	FZD3	Frizzled Class Receptor 3	Protein Coding	1
28	FZD4	Frizzled Class Receptor 4	Protein Coding	1
29	FZD5	Frizzled Class Receptor 5	Protein Coding	1
30	FZD6	Frizzled Class Receptor 6	Protein Coding	1
31	FZD7	Frizzled Class Receptor 7	Protein Coding	1
32	FZD8	Frizzled Class Receptor 8	Protein Coding	1
33	FZD9	Frizzled Class Receptor 9	Protein Coding	1
34	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
35	ITGA1	Integrin Subunit Alpha 1	Protein Coding	1
36	ITGA10	Integrin Subunit Alpha 10	Protein Coding	1
37	ITGA11	Integrin Subunit Alpha 11	Protein Coding	1
38	ITGA2	Integrin Subunit Alpha 2	Protein Coding	1
39	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	1
40	ITGA3	Integrin Subunit Alpha 3	Protein Coding	1
41	ITGA4	Integrin Subunit Alpha 4	Protein Coding	1
42	ITGA5	Integrin Subunit Alpha 5	Protein Coding	1
43	ITGA6	Integrin Subunit Alpha 6	Protein Coding	1
44	ITGA7	Integrin Subunit Alpha 7	Protein Coding	1
45	ITGA8	Integrin Subunit Alpha 8	Protein Coding	1
46	ITGA9	Integrin Subunit Alpha 9	Protein Coding	1
47	ITGAD	Integrin Subunit Alpha D	Protein Coding	1
48	ITGAE	Integrin Subunit Alpha E	Protein Coding	1
49	ITGAL	Integrin Subunit Alpha L	Protein Coding	1
50	ITGAM	Integrin Subunit Alpha M	Protein Coding	1
51	ITGAV	Integrin Subunit Alpha V	Protein Coding	1
52	ITGAX	Integrin Subunit Alpha X	Protein Coding	1
53	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
54	ITGB2	Integrin Subunit Beta 2	Protein Coding	1
55	ITGB3	Integrin Subunit Beta 3	Protein Coding	1
56	ITGB4	Integrin Subunit Beta 4	Protein Coding	1
57	ITGB5	Integrin Subunit Beta 5	Protein Coding	1
58	ITGB6	Integrin Subunit Beta 6	Protein Coding	1
59	ITGB7	Integrin Subunit Beta 7	Protein Coding	1
60	ITGB8	Integrin Subunit Beta 8	Protein Coding	1
61	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	1
62	KIF13A	Kinesin Family Member 13A	Protein Coding	1
63	KIF1B	Kinesin Family Member 1B	Protein Coding	1
64	KIF1C	Kinesin Family Member 1C	Protein Coding	1
65	KIF2A	Kinesin Family Member 2A	Protein Coding	1
66	KIF21A	Kinesin Family Member 21A	Protein Coding	1
67	KIF2C	Kinesin Family Member 2C	Protein Coding	1
68	LRP5	LDL Receptor Related Protein 5	Protein Coding	1
69	LRP6	LDL Receptor Related Protein 6	Protein Coding	1
70	LRP8	LDL Receptor Related Protein 8	Protein Coding	1
71	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1
72	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
73	MAPK10	Mitogen-Activated Protein Kinase 10	Protein Coding	1
74	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
75	MAPK8IP1	Mitogen-Activated Protein Kinase 8 Interacting Protein 1	Protein Coding	1
76	MAPK8IP2	Mitogen-Activated Protein Kinase 8 Interacting Protein 2	Protein Coding	1
77	MAPK8IP3	Mitogen-Activated Protein Kinase 8 Interacting Protein 3	Protein Coding	1
78	MAPK9	Mitogen-Activated Protein Kinase 9	Protein Coding	1
79	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
80	NDEL1	NudE Neurodevelopment Protein 1 Like 1	Protein Coding	1
81	PCDHA4	Protocadherin Alpha 4	Protein Coding	1
82	PPP2CA	Protein Phosphatase 2 Catalytic Subunit Alpha	Protein Coding	1
