Reelin signaling pathway

No Pathway Network information available for Reelin signaling pathway

Pathways in the Reelin signaling pathway SuperPath

#	Name	Source	Genes
1	Reelin signaling pathway	PubChem	AKT1 ARHGEF2 CBL CDK5 CDK5R1 CRKL DAB1 FYN GRIN2A GRIN2B GSK3B ITGA3 ITGB1 LRP8 LRPAP1 MAP1B MAP2K7 MAP3K11 MAPK8 MAPT NCK2 PAFAH1B1 PIK3CA PIK3R1 RAP1A RAPGEF1 RELN VLDLR (see all 28) (see less)

Ordered by rank within the SuperPath, via the multiplicity of each gene in the constituent pathways

#	Symbol	Description	Category	# Related Pathways
1	LRPAP1	LDL Receptor Related Protein Associated Protein 1	Protein Coding	1
2	ARHGEF2	Rho/Rac Guanine Nucleotide Exchange Factor 2	Protein Coding	1
3	MAP1B	Microtubule Associated Protein 1B	Protein Coding	1
4	GRIN2A	Glutamate Ionotropic Receptor NMDA Type Subunit 2A	Protein Coding	1
5	MAP3K11	Mitogen-Activated Protein Kinase Kinase Kinase 11	Protein Coding	1
6	RAPGEF1	Rap Guanine Nucleotide Exchange Factor 1	Protein Coding	1
7	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	1
8	MAPT	Microtubule Associated Protein Tau	Protein Coding	1
9	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	1
10	RAP1A	RAP1A, Member Of RAS Oncogene Family	Protein Coding	1
11	LRP8	LDL Receptor Related Protein 8	Protein Coding	1
12	ITGA3	Integrin Subunit Alpha 3	Protein Coding	1
13	DAB1	DAB Adaptor Protein 1	Protein Coding	1
14	RELN	Reelin	Protein Coding	1
15	GRIN2B	Glutamate Ionotropic Receptor NMDA Type Subunit 2B	Protein Coding	1
16	NCK2	NCK Adaptor Protein 2	Protein Coding	1
17	ITGB1	Integrin Subunit Beta 1	Protein Coding	1
18	CDK5R1	Cyclin Dependent Kinase 5 Regulatory Subunit 1	Protein Coding	1
19	CDK5	Cyclin Dependent Kinase 5	Protein Coding	1
20	GSK3B	Glycogen Synthase Kinase 3 Beta	Protein Coding	1
21	FYN	FYN Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	1
22	PAFAH1B1	Platelet Activating Factor Acetylhydrolase 1b Regulatory Subunit 1	Protein Coding	1
23	VLDLR	Very Low Density Lipoprotein Receptor	Protein Coding	1
24	CBL	Cbl Proto-Oncogene	Protein Coding	1
25	CRKL	CRK Like Proto-Oncogene, Adaptor Protein	Protein Coding	1
26	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	1
27	PIK3R1	Phosphoinositide-3-Kinase Regulatory Subunit 1	Protein Coding	1
28	MAP2K7	Mitogen-Activated Protein Kinase Kinase 7	Protein Coding	1