83	PPP2CB	Protein Phosphatase 2 Catalytic Subunit Beta	Protein Coding	1
84	PPP2R1A	Protein Phosphatase 2 Scaffold Subunit Aalpha	Protein Coding	1
85	PPP2R1B	Protein Phosphatase 2 Scaffold Subunit Abeta	Protein Coding	1
86	PPP2R2A	Protein Phosphatase 2 Regulatory Subunit Balpha	Protein Coding	1
87	PPP2R2B	Protein Phosphatase 2 Regulatory Subunit Bbeta	Protein Coding	1
88	PPP2R2C	Protein Phosphatase 2 Regulatory Subunit Bgamma	Protein Coding	1
89	PPP2R3A	Protein Phosphatase 2 Regulatory Subunit B''''Alpha	Protein Coding	1
90	PTPA	Protein Phosphatase 2 Phosphatase Activator	Protein Coding	1
91	PPP2R5A	Protein Phosphatase 2 Regulatory Subunit B''Alpha	Protein Coding	1
92	PPP2R5B	Protein Phosphatase 2 Regulatory Subunit B''Beta	Protein Coding	1
93	PPP2R5C	Protein Phosphatase 2 Regulatory Subunit B''Gamma	Protein Coding	1
94	PPP2R5E	Protein Phosphatase 2 Regulatory Subunit B''Epsilon	Protein Coding	1
95	PPP2R3B	Protein Phosphatase 2 Regulatory Subunit B''''Beta~Name Same As:- HGNC:9310	Protein Coding	1
96	RELN	Reelin	Protein Coding	1
97	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	1
98	VLDLR	Very Low Density Lipoprotein Receptor	Protein Coding	1
99	WNT1	Wnt Family Member 1	Protein Coding	1
100	WNT2	Wnt Family Member 2	Protein Coding	1
101	WNT3	Wnt Family Member 3	Protein Coding	1

Disorders associated with Reelin Pathway (Cajal-Retzius cells) SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Exudative vitreoretinopathy 1	Enrichment	CTNNB1, FZD4, LRP5	5.40
2	Fetomaternal alloimmune thrombocytopenia 1	Enrichment	ITGA2, ITGA2B, ITGB3	5.10
3	Exudative vitreoretinopathy	Enrichment	CTNNB1, FZD4, LRP5	4.66
4	Baraitser-winter cerebrofrontofacial syndrome	Enrichment	ACTB, ACTG1	4.26
5	Alzheimer's disease	Enrichment	APOE, APP, MAPT	3.96
6	Osteoporosis	Enrichment	LRP5, SRC, WNT1	3.86
7	Desmoid disease, hereditary	Enrichment	APC, CTNNB1	3.79
8	Bleeding disorder, platelet-type, 16	Enrichment	ITGA2B, ITGB3	3.79
9	Osteoporosis, juvenile	Enrichment	DKK1, WNT1	3.79
10	Desmoid tumor	Enrichment	APC, CTNNB1	3.79
11	Alzheimer disease, familial, 1	Enrichment	APOE, APP, MAPT	3.60
12	Polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	3.60
13	Autosomal dominant polycystic liver disease	Enrichment	CTNNB1, LRP5, LRP6	3.60
14	Robinow syndrome, autosomal dominant 1	Enrichment	DVL1, FZD2	3.49
15	Retinopathy of prematurity	Enrichment	FZD4, LRP5	3.49
16	Craniopharyngioma	Enrichment	APC, CTNNB1	3.49
17	Autosomal dominant robinow syndrome	Enrichment	DVL1, FZD2	3.49
18	Robinow syndrome, autosomal recessive 1	Enrichment	DVL1, FZD2	3.27
19	Robinow syndrome, autosomal dominant 2	Enrichment	DVL1, FZD2	3.27
20	Coloboma of choroid and retina	Enrichment	ACTG1, FZD5	3.27
21	Hepatocellular carcinoma	Enrichment	APC, AXIN1, CTNNB1	3.25
22	Epidermolysis bullosa, junctional 5b, with pyloric atresia	Enrichment	ITGA6, ITGB4	3.09
23	Autosomal recessive robinow syndrome	Enrichment	DVL1, FZD2	3.09
24	Glanzmann thrombasthenia 1	Enrichment	ITGA2B, ITGB3	2.95
25	Adult hepatocellular carcinoma	Enrichment	AXIN1, CTNNB1	2.72
26	Junctional epidermolysis bullosa	Enrichment	ITGA6, ITGB4	2.72
27	Cat eye syndrome	Enrichment	ACTG1, FZD5	2.62
28	Autosomal dominant macrothrombocytopenia	Enrichment	ITGA2B, ITGB3	2.62
29	Colorectal cancer	Enrichment	APC, CTNNB1, FZD3, SRC	2.40
30	Medulloblastoma	Enrichment	APC, CTNNB1	2.33
31	Congenital myopathy 4a, autosomal dominant	Enrichment	ACTA1, ITGA7	2.27
32	Thrombocytopenia	Enrichment	ITGA2B, ITGB3, SRC	2.26
33	Arthritis, sacroiliac	Enrichment	RELN	2.13
34	Chiari malformation type i	Enrichment	DKK1	2.13
35	Fibrosis of extraocular muscles, congenital, 1	Enrichment	KIF21A	2.13
36	Charcot-marie-tooth disease, axonal, type 2a1	Enrichment	KIF1B	2.13
37	Endosteal hyperostosis, autosomal dominant	Enrichment	LRP5	2.13
38	Nail disorder, nonsyndromic congenital, 1	Enrichment	FZD6	2.13
39	Baraitser-winter syndrome 1	Enrichment	ACTB	2.13
40	Sea-blue histiocyte disease	Enrichment	APOE	2.13
41	Bone mineral density quantitative trait locus 1	Enrichment	LRP5	2.13
42	Exudative vitreoretinopathy 4	Enrichment	LRP5	2.13
43	Systemic lupus erythematosus 6	Enrichment	ITGAM	2.13
44	Spinocerebellar ataxia 12	Enrichment	PPP2R2B	2.13
45	Congenital myopathy 2a, typical, autosomal dominant	Enrichment	ACTA1	2.13
46	Omodysplasia 2	Enrichment	FZD2	2.13
47	Lipoprotein glomerulopathy	Enrichment	APOE	2.13
48	Tooth agenesis, selective, 7	Enrichment	LRP6	2.13
49	Myopathy, scapulohumeroperoneal	Enrichment	ACTA1	2.13
50	Caudal duplication anomaly	Enrichment	AXIN1	2.13
51	Neuroblastoma 1	Enrichment	KIF1B	2.13
52	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.13
53	Cortical dysplasia, complex, with other brain malformations 3	Enrichment	KIF2A	2.13
54	Exudative vitreoretinopathy 8	Enrichment	LRP6	2.13
55	Megacystis-microcolon-intestinal hypoperistalsis syndrome 5	Enrichment	ACTG2	2.13
56	Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development	Enrichment	PTPA	2.13
57	Houge-janssens syndrome 4	Enrichment	PPP2R5C	2.13
58	Fetomaternal alloimmune thrombocytopenia 2	Enrichment	ITGA2B	2.13
59	Congenital smooth muscle hamartoma, with or without hemihypertrophy	Enrichment	ACTB	2.13
60	Parkinson-dementia syndrome	Enrichment	MAPT	2.13
61	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.13
62	Osteoporosis-pseudoglioma syndrome	Enrichment	LRP5	2.13
63	Coronary artery disease, autosomal dominant 2	Enrichment	LRP6	2.13
64	Bone mineral density quantitative trait locus 16	Enrichment	WNT1	2.13
65	Houge-janssens syndrome 2	Enrichment	PPP2R1A	2.13
66	Progressive supranuclear palsy	Enrichment	MAPT	2.13
67	Polycystic liver disease 4 with or without kidney cysts	Enrichment	LRP5	2.13
68	Cerebral amyloid angiopathy, app-related	Enrichment	APP	2.13
69	Becker nevus syndrome	Enrichment	ACTB	2.13
70	Ocular motility disease	Enrichment	KIF21A	2.13
71	Dystonia-deafness syndrome 1	Enrichment	ACTB	2.13
72	Visceral neuropathy, familial, 3, autosomal dominant	Enrichment	ACTG2	2.13
73	Charcot-marie-tooth disease type 2a1	Enrichment	KIF1B	2.13
74	Congenital myopathy 2b, severe infantile, autosomal recessive	Enrichment	ACTA1	2.13
75	Spinocerebellar ataxia 37	Enrichment	DAB1	2.13