Disorders associated with Reelin signaling pathway SuperPath

according to GeneCards Suite gene sharing

#	Disorder	Type	Genes	Score
1	Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi	Enrichment	PIK3CA, PIK3R1	4.91
2	Breast adenocarcinoma	Enrichment	AKT1, PIK3CA	4.21
3	Cowden syndrome	Enrichment	AKT1, PIK3CA	3.83
4	Meningioma	Enrichment	AKT1, PIK3CA	3.57
5	Colorectal cancer	Enrichment	AKT1, PIK3CA, PIK3R1	3.13
6	Lissencephaly	Enrichment	PAFAH1B1, RELN	3.07
7	Scoliosis	Enrichment	GRIN2B, RELN	2.96
8	Arthritis, sacroiliac	Enrichment	RELN	2.69
9	Macrodactyly	Enrichment	PIK3CA	2.69
10	Proteus syndrome	Enrichment	AKT1	2.69
11	Epilepsy, focal, with speech disorder and with or without impaired intellectual development	Enrichment	GRIN2A	2.69
12	Megalencephaly, autosomal dominant	Enrichment	PIK3CA	2.69
13	Cowden syndrome 5	Enrichment	PIK3CA	2.69
14	Developmental and epileptic encephalopathy 27	Enrichment	GRIN2B	2.69
15	Lissencephaly 7 with cerebellar hypoplasia	Enrichment	CDK5	2.69
16	Cerebral cavernous malformations 4	Enrichment	PIK3CA	2.69
17	Neurodevelopmental disorder with midbrain and hindbrain malformations	Enrichment	ARHGEF2	2.69
18	Short syndrome	Enrichment	PIK3R1	2.69
19	Parkinson-dementia syndrome	Enrichment	MAPT	2.69
20	Supranuclear palsy, progressive, 1	Enrichment	MAPT	2.69
21	Deafness, autosomal dominant 83	Enrichment	MAP1B	2.69
22	Progressive supranuclear palsy	Enrichment	MAPT	2.69
23	Hemifacial myohyperplasia	Enrichment	PIK3CA	2.69
24	Capillary malformation of the lower lip, lymphatic malformation of face and neck, asymmetry of face and limbs, and partial/generalized overgrowth	Enrichment	PIK3CA	2.69
25	Intellectual developmental disorder, autosomal dominant 6, with or without seizures	Enrichment	GRIN2B	2.69
26	Immunodeficiency 36 with lymphoproliferation	Enrichment	PIK3R1	2.69
27	Cowden syndrome 6	Enrichment	AKT1	2.69
28	Spinocerebellar ataxia 37	Enrichment	DAB1	2.69
29	Synovitis	Enrichment	RELN	2.69
30	Agammaglobulinemia 7, autosomal recessive	Enrichment	PIK3R1	2.69
31	Classic progressive supranuclear palsy syndrome	Enrichment	MAPT	2.69
32	Segmental progressive overgrowth syndrome with fibroadipose hyperplasia	Enrichment	PIK3CA	2.69
33	Cerebellar hypoplasia	Enrichment	VLDLR	2.69
34	Atypical progressive supranuclear palsy syndrome	Enrichment	MAPT	2.69
35	Hypospadias	Enrichment	PIK3CA	2.69
36	Grin2b-related neurodevelopmental disorder	Enrichment	GRIN2B	2.69
37	Landau-kleffner syndrome	Enrichment	GRIN2A	2.69
38	Rare venous malformation	Enrichment	PIK3CA	2.69
39	Diaphragmatic eventration	Enrichment	PIK3CA	2.69
40	Pik3ca-related overgrowth spectrum	Enrichment	PIK3CA	2.69
41	Rare combined vascular malformation	Enrichment	PIK3CA	2.69
42	Cavernous lymphangioma	Enrichment	PIK3CA	2.69
43	Pik3ca-related overgrowth syndrome	Enrichment	PIK3CA	2.69
44	Early-onset epileptic encephalopathy and intellectual disability due to grin2a mutation	Enrichment	GRIN2A	2.69
45	Grin2a-related disorders	Enrichment	GRIN2A	2.69
46	Lissencephaly due to lis1 mutation	Enrichment	PAFAH1B1	2.69
47	Hemihyperplasia-multiple lipomatosis syndrome	Enrichment	PIK3CA	2.69
48	Eccrine angiomatous hamartoma	Enrichment	PIK3CA	2.69