76	Synovitis	Enrichment	RELN	2.13
77	Autosomal dominant familial visceral neuropathy	Enrichment	ACTG2	2.13
78	Microphthalmia/coloboma 11	Enrichment	FZD5	2.13
79	Thrombocytopenia 6	Enrichment	SRC	2.13
80	Congenital myopathy 2c, severe infantile, autosomal dominant	Enrichment	ACTA1	2.13
81	Thrombocytopenia 8, with dysmorphic features and developmental delay	Enrichment	ACTB	2.13
82	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.13
83	Craniometadiaphyseal osteosclerosis with hip dysplasia	Enrichment	AXIN1	2.13
84	Adenoid ameloblastoma	Enrichment	CTNNB1	2.13
85	Amelogenesis imperfecta, type ih	Enrichment	ITGB6	2.13
86	Baraitser-winter syndrome	Enrichment	ACTB	2.13
87	Cerebellar hypoplasia	Enrichment	VLDLR	2.13
88	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.13
89	Lrp5-related primary osteoporosis	Enrichment	LRP5	2.13
90	Fetomaternal alloimmune thrombocytopenia 3	Enrichment	ITGA2	2.13
91	Immune dysregulation, neurodevelopmental defects, and colitis	Enrichment	ITGAV	2.13
92	Familial adenomatous polyposis	Enrichment	APC	2.13
93	Zebra body myopathy	Enrichment	ACTA1	2.13
94	Congenital smooth muscle hamartoma	Enrichment	ACTB	2.13
95	Developmental malformations-deafness-dystonia syndrome	Enrichment	ACTB	2.13
96	Gardner syndrome	Enrichment	APC	2.13
97	Osteosclerosis-developmental delay-craniosynostosis syndrome	Enrichment	LRP5	2.13
98	5q22 microdeletion syndrome	Enrichment	APC	2.13
99	Ppp2r1a-related neurodevelopmental disorder	Enrichment	PPP2R1A	2.13
100	Actin-accumulation myopathy	Enrichment	ACTA1	2.13
101	Attenuated familial adenomatous polyposis	Enrichment	APC	2.13
102	Myopathic intestinal pseudoobstruction	Enrichment	ACTG2	2.13
103	Microcystic stromal tumor	Enrichment	CTNNB1	2.13
104	Actg2 visceral myopathy	Enrichment	ACTG2	2.13
105	Lissencephaly	Enrichment	ACTG1, RELN	1.98
106	Hepatoblastoma	Enrichment	APC, CTNNB1	1.98
107	Myocardial infarction	Enrichment	ITGB3, LRP8	1.94
108	Brittle bone disorder	Enrichment	LRP5, WNT1	1.90
109	Cerebral amyloid angiopathy, cst3-related	Enrichment	APP	1.83
110	Leukocyte adhesion deficiency, type i	Enrichment	ITGB2	1.83
111	Van buchem disease	Enrichment	LRP5	1.83
112	Bladder exstrophy and epispadias complex	Enrichment	WNT3	1.83
113	Osteopathia striata with cranial sclerosis	Enrichment	CTNNB1	1.83
114	Alzheimer disease 3	Enrichment	APOE	1.83
115	Tetraamelia syndrome 1	Enrichment	WNT3	1.83
116	Aortic aneurysm, familial thoracic 2	Enrichment	ACTA2	1.83
117	Pick disease of brain	Enrichment	MAPT	1.83
118	Deafness, autosomal dominant 20	Enrichment	ACTG1	1.83
119	Osteogenesis imperfecta, type xv	Enrichment	WNT1	1.83
120	Smooth muscle dysfunction syndrome	Enrichment	ACTA2	1.83
121	Leukocyte adhesion deficiency, type iii	Enrichment	ITGB2	1.83
122	Aortic aneurysm, familial thoracic 6	Enrichment	ACTA2	1.83
123	Baraitser-winter syndrome 2	Enrichment	ACTG1	1.83
124	Robinow syndrome, autosomal dominant 3	Enrichment	FZD2	1.83
125	Moyamoya disease 5	Enrichment	ACTA2	1.83
126	Epidermolysis bullosa, junctional 5a, intermediate	Enrichment	ITGB4	1.83
127	Neurodevelopmental disorder with or without variable brain abnormalities	Enrichment	MAPK8IP3	1.83
128	Hyperlipoproteinemia, type iii	Enrichment	APOE	1.83
129	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome	Enrichment	VLDLR	1.83
130	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	1.83
131	Childhood hepatocellular carcinoma	Enrichment	CTNNB1	1.83
132	Periampullary adenoma	Enrichment	APC	1.83
133	Gastric adenocarcinoma and proximal polyposis of the stomach	Enrichment	APC	1.83
134	Houge-janssens syndrome 3	Enrichment	PPP2CA	1.83
135	Juvenile nasopharyngeal angiofibroma	Enrichment	CTNNB1	1.83
136	Localized junctional epidermolysis bullosa, non-herlitz type	Enrichment	ITGB4	1.83
137	Arthritis	Enrichment	RELN	1.83
138	Teratoma	Enrichment	CTNNB1	1.83
139	Osteosclerosis	Enrichment	LRP5	1.83
140	Bladder exstrophy-epispadias-cloacal exstrophy complex	Enrichment	WNT3	1.83
141	Intestinal obstruction	Enrichment	ACTG2	1.83
142	Hydrops fetalis, nonimmune	Enrichment	ACTA1, FZD6	1.80
143	Hyper-ige syndrome 1, autosomal dominant, with recurrent infections	Enrichment	ITGB3	1.65
144	Niemann-pick disease, type a	Enrichment	APBB1	1.65
145	Osteopetrosis, autosomal dominant 1	Enrichment	LRP5	1.65
146	Alzheimer disease 4	Enrichment	APOE	1.65
147	Niemann-pick disease, type b	Enrichment	APBB1	1.65
148	Spastic ataxia 2, autosomal recessive	Enrichment	KIF1C	1.65
149	Neurodevelopmental disorder with spastic diplegia and visual defects	Enrichment	CTNNB1	1.65
150	Muscular dystrophy, congenital, due to integrin alpha-7 deficiency	Enrichment	ITGA7	1.65
151	Cenani-lenz syndactyly syndrome	Enrichment	APC	1.65
152	Epilepsy, familial temporal lobe, 7	Enrichment	RELN	1.65
153	Anus, imperforate	Enrichment	CTNNB1	1.65
154	Exudative vitreoretinopathy 7	Enrichment	CTNNB1	1.65
155	Epidermolysis bullosa, junctional 6, with pyloric atresia	Enrichment	ITGA6	1.65
156	Spastic ataxia 2	Enrichment	KIF1C	1.65
157	Nail disease	Enrichment	FZD6	1.65
158	Kyphosis	Enrichment	RELN	1.65
159	Tetraamelia syndrome	Enrichment	WNT3	1.65
160	Colon adenocarcinoma	Enrichment	APC	1.65
161	Bleeding disorder, platelet-type, 24	Enrichment	ITGB3	1.65
162	Alopecia - intellectual disability syndrome	Enrichment	ITGB6	1.65
163	Apc-associated polyposis conditions	Enrichment	APC	1.65
164	Epilepsy with auditory features	Enrichment	RELN	1.65
165	Non-immune hydrops fetalis	Enrichment	ACTA1, FZD6	1.65
166	Lung cancer	Enrichment	ACTA2, PPP2R1B	1.63
167	Amelogenesis imperfecta, type iiia	Enrichment	ITGB6	1.53
168	Nemaline myopathy 2	Enrichment	ACTA1	1.53
169	Megacystis-microcolon-intestinal hypoperistalsis syndrome 1	Enrichment	ACTG2	1.53
170	Macular degeneration, age-related, 1	Enrichment	APOE	1.53
171	Autoimmune lymphoproliferative syndrome	Enrichment	ACTA2	1.53
172	Epidermolysis bullosa simplex 5c, with pyloric atresia	Enrichment	ITGB4	1.53
173	Pilomatrixoma	Enrichment	CTNNB1	1.53
174	Retinitis pigmentosa 26	Enrichment	ITGA4	1.53
175	Aminoacylase 1 deficiency	Enrichment	ACTB	1.53
176	Alazami syndrome	Enrichment	CTNNB1	1.53
177	Orofacial cleft	Enrichment	LRP6	1.53
178	Eyelid coloboma	Enrichment	FZD5	1.53