49	Macrodactyly of toe	Enrichment	PIK3CA	2.69
50	Epilepsy	Enrichment	GRIN2A, GRIN2B	2.52
51	Benign epilepsy with centrotemporal spikes	Enrichment	GRIN2A, RELN	2.49
52	Centralopathic epilepsy	Enrichment	GRIN2A, RELN	2.45
53	Hereditary breast carcinoma	Enrichment	AKT1, PIK3CA	2.43
54	Ovarian germ cell cancer	Enrichment	CBL	2.38
55	Pick disease of brain	Enrichment	MAPT	2.38
56	Keratosis, seborrheic	Enrichment	PIK3CA	2.38
57	Lissencephaly 1	Enrichment	PAFAH1B1	2.38
58	Noonan syndrome 8	Enrichment	PIK3CA	2.38
59	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome	Enrichment	VLDLR	2.38
60	Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome	Enrichment	ITGA3	2.38
61	Periventricular nodular heterotopia 9	Enrichment	MAP1B	2.38
62	Intellectual developmental disorder, autosomal dominant 21	Enrichment	GRIN2A	2.38
63	Rosette-forming glioneuronal tumor	Enrichment	PIK3CA	2.38
64	Rolandic epilepsy-speech dyspraxia syndrome	Enrichment	GRIN2A	2.38
65	Arthritis	Enrichment	RELN	2.38
66	Malignant germ cell tumor of ovary	Enrichment	CBL	2.38
67	Epilepsy-aphasia spectrum	Enrichment	GRIN2A	2.38
68	Pompe disease, infantile-onset	Enrichment	PIK3CA	2.21
69	Band heterotopia	Enrichment	PAFAH1B1	2.21
70	Chromosome 5q14.3 deletion syndrome, distal	Enrichment	MAP1B	2.21
71	Epilepsy, familial temporal lobe, 7	Enrichment	RELN	2.21
72	Immunodeficiency 14a with lymphoproliferation, autosomal dominant	Enrichment	PIK3R1	2.21
73	Miller-dieker lissencephaly syndrome	Enrichment	PAFAH1B1	2.21
74	Chromosome 17p13.3, centromeric, duplication syndrome	Enrichment	PAFAH1B1	2.21
75	Myopia 23, autosomal recessive	Enrichment	LRPAP1	2.21
76	Immunodeficiency 14	Enrichment	PIK3R1	2.21
77	Pyloric stenosis	Enrichment	MAP1B	2.21
78	Kyphosis	Enrichment	RELN	2.21
79	Keratoacanthoma	Enrichment	PIK3CA	2.21
80	Epilepsy with auditory features	Enrichment	RELN	2.21
81	Astigmatism	Enrichment	GRIN2B	2.08
82	Megalencephaly-capillary malformation-polymicrogyria syndrome	Enrichment	PIK3CA	2.08
83	Chromosome 22q11.2 deletion syndrome, distal	Enrichment	CRKL	2.08
84	Cerebrovascular disease	Enrichment	PIK3CA	2.08
85	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia	Enrichment	CBL	2.08
86	Familial cerebral cavernous malformations	Enrichment	PIK3CA	2.08
87	Capillary malformations, congenital	Enrichment	PIK3CA	1.99
88	Chromosome 15q11.2 deletion syndrome	Enrichment	PAFAH1B1	1.99
89	Lissencephaly 2	Enrichment	RELN	1.99
90	Myeloproliferative neoplasm	Enrichment	CBL	1.99
91	Hemimegalencephaly	Enrichment	PIK3CA	1.99
92	Dementia	Enrichment	MAPT	1.99
93	Aggressive systemic mastocytosis	Enrichment	CBL	1.99
94	Rare isolated myopia	Enrichment	LRPAP1	1.99
95	Sleep disorder	Enrichment	GRIN2B	1.99
96	Breast cancer	Enrichment	AKT1, PIK3CA	1.98
97	Klippel-trenaunay-weber syndrome	Enrichment	PIK3CA	1.91
98	Cowden syndrome 1	Enrichment	PIK3CA	1.91
99	Cerebellar ataxia, impaired intellectual development, and dysequilibrium syndrome 1	Enrichment	VLDLR	1.91
100	Hemihyperplasia, isolated	Enrichment	PIK3CA	1.91
101	Lung squamous cell carcinoma	Enrichment	PIK3CA	1.91
102	Nevus, epidermal	Enrichment	PIK3CA	1.84