179	Intermediate nemaline myopathy	Enrichment	ACTA1	1.53
180	Vitreoretinopathy	Enrichment	LRP5	1.53
181	Orofacial clefting syndrome	Enrichment	LRP6	1.53
182	Lens coloboma	Enrichment	FZD5	1.53
183	Pseudomyogenic hemangioendothelioma	Enrichment	ACTB	1.53
184	Fetal akinesia deformation sequence 1	Enrichment	ACTA1, KIF21A	1.51
185	Alzheimer disease 2	Enrichment	APOE	1.44
186	Visceral myopathy 1	Enrichment	ACTG2	1.44
187	Epidermolysis bullosa simplex 1c, localized	Enrichment	ITGB4	1.44
188	Multiple endocrine neoplasia, type iia	Enrichment	KIF1B	1.44
189	Niemann-pick disease, type c1	Enrichment	APBB1	1.44
190	Congenital myopathy 3 with rigid spine	Enrichment	ACTA1	1.44
191	Norrie disease	Enrichment	FZD4	1.44
192	Familial adenomatous polyposis 1	Enrichment	APC	1.44
193	Lissencephaly 2	Enrichment	RELN	1.44
194	Glanzmann thrombasthenia 2	Enrichment	ITGB3	1.44
195	Niemann-pick disease	Enrichment	APBB1	1.44
196	Epidermolysis bullosa	Enrichment	ITGA6	1.44
197	Persistent hyperplastic primary vitreous	Enrichment	FZD4	1.44
198	Aplasia cutis congenita	Enrichment	ITGB4	1.44
199	Dementia	Enrichment	MAPT	1.44
200	Severe congenital nemaline myopathy	Enrichment	ACTA1	1.44
201	Distal arthrogryposis	Enrichment	ACTA1, FZD3	1.41
202	Ovarian cancer	Enrichment	APC, CTNNB1, KIF1B	1.40
203	Coloboma of optic nerve	Enrichment	FZD5	1.36
204	Weyers acrofacial dysostosis	Enrichment	CTNNB1	1.36
205	Epidermolysis bullosa, junctional 1a, intermediate	Enrichment	ITGB4	1.36
206	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	VLDLR	1.36
207	Moyamoya disease 1	Enrichment	ACTA2	1.36
208	Junctional epidermolysis bullosa non-herlitz type	Enrichment	ITGB4	1.36
209	Intestinal pseudo-obstruction	Enrichment	ACTG2	1.36
210	Congenital fibrosis of the extraocular muscles	Enrichment	KIF21A	1.36
211	Lipid metabolism disorder	Enrichment	APOE	1.36
212	Adrenocortical carcinoma	Enrichment	CTNNB1	1.36
213	Multicystic kidney dysplasia	Enrichment	FZD3	1.36
214	Typical nemaline myopathy	Enrichment	ACTA1	1.36
215	Multicystic dysplastic kidney	Enrichment	FZD3	1.36
216	Myelofibrosis	Enrichment	SRC	1.29
217	Coats disease	Enrichment	FZD4	1.29
218	Semantic dementia	Enrichment	MAPT	1.29
219	Alzheimer's disease 1	Enrichment	APP	1.29
220	Gallbladder cancer	Enrichment	CTNNB1	1.29
221	Epidermolysis bullosa simplex	Enrichment	ITGB4	1.29
222	Childhood-onset nemaline myopathy	Enrichment	ACTA1	1.29
223	Early-onset autosomal dominant alzheimer disease	Enrichment	APP	1.29
224	Renal hypodysplasia/aplasia 1	Enrichment	ITGA8	1.24
225	Lennox-gastaut syndrome	Enrichment	MAPK10	1.24
226	Neuroblastoma	Enrichment	KIF1B	1.24
227	Spastic ataxia	Enrichment	DAB1, KIF1C	1.23
228	Microcephaly	Enrichment	ACTB, ACTG1, CTNNB1	1.19
229	Progressive non-fluent aphasia	Enrichment	MAPT	1.19
230	Colonic benign neoplasm	Enrichment	APC	1.19
231	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	1.19
232	Renal agenesis, bilateral	Enrichment	ITGA8	1.19
233	Amelogenesis imperfecta, type ie	Enrichment	ITGB6	1.14
234	Nemaline myopathy	Enrichment	ACTA1	1.14
235	Frontotemporal dementia 1	Enrichment	MAPT	1.10
236	Microphthalmia/coloboma 12	Enrichment	FZD5	1.03
237	Osteogenesis imperfecta, type iv	Enrichment	WNT1	1.03
238	Neural tube defects	Enrichment	ITGB1	1.03
239	Multiple sclerosis	Enrichment	ITGB4	1.00
240	Lung cancer susceptibility 3	Enrichment	ACTA2	1.00
241	Isolated macular dystrophy	Enrichment	ITGA4	1.00
242	Coloboma of macula	Enrichment	FZD5	0.97
243	Osteogenesis imperfecta, type iii	Enrichment	WNT1	0.97
244	Hydrocephalus	Enrichment	FZD3	0.97
245	Familial hypercholesterolemia	Enrichment	APOE	0.97
246	Breast cancer	Enrichment	APC, JUN	0.97
247	Neuromuscular disease	Enrichment	ACTA1	0.90
248	Congenital myopathy	Enrichment	ACTA1	0.88
249	Centronuclear myopathy	Enrichment	ACTA1	0.84
250	Hereditary paraganglioma-pheochromocytoma syndromes	Enrichment	KIF1B	0.84
251	Tooth agenesis	Enrichment	LRP6	0.82
252	Skin disease	Enrichment	ITGB4	0.82
253	Parkinson disease, late-onset	Enrichment	MAPT	0.78
254	Scoliosis	Enrichment	RELN	0.78
255	Congenital nervous system abnormality	Enrichment	CTNNB1, VLDLR	0.73
256	Nervous system disease	Enrichment	CTNNB1, VLDLR	0.73
257	Bladder cancer	Enrichment	CTNNB1	0.71
258	Severe covid-19	Enrichment	ITGAV	0.71
259	Connective tissue disease	Enrichment	ACTA2	0.67
260	Cakut	Enrichment	ACTG1	0.65
261	Complex neurodevelopmental disorder	Enrichment	MAPK8IP3, PPP2CA	0.63
262	Non-syndromic genetic deafness	Enrichment	ACTG1	0.63
263	Systemic lupus erythematosus	Enrichment	ITGAM	0.60
264	Myopathy	Enrichment	ACTA1	0.59
265	Benign epilepsy with centrotemporal spikes	Enrichment	RELN	0.58
266	Type 2 diabetes mellitus	Enrichment	MAPK8IP1	0.57
267	Hereditary spastic paraplegia	Enrichment	KIF1C	0.57
268	Nonsyndromic hearing loss	Enrichment	ACTG1	0.57
269	Centralopathic epilepsy	Enrichment	RELN	0.56
270	Gastric cancer	Enrichment	APC	0.56
271	Nephrotic syndrome	Enrichment	ITGA3	0.56
272	Familial thoracic aortic aneurysm and aortic dissection	Enrichment	ACTA2	0.55
273	Hereditary breast carcinoma	Enrichment	APC	0.55
274	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	ACTG1	0.49
275	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT	0.45
276	Schizophrenia	Enrichment	RELN	0.45
277	Hereditary retinal dystrophy	Enrichment	FZD4, ITGA4, LRP5	0.44
278	Fundus dystrophy	Enrichment	FZD4, ITGA4, LRP5	0.44
279	Cone-rod dystrophy 2	Enrichment	ITGA4	0.40
280	Rare genetic deafness	Enrichment	ACTG1	0.35
281	Dilated cardiomyopathy	Enrichment	ACTA1	0.35
282	Inherited cancer-predisposing syndrome	Enrichment	APC	0.20

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Reelin Pathway (Cajal-Retzius cells)

Pathway Network for Reelin Pathway (Cajal-Retzius cells)

Member Pathways for Reelin Pathway (Cajal-Retzius cells)

Pathways in the Reelin Pathway (Cajal-Retzius cells) SuperPath

Associated Genes for Reelin Pathway (Cajal-Retzius cells)

Associated Disorders for Reelin Pathway (Cajal-Retzius cells)

Disorders associated with Reelin Pathway (Cajal-Retzius cells) SuperPath

STRING Interaction Network for Reelin Pathway (Cajal-Retzius cells)

Sources for Reelin Pathway (Cajal-Retzius cells)