103	Capillary malformation-arteriovenous malformation 1	Enrichment	PIK3CA	1.84
104	Semantic dementia	Enrichment	MAPT	1.84
105	Gallbladder cancer	Enrichment	PIK3CA	1.84
106	Overgrowth syndrome	Enrichment	PIK3R1	1.84
107	Ovarian cancer	Enrichment	AKT1, PIK3CA	1.74
108	Arteriovenous malformation	Enrichment	PIK3CA	1.73
109	Adult hepatocellular carcinoma	Enrichment	PIK3CA	1.73
110	Progressive non-fluent aphasia	Enrichment	MAPT	1.73
111	Behavioral variant of frontotemporal dementia	Enrichment	MAPT	1.73
112	Myopathy, x-linked, with excessive autophagy	Enrichment	PIK3CA	1.69
113	Autosomal non-syndromic agammaglobulinemia	Enrichment	PIK3R1	1.69
114	Autism spectrum disorder	Enrichment	GRIN2B, MAP1B	1.68
115	Frontotemporal dementia 1	Enrichment	MAPT	1.65
116	Lung non-small cell carcinoma	Enrichment	PIK3CA	1.65
117	Juvenile myelomonocytic leukemia	Enrichment	CBL	1.61
118	Lip and oral cavity carcinoma	Enrichment	PIK3CA	1.61
119	Neural tube defects	Enrichment	ITGB1	1.58
120	Alzheimer's disease	Enrichment	MAPT	1.58
121	Periventricular nodular heterotopia	Enrichment	MAP1B	1.54
122	Lynch syndrome	Enrichment	PIK3CA	1.52
123	Noonan syndrome and noonan-related syndrome	Enrichment	CBL	1.52
124	Rhabdomyosarcoma	Enrichment	CBL	1.49
125	Alzheimer disease, familial, 1	Enrichment	MAPT	1.46
126	Craniosynostosis	Enrichment	GRIN2B	1.39
127	Endometrial cancer	Enrichment	PIK3CA	1.37
128	Hepatocellular carcinoma	Enrichment	PIK3CA	1.35
129	Attention deficit-hyperactivity disorder	Enrichment	MAP1B	1.35
130	Myocardial infarction	Enrichment	LRP8	1.35
131	Noonan syndrome 1	Enrichment	CBL	1.33
132	Parkinson disease, late-onset	Enrichment	MAPT	1.31
133	Rasopathy	Enrichment	CBL	1.28
134	Bladder cancer	Enrichment	PIK3CA	1.23
135	Prostate cancer	Enrichment	PIK3CA	1.23
136	Lung cancer	Enrichment	PIK3CA	1.19
137	Cerebral palsy	Enrichment	GRIN2B	1.11
138	Gastric cancer	Enrichment	PIK3CA	1.07
139	Nephrotic syndrome	Enrichment	ITGA3	1.07
140	West syndrome	Enrichment	GRIN2B	1.06
141	Autosomal dominant non-syndromic intellectual disability	Enrichment	GRIN2B	1.01
142	Hypertelorism	Enrichment	PIK3CA	0.99
143	Rare autosomal dominant non-syndromic sensorineural deafness type dfna	Enrichment	MAP1B	0.99
144	Spastic ataxia	Enrichment	DAB1	0.98
145	Frontotemporal dementia and/or amyotrophic lateral sclerosis 7	Enrichment	MAPT	0.95
146	Schizophrenia	Enrichment	RELN	0.94
147	Congenital nervous system abnormality	Enrichment	VLDLR	0.70
148	Nervous system disease	Enrichment	VLDLR	0.70
149	Microcephaly	Enrichment	GRIN2B	0.65
150	Complex neurodevelopmental disorder	Enrichment	GRIN2B	0.64

¹ WikiPathways

² PubChem

³ R&D Systems

⁴ Reactome

⁵ GeneGo (Thomson Reuters)

⁶ QIAGEN

⁷ PharmGKB

⁸ Cell Signaling Technology

⁹ Sino Biological

¹⁰ Tocris

¹¹ MalaCards

Reelin signaling pathway

Pathway Network for Reelin signaling pathway

Member Pathways for Reelin signaling pathway

Pathways in the Reelin signaling pathway SuperPath

Associated Genes for Reelin signaling pathway

Associated Disorders for Reelin signaling pathway

Disorders associated with Reelin signaling pathway SuperPath

STRING Interaction Network for Reelin signaling pathway

Sources for Reelin signaling pathway